Clinical trials: Primary Care
Hypertension, Hyperlipidemia
Prioritized Clinical Decision Support (CDS) to Reduce Cardiovascular Risk
The objective of this project is to develop and implement sophisticated point-of-care Electronic Health Record (EHR)-based clinical decision support that (a) identifies and (b) prioritizes all available evidence-based treatment…
- Conditions
- Hypertension, Hyperlipidemia, Diabetes, Smoking
- Trial name
- NCT01420016
- Testing
- Prioritized Clinical Decision Support
- Volunteers
- 7,914 people, healthy volunteers welcome
- Sponsor
- HealthPartners Institute
Lung Diseases
AI in PRImary Care Spirometry Pathways for Diagnosis of Lung Disease (APRIL)
To investigate the feasibility of performing a future real-world randomised controlled trial to determine the clinical effectiveness of ArtiQ.Spiro in supporting diagnostic performance of primary care staff in the interpretation…
- Trial name
- APRIL (NCT05865249)
- Testing
- Spirometry decision support software (ArtiQ.Spiro)
- Where
- 2 sites in United Kingdom
- Volunteers
- 63 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Liver Failure
Understanding Patient's Knowledge and Use of Acetaminophen
Introduction to Study Objectives: In a joint collaboration of the Centers for Education and Research on Therapeutics (CERTS) at The University of Pennsylvania and the M.D.
- Trial name
- NCT00823758
- Testing
- Focus Groups, Personal Interviews
- Where
- 4 sites in United States
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Obesity, Overweight
A Trial of One to One Weight Management in Primary Care
The purpose of this study is to conduct a randomised controlled trial to assess the sustained effects on weight, selected risk factors and sense of well-being of offering individualized weight management advice in the primary…
- Trial name
- NCT00891943
- Testing
- Structured lifestyle support
- Where
- 2 sites in United Kingdom
- Volunteers
- 380 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Diabetes, Chronic Kidney Diseases
Benchtop NMR Spectroscopy for Assessment of Clinical Human Pathologies (BRANCH-P STUDY)
This research programme seeks to combine the resources of NHS primary care, with the leading spectroscopic work in low-magnetic fields of the Wilson Group (Nottingham Trent University) to demonstrate the potential for benchtop…
- Conditions
- Diabetes, Chronic Kidney Diseases, Cancer, Bowel Disease
- Trial name
- BRANCH-P (NCT05473325)
- Where
- United Kingdom
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Willows Health
Psychological Trauma, Stress Disorders, Post-Traumatic; Mental Disorders
Trauma-Focused Group Therapy for Adults With Trauma-Related Symptoms in Primary Care
Psychological trauma is common and can lead to long-lasting emotional distress, difficulties in daily functioning, and reduced quality of life.
- Trial name
- NCT07757334
- Testing
- Trauma-Focused Group Intervention, Treatment as Usual (TAU)
- Where
- Spain
- Volunteers
- 150 people
- Sponsor
- Luis Eduardo Estévez Cachafeiro
Initial Radiological Diagnosis Eligible for Tumor Resection, Initial Radiological Diagnosis Compatible With Newly Diagnosed Glioblastoma (IDH Wild-type)
Innovative SonoCloud-9 Device for Blood Brain Barrier Opening in First Line Temozolomide Glioblastoma Patients.
Glioblastoma (GBM) is an aggressive cancer with a progression-free survival (PFS) of 7 months and an overall survival (OS) of 15 months. Many therapeutic approaches have failed to improve the prognosis of patients to date.
- Conditions
- Initial Radiological Diagnosis Eligible for Tumor Resection, Initial Radiological Diagnosis Compatible With Newly Diagnosed Glioblastoma (IDH Wild-type), Eligible for the Standard of Care Including Concurrent Temoradiation and Adjuvant Temozolomide
- Trial name
- SonoFIRST (NCT04614493)
- Testing
- SonoCloud-9 (SC9) device, Temozolomide according Stupp protocol
- Where
- 7 sites in Belgium, France and 1 more
- Volunteers
- 66 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Mediterranean Diet, Overweight or Obese Adults
ENERGY2MOB STUDY: OBESITY MANAGEMENT IN BERGUEDÀ
Background: Obesity is a prevalent multifactorial disease worldwide and has become a significant public health concern. The latest data from the 2022 Catalonia Health Survey show that 56.2% of men and 43.7% of women are…
- Conditions
- Mediterranean Diet, Overweight or Obese Adults, Exercise Therapy, Cardiovascular Diseases
- Trial name
- ENERGY2MOB (NCT06988904)
- Testing
- Energy2MOB
- Where
- Spain
- Volunteers
- 136 people
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
Hip Osteoarthritis, Knee Osteoarthritis
Determining the Impact of a Physiotherapist-Led Primary Care Model for Hip and Knee Pain - A Pilot Trial
This is a pilot cluster randomized controlled trial to to evaluate the individual and health system impacts of implementing a new physiotherapist-led primary care model for hip and knee pain in Canada.
- Trial name
- NCT05736133
- Testing
- Physiotherapist-led primary care model for hip and knee pain, Usual physician-led primary care model for hip and knee pain
- Where
- Canada
- Volunteers
- 205 people, healthy volunteers welcome
- Sponsor
- Jordan Miller, PT, PhD
Asthma
Asthma Care With Alvesco® (Ciclesonide) in Primary Care in Adults - The ACCEPT-study (BY9010/CA-102)
The purpose of this study is to investigate the effectiveness of Alvesco® (Ciclesonide) compared with usual asthma care in the primary care setting.
- Trial name
- NCT00404547
- Testing
- Ciclesonide, Usual Care Inhaled Glucocorticosteroids
- Where
- 186 sites in Canada
- Volunteers
- 1,121 people
- Sponsor
- AstraZeneca
COVID-19, Long COVID
Long COVID-19 Syndrome in Primary Care: A Novel Protocol of Exercise Intervention "CON-VIDA Clinical Trial"
This is a randomized controlled trial of the efficacy of an individualized, progressive, exercise program (strength, cardiovascular, and breathing exercises) in recovering people from the post-COVID-19 syndrome (i.e., patients…
- Conditions
- COVID-19, Long COVID, Post-COVID-19 Syndrome
- Trial name
- CON-VIDA (NCT05543408)
- Testing
- EXERCISE
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Universidad San Jorge
Sepsis, Bacteraemia
Optimising Diagnosis and Antibiotic Prescribing for Acutely Ill Children in Primary Care
Acute illness is the most common presentation of children attending ambulatory care settings. Serious infections (e.g. meningitis, sepsis, pyelonephritis, pneumonia) are rare, but their impact is quite large (increased morbidity…
- Conditions
- Sepsis, Bacteraemia, Meningitis, Abscess
- Trial name
- ERNIE2 (NCT02024282)
- Testing
- Use of C-reactive protein (CRP) point of care test, Brief intervention and parent leaflet, Finger Pulse Oximeter
- Where
- 2 sites in Belgium
- Volunteers
- 8,962 people
- Sponsor
- KU Leuven
Erectile Dysfunction
Evaluation of LEVITRA to Advance the Treatment of Erectile Dysfunction
This is a multicentre, cluster-randomized, open-label flexible dose study with a 2x2 factorial design with administration of vardenafil at a dose of 5, 10 and 20 mg doses in males with erectile dysfunction.The treatment period is…
- Trial name
- NCT00664833
- Testing
- Levitra (Vardenafil, BAY38-9456), No Education
- Volunteers
- 1,029 people
- Sponsor
- Bayer
Depression
Major Depressive Disorder (MDD)
The purpose of this study is to assess the effectiveness of systematic screening for depression in high-risk patient participants in everyday clinical practice.
- Trial name
- NCT01662817
- Testing
- Intervention, Control
- Where
- Spain
- Volunteers
- 525 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Decision Making, Shared
DECIdE, Shared DECIsion in hEalth : the Real-life Impact Study
The aim of the DECIdE study is to evaluate the effect of a decision aid (the DECIdE tool) for shared decision making concerning optional prescription drugs on the level of uncertainty-certainty or comfort-inconfort (= decisional…
- Trial name
- DECIdE (NCT06052917)
- Testing
- DECIdE
- Where
- 4 sites in France
- Volunteers
- 288 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Digital Health, Maternal Health Services
The Effect of Digitally Enabled District (DED 2.0) Ecosystem on the Completeness and Timeliness of Maternal and Neonatal Services in Primary Health Care
DED 2.0 is a stepped-wedge cluster-randomized trial testing whether an integrated digital health ecosystem (KuApps, a service-monitoring dashboard, AI-assisted OCR for handwritten records, two-way WhatsApp-based health…
- Conditions
- Digital Health, Maternal Health Services, Prenatal Care, Intensive Care, Neonatal
- Trial name
- DED (NCT07842224)
- Testing
- Digitally Enabled District (DED)
- Where
- Indonesia
- Volunteers
- 10,800 people, healthy volunteers welcome
- Sponsor
- Summit Institute for Development, Indonesia
Heart Failure
Exercise for Patients With Heart Failure in Primary Care: the EFICAR
Quality of life decreases as the heart failure worsens and is one of the biggest worries of these patients. Physical exercise has been shown as a safe intervention for people with heart failure.
- Trial name
- EFICAR (NCT01033591)
- Testing
- Supervised progressive exercise program with an aerobic and a strength component + Optimized treatment, Optimized treatment according to the European Society of Cardiology guidelines
- Where
- Spain
- Volunteers
- 150 people
- Sponsor
- Basque Health Service
Migraine
Efficacy of Smartphone Based Digital Application in Improving Headache Related Parameters in Patients With Migraine
Migraine is a common headache disorder and affects 1 in 5 adults during their lifetime. It is a disorder which leads to significantly impaired quality of life, absence from work, loss of productivity in workplace and reduced…
- Trial name
- NCT04984720
- Testing
- Smartphone based digital application
- Where
- India
- Volunteers
- 403 people
- Sponsor
- All India Institute of Medical Sciences
Amblyopia, Strabismus
Multimodal Physician Intervention to Detect Amblyopia
Current research shows low rates of quantitative vision screening at preschool ages in the medical home. This study targets providers (PCPs) to evaluate the effectiveness of a web-based intervention to improve knowledge about…
- Trial name
- EPPICC (NCT01109459)
- Testing
- Pediatric blood pressure screening, Pediatric vision screening
- Where
- United States
- Volunteers
- 136 people
- Sponsor
- University of Alabama at Birmingham
Fibrinogen Abnormality, Telomere Length, Mean Leukocyte
Pediatric ACEs Screening and Resiliency Study
Stressful and traumatic experiences in childhood (Adverse Childhood Events, or ACEs) have been associated with poor health outcomes that extend into adulthood.
- Conditions
- Fibrinogen Abnormality, Telomere Length, Mean Leukocyte, Atopic, Acute Infection
- Trial name
- PEARLS (NCT04182906)
- Testing
- Care Coordination, Resiliency Clinic, Usual Care
- Where
- United States
- Volunteers
- 555 people, healthy volunteers welcome
- Sponsor
- UCSF Benioff Children's Hospital Oakland