Clinical trials: Probiotics
Microecological Therapy, Probiotic Intervention
Effects of DL-endopeptidase Producing Probiotics on Human Intestinal NOD2 Ligands and Related Functions
We have discovered a type of probiotic that can target activating intestinal NOD2, which is related to a series of human health issues.
- Trial name
- probiotics (NCT06716047)
- Testing
- Oral administration
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Zhujiang Hospital
Infective Endocarditis, Endocarditis, Bacterial
Combined Rehabilitation and Nutritional Support vs. Standard Care in In-Hospital Endocarditis Treatment
Infective endocarditis (IE) is associated with high morbidity and mortality. Patients with IE are affected by a lengthy hospitalization, leading to physical deconditioning and a rapid decline in physical fitness, muscle mass and…
- Conditions
- Infective Endocarditis, Endocarditis, Bacterial, Infection; Heart, Bacteremia
- Trial name
- ENDOCARE (NCT06563609)
- Testing
- Intensive physical Therapy, Probiotic treatment, Individualised Nutritional Support
- Where
- Denmark
- Volunteers
- 15 people
- Sponsor
- Johannes Grand
Probiotic, Influence
Probiotic Intervention and Its Influence on Serum Leucine-Rich Alpha-2 Glycoprotein 1 Levels in Acne Vulgaris Patients
This study aimed to assess the serum level of Leucine-rich alpha-2 glycoprotein 1 (LRG1) in Acne vulgaris (AV) individuals and evaluate the effect of probiotic therapy on these serum levels.
- Conditions
- Probiotic, Influence, Serum Leucine-Rich Alpha-2 Glycoprotein 1, Acne Vulgaris
- Trial name
- NCT07277075
- Testing
- Serum Leucine-rich alpha-2 glycoprotein 1 (LRG1) level
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Benha University
Halitosis, Probiotics
The Effect of Oral Probiotics on Oral Hygiene and Halitosis in Orthodontic Patients.
Brackets, bands, ligatures and wires in patients receiving orthodontic treatment with fixed appliances are areas that trap food and impede oral hygiene.
- Conditions
- Halitosis, Probiotics, Orthodontic Appliance Complication
- Trial name
- NCT05651503
- Testing
- Probiotics
- Where
- Greece
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Athens
Infant, Newborn, Gut -Microbiota
Infant Microbiota Restoration With Maternal Microbes
The goal of this clinical trial is to test the ability of different bacterial products in restoring natural gut microbiota in C-section born infants.
- Conditions
- Infant, Newborn, Gut -Microbiota, Gut Dysbiosis, Cesarean Delivery Affecting Newborn
- Trial name
- MaMi (NCT07212361)
- Testing
- Probiotic
- Where
- 2 sites in Finland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Helsinki
Microbiota, Probiotic Therapy
Microbiota and Probiotic Therapy in Ulcerative Colitis Patients
This study aimed to evaluate the role of microbiota and probiotics in Egyptian patients with ulcerative colitis.
- Conditions
- Microbiota, Probiotic Therapy, Ulcerative Colitis
- Trial name
- NCT07180186
- Testing
- Mesalamine, Probiotics (Bacillus Clausii), Mesalamine and probiotics (Bacillus Clausii)
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Tanta University
Ventilator Acquired Pneumonia, Catheter Related Bloodstream Infection
Effect of Use of Probiotics on Systemic Infection in Critically Ill Patients: a Double Blind, Randomized, Placebo-controlled Trial
The primary goal of this study is to assess the benefit of probiotics in preventing or minimizing of various type of systemic infection in critically ill adult patients.
- Conditions
- Ventilator Acquired Pneumonia, Catheter Related Bloodstream Infection, Urinary Tract Infection, Diarrhea
- Trial name
- NCT07164781
- Testing
- Bacillus clausii, Sugar tablets
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Benha University
Probiotics, Acute Exercise
The Effect of Probiotics on Exercise Performance and Recovery
This project will involve administering a multi-strain probiotic supplement to investigate the capacity to improve exercise performance and/or recovery. This will be done by assessing physiological measures (e.g.
- Trial name
- NCT05588674
- Testing
- Probiotic Supplement
- Where
- United Kingdom
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Obesity, Mental Health
Psychobiotics and Mental Health in Obese Women on a Weight-Loss Diet
The aim of this study was to evaluate the effect of psychobiotic supplementation containing Lactobacillus helveticus R0052, Bifidobacterium bifidum R0071 and Bifidobacterium longum R0175 strains on mental health, quality of life…
- Conditions
- Obesity, Mental Health, Probiotic
- Trial name
- NCT06861049
- Testing
- Psychobiotic Supplement
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Medipol University
Dental Hygiene, Probiotics, Periodontitis
Probiotic Nanofiber Floss and Subgingival Pathogen Suppression
This randomized, double-blind, crossover clinical trial evaluated the effect of a probiotic-containing nanofiber dental floss on subgingival red complex periopathogens and gingival health in periodontally healthy individuals.
- Conditions
- Dental Hygiene, Probiotics, Periodontitis, Prevention of Dental Caries, Gingivitis and Periodontal Diseases
- Trial name
- NCT07149493
- Testing
- Probiotic nanofiber floss
- Where
- Czechia
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- St. Anne's University Hospital Brno, Czech Republic
Cross Infection (Hospital-Acquired Infections), Critical Illness
Probiotics for Preventing ICU-Acquired Infections in Critically Ill Patients: A Pilot Study
This pilot randomized clinical trial investigated the effect of probiotic supplementation on the incidence of intensive care unit-acquired infections (ICU-AIs) in critically ill patients.
- Conditions
- Cross Infection (Hospital-Acquired Infections), Critical Illness, Probiotic Intervention
- Trial name
- NCT07144124
- Testing
- Biopro-max 8 Billion Probiotics (Bioserv Healthcare)
- Where
- Saudi Arabia
- Volunteers
- 25 people
- Sponsor
- Imam Abdulrahman Bin Faisal University
Congenital Heart Disease, Dysbiosis
The Influence of Probiotics on Metabolome and Heart Rate Variability in Heart Failure of Structure Heart Disease
Poor body weight gain and failure to thrive is a very common condition in patients with congenital heart disease (CHD) with advanced HF and/or cyanosis, which are considered a predictor of morbidity and complicate the prognosis…
- Conditions
- Congenital Heart Disease, Dysbiosis, Malnutrition, Child, Probiotics
- Trial name
- NCT06872320
- Testing
- Lactobacillus Rhamnosus
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Chang Gung Memorial Hospital
Sleep Disorder, Anxiety
Evaluating the Potential of Probiotic Supplementation Sleep Quality
This study aims to evaluate the feasibility of probiotics in improving sleep indicators through clinical human studies. Previous animal experiments have confirmed that Limosilactob acillus fermentum PS150 and heat-treated…
- Conditions
- Sleep Disorder, Anxiety, Depression, Stress
- Trial name
- NCT06486064
- Testing
- heat-treated Limosilactobacillus fermentum
- Where
- Taiwan
- Volunteers
- 84 people
- Sponsor
- Chi-Chang Huang
Colitis, IBD (Inflammatory Bowel Disease)
Evaluate the Efficacy and Safety of Probiotic 6600 as an Adjuvant Therapy for Colitis
This study was conducted in two phases. In Phase I, 40 UC participants, 40 CD participants, and 40 colitis participants were randomly assigned in a 1:1 ratio to the experimental group and the control group, respectively.
- Conditions
- Colitis, IBD (Inflammatory Bowel Disease), Probiotic Intervention
- Trial name
- NCT07047339
- Testing
- Probiotics 6600
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Changhai Hospital
Gut -Microbiota, Older People
Probiotics and Active Aging: Enhancing Gut Health
The general objective of this clinical trial is to assess the physical fitness and gut microbiota of older adults, thereby highlighting the importance of focusing on health maintenance.
- Conditions
- Gut -Microbiota, Older People, Physical Activity, Physical Fitness
- Trial name
- PAAEGH (NCT07033637)
- Testing
- Dietary Supplement, Structured Physical Activity Program
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Jose Luis Felipe
Periodontitis, Chlorhexidine
The Use of Chlorhexidine and a Probiotic Lozenge in the Nonsurgical Therapy of Periodontitis
The aim of this study is determining the additional effect of a 2-week home usage of chlorhexidine in periodontitis patients undergoing scaling and root planing supplemented with a dual-strain probiotic lozenge.
- Conditions
- Periodontitis, Chlorhexidine, Probiotic
- Trial name
- NCT05548361
- Testing
- active chlorhexidine and active probiotic
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Cukurova University
Probiotics, Cancer, Therapy-Related
The Effect of Survival, Response and Microbiota Change in Different Therapy Under Probiotic Supplement
Probiotics are a group of viable microorganisms including bacteria and yeasts that if consumed in sufficient amounts, may afford health benefits to the host.
- Trial name
- NCT06998823
- Testing
- Probiotics
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Chang Gung Memorial Hospital
Atopic Dermatitis (Eczema), Atopic Dermatitis, Probiotics
Prebiotic Effects of Mulberry Fruit in Children and Adolescents With Atopic Dermatitis
This project proposes a randomized controlled human study to explore the prebiotic effects of consuming mulberry juice on atopic dermatitis in children and adolescents.
- Trial name
- NCT06636240
- Testing
- Mulberry fruit juice, Mometasone furoate 0.1% cream
- Where
- 2 sites in Taiwan
- Volunteers
- 120 people
- Sponsor
- Taipei Medical University Shuang Ho Hospital
Pneumonia, Probiotics
Impact of Probiotics on Antibiotic-associated Diarrhea in Community-acquired Pneumonia
The study goal is to determine whether oral administration of a probiotic mixture can reduce the incidence of antibiotic-associated diarrhea in patients with community-acquired pneumonia.
- Conditions
- Pneumonia, Probiotics, Diarrhea
- Trial name
- PROBIO (NCT06990568)
- Testing
- Lacidofil
- Volunteers
- 100 people
- Sponsor
- National Health Insurance Service Ilsan Hospital
Irritable Bowel Syndrome, Irritable Bowel Syndrome With Diarrhea (IBS-D)
Efficacy of Repeated Transcranial Magnetic Stimulation Combined With a Live Probiotic Tablet (Combined Bifidobacterium, Lactobacillus, Enterococcus and Bacillus Cereus Tablets, Live) in Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D)
To evaluate the overall efficacy of repeated Transcranial Magnetic Stimulation(rTMS) combined with a Live Probiotic tablet (Combined Bifidobacterium, Lactobacillus, Enterococcus and Bacillus cereus Tablets, Live) in…
- Conditions
- Irritable Bowel Syndrome, Irritable Bowel Syndrome With Diarrhea (IBS-D), Repetitive Transcranial Magnetic Stimulation (rTMS), Probiotic
- Trial name
- NCT06960369
- Testing
- rTMS combined with Live Probiotic tablet
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital of Soochow University