Clinical trials: Procedural Sedation
Procedural Pain
Pharmacogenetics of Ketamine in Children
The need to treat the children with painful diagnostic-therapeutic procedures has increased in the last years. There is evidence from a wide scientific literature that drugs available in the setting of procedural sedation and…
- Trial name
- NCT05796232
- Where
- Italy
- Volunteers
- 250 people
- Sponsor
- IRCCS Burlo Garofolo
Bronchoscopy, Procedural Sedation
Ciprofol Versus Propofol With Low-Dose Sufentanil for Painless Bronchoscopy
Bronchoscopy may cause coughing, discomfort, body movement, and changes in breathing or blood pressure. Propofol is commonly used for sedation during bronchoscopy, but it may cause respiratory depression, circulatory depression…
- Trial name
- NCT07744061
- Testing
- Ciprofol, Propofol, Sufentanil
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Wenzhou Central Hospital
Bronchoscopy
A Phase III Study of Remimazolam in Patients Undergoing Bronchoscopy
A prospective, double-blind, randomized, placebo and active controlled, multi-center, parallel group study comparing remimazolam to placebo, with an additional open label arm for midazolam, in patients undergoing a bronchoscopy.
- Trial name
- NCT02296892
- Testing
- Remimazolam, Midazolam
- Where
- 14 sites in United States
- Volunteers
- 446 people
- Sponsor
- Paion UK Ltd.
ENDOBRONCHIAL ULTRASOUND - TRANSBRONCHIAL NEEDLE ASPIRATION, Procedural Sedation and Analgesia
Consent Understanding and Propofol Requirement During Endobronchial Ultrasound
The goal of this observational study is to learn whether a participant's understanding of the informed consent information is related to the amount of propofol needed during endobronchial ultrasound (EBUS).
- Conditions
- ENDOBRONCHIAL ULTRASOUND - TRANSBRONCHIAL NEEDLE ASPIRATION, Procedural Sedation and Analgesia, Informed Consent
- Trial name
- NCT07677982
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Uludag University
MRI Sedation
Safety and Efficacy of Dexmedetomidine (DEX) for Sedation of Subjects ≥1 Month to <17 Years Undergoing MRI Scans
This is a randomized, double-blind, dose-ranging study of the efficacy and safety of dexmedetomidine (DEX) when used with propofol as needed, for procedural sedation of pediatric subjects ≥1 month to <17 years of age undergoing…
- Trial name
- NCT04237792
- Testing
- dexmedetomidine, propofol
- Where
- 23 sites in United States, Japan
- Volunteers
- 128 people
- Sponsor
- Pfizer
Analgesia
Techniques to Reduce the Severity and Frequency of Emergent Reactions
The objectives of this study are first to determine if the power of suggestion will decrease the frequency and severity of emergence reactions after procedural sedation and analgesia with ketamine in the setting of the emergency…
- Trial name
- NCT03832309
- Testing
- Do we speak to them in a way that convinces them to have the dream, Speaking to them as a regualar person
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- CHRISTUS Health
Sedation, Gastrointestinal Endoscopy
Remimazolam Combined With Oliceridine for Sedation in Elderly Patients Undergoing Gastrointestinal Endoscopy
This study aims to evaluate the sedative efficacy and safety of remimazolam combined with oliceridine in elderly patients undergoing painless gastrointestinal endoscopy.
- Trial name
- RMZ-OLI-ENDO (NCT07707258)
- Testing
- Remimazolam Tosilate for Injection, Oliceridine Fumarate
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Baoshan Branch, Renji Hospital, Shanghai Jiao Tong University School of Medicine
Procedural Sedation, Endoscopy
Dose-Finding Safety Study Evaluating Remimazolam (CNS 7056) in Patients Undergoing Diagnostic Upper GI Endoscopy
The purpose of this study was to assess the safety and efficacy of CNS 7056 as a procedural sedative at three dose levels compared to midazolam during a diagnostic upper GI endoscopy.
- Trial name
- NCT00869440
- Testing
- CNS 7056, Midazolam
- Where
- 7 sites in United States
- Volunteers
- 100 people
- Sponsor
- Paion UK Ltd.
Procedural Sedation, Propofol
Safety and Efficacy of Propofol Only Sedation in Oral and Maxillofacial Surgery
The purpose of this study is to determine if the use of propofol only to achieve procedural sedation for the removal of third molars is both safe and effective.
- Trial name
- NCT01227174
- Testing
- Propofol
- Where
- Canada
- Volunteers
- 169 people, healthy volunteers welcome
- Sponsor
- Atlantic Center for Oral and Maxillofacial Surgery
Fracture, Dislocation
Intranasal Dexmedetomidine Plus Ketamine for Procedural Sedation
Orthopedic injuries comprise more than 10% of ED visits in children and 25 to 50% of children will sustain a fracture before age 16 years.
- Trial name
- Ketodex (NCT04195256)
- Testing
- IN Ketodex (D4K2), IN Ketodex (D3K3), IN Ketodex (D2K4)
- Where
- 6 sites in Canada
- Volunteers
- 400 people
- Sponsor
- Naveen Poonai
Pain
Analgesia During Pediatric Digestive Endoscopy: a Comparison of Two Protocols for Procedural Sedation
The purpose of this study is to determine whether ketamine, midazolam, and meperidine are more effective than midazolam and meperidine alone for procedural sedation and analgesia in pediatric digestive endoscopy.
- Trial name
- NCT01168492
- Testing
- ketamine
- Where
- Canada
- Volunteers
- 90 people
- Sponsor
- Université de Montréal
Bone Fractures, Dislocations
Intranasal Ketamine for Procedural Sedation
This study will examine the effectiveness of intranasal (IN) ketamine compared to standard intravenous (IV) ketamine administration for simple reductions of orthopaedic injuries in the paediatric population.
- Trial name
- INK (NCT02828566)
- Testing
- IN ketamine, IV ketamine, IN saline 0.9%
- Volunteers
- 470 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Conscious Sedation Failure During Procedure, Analgesia
Lidocaine as Local Anesthetics in Children Under Ketamine Sedation
Ketamine seems an obvious choice in the setting of an emergency department in laceration repair. Lidocaine is the local anesthetics widespread used. Ketamine leads to dissociative amnesia.
- Conditions
- Conscious Sedation Failure During Procedure, Analgesia, Anesthesia
- Trial name
- NCT02205502
- Testing
- Lidocaine, Normal saline
- Where
- South Korea
- Volunteers
- 58 people
- Sponsor
- Seoul National University Hospital
Procedural Sedation
Dexmedetomidine and Midazolam Nebulization as Sedation During Cesarean Delivery in Pre-eclampsia
Null hypothesis: There is no difference between the effects of nebulization of dexmedetomidine and midazolam as procedural sedation during cesarean delivery under spinal Anesthesia in pre-eclamptic parturients Alternative…
- Trial name
- NCT04873596
- Testing
- Nebulized dexmedetomidine, Nebulized midazolam
- Where
- Egypt
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Sedation
The Effect of Music on the Sedation Quality Among Children in the Emergency Department.
Children presenting to the emergency department frequently experience anxiety and may undergo various painful procedures. While sedative agents are administered to these patients, they do not consistently provide adequate relief…
- Trial name
- NCT06876194
- Testing
- Music intervention
- Where
- Iran
- Volunteers
- 88 people
- Sponsor
- Tehran University of Medical Sciences
Conscious Sedation
Ondansetron Reduce Vomiting Associated With Ketamine PSA
Ondansetron, a commonly used anti-vomiting medication, may reduce the occurrence of vomiting associated with ketamine during procedural sedation in the pediatric emergency department.
- Trial name
- NCT00387556
- Testing
- Ondansetron
- Where
- United States
- Volunteers
- 268 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Patient Comfort
Evaluation of Pain and Discomfort in the Cardiac Catheterization Lab
The purpose of this study is to explore how the timing of procedural sedation medications influences patient comfort and satisfaction with sedation.
- Trial name
- NCT04490369
- Where
- United States
- Volunteers
- 175 people
- Sponsor
- Duke University
Hyperoxia, Cardiac Output, Low
The Effect of Hyperoxia on Cardiac Output
Rational: Preoxygenation is a standard procedure before (deep) sedation in the ED. However, there is literature suggesting that too much oxygen can be harmful.
- Trial name
- NCT03930979
- Where
- Netherlands
- Volunteers
- 60 people
- Sponsor
- Frisius Medisch Centrum
Moderate, Deep Sedation
Optimal Dosing of Ketamine for Procedural Sedation and Analgesia in Children
There is a wide variation of published IV ketamine dosing regimens used for procedural sedation in children in the Emergency Department (ED).
- Trial name
- NCT02519595
- Testing
- Ketamine IV 1mg/kg, Ketamine IV 1.5mg/kg, Ketamine IV 2mg/kg
- Volunteers
- 182 people
- Sponsor
- Children's Hospital of Michigan
Fractures, Dislocations
Ketamine Versus Fentanyl as an Adjunct to Propofol-Assisted Emergency Department Procedural Sedation
We, the investigators at Queen's University, propose to conduct a randomized, double-blind, feasibility trial comparing low-dose ketamine versus fentanyl as adjuncts to Emergency Department procedural sedation with propofol.
- Conditions
- Fractures, Dislocations, Abscess, Anesthesia
- Trial name
- NCT00137085
- Testing
- ketamine
- Where
- Canada
- Volunteers
- 124 people
- Sponsor
- Queen's University