Clinical trials: Probiotics
Diabetes type2, Obesity
Epigenetic and Microbiota Modifications
In order to investigate how gut microbiota interventions are able to change gut microbiota population and impact insulin resistance, 30 type2 diabetes volunteers with obesity will be randomized to one of the three treatment…
- Trial name
- EPI-MICROBIO (NCT05076656)
- Testing
- Lactobacillus fermentum D3, Fecal microbiota transplant (FMT)
- Where
- Spain
- Volunteers
- 22 people
- Sponsor
- Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud
Bacterial Vaginosis
Effect of Flourish HEC Vaginal Care System on BV Recurrence and the Vaginal Microbiome
The goal of this clinical trial is to learn about the vaginal microbiome in premenopausal women with recurrent bacterial vaginosis (BV).
- Trial name
- NCT05701722
- Testing
- Flourish HEC Vaginal Care System
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Vaginal Biome Science
Oral Lichen Planus
Efficacy of Probiotic Capsules With Topical Clobetasol Propionate in OLP Treatment
Oral lichen planus patients who will meet inclusion criteria will be divided into 2 groups -The intervention group (Group P): This group will be randomly allocated to take one capsule twice daily during meal time at morning and…
- Trial name
- NCT06119672
- Testing
- Probiotic Blend Oral capsules, Corticosteroids for Local Oral Treatment
- Where
- Egypt
- Volunteers
- 36 people
- Sponsor
- October 6 University
Emotion, Well-being
Evaluation of the Effect of Kefir Consumption
Many societies traditionally use fermentation as a means of producing beverages, whose microbial transformation is spontaneously triggered or facilitated by the addition of a catalyst (yeasts, bacteria).
- Trial name
- Kefirness (NCT07522372)
- Testing
- Consumption of a control beverage, non-fermented carbonated drink, Consumption of fruit kefir, Consumption of micro-filtered fruit kefir
- Where
- France
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Sys2Diag
Antibiotic, Allergic Diseases
Probiotic Intervention on the Development of Allergic Diseases in Infants Exposed to Antibiotics Early in Life
Early antibiotic exposure is an important environmental factor that disrupts the establishment of the infant gut microbiota and leads to microbial dysbiosis.
- Conditions
- Antibiotic, Allergic Diseases, Infants, Probiotic
- Trial name
- NCT07532421
- Testing
- Probiotic mixture
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
COVID-19
Changes in Viral Load in COVID-19 After Probiotics
The main objective of the study is to evaluate the capacity of a novel nutritional supplement intervention including strains from the species Bifidobacterium longum, Bifidobacterium animalis subsp.
- Trial name
- NCT04666116
- Testing
- Dietary supplementation in patients with covid disease admitted to hospital
- Where
- 2 sites in Spain
- Volunteers
- 96 people
- Sponsor
- Hospital de Sagunto
Depression, Anxiety Disorder
Probiotics for Depression in Cancer Patients
Anxiety and depressive disorders are quite prevalent in the general population. In 2015, it was estimated that 3.6% of the world population (around 264 million individuals) live with depression and 4.4% (around 322 million) with…
- Conditions
- Depression, Anxiety Disorder, Probiotics, Gastrointestinal Cancer
- Trial name
- NCT06496438
- Testing
- Psychobiotics
- Where
- Greece
- Volunteers
- 270 people
- Sponsor
- Aristotle University Of Thessaloniki
Healthy
Probiotics Effect on the Female Urinary Microbiome ProFUM Trial (Probiotics Effect on the Female Urinary Microbiome)
The study will enroll healthy pre-menopausal female volunteers in the community. These subjects will act as their own controls. The subjects will collect voided urine and peri-urethral swab specimens daily for several months.
- Trial name
- ProFUM (NCT03250208)
- Testing
- Probiotic
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Loyola University
Ulcerative Colitis Chronic Moderate
Probiotic Treatment of Ulcerative Colitis With Trichuris Suis Ova (TSO)
The PROCTO trial is a double-blind randomized, placebo-controlled, 24-week, comparative, exploratory phase II proof of concept trial.
- Trial name
- PROCTO (NCT03565939)
- Testing
- Trichuris suis ova
- Where
- Denmark
- Volunteers
- 119 people
- Sponsor
- ParaTech A/S
Adenomatous Polyposis Coli
Influence of Sulindac and Probiotics on the Development of Pouch Adenomas in Patients With Familial Adenomatous Polyposis
The purpose of this study is to determine whether sulindac and VSL#3 - inulin, either combined or alone, are effective in treating or preventing adenoma development in the ileal anal pouch in patients with familial adenomatous…
- Trial name
- NCT00319007
- Testing
- Sulindac (drug), VSL#3 (probiotic), Inulin (probiotic)
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Radboud University Medical Center
HSIL, High Grade Squamous Intraepithelial Lesion, HPV-Related Squamous Cell Carcinoma
CASCADE 2002: PROTECT Study, "PRObiotics to TrEat Anal preCancer Trial
This study is focused on treatment of anal high-grade squamous intraepithelial lesions (HSIL) in persons with HIV (PWH), with the ultimate goal of applying the approach toward prevention of anal cancer in this population
- Conditions
- HSIL, High Grade Squamous Intraepithelial Lesion, HPV-Related Squamous Cell Carcinoma, Anal HSIL
- Trial name
- NCT06949800
- Testing
- EXE-346 Probiotic, Usual Care High Resolution Anoscopy (HRA)
- Where
- 2 sites in United States, Puerto Rico
- Volunteers
- 90 people
- Sponsor
- University of California, San Francisco
Gastrointestinal Diseases
Probiotics Improve Health Young Volunteers' Gut Microbiota
The goal of this clinical trial is to evaluate whether daily supplementation with the probiotic Bifidobacterium breve BBr60 can improve metabolic, gastrointestinal, and emotional health in healthy adult volunteers aged 19 to 45…
- Trial name
- NCT06196892
- Testing
- Probiotic BBr60
- Where
- China
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- Wecare Probiotics Co., Ltd.
Cholera
Effect of Probiotic on Immunogenicity of Oral Cholera Vaccine
Cholera is a major health problem of many developing countries and marked increase in the prevalence has been seen on all continents in the last decade (WHO 1998).
- Trial name
- NCT00464867
- Testing
- Whole cell killed cholera vaccine & probiotic
- Where
- Bangladesh
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Appetite; Lack or Loss, Nonorganic Origin
Encapsulated Nutrients' Acute Effects on Appetite; ENcapsulated, lipiD, aminO, pRobiotic, SatiEty
A double-blind, randomized crossover design with five arms including four experimental conditions and placebo will be applied. After having successfully completed screening procedures, eligible participants will be invited to…
- Trial name
- ENDORSE (NCT03080909)
- Testing
- Encapsulated nutrients
- Where
- Denmark
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Arne Astrup
Skin Problems
Efficacy Evaluation of the Probiotics Containing Skincare Products on Skin
Previous studies on skin health with Lactic acid bacteria (LAB) have been published for many years, including prevention of skin diseases and improvement of skin conditions.
- Trial name
- NCT03350893
- Testing
- Emulsion base with probiotics, Emulsion base
- Where
- Taiwan
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- GenMont Biotech Incorporation
Rectal Cancer, Gut Microbiomes
Autologous Probiotics in Patients With Defunctioning Ileostomy Following LAR for Rectal Cancer
Rectal cancer patients who received low anterior resection combined with ileostomy may effectively reduce the probability of anastomotic leakage after surgery.
- Conditions
- Rectal Cancer, Gut Microbiomes, Autologous Probiotic Transplantation, Defunctioning Ileostomy
- Trial name
- NCT07366047
- Testing
- Autologous Probiotics
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Peking University Cancer Hospital & Institute
Type 1 Diabetes (T1D)
Lactobacillus Johnsonii Supplementation in Adults With T1D
While genetics demonstrated a major risk factor for the development of type 1 diabetes (T1D), microbiota dysbiosis has been suggested as an elicitor in immunological tolerance and of beta cell autoimmunity.
- Trial name
- NCT03961347
- Testing
- L. johnsonii Probiotic
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- University of Florida
Constipation, Dyspepsia
Study of Yili "Changqing" Pro-ABB Yoghurt in the Improvement of Human Gastrointestinal Tract System
The purpose of this study is to determine whether Yili "Chang Qing" Pro-ABB yoghurt is effective in improving mild constipation and the intestinal micro-ecology environment \& alimentation.
- Conditions
- Constipation, Dyspepsia, Flatulence, Abdominal Pain
- Trial name
- NCT01682798
- Testing
- Yili "Chang Qing" Pro-ABB yoghurt (Formula 1), Yili "Chang Qing" Pro-ABB yoghurt (Formula 2)
- Where
- 2 sites in China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Inner Mongolia Yili Industrial Group Co., Ltd
Feeding; Difficult, Newborn, Necrotizing Enterocolitis
A Multi-strain Synbiotic Versus a Multi-strain Probiotic in Premature Infants
The aims are to 1) compare two probiotic treatments (multi-strain synbiotic vs. multi-strain probiotic) on bifidobacteria fecal colonization counts at 1, 2, 3, and 4 weeks of life, 34 weeks corrected gestation age (CGA) ; 2)…
- Trial name
- NCT01337921
- Testing
- Multi-strain Probiotic
- Sponsor
- University of Nebraska
Antibiotic-associated Diarrhea, Clostridium Difficile
Lactobacillus Reuteri in the Prevention of Antibiotic Associated-diarrhea and Clostridium Difficile
The purpose of this study is to find whether Lactobacillus reuteri prevents antibiotic-associated diarrhea and related Clostridium difficile infections. Subjects will be admitted from the University Hospitals Case Medical Center.
- Trial name
- NCT02127814
- Testing
- Lactobacillus reuteri
- Where
- United States
- Volunteers
- 73 people
- Sponsor
- Case Western Reserve University