Clinical trials: Progesterone Receptor Negative
Anatomic Stage IA Breast Cancer AJCC v8, Anatomic Stage IB Breast Cancer AJCC v8
Nipple Aspirate Fluid in Detecting Breast Cancer
This trial studies nipple aspirate fluid in detecting breast cancer. Nipple aspirate fluid may better detect breast cancer earlier than current methods used for screening such as mammograms and breast examinations.
- Conditions
- Anatomic Stage IA Breast Cancer AJCC v8, Anatomic Stage IB Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage IIA Breast Cancer AJCC v8
- Trial name
- NCT03715959
- Testing
- Aspiration of Breast, Biospecimen Collection
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
HIV
A Clinical Trial in Adult Participants Without HIV and in Overall Good Health to Evaluate the Safety and Immunogenicity of CD4BS CH505M5 Pr-NP1 Followed by CH505 TF chTrimer Boost Both Adjuvanted With Either Lipid Nanoparticles (LNPs) or 3M-052-AF + Alum
This is a multicenter, open-label, phase 1 clinical trial to test two human immunodeficiency virus (HIV) vaccines with two adjuvants.
- Trial name
- NCT06267872
- Testing
- CD4BS CH505M5 Pr-NP1, CH505TF chTrimer, 3M-052-AF (labeled as AP 60-702)
- Where
- 6 sites in United States, South Africa
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Diabetes Mellitus, Type 2, Obesity
Culturally Adapted Dietary Clinical Trial in PR
This project will determine whether a diet culturally adapted to adults in Puerto Rico can effectively decrease cardiometabolic risk factors.
- Conditions
- Diabetes Mellitus, Type 2, Obesity, Hypertension, Dyslipidemias
- Trial name
- PRECISION (NCT05962372)
- Testing
- Culturally tailored food and diet advice, Standard healthy eating advice
- Where
- Puerto Rico
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Harvard School of Public Health (HSPH)
Hypoxia
Accuracy of Pulse Oximeters With Profound Hypoxia At Rest (NIHO19)
The aim of this study is to determine the accuracy of devices called pulse oximeters, which measure blood oxygen by shining light through fingers, ears or other skin, without requiring blood sampling.
- Trial name
- NCT05807477
- Testing
- Pulse Oximeter
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Nihon Kohden
Healthy, ECG
Evaluation of CSF-3 in Performing ECG
CSF-3 is a wrist-worn medical device similar to a watch. It is designed to monitor a user's heart rate based on ECG (electrocardiogram) and PPG (Photoplethysmograph) readings, using off-the-shelf ECG and unique PPG chipsets with…
- Trial name
- ECG (NCT05591157)
- Testing
- CSF-3 watch, designed to monitor a user's heart rate based on ECG (electrocardiogram) and PPG (Photoplethysmograph) readings
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- CardiacSense Ltd.
Hemorrhage, Postpartum, Placenta Previa
Tranexamic Acid for the Prevention of Postpartum Hemorrhage in Pregnant Women With Placenta Previa
Many RCT(randomized controlled trial) studies reported that tranexamic acid reduced blood loss in women who had elective cesareans.
- Trial name
- TRAPP (NCT05811676)
- Testing
- Tranexamic acid, 0.9% sodium chloride
- Where
- 27 sites in China
- Volunteers
- 1,732 people, healthy volunteers welcome
- Sponsor
- Guangzhou Medical University
Pharmacokinetics
Pharmacokinetic Characterization of Two Novel CG5503 Tablet Formulations in Healthy Volunteers
This study investigated the pharmacokinetics (how a drug is taken up and excreted from the body), safety, and tolerability of 2 new tapentadol (CG5503) tablet formulations compared to a previously characterized tapentadol…
- Trial name
- NCT03956134
- Testing
- Tapentadol Test Product 1, Tapentadol Test Product 2, Tapentadol Prolonged-release Reference Product
- Where
- Germany
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Grünenthal GmbH
Adequate Reporting in Published Study Protocols of Randomized Controlled Trials
A Short SPIRIT Checklist for Peer Reviewers to Improve the Reporting Quality in Published Articles (SPIRIT-PR)
Transparent and accurate reporting is key, so that readers can adequately interpreting the results of a study. The aim of this project is to evaluate whether reminding peer reviewers of the most important SPIRIT reporting items…
- Trial name
- SPIRIT-PR (NCT05820984)
- Testing
- SPIRIT checklist plus usual practice, Usual practice
- Where
- United Kingdom
- Volunteers
- 178 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Healthy
A Pharmacokinetics (PK) and Safety Study of Oral Fampridine-PR 10 mg in Chinese, Japanese, and Caucasian Adult Healthy Volunteers
The primary objective of the study is to determine the Pharmacokinetic (PK) and safety profiles of fampridine-PR 10 mg in Chinese and Japanese adult healthy volunteers.
- Trial name
- NCT01215084
- Testing
- BIIB041 (Fampridine-PR)
- Where
- 2 sites in Australia, Hong Kong
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Biogen
Cardiorespiratory Fitness
Sprint Snacks: The Effects of Prolonged Rest on Reduced Exertion Interval Training.
An adapted sprint interval training protocol involving 2-3 repeated 20-second sprints separated by 2-3 minutes rest (termed reduced exertion high- intensity interval training (REHIIT)) has been developed and has been shown to…
- Trial name
- NCT03159949
- Testing
- REHIIT, PR-REHIIT
- Where
- Canada
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
HIV Infection
Safety and Immunogenicity Study of tgAAC09, a Gag-PR-RT AAV HIV Vaccine
The purpose of this study is to determine safety and immunogenicity (ability to induce an immune response) of a novel HIV vaccine based on adeno-associated virus (AAV)
- Trial name
- A001 (NCT00482027)
- Testing
- tgAAC09
- Where
- 5 sites in Belgium, Germany and 1 more
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- International AIDS Vaccine Initiative
Hypoxia
Accuracy of Pulse Oximeters With Profound Hypoxia During Motion
The aim of this study is to determine the accuracy of devices called pulse oximeters, which measure blood oxygen by shining light through fingers, ears or other skin, without requiring blood sampling.
- Trial name
- NIHO12 (NCT04814342)
- Testing
- Pulse oximeter
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Nihon Kohden
Human Immunodeficiency Virus Infections, HIV Infections
Safety and Immunogenicity Study of tgAAC09, an HIV Vaccine in an Adeno-associated Virus (AAV) Capsid
This phase 2 study will evaluate the safety, immunogenicity and optimal timing of two injections at three dose levels of the tgAAC09 vaccine in healthy volunteers.
- Trial name
- TGC14F (NCT00888446)
- Testing
- tgAAC09, Formulation buffer
- Where
- 5 sites in South Africa, Uganda and 1 more
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- International AIDS Vaccine Initiative
Mantle Cell Lymphoma
Phase II Study of Pirtobrutinib, Rituximab (PR) in Previously Untreated Low and Intermediate Risk MCL (Mantle Cell Lymphoma) Patients
To learn if the chemotherapy-free combination of pirtobrutinib (also called LOXO-305) and rituximab can help provide long term remission in low and intermediate risk MCL.
- Trial name
- NCT06263491
- Testing
- Rituximab, Pirtobrutinib
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Congenital Heart Block, Neonatal Lupus
Dexamethasone Treatment for Congenital Heart Block (CHB) in Newborns With Lupus
Some newborns are born with congenital heart block (CHB), a condition occurring in babies with neonatal lupus. The first part of the study will test the effectiveness of fluorinated steroids, including dexamethasone, in improving…
- Conditions
- Congenital Heart Block, Neonatal Lupus, Atrioventricular Nodal Dysfunction, Myocardial Injury
- Trial name
- NCT00007358
- Testing
- Dexamethasone or other corticosteroid
- Where
- 4 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Sudden Unexplained Infant Death, Apnea of Newborn
Advanced Wireless Sensors for Neonatal Care in the Delivery Room
The goals of this observational study is to assess whether a new advanced wireless skin sensor vital sign monitoring system can effectively monitor the vital signs of healthy newborn infants (≥ 35 weeks gestational age).
- Conditions
- Sudden Unexplained Infant Death, Apnea of Newborn, Newborn Morbidity, Newborn Asphyxia
- Trial name
- AWARD (NCT06693817)
- Testing
- Wireless skin sensors vital sign monitoring system, Wired vital sign monitoring system
- Where
- 5 sites in Brazil, Canada and 2 more
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Guilherme Sant'Anna, MD
Non Invasive Blood Pressure
Philips Non-Invasive Blood Pressure Validation Study of VS30 Monitor
The purpose of this study is to provide supporting documentation of the blood pressure performance for the Philips EarlyVue VS30 monitor on the intended adult and pediatric population.
- Trial name
- NCT06980766
- Testing
- Non Invasive Blood Pressure
- Where
- United States
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Philips Clinical & Medical Affairs Global
Hypertension
Lifelight Non-Invasive Blood Pressure and Heart Rate Validation Study
Lifelight is a novel, calibration-free, software-only medical device that contactlessly measures pulse rate and blood pressure by measuring remote photoplethysmography (rPPG) signals of a patient's face using a standard…
- Trial name
- NCT06535152
- Testing
- Lifelight, Manual sphygmomanometer
- Where
- United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Xim Limited
Opioid Substitution Treatment
Study to Assess Pharmacokinetic (PK), Bioavailability & Food Effect of MR902 Compared With Immediate Release (IR) Morphine Sulphate Oral Solution
A study to assess bioavailability of a single dose of MR902 and to assess the effect of food on absorption
- Trial name
- NCT02773316
- Testing
- MR902, IR morphine sulphate
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Mundipharma Research Limited
Fasting
Bioequivalence Study of Amlodipine / Losartan/ Hydrochlorothiazide of PHARMALINE, Lebanon Under Fastion Conditions
To assess the bioequivalence of the investigational TEST product with the marketed REFERENCE products by measurement of Plasma concentrations of Amlodipine ,Losartan, Carboxylic acid losartan metabolite \& Hydrochlorothiazide in…
- Trial name
- NCT01713647
- Testing
- Amlodipin, losartan, HCTZ
- Where
- Jordan
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Pharmaceutical Research Unit, Jordan