Clinical trials: Primary Infertility
Primary Ovarian Insufficiency, Infertility
Parental Project and Premature Ovarian Insufficiency
One of the main repercussions of POI is infertility. When the diagnosis of POI is announced, the question of fertility is addressed and the patient is often directed towards egg donation or adoption when she has a parental…
- Trial name
- ParentIOP (NCT05310617)
- Testing
- Survey
- Where
- France
- Volunteers
- 324 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Diminished Ovarian Reserve, Premature Ovarian Insufficiency
Autologous Platelet-rich Plasma (PRP) Infusion to Improve Outcomes in Women With Ovarian Insufficiency: a Pilot Study
The investigators propose a pilot study to determine if autologous platelet-rich plasma (PRP) improves ovarian reserves and In-vitro fertilisation (IVF) outcomes in women with diminished ovarian reserve / premature ovarian…
- Conditions
- Diminished Ovarian Reserve, Premature Ovarian Insufficiency, Fertility Issues, IVF
- Trial name
- NCT05385848
- Testing
- Autologous Platelet-rich Plasma (PRP) Injection
- Where
- Singapore
- Volunteers
- 30 people
- Sponsor
- KK Women's and Children's Hospital
Second Cancer, Survivorship
The Prospective Observational COMPRAYA Cohort Study
Rationale: Childhood cancer survivorship attracts attention globally, because successes in treatment have led to increasing number of survivors who reach adulthood, in which survivorship issues affecting health-related quality of…
- Conditions
- Second Cancer, Survivorship, Fertility Issues, Distress, Emotional
- Trial name
- COMPRAYA (NCT04682470)
- Testing
- No intervention ; observational
- Where
- Netherlands
- Volunteers
- 4,000 people
- Sponsor
- The Netherlands Cancer Institute
Primary Ovarian Insufficiency, Low Ovarian Reserve
Rejuvenation of Premature Ovarian Failure With Stem Cells
The ROSE-1 study is designed to determine the efficacy of bone marrow derived stem cell therapy on ovarian function recovery in subjects with idiopathic and other types of premature or primary ovarian failure (POF or POI) and low…
- Conditions
- Primary Ovarian Insufficiency, Low Ovarian Reserve, Premature Ovarian Failure
- Trial name
- ROSE-1 (NCT02696889)
- Testing
- ROSE-1 Protocol
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Illinois at Chicago
Primary Infertility
Analysis of Lipid Profiles in Samples Sperm and Seminal Plasma Under Artificial Insemination
Identify, by Lipidomics approaches, biochemical markers of fertility / infertility in sperm and seminal plasma linking the success or failure of the artificial insemination (IUI)
- Trial name
- NCT02704936
- Where
- Spain
- Volunteers
- healthy volunteers welcome
- Sponsor
- IVI Bilbao
Premature Ovarian Failure (POF)
Evaluation of Child Desire in Young Women With Premature Ovarian Failure
Premature ovarian failure (POF) is a rare condition, affecting 1 in 10,000 women before age 20 and 1 in 1,000 women before age 30. The two main causes of POF are congenital and acquired.
- Trial name
- DESIOP (NCT04881695)
- Testing
- Questionary patients, Questionary controls
- Where
- France
- Volunteers
- 160 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Primary Uterine Infertility
First Clinical Live-Donor Uterus Transplantation Trial In Egypt
More than a decade ago, uterus transplantation (UTx) as a highly experimental procedure was the treatment which had been developed for women suffering from absolute uterine factor infertility (AUFI) [uterus absence (congenital…
- Trial name
- NCT03284073
- Testing
- Uterus transplantation
- Where
- Egypt
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Amro M. Hetta, M.Sc.
Primary Infertility, Secondary Infertility
Minimal Stimulation Protocol Using Aromek(Letrozole) and Follitrope(recFSH) Combined With INVOCell-Low Cost IVF
The purpose of this study to evaluate a low cost minimal stimulation protocol combined with Intravaginal Culturing, to make IVF affordable and available across the large infertile/subfertile population
- Conditions
- Primary Infertility, Secondary Infertility, Low Responders, Mild to Moderate Male Factor Infertility
- Trial name
- MSP-INVO IVF (NCT01058252)
- Testing
- INVOCell, Letrozole 2.5 mg, recFSH 75 IU, STEP-3: LH Suppression & Monitoring, STEP-4: HCG Timing
- Where
- 2 sites in Pakistan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Galaxy Pharma (Pvt) Limited
Infertility Primary
AOA in Recurrent Fertilization Failure
Background: Despite the high success rate of ICSI, total fertilization failure still occurs in 1-3% of all ICSI cycles and can recur in subsequent cycles, even when a sufficient number of oocytes and motile spermatozoa are…
- Trial name
- AOA (NCT04744753)
- Testing
- Calcium Ionophore A23187
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- MOHAMED BEHERY
Primary Ovarian Insufficiency, Female Infertility Due to Diminished Ovarian Reserve
Effect of Testosterone Treatment on Embryo Quality
The purpose of this study is to determine the effect of treatment with trans-dermal testosterone cream compared to placebo on measures of ovarian reserve, oocyte and embryo quality, and pregnancy rates among women with evidence…
- Trial name
- NCT01662466
- Testing
- Testosterone cream (0.5mg per gram), DHEA
- Where
- 2 sites in United States
- Volunteers
- 180 people
- Sponsor
- Center for Human Reproduction
Infertility, Premature Ovarian Failure
Single Follicular Dexarelix for LH Suppression During Ovarian Stimulation in Oocyte Donors.
A randomized prospective study in the evaluation of the long acting GnRH antagonist Degarelix against the classical multidose regime with Ganirelix for LH suppression during the follicular phase of an ovarian stimulation cycle in…
- Trial name
- NCT03861715
- Testing
- live birth rate
- Where
- Greece
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Assisting Nature
Diminished Ovarian Reserve
Follicular Activation by Fragmentation of Ovarian Tissue
The primary objective of this study is to assess the chances of increasing the number of antral follicles in ovarian tissue of patients with diminished ovarian reserve by activation of primordial follicles through ovarian cortex…
- Trial name
- FAFOT (NCT03670407)
- Testing
- Ovarian tissue fragmentation
- Where
- Croatia
- Volunteers
- 40 people
- Sponsor
- Podobnik Maternity and Gynecology Hospital
Infertility, Ovarian Failure, Premature
Maturation of Follicles After Transplantation of Ovarian Tissue Into the Pelvic Wall and the Ovary
The purpose of this study is to determine whether the pelvic wall or the ovary represents a better location for the maturation of follicles in the context of ovarian transplantation after cryopreservation of ovarian tissue before…
- Trial name
- Ovartrans (NCT02780791)
- Testing
- Transplantation into pelvic wall, Transplantation into the ovary
- Where
- Switzerland
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Perimenopausal Disorder, Menopause
Inovium Ovarian Rejuvenation Trials
The Inovium Ovarian Rejuvenation Treatment is a PRP-based autologous treatment used in combination with a stimulated IVF sequence and Pre-Implantation Genetic Screening to treat infertility in women experiencing menopause…
- Conditions
- Perimenopausal Disorder, Menopause, Menopause, Premature, Menopause Related Conditions
- Trial name
- NCT03178695
- Testing
- Autologous PRP injection into human ovarian tissue
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Ascendance Biomedical
Female Infertility Due to Diminished Ovarian Reserve
Human Growth Hormone Pre-treatment for 6 Weeks Prior to Ovulation Induction for IVF
Synthetic human growth hormone (HGH) has been available for more than a decade for specific indication in children and adults. Past Randomized Control Trials (RCT)s of HGH (under off-label use) for improving ovarian function have…
- Trial name
- NCT02179255
- Testing
- Human Growth Hormone, Follicle Stimulating Hormone
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Center for Human Reproduction
Infertility
Ovarian Stem Cells From Women With Ovarian Insufficiency
Background: Primary ovarian insufficiency (POI) is a condition that affects ovary function. It means that the ovaries are not able to function at a level appropriate for a woman's age.
- Trial name
- NCT01702935
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Primary Ovarian Insufficiency, Infertility
In Vitro Follicle Activation
The purpose of this study is to evaluate the effectiveness of an experimental treatment, known as in vitro activation (IVA) of dormant ovarian follicles, for infertility in women diagnosed with primary ovarian insufficiency (POI).
- Trial name
- IVA (NCT02496598)
- Testing
- In Vitro Follicle Activation (IVA), Follicle Activation
- Where
- 2 sites in United States
- Volunteers
- 2 people
- Sponsor
- National Foundation for Fertility Research
Infertility, Female, Premature Ovarian Failure
Second Step Protocol in Poor Ovarian Responder (POR)
Reduced ovarian reserve and the consequent poor ovarian response are very recurent in infertile patients, indeed a percentage of 10%-24% of couples addressed to infertility program may be classified as Poor Ovarian Responder…
- Conditions
- Infertility, Female, Premature Ovarian Failure, Fertility Disorders
- Trial name
- POR (NCT03480412)
- Testing
- Follicular Phase, Luteal Phase
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Università degli Studi 'G. d'Annunzio' Chieti e Pescara
Amenorrhea, Hypoaldosteronism
Ovarian Follicle Function in Patients With Primary Ovarian Failure
No proven therapy to restore ovarian function and fertility is available to patients with karyotypically normal spontaneous premature ovarian failure.
- Conditions
- Amenorrhea, Hypoaldosteronism, Hypogonadism, Infertility
- Trial name
- NCT00001275
- Where
- United States
- Volunteers
- 1,134 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Autoimmune Disease, Infertility
Steroid Therapy in Autoimmune Premature Ovarian Failure
No therapy for infertile patients with premature ovarian failure has been proven effective. Some anecdotal reports have suggested that high dose, long term prednisone (steroid) therapy may be useful in treating autoimmune ovarian…
- Conditions
- Autoimmune Disease, Infertility, Premature Ovarian Failure
- Trial name
- NCT00001306
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)