Clinical trials: Primary Motor Cortex
Stroke
Role of Ipsilateral Motor Cortex in Executing Movements With Increasing Demand on Precision
It is well known that the motor area of one hemisphere of the brain (motor cortex) controls the movement of the opposite of the body.
- Trial name
- RIMC (NCT01726218)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cathrin Buetefisch
Stroke
The Modulatory Effect of Low-intensity Priming Intermittent Theta Burst Stimulation on Motor Cortex Poststroke: a Concurrent TMS-EEG Study
Background: The optimization of the intensity of priming theta burst stimulation increases the probability of success in a randomized controlled trial.
- Trial name
- NCT06241508
- Testing
- Transcranial magnetic stimulation
- Where
- Hong Kong
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Healthy
Stimulating Deep Brain Regions With a Magnetic Stimulator
The purpose of this study is to determine whether a special coil designed for magnetic stimulation of areas deep in the brain can affect mood and emotion in healthy volunteers.
- Trial name
- NCT00063245
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Parkinson Disease (PD), Gait Disorders
Effects of Transcranial Direct Current Stimulation Combined With Nordic Walking on Gait and Balance in Parkinson's Disease
Parkinson's disease can cause slow or unsteady walking and balance problems that raise the risk of falls. This study will test whether adding a gentle, non-invasive brain stimulation called transcranial direct current stimulation…
- Conditions
- Parkinson Disease (PD), Gait Disorders, Postural Balance
- Trial name
- tDCS+NW-PD (NCT07381907)
- Testing
- Transcranial Direct Current Stimulation (tDCS), active, Standardized Nordic Walking program
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Universidade Metodista de Piracicaba
Temporomandibular Joint Disorders
Motor Cortex as a Research & Therapeutic Target in TMD
The investigators are doing a study to learn about the effects of a type of low-energy non-surgical electrical brain stimulation (HD-tDCS) on chronic pain in people's jaw joints.
- Trial name
- NCT02247063
- Testing
- High-Definition Transcranial Direct Current Stimulation (HD-tDCS)
- Volunteers
- 24 people
- Sponsor
- University of Michigan
Pharmacoresistant Neuropathic Pain
Analgesic Effect of Non Invasive Stimulation : Comparison of rTMS and tDCS Efficacy
The aim of this study is to compare analgesic efficacy of two non invasive techniques based on motor cortex stimulation in neuropathic pain patients.
- Trial name
- NI-MCS (NCT01800136)
- Testing
- Repetitive Transcranial Magnetic Stimulation and Transcranial Direct Current Stimulation
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Hospices Civils de Lyon
Stroke, Upper Extremity Paresis
tDCS + CCFES-mediated Functional Task Practice for Post-stroke Upper Extremity Hemiplegia
After a stroke, it is very common to lose the ability to open the affected hand. Occupational and physical rehabilitation therapy (OT and PT) combined with non-invasive brain stimulation may help a person recover hand movement.
- Conditions
- Stroke, Upper Extremity Paresis, Hemiplegia
- Trial name
- NCT05866003
- Testing
- Active conventional tDCS montage plus CCFES, Active unconventional tDCS montage plus CCFES, CCFES with Occupational Therapy
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- MetroHealth Medical Center
Motor Function of Healthy Physiology
Modulation of Motor Function by Stimulation of the Central and Peripheral Nervous System
Objectives When a stroke damages the part of the brain that controls movement, people have weakness and difficulty using their hand.
- Trial name
- NCT00453505
- Testing
- TMS, tDCS, tACS
- Where
- United States
- Volunteers
- 976 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Alzheimer Disease and Related Dementias, Cognition
Home-Based Brain Stimulation for Motoric Cognitive Risk Syndrome
The objective of this study is to determine the effects of a 6-month, home-based personalized transcranial direct current stimulation (tDCS) intervention targeting the left dorsolateral prefrontal cortex on cognitive function…
- Conditions
- Alzheimer Disease and Related Dementias, Cognition, Mobility Disability
- Trial name
- TDCS4MCR (NCT06821568)
- Testing
- Personalized Transcranial Direct Current Stimulation (tDCS)
- Where
- 2 sites in United States, Israel
- Volunteers
- 128 people
- Sponsor
- Hebrew SeniorLife
Amyotrophic Lateral Sclerosis
CNS10-NPC-GDNF Delivered to the Motor Cortex for ALS
The investigator is examining the safety of transplanting cells, that have been engineered to produce a growth factor, into the motor cortex (brain) of patients with Amyotrophic Lateral Sclerosis (ALS).
- Trial name
- NCT05306457
- Testing
- CNS10-NPC-GDNF
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Cedars-Sinai Medical Center
Motor Cortex, Primary Motor Cortex
Evaluation of Motor-Related Beta-Activity in Relation to Naturalistic Movement in Healthy Adult Subjects
The whole body's voluntary movements are controlled by the brain. One of the brain areas most involved in controlling these voluntary movements is the motor cortex and it is often viewed as the primary 'output' region of the…
- Trial name
- MOBETA (NCT04727944)
- Testing
- Reach and grasp tasks in healthy participants using MEG technique (Experiment 1), Reach and grasp tasks in healthy participants using EEG technique (Experiment 2)
- Where
- France
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Neuropathic Pain
Electroencephalography Based Neurofeedback in Chronic Neuropathic Pain
Chronic neuropathic pain is a global health concern, affecting millions of patients worldwide. It is often extremely debilitating and poses a diagnostic and therapeutic challenge.
- Trial name
- NCT01560039
- Testing
- TMS, Neurofeedback
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Stroke, Healthy
Effects of Flumazenil on Brain Excitability
This study will investigate the effects of the drug flumazenil on brain excitability and the drug's relationship to a natural brain chemical called GABA.
- Trial name
- NCT00015678
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Chronic Neuropathic Pain
Study of RTMS Analgesic Effect in Chronic Neuropathic Pain,
The purpose of this study is to compare the analgesic effectiveness of three modes of repetitive Transcranial Magnetic Stimulation (rTMS) in chronic neuropathic pain: Classical rTMS stimulation Deeper rTMS stimulation Sham rTMS…
- Trial name
- NEUROSTIM (NCT04936646)
- Testing
- RepetitiveTranscranial Magnetic Stimulation (rTMS)
- Where
- France
- Volunteers
- 45 people
- Sponsor
- University Hospital, Grenoble
Generalized Anxiety Disorder
Mapsd Dual-target cTBS (Auditory Cortex and M1) for Generalized Anxiety Disorder
The purpose of this study is to investigate the effectiveness of a dual-target non-invasive brain stimulation technique called continuous Theta Burst Stimulation (cTBS) for treating Generalized Anxiety Disorder (GAD).
- Trial name
- Dual-ACM1-GAD (NCT07403591)
- Testing
- Active Dual-target cTBS
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Anhui Medical University
Multiple Sclerosis, Lower Urinary Tract Symptoms
Effect of Motor Cortex Versus Sacral Magnetic Stimulation in Multiple Sclerosis Patients With Urinary Tract Dysfunction
This work is intended to assess the effect of repetitive magnetic stimulation on the sacral roots versus repetitive magnetic stimulation on motor cortex in multiple sclerosis patients with the lower urinary tract dysfunction.
- Trial name
- NCT03434873
- Testing
- magnetic stimulation
- Volunteers
- 40 people
- Sponsor
- Cairo University
Autism Spectrum Disorder, Motor Activity
rTMS to Improve Motor Function in Autism
In the current project, investigators have two main goals: i) Testing whether an excessive plasticity, i.e. hyperplasticity in the motor cortex underlies motor function difficulties in autistic adults, and ii) Using repetitive…
- Trial name
- (AMBLE Autism) (NCT06497920)
- Testing
- Active rTMS to the motor cortex
- Where
- Canada
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Low Back Pain, Transcranial Direct Current Stimulation
Transcranial Direct Current Stimulation Combined With Exercise in Low Back Pain
The purpose of this study is to evaluate the effects of transcranial direct current stimulation combined with Pilates based exercise on chronic low back pain. This is a randomized clinical trial composed of two arms.
- Trial name
- NCT05467566
- Testing
- Transcranial direct current stimulation
- Volunteers
- 42 people
- Sponsor
- Universidade Federal do Rio Grande do Norte
Dysarthria, Stroke
Non-invasive Brain Stimulation to Enhance Treatment of Dysarthria Post-stroke
The proposed study aims to determine if transcranial direct current stimulation can enhance the effect of speech therapy in post-stroke patients with dysarthria.
- Trial name
- NCT04780230
- Testing
- tDCS active
- Where
- Hong Kong
- Volunteers
- 3 people
- Sponsor
- The Hong Kong Polytechnic University
Ultrasound in MRI
Effects of Transcranial Focused Ultrasound on Human Primary Motor Cortex Using 7T fMRI
Transcranial focused ultrasound (tFUS) is a form of neuromodulation that uses a single element transducer to produce highly focused low-intensity acoustic energy that can be used to affect cortical excitability in humans.
- Trial name
- NCT03634631
- Testing
- Focused Ultrasound
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Minnesota