Clinical trials: Primary Motor Cortex
Spinal Cord Injury
Repetitive Transcranial Magnetic Stimulation in Individuals With Spinal Cord Injury: A Pilot Study
This study will investigate how repetitive transcranial magnetic stimulation delivered as a protocol called 'continuous theta-burst stimulation (cTBS)' alters motor output and force control to a muscle in the forearm and touch…
- Trial name
- NCT02351921
- Testing
- Transcranial magnetic stimulation
- Where
- Canada
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- McMaster University
Motor Neuron Disease
Brain Function in Primary Lateral Sclerosis
This study will examine whether the motor cortex (the part of the brain that controls movement) works properly in patients with primary lateral sclerosis (PLS), a disorder in which voluntary movements are very slow.
- Trial name
- NCT00071435
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Transcranial Direct Current Stimulation, Dorsolateral Prefrontal Cortex
Impact of Transcranial Direct Current Stimulation on the Capacity to Perform Burpees
Introduction and Background: Transcranial direct current stimulation (tDCS) has emerged as a potential intervention to improve physical performance.
- Conditions
- Transcranial Direct Current Stimulation, Dorsolateral Prefrontal Cortex, Primary Motor Cortex
- Trial name
- NCT06472882
- Testing
- tDCS targeting DLPFC, tDCS targeting M1
- Where
- Spain
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universidad Católica San Antonio de Murcia
Healthy, Gait Disorders, Neurologic
Exoskeleton and Brain Activity With fNIRS
Background. Force control is one of the major parameter of motor activity. There is few study concerning the cortical activity imply for different levels of force during gait. Objective.
- Trial name
- ExoNIRS (NCT05298943)
- Testing
- walking in 4 situations
- Where
- France
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Régional d'Orléans
Healthy
Effect of Transcranial Magnetic Stimulation on Free Will
This study will use transcranial magnetic stimulation (TMS) to investigate how the brain controls movement by sending messages to the spinal cord and muscles.
- Trial name
- NCT00029653
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Obsessive Compulsive Disorder, Healthy
Cortical Excitability in Obsessive-Compulsive and Related Disorders
This study will use transcranial magnetic stimulation (TMS) to study the function of the cerebral cortex (outer layer of the brain) in people with obsessive compulsive disorder (OCD) and related disorders.
- Trial name
- NCT00029068
- Where
- United States
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Healthy Subjects (HS)
Aftereffects of PES Preconditioned with RTMS on the Human Pharyngeal Motor Cortex
The goal of this interventional study is to optimize the excitatory brain effects of combined neuromodulatory therapies on swallowing areas of the brain.
- Trial name
- NCT06884488
- Testing
- repetitive transcranial magnetic stimulation (Magstim Super Rapid stimulator, The Magstim Company Ltd, Whitland, UK), pharyngeal electrical stimulation (Digitimer model DS7; Welwyn-Garden City, Herts, UK)
- Where
- United Kingdom
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Voice Disorders, Voice Fatigue
Brain and Voice Signatures in Teachers
Primary muscle tension dysphonia voice disorder with symptoms of vocal strain and vocal fatigue is common and can have a significant negative impact on quality of Life.
- Trial name
- BRAVO1 (NCT06126627)
- Testing
- Stress induction
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bonn
Healthy Subject
Role of the Posterior Parietal Cortex in the Processing of Sensory Information
Although the primary motor cortex is considered has the common final pathway of motor commands, it is influenced by several structures as, for example, the premotor cortex and the posterior parietal cortex which are involved in…
- Trial name
- CORTEX (NCT03386188)
- Testing
- Transcranial Magnetic Stimulation (TMS), Electrical Muscle Activity (EMG)
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Parkinson Disease
Parkinson's Disease and Gamma-transcranial Alternating Current Stimulation
Cortical-basal ganglia gamma oscillations are pathologically reduced in Parkinson's disease (PD) and the plasticity of the primary motor cortex (M1) is impaired.
- Trial name
- NCT06297538
- Testing
- gamma transcranial alternating current stimulation (tACS)
- Where
- Italy
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Neuromed IRCCS
Cortical Excitability, Primary Motor Cortex
rTMS Induced Reduction in M1 Excitability
When learning a new skill, much of the improvement comes from small alterations the brain makes with each repetition during practice, but this isn't the only time that improvements are made during the learning process.
- Conditions
- Cortical Excitability, Primary Motor Cortex, Motor Skills
- Trial name
- NCT07588113
- Testing
- rTMS
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Indiana University
Stroke, Neurologic Disorder
Manual Dexterity Modifications After Application of tSMS Over the Primary Motor Cortex (M1)
Transcranial static magnetic field stimulation (tSMS) is a novel brain stimulation technique that has been shown to be safe and effective in modifying biological parameters when applied to the cerebral cortex.
- Conditions
- Stroke, Neurologic Disorder, Manual Dexterity
- Trial name
- NCT05260190
- Testing
- tSMS
- Where
- Spain
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Universidad Rey Juan Carlos
Healthy
Metaplasticity Experimental Design and Comparison of Motor Outcome Measure Sensitivity to Change
The overall objective is to validate the methodology of a metaplasticity experimental design by assessing change in motor excitability after administration of priming transcranial direct current stimulation (tDCS) followed by…
- Trial name
- NCT03304262
- Testing
- rTMS
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
Spinocerebellar Ataxia
Neuromuscular Electrical Stimulation on Median Nerve Facilitates Low Motor Cortex Excitability in Human With Spinocerebellar Ataxia
Spinocerebellar ataxia (SCA) is a hereditary disorder with movement incoordination. The ataxia performed low intra-cortical facilitation mainly due to the degenerative cerebellum.
- Trial name
- NCT02103075
- Testing
- Neuromuscular electrical stimulation
- Where
- Taiwan
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Chang Gung University
Cortical Activation
Menstrual Cycle TMS Plasticity Pilot
Aim 1: Assess how menstrual cycle phase affects motor cortex plasticity in females. Aim 2: Compare motor cortex plasticity between males and females across the same time points, identifying potential sex differences in TMS…
- Trial name
- NCT07180654
- Testing
- transcranial magnetic stimulation
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Cortical Excitability, Brain Stimulation
Neuroplastic Alterations of the Motor Cortex by Caffeine
Caffeine is a psychostimulant drug. It acts as a competitive antagonist at adenosine receptors, which modulate cortical excitability as well.
- Conditions
- Cortical Excitability, Brain Stimulation, Caffeine
- Trial name
- NCT04011670
- Testing
- 200 mg caffeine tablet, Non-active tablet
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Medical Center Goettingen
Movement Disorder, Healthy
Brain Excitability During Self-Paced Voluntary Movements
This study will use transcranial magnetic stimulation to examine how the brain controls movement by sending messages to the spinal cord and muscles and what goes wrong with this process in disease.
- Trial name
- NCT00017966
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Chronic Pain, Spinal Cord Injury
Effects of Transcranial Direct Current Stimulation (tDCS) and Visual Illusion on Chronic Pain Due to Spinal Cord Injury
The purpose of this study is to investigate the effects of Transcranial Direct Current Stimulation (tDCS) combined with watching a visual illusion on chronic pain due to spinal cord injury.
- Trial name
- NCT01404065
- Testing
- Transcranial Direct Current Stimulation (tDCS)
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Spaulding Rehabilitation Hospital
Parkinson Disease, Parkinson
tDCS of the Primary Motor Cortex to Improve Implicit Motor Sequence Learning in Parkinson's Disease
Implicit motor sequence learning (IMSL) is a form of cognitive function that is known to be directly associated with impaired motor function in Parkinson's disease (PD).
- Conditions
- Parkinson Disease, Parkinson, Healthy
- Trial name
- NCT04606979
- Testing
- 1x1 Low Intensity Transcranial Direct Current Stimulation (tDCS)
- Where
- Belgium
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Healthy
Detecting a Reward Signal in the Motor Cortex
This study will use transcranial magnetic stimulation (TMS) to determine whether the activity in the brain when someone wins something affects the part of the brain that controls movement.
- Trial name
- NCT00422071
- Where
- United States
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)