Clinical trials: Procedure
Aortic Valve Stenosis
Impact of Postdilatation With the InterValve V8 Aortic Valvuloplasty Balloon Following TAVI Procedure
This study is designed to monitor the safety and performance of the V8 balloon when used as a postdilatation balloon in self-expanding Transcatheter Aortic Valve Implantation (TAVI) device procedures.
- Trial name
- PostCorE (NCT02472106)
- Testing
- Post-dilatation
- Volunteers
- 9 people
- Sponsor
- InterValve, Inc.
Bariatric Surgery Candidate
Exercise Training Study Before Bariatric Surgery
The goal of this clinical trial is to figure out if 8 weeks of walking exercise before bariatric surgery improves risk factors for diabetes and other markers of health.
- Trial name
- BaSE (NCT06274606)
- Testing
- Exercise Group
- Where
- United States
- Sponsor
- University of Virginia
Breast Cancer, Colorectal Cancer
A Guided Written Disclosure Intervention to Promote Post-traumatic Growth in Cancer Patients GUIDED WRITTEN DISCLOSURE
This study aims to investigate the efficacy of Guided Written Disclosure Protocol (GWDP) in promoting post-traumatic growth through a process of meaning reconstruction in cancer patients at the end of chemotherapy.
- Trial name
- NCT02824484
- Testing
- GWDP, Control
- Where
- Italy
- Volunteers
- 250 people
- Sponsor
- Azienda USL Reggio Emilia - IRCCS
Muscle Loss, Physical Disability
Effects of High Protein Diet on Muscle Mass, Strength, and Physical Performance in Postmenopausal Women
Despite the importance of preventing muscle mass loss during senescence, only a few studies have investigated the relationship between diet and muscle mass in postmenopausal women.
- Trial name
- NCT03652584
- Testing
- High Protein Diet, Control Diet
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas de Porto Alegre
Misophonia
Psychological Intervention for Misophonia
The investigators are proposing to test Acceptance and Commitment Therapy (ACT)+ traditional audiological behavioral intervention as an integrated, multi-disciplinary approach for the assessment and treatment of misophonia.
- Trial name
- NCT05601284
- Testing
- Acceptance and commitment therapy, Progressive relaxation training
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Utah State University
Diabetes Mellitus, Type 2
A Research Study to Understand How Oral Semaglutide Works in People With Type 2 Diabetes in India
The purpose of the study is to look at the change in blood sugar levels in participants with type 2 diabetes who start using oral semaglutide. Participants will get oral semaglutide as prescribed to them by the study doctor.
- Trial name
- PIONEER REAL (NCT05502562)
- Testing
- Oral semaglutide
- Volunteers
- 388 people
- Sponsor
- Novo Nordisk A/S
Aging, Physical Activity
A 12-week Intervention With Motivational Interviewing and Physical Activity Monitoring, to Enhance the Daily Amount of Physical Activity in Community Dwelling Older Adults - a Randomized Controlled Trial
To investigate if motivational-interviewing will enhance the expected effect from physical activity monitors, on physical activity in older adults, we will conduct a two-arm randomized controlled trial in 2019.
- Conditions
- Aging, Physical Activity, Older Adults
- Trial name
- MIPAM (NCT03906162)
- Testing
- Motivational interviews, Base intervention
- Where
- Denmark
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Post-COVID Syndrome
Complementary and Integrative Medicine as an Online Intervention in Patients With Post-covid Syndrome After COVID-19
The Post-COVID syndrome is a COVID-19 sequelae disease with high individual burden. We conduct a prospective, two-arm, randomized-controlled intervention study with embedded qualitative and physiological sub-studies in a…
- Trial name
- NCT06004362
- Testing
- Complementary and Integrative Medicine online intervention, routine care and book, Routine care and book
- Where
- Germany
- Volunteers
- 120 people
- Sponsor
- Charite University, Berlin, Germany
Breast Cancer
TACTIVE-U: A Study to Learn About the Study Medicine (Vepdegestrant) When Given With Other Medicines in People With Advanced or Metastatic Breast Cancer (Sub-Study A)
The purpose of this clinical trial is to learn about the safety and effects of the study medicine (called ARV-471) when given together with other medicines for the potential treatment of advanced or metastatic breast cancer.
- Trial name
- NCT05548127
- Testing
- ARV-471, Abemaciclib
- Where
- 37 sites in United States, Canada and 2 more
- Volunteers
- 37 people
- Sponsor
- Pfizer
Pediatric Obesity
Impact of Comprehensive Intervention on the Cardiometabolic Risk in Children With Central Obesity (IGENOI)Obesity
Central obesity, present in the metabolic syndrome (MS), is associated with increased risk of insulin resistance (RI). The aim of the project is to evaluate the protective effect of comprehensive intervention (Mediterranean diet…
- Trial name
- IGENOI (NCT03147261)
- Testing
- Lifestyle intervention
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Dementia, Mobile Applications
Pilot Study Person-centred Tablet Intervention
First evaluation of FindMyApps, a tablet intervention consisting of a selection tool for usable apps for self-management and meaningful activities and a training that supports informal carers to help people with dementia to learn…
- Conditions
- Dementia, Mobile Applications, Computers, Neurological Rehabilitation
- Trial name
- NCT04026061
- Testing
- FMA group, Control group
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Saxion University of Applied Sciences
Upper Limb Spasticity
A Study to Compare the Safety and Efficacy of Dysport® and Botox® in Adults With Upper Limb Spasticity.
This study is aiming to demonstrate the non-inferiority of AbobotulinumtoxinA (aboBoNT-A) versus OnabotulinumtoxinA (onaBoNT-A) as the primary safety endpoint, and the superiority of aboBoNT-A over onaBoNT-A with respect to…
- Trial name
- DIRECTION (NCT04936542)
- Testing
- AboBoNT-A, OnaBoNT-A
- Where
- 76 sites in United States, Canada and 2 more
- Volunteers
- 464 people
- Sponsor
- Ipsen
Suicide, Attempted
Socio-Educational Intervention for Rural Suicide Attempters
Compared to a treatment-as-usual group, providing brief mental health education to suicide attempters from rural parts of China at the time of their treatment in the emergency departments of general hospitals or local clinics and…
- Trial name
- NCT00808873
- Testing
- socio-educational intervention
- Where
- China
- Volunteers
- 450 people
- Sponsor
- Beijing HuiLongGuan Hospital
Any Chronic, Non-traumatic Orthopedic Condition
Testing an AI Large Language Model Tool for Cognitive Debiasing in Musculoskeletal Care
The goal of this clinical trial is to find out whether using an artificial intelligence (AI) tool called a Large Language Model (LLM) can help patients think more clearly about their symptoms and improve their trust and…
- Trial name
- NCT07022769
- Testing
- LLM-facilitated cognitive debiasing aid
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Texas at Austin
Chronic Interstitial Cystitis, Bladder Pain Syndrome
Pain Type and Interstitial Cystitis/Bladder Pain Syndrome Treatment
Interstitial cystitis/bladder pain syndrome (IC/BPS) is a severe pain condition affecting 3-8 million people in the United States lacking treatments that work.
- Conditions
- Chronic Interstitial Cystitis, Bladder Pain Syndrome, Painful Bladder Syndrome, Cystitis, Interstitial
- Trial name
- NCT06299683
- Testing
- Psychosocial Treatment, Pelvic Floor Physical Therapy
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- Vanderbilt University Medical Center
HIV/AIDS, Cancer
Suubi4Cancer: Improving Access to Pediatric Cancer Services and Treatment Adherence Among Children Living With HIV/AIDS
This study will tailor and explore the short-term preliminary outcomes of an existing evidence-based Economic Empowerment (EE) Intervention, Suubi (Hope in Luganda -local Ugandan language), on access to pediatric cancer…
- Trial name
- NCT03916783
- Testing
- Combination intervention
- Where
- Uganda
- Sponsor
- Washington University School of Medicine
Esophageal Achalasia, Esophageal Motility Disorders
Different Surgical Procedures of Peroral Endoscopic Myotomy(POEM) for Esophageal Achalasia
This study compares the clinical efficacy of safety of circular myotomy and full-thickness myotomy guided by peroral endoscopic in treatment of incision length of ≤7cm and of ≥7cm in achalasia patients.
- Trial name
- NCT03012854
- Testing
- short-myotomy, long-myotomy, full-thickness myotomy
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Anemia, Iron Deficiency
Efficacy of Double Fortified Salt (DFS) to Improve Work Productivity in Women in India
The main objective of the present study is to assess the impact of double fortified salt containing iron and iodine on work performance (productivity) of women plantation workers in India.
- Trial name
- DFS (NCT01032005)
- Testing
- double fortified salt
- Where
- India
- Volunteers
- 248 people, healthy volunteers welcome
- Sponsor
- Micronutrient Initiative
CR Before:Engaging in Cognitive Intervention Before Exposure, CR After:Engaging in Cognitive Intervention After Exposure
The Effect of Cognitive Restructuring Before Exposure for Claustrophobia on Expectancy and Outcome
Whether used alone or in combination with other approaches, strategies such as cognitive restructuring (CR) and exposure are well-established treatments for anxiety.
- Trial name
- NCT03628105
- Testing
- CR Before Exposure, CR After Exposure
- Where
- Canada
- Volunteers
- 97 people
- Sponsor
- Kirstyn L. Krause
Postmenopausal Osteoporosis
Molecular Mechanism of POP Kidney Yin Deficiency Syndrome From the Interventional Effects of CLCF1
This study use RT-PCR and Western Blot technique to detect the expression of CLCF1 mRNA and protein in POP Kidney Yin deficiency group and healthy group to verify the relevance between CLCF1 and POP the kidney Yin deficiency…
- Trial name
- pop (NCT01834105)
- Testing
- Liuwei Dihuang Pills
- Where
- China
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Fujian Academy of Traditional Chinese Medicine