Clinical trials: Progesterone
Fibroid
Ulipristal Use in Chinese Population
Uterine leiomyomas is the commonest benign tumour of the female genital tract. It lead to menorrhagia, anaemia, pain and pressure symptoms. Due to the enlarged uterus, the use of minimal invasive surgery is limited.
- Trial name
- NCT02825719
- Testing
- Ulipristal acetate, Ferrous sulphate, Tranexamic Acid
- Where
- Hong Kong
- Volunteers
- 31 people
- Sponsor
- Queen Mary Hospital, Hong Kong
Endometrial Receptivity
Serum and Uterine Progesterone Levels and ERA Test.
Since the implantation is related with endometrial receptivity, the patient specific plasma progesterone concentration influences this pattern.
- Trial name
- NCT03456375
- Where
- Spain
- Volunteers
- 75 people
- Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA
Pregnancy Related, Infertility, Female
Comparison of Live Birth Rate in Natural Cycle Single Euploid FET Versus Without Luteal Phase Support
To evaluate whether single euploid embryo transfer in NC without routinely administered LPS is non-inferior to NC with routinely administered LPS.
- Trial name
- NCT05969795
- Testing
- Transvaginal ultrasound, Serial serum LH, E2, P4, Progesterone 100 Mg Vaginal Insert
- Where
- 3 sites in United Arab Emirates
- Volunteers
- 342 people, healthy volunteers welcome
- Sponsor
- ART Fertility Clinics LLC
Ovulation, Female Fertility
FemiClock: Non-invasive Tools Development (Salivary and Hair Progesterone) for Ovulation Detection in Heathy Women With Regular Menstrual Cycles Without Contraception.
Currently, the gold standard to confirm ovulation is measuring LH and/or progesterone in blood. However, because confirmation requires a blood sample, this approach is not suitable for epidemiological studies evaluating the…
- Conditions
- Ovulation, Female Fertility, Menstrual Cycle
- Trial name
- FemiClock (NCT07687823)
- Testing
- Diagnostic Test: Non-invasive ovulation biomarker assessment - Smartwatch, Diagnostic Test: Non-invasive ovulation biomarker assessment - Questionnaires, Hormonal blood assessment
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
Early-stage Breast Cancer, Hormone Receptor Positive Tumor
A Window of Opportunity Study of Pre-operative Endocrine Therapy With and Without Prometrium in Postmenopausal Women With Early Stage Breast Hormone Receptor Positive (HR+) Human Epidermal Receptor 2 Negative (HER2-) Breast Cancer.
A phase II randomised, open label study of pre-operative endocrine therapy with \& without prometrium in postmenopausal women with early stage breast hormone receptor positive (HR+) human epidermal receptor 2 negative (HER2-)…
- Trial name
- WinPro (NCT03906669)
- Testing
- Letrozole, Letrozole and Prometrium, Tamoxifen and Prometrium
- Where
- Australia
- Volunteers
- 200 people
- Sponsor
- St Vincent's Hospital
Adult Solid Tumor, Adenocarcinoma of the Colon
Phase II Trial of the Cyclin-Dependent Kinase Inhibitor PD 0332991 in Patients With Cancer
RATIONALE: PD 0332991 may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. PURPOSE: This phase II trial is studying the side effects and how well PD 0332991 works in treating patients with…
- Conditions
- Adult Solid Tumor, Adenocarcinoma of the Colon, Adenocarcinoma of the Rectum, Adult Central Nervous System Germ Cell Tumor
- Trial name
- NCT01037790
- Testing
- PD-0332991
- Where
- United States
- Volunteers
- 304 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Endometrium Cancer
Risk Evaluation and Screening to Tailor Prevention and Reduce the Incidence of Endometrial Cancer
This study proposes to assess feasibility and acceptability of screening and risk reducing interventions in individuals at increased for endometrial cancer (EC).
- Trial name
- RESToRE (NCT05651282)
- Testing
- Provera
- Where
- Canada
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Pre-term Birth, HIV-1-infection
Improving Pregnancy Outcomes With Progesterone
This is a phase III, double-masked, placebo-controlled, randomized controlled trial taking place in Zambia.
- Trial name
- IPOP (NCT03297216)
- Testing
- 17P
- Where
- 2 sites in Zambia
- Volunteers
- 800 people
- Sponsor
- University of North Carolina, Chapel Hill
Preterm Birth, Obstetric Labor, Premature
Prevention of Preterm Labor in Patients With a Previous Episode of Threatened Preterm Labor With Progesterone
The purpose of this study is to determine if the use of 250 mg of intramuscular progesterone biweekly can reduce the incidence of preterm labor in patients with an episode of threatened preterm labor during the current pregnancy.
- Trial name
- NCT01317225
- Testing
- 17 α hydroxyprogesterone caproate
- Where
- Panama
- Volunteers
- 80 people
- Sponsor
- Saint Thomas Hospital, Panama
Infertility
Luteal Support and Intrauterine Insemination (IUI) With Clomiphene Citrate
The purpose of this study is to assess the effect of luteal phase supplement (LPS) on pregnancy rate in IUI cycles stimulated with clomiphene citrate.
- Trial name
- NCT01046708
- Testing
- micronized progesterone
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Menopause
Vasomotor Symptoms (VMS) Progesterone Study: Vasomotor Symptoms and Endothelial Function - Trial of Oral Micronized Progesterone
The primary purpose of this study is to determine the effects of a full dose (300 mg at hs) of oral micronized progesterone (OMP) on vasomotor symptoms [VMS] (hot flushes/night sweats), on forearm blood flow and on lipid levels…
- Trial name
- NCT00152438
- Testing
- Oral Micronized Progesterone (Prometrium®)
- Where
- Canada
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Estrogen Receptor Negative, Estrogen Receptor Positive
Pembrolizumab and Doxorubicin Hydrochloride or Anti-Estrogen Therapy in Treating Patients With Triple-Negative or Hormone Receptor-Positive Metastatic Breast Cancer
This phase II trial studies how well pembrolizumab and doxorubicin hydrochloride works compared to pembrolizumab with anti-estrogen therapy (anastrozole, letrozole, or exemestane) in treating patients with triple-negative or…
- Conditions
- Estrogen Receptor Negative, Estrogen Receptor Positive, HER2/Neu Negative, Progesterone Receptor Negative
- Trial name
- NCT02648477
- Testing
- Anastrozole, Doxorubicin Hydrochloride, Exemestane
- Where
- 6 sites in United States
- Volunteers
- 30 people
- Sponsor
- City of Hope Medical Center
Premenstrual Syndrome, Depression
Combined Hormone Replacement in Menstrually-Related Mood Disorders
This study investigates the effects on symptoms of combined treatment with estrogen and progesterone in women with severe premenstrual syndrome (PMDD).
- Trial name
- NCT00005011
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- National Institute of Mental Health (NIMH)
Infertility
Sexual Intercourse and Vaginal Absorption of Progesterone
The objective of this project is to compare the vaginal absorption of progesterone administered in the vaginal ovum by measuring progesteroneemia in 3 situations (or "sexual event"): abstinence, sex protected by condoms and…
- Trial name
- SexVAP (NCT05232344)
- Testing
- Estradiol / Progesterone, Sexual event
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Placenta Previa
Vaginal Progesterone Versus 17-Alpha-Hydroxyprogesterone Caproate in Placenta Previa
Purpose to evaluate the effects of Vaginal Progesterone versus 17-Alpha-Hydroxyprogesterone Caproate for prevention of Emergent Cesarean Delivery in Asymptomatic Pregnant Women with Placenta Previa
- Trial name
- NCT03779451
- Testing
- 17-OHPC, vaginal progesterone
- Where
- Egypt
- Volunteers
- 400 people
- Sponsor
- Aswan University Hospital
Nicotine Dependence
Effects of Progesterone on Smoked Nicotine Induced Changes in Hormones and Subjective Ratings of Stimulant Drug Effects
The clinical studies propose to study the abuse-related effects of nicotine after progesterone administration during the follicular phase in women of reproductive age.
- Trial name
- NCT01636336
- Testing
- Nicotine, Progesterone
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Breast Tumor, Breast Cancer
Evaluate Risk/Benefit of Nab Paclitaxel in Combination With Gemcitabine and Carboplatin Compared to Gemcitabine and Carboplatin in Triple Negative Metastatic Breast Cancer (or Metastatic Triple Negative Breast Cancer)
The purpose of this study is to compare the safety and efficacy of nab-paclitaxel in combination with either gemcitabine or carboplatin to the combination of gemcitabine and carboplatin as first line treatment in female subjects…
- Conditions
- Breast Tumor, Breast Cancer, Cancer of the Breast, Estrogen Receptor- Negative Breast Cancer
- Trial name
- tnAcity (NCT01881230)
- Testing
- nab-Paclitaxel, Carboplatin, Gemcitabine
- Where
- 140 sites in United States, Australia and 10 more
- Volunteers
- 191 people
- Sponsor
- Celgene
Preeclampsia
Oral Progesterone and Low Dose Aspirin in the Prevention of Preeclampsia
This study investigates whether low dose aspirin combined with progesterone will decrease the risk of preeclampsia in pregnant women with a history of preeclampsia in a previous pregnancy.
- Trial name
- NCT00719537
- Testing
- Aspirin, Progesterone
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- John Uckele
Threatened Abortion, Progesterone Resistance
Progesterone Supplementation in Threatened Abortion
To decide whether progesterone supplementation in threatened abortion is a sound practice.
- Trial name
- Prothreat (NCT03930212)
- Testing
- Progesterone
- Where
- Egypt
- Volunteers
- 190 people
- Sponsor
- Tanta University
Breast Cancer, Metastasis
Study of Dasatinib (BMS-354825) in Patients With Advanced Estrogen/Progesterone Receptor-positive (ER+/PR+) or Her2/Neu-positive (Her2/Neu+)Breast Cancer
This study will determine whether the investigational drug dasatinib is effective in treatment of women with progressive advanced ER+/PR+ or Her2/neu+ breast cancer
- Trial name
- NCT00371345
- Testing
- Dasatinib, Dasatinib 100 mg
- Where
- 23 sites in United States, Argentina and 5 more
- Volunteers
- 92 people
- Sponsor
- Bristol-Myers Squibb