Clinical trials: Procedural Sedation, open to volunteers
Hypoxemia, Eldery People
HFNC vs Conventional Oxygen During Gastrocolonoscopy in Elderly Patients
This study aims to compare high-flow nasal oxygen (HFNO) with conventional nasal cannula oxygen during sedation for combined upper and lower gastrointestinal endoscopy (gastroscopy and colonoscopy) in patients aged 75 years and…
- Conditions
- Hypoxemia, Eldery People, Endoscopy, Colonoscopy
- Trial name
- NCT07916298
- Testing
- HİGH FLOW NASAL CANNULA OXYGEN, NASAL CANNULA OXYGEN
- Where
- Turkey (Türkiye)
- Volunteers
- 154 people, healthy volunteers welcome
- Sponsor
- Turkish Society of Anesthesiology and Reanimation
ENDOBRONCHIAL ULTRASOUND - TRANSBRONCHIAL NEEDLE ASPIRATION, Procedural Sedation and Analgesia
Consent Understanding and Propofol Requirement During Endobronchial Ultrasound
The goal of this observational study is to learn whether a participant's understanding of the informed consent information is related to the amount of propofol needed during endobronchial ultrasound (EBUS).
- Conditions
- ENDOBRONCHIAL ULTRASOUND - TRANSBRONCHIAL NEEDLE ASPIRATION, Procedural Sedation and Analgesia, Informed Consent
- Trial name
- NCT07677982
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Uludag University
Procedural Sedation and Analgesia
PRedictors Of Maladaptive Behaviors in Children Undergoing Procedural SEDation
Procedural sedation for children outside of the operating room is a common practice in emergency departments, outpatient clinics, radiology suites, and dental offices for painful and anxiety-provoking procedures.
- Trial name
- PRoSEED (NCT07495826)
- Where
- 2 sites in Canada
- Volunteers
- 2,145 people
- Sponsor
- London Health Sciences Centre Research Institute
Hypotension, Hypoxemia
Predictors of Clinically Relevant Hypotension and Hypoxemia During Propofol-Based Diagnostic Gastrointestinal Endoscopy
This prospective observational cohort study will evaluate the incidence and independent predictors of clinically relevant hypotension and hypoxemia during propofol-based diagnostic gastrointestinal endoscopy in adult patients at…
- Trial name
- PRO-GI SAFE (NCT07613073)
- Testing
- Propofol, Diagnostic gastrointestinal endoscopy
- Where
- Vietnam
- Volunteers
- 1,000 people
- Sponsor
- Bach Mai Hospital
Deep Sedation, High Flow Nasal Canula
HFNO Flow Rates and Cerebral Oxygenation During Deep Sedation for Cystoscopy
For Patients and Families This study aims to investigate how high-flow oxygen therapy affects oxygen levels, especially brain oxygenation, during cystoscopy procedures performed under sedation.
- Conditions
- Deep Sedation, High Flow Nasal Canula, Cerebral Oxygenation, PSI
- Trial name
- NCT07630038
- Testing
- High-Flow Nasal Oxygen 40 L/min (HF40), High-Flow Nasal Oxygen 55 L/min (HF55), High-Flow Nasal Oxygen 70 L/min (HF70)
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Firat University
Procedural Sedation, Gastrointestinal Endoscopy
Therapeutic Effects of Music on Procedural Outcomes
This study will evaluate whether listening to low-tempo instrumental music during gastroscopy and/or colonoscopy can reduce the amount of sedative medication needed during the procedure.
- Conditions
- Procedural Sedation, Gastrointestinal Endoscopy, Music Intervention
- Trial name
- TEMPO (NCT07763860)
- Testing
- Low-Tempo Instrumental Music, Silent Audio Control
- Where
- Lebanon
- Volunteers
- 180 people
- Sponsor
- Bahaa Bou Dargham
Anxiety, Biliary and Pancreatic Diseases
Effect of Patient Anxiety Level Prior to Undergoing ERCP and Procedure Tolerability and Outcomes.
Endoscopic Retrograde Cholangiopancreatography (ERCP) is a specialized procedure combining upper GI endoscopy and x-rays to treat hepatopancreaticobiliary diseases. Patient experiences after ERCP has been relatively understudied.
- Conditions
- Anxiety, Biliary and Pancreatic Diseases, ERCP
- Trial name
- NCT07699731
- Testing
- Not applicable- observational study
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- Mandip Rai
Anesthesia, Sedation
EEG Signal Correlates During Anesthesia and Sedation in Adults and Children
This prospective, multicenter, non-interventional observational study investigates the correlates between electroencephalographic (EEG) signals and pharmacological/clinical parameters during general anesthesia and procedural…
- Conditions
- Anesthesia, Sedation, Consciousness Monitors
- Trial name
- SPECTRALADUPED (NCT07460414)
- Where
- 2 sites in France
- Volunteers
- 330 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pregnant People, Anxiety
Remimazolam Versus Dexmedetomidine for Sedation During Neuraxial
Patients presenting for a scheduled cesarean delivery who require a neuraxial anesthetic will be randomized to receive intravenous remimazolam or dexmedetomidine for procedural sedation during the placement of their spinal or…
- Trial name
- NCT07651956
- Testing
- Remimazolam, Dexmedetomidine
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Drug Safety
Use of Intranasal Midazolam to Reduce Stress and Procedural Pain in Premature Infants During Routine ROP Examination.
The goal of this study is to learn about the safety and effectiveness of intranasal midazolam in newborns and infants born prematurely, undergoing Retinopathy of Prematurity (ROP) screening.
- Trial name
- NCT06889376
- Testing
- Intranasal midazolam administration via the DART™ intranasal atomization device along with routine comfort care.
- Where
- Poland
- Volunteers
- 40 people
- Sponsor
- Polish Mother Memorial Hospital Research Institute
Procedural Sedation, Hypoxemia
HFNO Versus Face Mask for Cerebral Oxygenation During Procedural Sedation
This prospective randomized controlled trial aims to compare the effects of high-flow nasal oxygen (HFNO) and conventional face mask oxygen therapy on cerebral oxygenation during procedural sedation performed outside the…
- Conditions
- Procedural Sedation, Hypoxemia, Cerebral Oxygenation, SEDLine
- Trial name
- NCT07718295
- Testing
- High-Flow Nasal Oxygen (HFNO), Conventional Face Mask Oxygen
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Firat University
Biliary Tract Diseases, Procedural Sedation and Analgesia
Esketamine Versus Sufentanil for Sedation in Patients Undergoing ERCP
This study compares two anesthesia medications, esketamine and sufentanil, used together with propofol during ERCP procedures. The goal is to find out which combination provides better safety and comfort for people undergoing…
- Trial name
- ES-ERCP (NCT07702240)
- Testing
- Esketamine, Sufentanil
- Volunteers
- 530 people
- Sponsor
- Ren Da
Procedural Sedation, Gastrointestinal Endoscopy
SED Pack: Safety and Performance of a Medical Device Software for Predictive Monitoring During Sedation
The SED-PACK study is a prospective, observational, single-center clinical investigation evaluating the clinical performance and safety of SED Pack, a Medical Device Software (MDSW) developed by Predictheon Medical S.L., in a…
- Trial name
- NCT07749781
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Predictheon Medical, S.L.
Fracture, Dislocation
Intranasal Dexmedetomidine Plus Ketamine for Procedural Sedation
Orthopedic injuries comprise more than 10% of ED visits in children and 25 to 50% of children will sustain a fracture before age 16 years.
- Trial name
- Ketodex (NCT04195256)
- Testing
- IN Ketodex (D4K2), IN Ketodex (D3K3), IN Ketodex (D2K4)
- Where
- 6 sites in Canada
- Volunteers
- 400 people
- Sponsor
- Naveen Poonai
Burn Scar, Hypertrophic Scarring
Remimazolam vs Propofol in Laser Burn Cases
This randomized, single-blind, crossover study compares remimazolam and propofol for monitored anesthetic care during fractional ablative CO₂ laser therapy for burn scars.
- Conditions
- Burn Scar, Hypertrophic Scarring, Procedural Sedation
- Trial name
- NCT07213544
- Testing
- Remimazolam besylate, Propofol
- Where
- United States
- Volunteers
- 136 people
- Sponsor
- Medical University of South Carolina
Sedation and Analgesia Management in Patients Undergoing Flexible Bronchoscopy
Midazolam Alone Versus Midazolam With Ketorolac for Sedation During Flexible Bronchoscopy.
Flexible bronchoscopy has evolved into a vital diagnostic and therapeutic intervention in respiratory medicine due to its frequent and diverse applications.
- Trial name
- NCT07352059
- Testing
- Midazolam Alone, Midazolam + ketorolac
- Volunteers
- 50 people
- Sponsor
- SYED HAIDER ALI
Pain, Abortion
Diphenhydramine as an Adjunct to Moderate Sedation for Procedural First Trimester Abortions
This single center, double blind, randomized controlled trial will evaluate whether adding intravenous diphenhydramine to a standard moderate sedation regimen improves pain control during first trimester procedural abortion.
- Conditions
- Pain, Abortion, Anxiety
- Trial name
- NCT07542730
- Testing
- Diphenhydramine
- Where
- United States
- Volunteers
- 98 people
- Sponsor
- University of Rochester
Procedural Pain, Procedural Sedation and Analgesia
Effect of Ketamine on Optic Nerve Sheath Diameter During Procedural Analgesia
The goal of this observational study is to learn whether ketamine given for procedural analgesia changes intracranial pressure in adult emergency department patients.
- Conditions
- Procedural Pain, Procedural Sedation and Analgesia, Intracranial Pressure
- Trial name
- NCT07916064
- Testing
- ketamine
- Where
- Turkey (Türkiye)
- Volunteers
- 160 people
- Sponsor
- Ankara Etlik City Hospital
Capnography
The Effect of Oxygen Flow Rate on End-tidal CO2 During Deep Sedation
This study aims to detect the effect of different O2 flow rates on end tidal carbon dioxide level in patients scheduled for minor gynaecological procedures under deep sedation using laryngeal mask airway.
- Trial name
- NCT06824610
- Testing
- capnography
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Minia University