Clinical trials: Primary Motor Cortex
Parkinson Disease
Motor Cortex Reward Signaling in Parkinson Disease
Background: The brain releases signals to mark rewards for certain behavior. Some medications for Parkinson disease (PD) can cause some patients to engage in compulsive behavior, possibly because the medications affect this…
- Trial name
- NCT00558766
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Stroke
Structurally Reorganizing Motor Cortex in Stroke Patients Through Hebbian-type Stimulation
Stroke is a leading cause of morbidity in the United States but identification of treatment strategies to improve outcome is limited by the incomplete understanding of the mechanisms of recovery.
- Trial name
- NCT01569607
- Testing
- Repetitive Transcranial Magnetic Stimulation (rTMS)
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Cathrin Buetefisch
Tetraplegia, Spinal Cord Injury
ECoG Direct Brain Interface for Individuals With Upper Limb Paralysis
The purpose of this research study is to demonstrate that individuals with upper limb paralysis due to spinal cord injury, brachial plexus injury, amyotrophic lateral sclerosis and brain stem stroke can successfully achieve…
- Conditions
- Tetraplegia, Spinal Cord Injury, Brachial Plexus Injury, Muscular Dystrophy
- Trial name
- NCT01393444
- Testing
- Implantation of ECoG sensors on the brain surface
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Pittsburgh
Cerebrovascular Stroke
Noninvasive Brain Stimulation to Evaluate Neural Plasticity After Stroke
The purpose of this study is to examine how different areas in the brain interact with each other and how using brain imaging and brain stimulation approaches can influence these interactions.
- Trial name
- NCT02465034
- Testing
- Transcranial Magnetic Stimulation, Traditional Paired Associative Stimulation, Median Nerve Stimulation
- Where
- 2 sites in United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Emory University
Fibromyalgia (FM)
Investigating the Effects of Repetitive Transcranial Magnetic Stimulation (rTMS) on the Brain in People With Fibromyalgia
The first goal of this study is to see how brain activity changes in people with fibromyalgia after they get a treatment called rTMS (repetitive transcranial magnetic stimulation).
- Trial name
- rTMS (NCT07260864)
- Testing
- rTMS
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Rochester
Stroke
The Immediate Effects of Intermittent Theta Burst Stimulation on Intracortical Excitability of the Primary Motor Cortex in Patients With Chronic Stroke
This study is to investigate the immediate effects of intermittent theta burst stimulation (iTBS) on intracortical excitatory and inhibitory circuits, neural connectivity, and network properties in patients with chronic stroke…
- Trial name
- NCT05509686
- Testing
- Intermittent theta burst stimulation (iTBS)
- Where
- Hong Kong
- Volunteers
- 21 people
- Sponsor
- The Hong Kong Polytechnic University
Cortical Plasticity
Network Effects of Left M1 rTMS: A TMS-EEG Study
This study investigates the modification of connectivity patterns in response to one session of active repetitive transcranial magnetic stimulation (rTMS) applied to the primary motor cortex.
- Trial name
- CORTEX-4 (NCT07580989)
- Testing
- rTMS
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Repetitive Transcranial Magnetic Stimulation, Motor Cortex
TMS-evoked Potentials During Repetitive Transcranial Magnetic Stimulation on the Primary Motor Cortex
This study investigates the modification of the local-to-global connectivity pattern in response to a session of repetitive transcranial magnetic stimulation (rTMS) applied to the primary motor cortex.
- Conditions
- Repetitive Transcranial Magnetic Stimulation, Motor Cortex, Transcranial Magnetic Stimulation, Pain Thresholds
- Trial name
- rTMS-TMS-EEG (NCT05714020)
- Testing
- Real rTMS
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Glucose Metabolism Disorders
Glucose and Non-Invasive Brain Stimulation
Purpose: In this study, the investigators will delineate how brain network dynamics are modulated by experimentally induced elevated blood glucose levels and examine how glucose levels gate neuronal excitability measured by the…
- Trial name
- NCT04031404
- Testing
- Single-pulse TMS
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Kinesiophobia (Fear of Movement), Experimental Pain
Pain Beliefs and Intracortical Excitability During Experimental Pain
Pain can influence the way the motor system functions. However, responses to pain vary widely between individuals, and this variability may be partly related to pain-related beliefs such as kinesiophobia.
- Trial name
- NCT07688525
- Testing
- Topical Capsaicin Cream (1%)
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Cortical Excitability, Primary Motor Cortex
rTMS Induced Reduction in M1 Excitability
When learning a new skill, much of the improvement comes from small alterations the brain makes with each repetition during practice, but this isn't the only time that improvements are made during the learning process.
- Conditions
- Cortical Excitability, Primary Motor Cortex, Motor Skills
- Trial name
- NCT07588113
- Testing
- rTMS
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Indiana University
Essential Tremor, Transcranial Direct Current Stimulation
Transcranial Direct Current Stimulation of the Motor Cortex in Essential Tremor
The current research is aimed at using Transcranial Direct Current Stimulation (tDCS) as complementary therapeutic tool in the treatment of essential tremor. Patients will be randomized into two groups (tDCS-cathode vs.
- Trial name
- NCT03952117
- Testing
- transcranial direct current stimulation
- Where
- Lebanon
- Volunteers
- 40 people
- Sponsor
- Lebanese American University
Stroke, Motor Cortex; Lesion
Imaging Laterality in Chronic Stroke Patients
In healthy individuals, unimanual movement (with either the left or right hand) is associated with activity in a network of predominantly contralateral brain regions, including the primary motor cortex (PMC).
- Trial name
- NCT03584425
- Testing
- Rasch modified version of the Fugl-Meyer Motor assessment, Anatomical image acquisition, Functional MRI task and acquisition
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Parkinson's Disease
Evaluation of the Effect of Repetitive Transcranial Magnetic Stimulation in Pain Perception in Parkinson's Disease
Pain is a frequent symptom in Parkinson's disease. Previous studies have shown that pain perception was altered in Parkinson's disease patients and could be related to nociceptive cortical area hyperactivation.
- Trial name
- rTMS (NCT01275573)
- Testing
- Repetitive Transcranial Magnetic Stimulation
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Fibromyalgia, Electric Shock
Comparison of the Efficacy of Transcranial Direct Current Stimulation (tDCS) of the Primary Motor Cortex (M1) or the Prefrontal Cortex Combined With Aerobic Activity for Alleviation of Fibromyalgia Symptoms.
The goal of this study is to demonstrate the effectiveness of treating fibromyalgia using combination of electrical stimulation with aerobic activity. Participants will be randomly assigned to stimulation in a ratio of 1:1:1.
- Trial name
- NCT06263972
- Testing
- Direct Stimulation Prefrontal Cortex, Direct Stimulation to Motor Cortex, erobic physical activity
- Volunteers
- 120 people
- Sponsor
- HaEmek Medical Center, Israel
Algoneurodystrophy
Comparison of the Analgesic Effect Between the Motor Cortex Stimulation and the Trans-spinal Stimulation in the Algoneurodystrophy.
The purpose of this study is to compare the analgesic effectiveness of two motor cortex neurostimulations (tDCS and rTMS) and the trans-spinal neurostimulation (tsDCS ) in the algoneurodystrophy.
- Trial name
- ALGOSTIM (NCT02817880)
- Testing
- rTMS, tDCS, tsDCS
- Where
- 2 sites in France
- Volunteers
- 36 people
- Sponsor
- University Hospital, Grenoble
Chronic Low Back Pain
Changes in Motor Cortex Following Exercises for Chronic Low Back Pain
The motor cortex of the brain changes following chronic pain and injury, and this is linked to pain-associated changes in motor behaviour.
- Trial name
- NCT00864422
- Testing
- Skilled motor training, Walking exercise
- Where
- Australia
- Volunteers
- 20 people
- Sponsor
- The University of Queensland
Stroke, Stroke Sequelae
Noninvasive VNS to Facilitate Excitability in Motor Cortex
Transcranial Magnetic Stimulation (TMS) positively influences motor rehabilitation in stroke recovery. Transcutaneous auricular vagus nerve stimulation (taVNS) has shown effects on cortical plasticity.
- Conditions
- Stroke, Stroke Sequelae, Motor Activity
- Trial name
- NCT04130646
- Testing
- Transcranial Magnetic Stimulation, transcutaneous auricular vagus nerve stimulation (taVNS)
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Pain, Intractable, Central Pain Syndrome
Long-term Effect of Motor Cortex Stimulation in Patients Suffering From Chronic Neuropathic Pain
In order to create insights in the effects of Motor cortex stimulation (MCS) on intractable pain, an open observational study was started in 2003. The aim of this research is to: 1.
- Conditions
- Pain, Intractable, Central Pain Syndrome, Facial Pain
- Trial name
- MCSNL (NCT03189823)
- Testing
- Specify, model 3998, Medtronic Inc., Minneapolis, MN, USA
- Volunteers
- 17 people
- Sponsor
- Radboud University Medical Center
Dysphagia, Swallowing Disorder
tACS and tRNS Studies on Brain Control of Swallowing
Transcranial alternating current stimulation (tACS) and transcranial random noise stimulation (tRNS) are two (CE marked medical devices) new, non-invasive (over the scalp) brain stimulation (NIBS) techniques.
- Trial name
- NCT04040803
- Testing
- Transcranial alternating current stimulation (tACS) and transcranial random noise stimulation (tRNS)
- Where
- United Kingdom
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Manchester