Clinical trials: Primary Prevention
Diabetes Mellitus
Effects of Exercise Behavior Modification on Plasma Adiponectin and Insulin Resistance in High Risk Subjects of Diabetes
Investigators hypothesized home-based exercise intervention was beneficial to those who have had diabetic risk factor for type 2 diabetes mellitus
- Trial name
- NCT01136096
- Testing
- Physical activity promoting intervention, General instruction and education
- Where
- Taiwan
- Volunteers
- 216 people
- Sponsor
- National Taiwan University Hospital
Risk Reduction, Cardiovascular Diseases
Exercise Training & Statins for Cardiovascular Health
Cardiovascular disease (CVD) refers to any condition that affects the heart and/or blood vessels (e.g. heart attack, stroke) and is the leading cause of death and disability worldwide.
- Trial name
- EXSTATIC (NCT05474079)
- Testing
- Moderate intensity exercise training
- Where
- United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Cardiff Metropolitan University
Primary Prevention, Shoulder
Primary Prevention Habits for the Shoulder: Survey of the Sportsman's Entourage
Purpose: To provide an update on the implementation of prevention among overhead athletes by their entourage. Materiel and method: This study will be conducted by the means of a questionnaire.
- Conditions
- Primary Prevention, Shoulder, Questionnaire and Survey
- Trial name
- NCT04307745
- Testing
- Primary prevention
- Where
- Belgium
- Volunteers
- 213 people
- Sponsor
- University of Liege
Type-2 Diabetes, Cardiovascular Diseases
Feasibility of a Preventive Program Against Lifestyle Related Diseases
The continuously increasing prevalence of cardiovascular diseases, type-2 diabetes, and COPD is a major health problem in developed countries and is mainly caused by an unhealthy lifestyle.
- Conditions
- Type-2 Diabetes, Cardiovascular Diseases, Chronic Obstructive Pulmonary Disease (COPD)
- Trial name
- NCT02797392
- Testing
- Lifestyle intervention
- Where
- 6 sites in Denmark, Norway and 1 more
- Volunteers
- 9,400 people
- Sponsor
- University of Southern Denmark
Peripheral Arterial Disease (PAD), Moderate Risk for Cardiovascular Disease (CVD)
Prevalence of Peripheral Arterial Disease in Subject With a Moderate Risk of Cardiovascular (CV) Disease (CVD) in Primary Prevention
Non interventional study aimed to establish the prevalence of lower extremity peripheral arterial disease (PAD), defined as an ankle-brachial index (ABI) not above 0.90 in subjects with a moderate risk of cardiovascular disease…
- Trial name
- PANDORA (NCT00689377)
- Where
- 331 sites in Belgium, France and 4 more
- Volunteers
- 9,000 people
- Sponsor
- AstraZeneca
Concussion, Brain
One Team: Changing the Culture of Youth Sport With Pregame Safety Huddles
Randomized controlled trial of a behavioral intervention (Pre-Game Safety Huddles) designed to study the impact of huddles on concussion safety in youth sport, primarily regarding intention to report concussive symptoms.
- Trial name
- NCT04099329
- Testing
- Pre-game Safety Huddles
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Seattle Children's Hospital
HIV
Barbershop Talk: HIV Prevention for African American Heterosexual Men
This program utilizes a community-engaged research approach to implementing and evaluating a program that seeks to reduce sexual risk behavior among Black adult heterosexual men.
- Trial name
- NCT01980771
- Testing
- BTWB intervention, Cancer prevention and screening
- Where
- 2 sites in United States
- Volunteers
- 860 people, healthy volunteers welcome
- Sponsor
- State University of New York - Downstate Medical Center
Menstrual Migraines, Menstrual Bleeding
Prevention of Menstrual Migraines: Effects of Estrogen Add-back During the HFI in Patients Using Continuous Oral Contraceptives.
This study will examine the combined effects of a continuous oral contraceptive (OC) regimen with supplemental estradiol therapy on headache severity and occurrence in subjects with documented Menstrually Associated Migraines…
- Conditions
- Menstrual Migraines, Menstrual Bleeding, Menstrual Spotting
- Trial name
- Estradiol/MAM (NCT01251263)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Scott and White Hospital & Clinic
Substance Use
Substance Use Screening and Prevention for Adolescents in Pediatric Primary Care
This study is to test the effectiveness of integrating and adapting two National Institute on Drug Abuse (NIDA)-funded procedures for use in primary care pediatric clinics serving low-income youth: 1)the Youth Risk Index (YRI)…
- Trial name
- SKY (NCT03074877)
- Testing
- Family Check-Up
- Where
- United States
- Volunteers
- 722 people
- Sponsor
- RTI International
Acute Myeloid Leukemia in Remission, Primary Myelofibrosis
Ruxolitinib Phosphate, Tacrolimus and Sirolimus in Preventing Acute Graft-versus-Host Disease During Reduced Intensity Donor Hematopoietic Cell Transplant in Patients With Myelofibrosis
This phase I trial studies the side effects and best dose of ruxolitinib phosphate when given together with tacrolimus and sirolimus in preventing acute graft-versus-host disease during reduced intensity donor hematopoietic cell…
- Conditions
- Acute Myeloid Leukemia in Remission, Primary Myelofibrosis, Primary Myelofibrosis, Prefibrotic Stage, Secondary Acute Myeloid Leukemia
- Trial name
- NCT02528877
- Testing
- Allogeneic Bone Marrow Transplantation, Allogeneic Hematopoietic Stem Cell Transplantation, Fludarabine Phosphate
- Where
- United States
- Sponsor
- City of Hope Medical Center
Network, Kinship
Enhancing Non-communicable Disease Prevention and Control Through Parent-Teachers-Development Agents Network in Ethiopia
Background: Primary health care is an inclusive, equitable, cost-effective, and efficient approach to enhance the health of the community. Ethiopia has been implementing the primary healthcare approach for the last four decades.
- Trial name
- NCT06639412
- Testing
- Networking the indigenous parent-teacher association and agriculture development agents with the PHC unit to enhance NCD prevention & control services., Usual care
- Where
- Ethiopia
- Volunteers
- 408 people
- Sponsor
- Bahir Dar University
Cardiac Death
Reduction of Inappropriate Implantable Cardioverter Defibrillator (ICD) Therapies in Primary Prevention Patients
The purpose of this study is to determine efficacy of a dedicated programming concept for avoidance of inappropriate implantable cardioverter defibrillator (ICD) therapies in patient with primary prevention ICD indication.
- Trial name
- DECREASE (NCT01217528)
- Testing
- device settings for group A, Device settings for group B
- Where
- 34 sites in Germany
- Volunteers
- 543 people
- Sponsor
- Abbott Medical Devices
Hereditary Angioedema (HAE)
Post Study Access of CSL312 (Garadacimab) for Pediatric Participants With Hereditary Angioedema Who Have Completed the CSL312_3003 Study
This protocol for post study access allows pediatric participants (2-11 years old at the time of consent) with HAE who have completed study CSL312_3003 (NCT05819775) to continue treatment with CSL312 for routine prevention of HAE…
- Trial name
- NCT07159464
- Testing
- CSL312
- Sponsor
- CSL Behring
Catheter-Related Infections
ATAPAC Study (TauroLock Activity in Adult Cancer Patients)
The purpose of this study is to compare the efficacy of a lock taurolidine-citrate solution vs standard saline solution for primary prevention of central venous catheter-associated bloodstream infection in adult patients treated…
- Trial name
- ATAPAC (NCT02279121)
- Testing
- Taurolock, saline solution
- Where
- France
- Volunteers
- 162 people
- Sponsor
- Centre Hospitalier Régional Metz-Thionville
HIV Prevention
Implantable Long-Acting Pre-Exposure Prophylaxis For MSM
The long-term goal of this project is to better understand factors at the patient and physician level that can be addressed to impact uptake of long-acting, implantable PrEP (LA-PrEP) products in the future and identify the…
- Trial name
- NCT05420207
- Testing
- No intervention
- Where
- 2 sites in United States
- Volunteers
- 69 people
- Sponsor
- Elizabeth Arnold
Emotion Regulation, Relationship Conflict
Get Better Together: Relationship Education For Military Couples
This study is testing a program called Get Better Together, a relationship education program designed to help military couples effectively navigate life stressors as a team.
- Conditions
- Emotion Regulation, Relationship Conflict, Suicide Risk, Alcohol Use
- Trial name
- GBT RCT (NCT07096271)
- Testing
- Get Better Together (GBT)
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Venous Thromboembolism
Evaluation of AVE5026 as Compared to Placebo for the Extended Prophylaxis of Venous Thromboembolism in Patients Having Undergone Hip Fracture Surgery
The primary objective is to evaluate the efficacy of once daily (QD) subcutaneous (SC) injections of Semuloparin sodium (AVE5026) versus placebo for 3 additional weeks following an initial 7 to 10-day venous thromboprophylaxis…
- Trial name
- SAVE-HIP3 (NCT00709904)
- Testing
- Open-label Semuloparin sodium, Semuloparin sodium
- Where
- 16 sites in United States, Belarus and 14 more
- Volunteers
- 469 people
- Sponsor
- Sanofi
Migraine
MicroRNA Profile and Erenumab Treatment
Erenumab, a monoclonal antibody acting on the calcitonin gene-related peptide (CGRP) receptor, is an effective and safe migraine-specific preventive drug.
- Trial name
- NCT04659226
- Testing
- Blood sampling for microRNA testing
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of L'Aquila
Breast Cancer
Using Technology to Improve Physical Activity Levels Among Postmenopausal Women (The Active & Aware Study)
Women who are overweight or do not exercise are at higher risk for breast cancer after menopause. This study will test a new electronic device that measures the body's movement and works alongside a website to help women increase…
- Trial name
- NCT01837147
- Testing
- Technology-Based Physical Activity Promotion, Pedometer Intervention
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Primary Prevention, Stress
Efficacy of Taiji Training as a Program for Stress Prevention
Background: Excessive exposure to psychosocial stress can be a potent trigger for somatic diseases and psychological disorders, a cause for missing work, and eventually lead to high economic loss.
- Conditions
- Primary Prevention, Stress, Tai ji, Adult
- Trial name
- NCT01122706
- Testing
- Taiji training
- Where
- Switzerland
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Bern