Clinical trials: Primary Ovarian Insufficiency
Premature Ovarian Insufficiency
Ventricular Repolarization in Patients With Premature Ovarian Insufficiency (QTIOP)
Ventricular repolarization, measured by corrected QT interval (QTc), is influenced by sex hormones. A QTc above 460msec predisposes to the risk of "torsades-de-pointes"(TdP).
- Trial name
- QTIOP (NCT04167033)
- Testing
- Hormone replacement therapy:effect on ventricular repolarization, ECG
- Where
- 3 sites in France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Effects of Chemotherapy, Premature Ovarian Failure
Ovarian Reserve After Cancer: Longitudinal Effects
Women of reproductive age who will receive treatment for cancer that includes chemotherapy may participate in a study measuring ovarian function over time.
- Trial name
- ORACLE (NCT02467231)
- Where
- United States
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Bone Loss, Bone Loss, Age-related
Strength Training for Osteoporosis Prevention During Early Menopause
The goal of this clinical pilot trial is to learn about the feasibility of a high-intensity resistance training intervention in peri- and early menopausal females.
- Conditions
- Bone Loss, Bone Loss, Age-related, Osteoporosis, Musculoskeletal Diseases
- Trial name
- STOP-EM (NCT05961371)
- Testing
- Resistance Training
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Premature Ovarian Insufficiency
Genetic Variants in Idiopathic Premature Ovarian Insufficiency
Premature ovarian insufficiency is a condition in which ovarian function decreases or is lost before the age of 40 years. In many patients, the underlying cause remains unexplained.
- Trial name
- NCT07587853
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Abdurrahman Hamdi İnan
Menopause, Premature, Menopause Related Conditions
Autologous PRP Infusion May Restore Ovarian Function and May Promote Folliculogenesis in POI Patients
Autologous PRP intra ovarian infusion may restore ovarian function, may promote folliculogenesis and may improve patients' hormonal profile in patients presenting with POI.
- Conditions
- Menopause, Premature, Menopause Related Conditions, Menopausal Syndrome, Premature Ovarian Failure
- Trial name
- PRP (NCT04031456)
- Testing
- Autologous Platelet Rich Plasma
- Where
- Greece
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Genesis Athens Clinic
Infertility, Premature Ovarian Failure
Single Follicular Dexarelix for LH Suppression During Ovarian Stimulation in Oocyte Donors.
A randomized prospective study in the evaluation of the long acting GnRH antagonist Degarelix against the classical multidose regime with Ganirelix for LH suppression during the follicular phase of an ovarian stimulation cycle in…
- Trial name
- NCT03861715
- Testing
- live birth rate
- Where
- Greece
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Assisting Nature
Primary Ovarian Insufficiency
Primary Ovarian Insufficiency: Phenotype and Optimal Treatment
This pilot study will observe the progression of newly diagnosed POI patients physical and psychology outcomes after initiating standard of care HRT treatment in comparison to healthy female control participants' physical and…
- Trial name
- NCT03568708
- Testing
- Transdermal Estrogen
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Premature Ovarian Insufficiency, Diminished Ovarian Reserve
The Correlation Between Ovarian Function and Serum Biomarkers
The goal of this observational study is to find differences in serum biomarkers between ovarian function and normal individuals.
- Conditions
- Premature Ovarian Insufficiency, Diminished Ovarian Reserve, Biomarker, Copper
- Trial name
- NCT06096766
- Testing
- blood test
- Where
- China
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Shi Yun
Primary Ovarian Insufficiency, Premature Menopause
Causes and Consequences of Primary Ovarian Insufficiency
100 women with primary ovarian insufficiency will be included for extensive diagnostic workup to improve diagnostic precision by extended autoantibody screening and genetic and toxicological testing.
- Trial name
- Clinical POI (NCT04082169)
- Where
- Norway
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Haukeland University Hospital
Infertility, Female, Polycystic Ovary Syndrome
Polycystic Ovary Syndrome, Mitochondrial Dysfunction, Obesity, Insulin Resistance Infertility (POMODORI) Cohort
Enrolling of 150 female patients of fertile age diagnosed with PCOS, insulin resistance, infertility, or mitochondrial disease, and the same number of age- and sex-matched controls are planned.
- Conditions
- Infertility, Female, Polycystic Ovary Syndrome, Insulin Resistance, Primary Ovarian Insufficiency
- Trial name
- POMODORI (NCT06167135)
- Where
- Hungary
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Semmelweis University
Effects of Chemotherapy
Assessing Fertility Potential in Female Cancer Survivors
Hypothesis: Girls and women exposed to chemotherapy and/or radiation therapy experience endocrine changes more similar to women in their late reproductive years than to same-age peers.
- Trial name
- NCT01143844
- Where
- 2 sites in United States
- Volunteers
- 391 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Primary Ovarian Insufficiency, Premature Menopause
Effects of Estrogen on Heart Health in Women With Primary Ovarian Insufficiency
The goal of this observational study is to study the effects of treating women with Primary Ovarian Insufficiency (POI) with estrogen replacement therapy to bolster the evidence backing cardiometabolic preventive care in women…
- Conditions
- Primary Ovarian Insufficiency, Premature Menopause, Metabolic Complications, Endothelial Function (FMD)
- Trial name
- ENCODE (NCT06866119)
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Cognitive Impairment, RRSO
IMProving Executive Function Study
This is a double-blind, placebo-controlled, crossover study testing whether Vyvanse (lisdexamfetamine; LDX) improves executive functioning (EF) in 100 postmenopausal women who report onset of EF difficulties after oophorectomy.
- Trial name
- IMPRES (NCT03187353)
- Testing
- Lisdexamfetamine
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Turner Syndrome, Hypogonadism
Estrogen Dosing in Turner Syndrome: Pharmacology and Metabolism
Estrogen is necessary for feminization during puberty and to decrease bone resorption, the latter critical for the achievement of peak bone mass and normal bone health in the female.
- Conditions
- Turner Syndrome, Hypogonadism, Premature Ovarian Failure
- Trial name
- NCT00837616
- Testing
- 17 B estradiol orally, 17 B estradiol
- Where
- 3 sites in United States, Chile
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Nemours Children's Clinic
Primary Ovarian Insufficiency
Hormone Replacement for Premature Ovarian Insufficiency
The investigators intend to establish feasibility/acceptability of a pilot randomized trial comparing hormone replacement therapy (HRT) and combined oral contraceptives (COCs) in women with premature ovarian insufficiency to…
- Trial name
- HOPE (NCT02922348)
- Testing
- Hormone Replacement Therapy, Combined Oral Contraceptives
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Ovarian Failure, Ovarian Insufficiency
Ovarian Tissue Allo-transplantation
Premature ovarian failure, also known as primary ovarian insufficiency (POI), or premature menopause, affects 1-2% of women under 40.
- Conditions
- Ovarian Failure, Ovarian Insufficiency, Menopause Ovarian Failure, Menopause, Premature
- Trial name
- NCT06673004
- Testing
- Ovarian tissue allo-transplantation
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Premature Ovarian Failure (POF)
The Influence of Gut Microbiota on Ovarian Function: A Single-center, Randomized,Double Blind, Parallel-controlled, Exploratory Clinical Trial
In order to study the community profile of the intestinal microbiome in women with ovarian dysfunction, as well as the relationship between the changes in the intestinal microbiota and sex hormones, this study recruited 30 women…
- Trial name
- NCT07308327
- Testing
- Akk Gut Bacteria Supplement
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Songling Zhang
Healthy, Premature Ovarian Failure
Feasibility Study for Development of an Early Test for Ovarian Failure
This purpose of this study is to gain information about normal ovarian function that will be useful in developing a test for early detection of ovarian failure.
- Trial name
- NCT00006156
- Testing
- Control, Drug: FSH
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Bone Diseases, Metabolic Syndrome X
Effect of Exercise and Phytoestrogen on Bone, Metabolic Syndrome Criteria and Complaints of the Early Menopause
The aim of the study is to compare the effect of a progressive, periodized exercise training designed to impact bone, CHD-risk-factors and menopausal complaints versus the combined effect of exercise and "phytoestrogen"…
- Conditions
- Bone Diseases, Metabolic Syndrome X, Coronary Disease
- Trial name
- NCT00663104
- Testing
- exercise, exercise + cimicifuga racemosa
- Where
- Germany
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Premature Ovarian Failure (POF)
Autologous Bone Marrow Stem Cell Ovarian Transplantation to Restore Ovarian Function in Premature Ovarian Failure
This study aims to recover ovarian function in POF/POI patients. With this pueprose we designed a study protocol including two arms: ASCOT arm, were patients receive the stem cell mobilization treatment with Granulocyte colony…
- Trial name
- ASCOT-2 (NCT03535480)
- Testing
- G-CSF, ASCOT
- Where
- Spain
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Instituto de Investigacion Sanitaria La Fe