Clinical trials: Primary Hypercholesterolaemia
Primary Hypercholesterolaemia
A Study to Evaluate the Safety and Pharmacokinetics of AD-228A Compared to Coadministration of AD-2281 and AD-2282
Primary endpoint of this study is to evaluate the pharmacokinetic characteristics of AD-228A in healthy subjects.
- Trial name
- NCT06858865
- Testing
- AD-228A, AD-2281 and AD-2282
- Where
- South Korea
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Addpharma Inc.
Primary Hypercholesterolaemia
A Study to Compare PK Characteristics and Safety Profiles Between AD-228B and AD-2284
Primary endpoint of this study is to evaluate the pharmacokinetic characteristics of AD-228B in healthy subjects.
- Trial name
- NCT06884098
- Testing
- AD-228B, AD-2284
- Where
- South Korea
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Addpharma Inc.
Familial Hypercholesterolemia
Improving Identification of Familial Hypercholesterolaemia in Primary Care (FAMCAT)
Multi-centre, non-randomised, non-controlled quasi-experimental study with nested qualitative study and economic appraisal. Improving the identification of patients at high risk of cardiovascular disease in primary care, caused…
- Trial name
- FAMCAT (NCT03934320)
- Testing
- FAMCAT
- Where
- United Kingdom
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Familial Hypercholesterolemia
EAS Familial Hypercholesterolaemia Studies Collaboration
Familial hypercholesterolaemia (FH) is a common genetic disorder resulting in marked elevations in low-density lipoprotein cholesterol (LDL-C).
- Trial name
- FHSC (NCT04272697)
- Where
- United Kingdom
- Volunteers
- 75,000 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Hyperlipidemias
A Phase 1 Study to Evaluate the Safety and Pharmacokinetics of Ezerosu Tab
A Phase 1 Study to Evaluate the Safety and Pharmacokinetics of Ezerosu Tab
- Trial name
- NCT06225635
- Testing
- Ezerosu(monolayer tablet), Ezerosu(double layer tablet)
- Where
- South Korea
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Shin Poong Pharmaceutical Co. Ltd.
Obesity, Hypercholesterolemia
Improving the Management of Obesity in Primary Care Practice (The Power-UP Trial)
The purpose of the study is to compare three methods of achieving weight loss in primary care medical practice. The study will be conducted in six primary care practices.
- Conditions
- Obesity, Hypercholesterolemia, Metabolic Syndrome, Hypertension
- Trial name
- Power-UP (NCT00826774)
- Testing
- Usual Care, Brief Lifestyle Counseling, Enhanced Brief Lifestyle Counseling
- Volunteers
- 390 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
High Blood Pressure, Hypercholesterolemia
Cardiovascular Risk Factors And Intensive Dietary Counselling
The Intensive Dietary Counselling (IDC) intervention is a prevention and health promotion activity. It is being implemented by the Andalusian Health Service to reinforce basic intervention advice on healthy diet and exercise.
- Conditions
- High Blood Pressure, Hypercholesterolemia, Tobacco Smoking
- Trial name
- NCT02173600
- Testing
- Group-level Intensive dietary Counselling, Individual-level Intensive Dietary Counselling
- Volunteers
- 630 people, healthy volunteers welcome
- Sponsor
- Andalusian Regional Ministry of Health
Diabetes, Chronic Kidney Diseases
Benchtop NMR Spectroscopy for Assessment of Clinical Human Pathologies (BRANCH-P STUDY)
This research programme seeks to combine the resources of NHS primary care, with the leading spectroscopic work in low-magnetic fields of the Wilson Group (Nottingham Trent University) to demonstrate the potential for benchtop…
- Conditions
- Diabetes, Chronic Kidney Diseases, Cancer, Bowel Disease
- Trial name
- BRANCH-P (NCT05473325)
- Where
- United Kingdom
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Willows Health
Primary Hypercholesterolemia
Evaluate the Pharmacokinetics and Safety of HCP1306 and Co-administration of HGP0816, HGP1404 in Healthy Male Volunteers
The purpose of this study is to evaluate Pharmacokinetic Properties and Safety after administration of HCP1306 tablet and Co-administration of HGP0816 tablet, HGP1404 tablet in the healthy adults.
- Trial name
- NCT02941848
- Testing
- HGP0816, HGP1404, HCP1306
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hanmi Pharmaceutical Company Limited
Hypercholesterolemia
Long-Term Safety and Tolerability of Ezetimibe (SCH 58235, MK-0653) With Atovastatin (P02154, MK-0653-017)
The purpose of this study is to examine the long-term safety and tolerability of ezetimibe (SCH 58235) 10 mg once daily or placebo in combination with atorvastatin (10 to 80 mg/day) for up to 12 consecutive months in participants…
- Trial name
- NCT03882892
- Testing
- Ezetimibe, Atovastatin
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Organon and Co
Hypercholesterolemia, Hyperbilirubinemia
Study of Efficacy and Safety of the Plasmapheresis Method With Albumin Compensation Compared With the Plasmapheresis Method Without Albumin Compensation for Aging Biomarkers Correction in Men and Women Aged 40 to 55 Years Old
Reaching active aging makes it important to implement new methods affecting the biological age of a person. Biochemical parameters of a blood test are aging biomarkers that are ones of the most accessible for testing.
- Conditions
- Hypercholesterolemia, Hyperbilirubinemia, Hyper IgE Syndrome, Hyper Beta Lipoproteinemia
- Trial name
- NCT04897113
- Testing
- plasma exchange with albumin, plasma exchange without albumin
- Where
- 2 sites in Russia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- National Medical Research Center for Rehabilitation and Balneology
Hypercholesterolemia, Primary Prevention
Phytosterol Supplementation and Lipoprotein Subfractions
The goal of this clinical trial was to evaluate the effects of phytosterol supplementation to the diet on lipids, LDL and HDL subfractions, and on the quality of LDL in apparently healthy subjects.
- Trial name
- Phyto (NCT06127732)
- Testing
- Phytosterol supplements
- Where
- 2 sites in Brazil
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Obesity, Hypercholesterolemia
Primary Prevention of Cardiovascular Diseases in Childhood and Adolescence: the Role of Physical Activity
This research project is about a physical activity intervention in pediatric outpatients to try control and prevent heart diseases such as hypertension, obesity, high cholesterol.
- Conditions
- Obesity, Hypercholesterolemia, High Blood Pressure, Sedentary Lifestyle
- Trial name
- NCT01580319
- Testing
- physical exercise
- Where
- Brazil
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Instituto de Cardiologia do Rio Grande do Sul
Primary Hypercholesterolemia
Effect of Probiotics on Lipid Management
Dysbiosis of gut microbiota has been reported to be involved in the development of hypercholesterolemia in both humans and animal models. Probiotics have been reported to have ameliorative effects in murine models.
- Trial name
- NCT03952169
- Testing
- Lactobacillus paracasei dietary supplement
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Hypercholesterolemia, Coronary Disease
Translating ATP III Cholesterol Management Guidelines Into Primary Care Practice
This quality improvement trial aims to evaluate whether giving patients information about their coronary heart disease risk via a computer kiosk in the doctors waiting room and providing primary care doctors with a personal…
- Conditions
- Hypercholesterolemia, Coronary Disease, Primary Health Care, Management, Risk
- Trial name
- NCT01242319
- Testing
- HeartAge intervention
- Where
- United States
- Volunteers
- 5,218 people, healthy volunteers welcome
- Sponsor
- Memorial Hospital of Rhode Island
Primary Hypercholesterolemia or Combined Hyperlipidemia Characterized by Elevated LDL-C
Pharmacokinetics and Pharmacodynamics Study
The purpose of this study is to compare the pharmacokinetics and pharmacodynamics behavior of the two formulation of QLC7401 injection to further evaluate the effect of the production site change.
- Trial name
- NCT07074236
- Testing
- QLC7401 injection, RBD7022 injection
- Where
- China
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Qilu Pharmaceutical Co., Ltd.
Diabetes, Hypertension
Effects of Dengzhanxixin Capsule on Platelet Function in Individuals at High Risk for Cardiovascular Disease
The main objective of this clinical trial is to evaluate whether the antiplatelet efficacy of the Dengzhanxixin capsule is better than that of placebo in individuals at high-risk for atherosclerotic cardiovascular disease (ASCVD).
- Conditions
- Diabetes, Hypertension, Hypercholesterolemia
- Trial name
- FUTURE (NCT05459519)
- Where
- China
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- China National Center for Cardiovascular Diseases
Healthy Population
Italian Digital Primary Cardiovascular Prevention Study
The CV-PREVITAL study is a randomised clinical trial (RCT) controlled versus usual-care designed to compare the effectiveness of a mobile health (mHealth) intervention with that of usual care in reducing specific cardiovascular…
- Trial name
- CV-PREVITAL (NCT05339841)
- Testing
- Mobile health application
- Where
- 32 sites in Italy
- Volunteers
- 27,520 people, healthy volunteers welcome
- Sponsor
- Centro Cardiologico Monzino
Essential Hypertension, Primary Hypercholesterolemia
A Study to Evaluate the Pharmacokinetics and the Safety After Administration of BR1018 and Coadministration of BR1018A and BR1018B in Healthy Adult Volunteers
The purpose of this clinical study is to evaluate the pharmacokinetics and the safety after administration of BR1018 and coadministration of BR1018A and BR1018B in healthy volunteers
- Trial name
- NCT06889012
- Testing
- BR1018, BR1018A, BR1018B
- Where
- South Korea
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Boryung Pharmaceutical Co., Ltd
Hypercholesterolemia
Effects of Ezetimibe on the Absorption of Oxidized Cholesterol
The purpose of this study is to test the effects of Zetia™ (ezetimibe) 10 milligrams (mg) on the absorption of oxysterol into the blood following a meal containing oxysterol.
- Trial name
- NCT00794677
- Testing
- ezetimibe
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- UCSF Benioff Children's Hospital Oakland