Clinical trials: Preventive Treatment of Migraine
Migraine
Study to Evaluate the Efficacy and Safety of Erenumab (AMG 334) in Migraine Prevention
The primary objective of the study was to evaluate the effect of erenumab compared to placebo on the change from baseline in monthly migraine days.
- Trial name
- STRIVE (NCT02456740)
- Testing
- Erenumab
- Where
- 129 sites in United States, Austria and 11 more
- Volunteers
- 955 people
- Sponsor
- Amgen
Migraine Disorders
American Migraine Prevention Study
The purpose of this study is to evaluate the use of nutritional supplementation and dietary management for the reduction in frequency, duration, and intensity of migraine headache pain.
- Trial name
- NCT00363506
- Testing
- Serotona Plus and dietary behavior management
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Dynamic Health Resources
Migraine
An Observational Study to Assess Change in Disease Activity When Ubrogepant Tablets Are Combined With Atogepant Tablets to Treat Migraine in Adult Participants
Migraine is a neurological disease characterized by moderate or severe headache, associated with nausea, vomiting, and/or sensitivity to light and sound.
- Trial name
- COURAGE II (NCT05653986)
- Where
- United States
- Volunteers
- 391 people
- Sponsor
- AbbVie
Migraine
ADX10059 Migraine Prevention Study
Evaluation of ADX10059 to prevent migraine attacks
- Trial name
- NCT00820105
- Testing
- ADX10059
- Where
- 31 sites in Austria, Belgium and 3 more
- Volunteers
- 350 people
- Sponsor
- Addex Pharma S.A.
Migraine Disorders
An Open Label, Study of DaxibotulinumtoxinA for Migraine Prevention
This is a prospective, multi-center, unblinded study in patients with migraine (≥ 8 MMDs(monthly migraine days)/month) requiring preventive treatment.
- Trial name
- NCT06154070
- Testing
- DaxibotulinumtoxinA
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Ki Health Partners. LLC
Migraine
Investigation of Safety and Efficacy of ABP-450 for Migraine Prevention in Adults
This Phase 2 trial will evaluate the efficacy and safety of ABP-450 for migraine prevention in adults who suffer from six or more migraine days per month.
- Trial name
- NCT04845178
- Testing
- ABP-450
- Where
- 62 sites in United States, Australia and 1 more
- Volunteers
- 797 people
- Sponsor
- AEON Biopharma, Inc.
Migraine Disorders
Open Label Study of BOTOX® (Botulinum Toxin Type A) as Headache Prophylaxis in Chinese Patients With Chronic Migraine
This study is an open-label extension study to evaluate the safety, tolerability and efficacy of BOTOX® as headache prophylaxis in Chinese patients with chronic migraine who have successfully completed the double-blind study…
- Trial name
- NCT03193359
- Testing
- botulinum toxin Type A
- Sponsor
- Allergan
Migraine Disorders
Nutrition for Migraine Prevention
Migraine is a widespread, debilitating, chronic pain disorder and a major public health challenge. Most conventional, pharmaceutical treatments fail to give satisfactory long-term relief and their repeated use can have important…
- Trial name
- NCT02012790
- Testing
- Diet
- Where
- United States
- Volunteers
- 182 people
- Sponsor
- University of North Carolina, Chapel Hill
Migraine
Eptinezumab as Preventive Treatment of Migraine in Adults With Migraine
This study evaluates the efficacy of eptinezumab to prevent migraine in participants with chronic migraine.
- Trial name
- Sunrise (NCT04921384)
- Testing
- Eptinezumab
- Where
- 87 sites in China, Georgia and 6 more
- Volunteers
- 981 people
- Sponsor
- H. Lundbeck A/S
Migraine Disorders
Preventive Role of Melatonin and Propranolol Administration in Pediatric Migraine
This randomized controlled trial evaluated whether adding melatonin to propranolol provided better prevention of migraine in children than propranolol alone.
- Trial name
- NCT07743255
- Testing
- Melatonin, Propranolol
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Nishtar Medical University
Episodic Migraine
The Effects of Vitamin D Plus Omega-3 Polyunsaturated Fatty Acids in Patients With Episodic Migraine
First, the aims of this study are to explore the effect of vitamin D versus placebo in the prevention of episodic migraine. Second, we would like to compare and evaluate the effect of vitamin D plus omega-3 fatty acids versus…
- Trial name
- NCT05449145
- Testing
- Vitamin D, Non-Vitamin D
- Where
- Taiwan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Kuang Tien General Hospital
Chronic Migraine
A Study With Intranasal Kinetic Oscillation Stimulation (KOS) in the Prevention of Chronic Migraine
An open pilot study, non-controlled, single center investigation.
- Trial name
- NCT05273151
- Testing
- KOS (Intranasal kinetic oscillation stimulation)
- Where
- 2 sites in United Kingdom
- Volunteers
- 13 people
- Sponsor
- Chordate Medical
Migraine
A Research Study Examining The Use Of Duloxetine In The Prevention Of Migraine Headache
This is a single-center, open-label, pilot trial to collect and evaluate data on the safety and efficacy of duloxetine in the preventive treatment of subjects experiencing episodic migraine headaches.
- Trial name
- NCT00443352
- Testing
- duloxetine
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Thomas Jefferson University
Adolescent Migraine
Evaluation of Efficacy and Safety of add-on Alpha-lipoic Acid on Migraine Prophylaxis in Adolescent Population
Migraine causes a substantial impact on the physical and mental health of a child and it is a major cause for time-off school leading to impaired academic performance.
- Trial name
- NCT04064814
- Testing
- Flunarizine 5mg, Alpha lipoic acid 300mg
- Where
- India
- Volunteers
- 60 people
- Sponsor
- All India Institute of Medical Sciences, Bhubaneswar
Migraine Headache
An Evaluation Of The Efficacy And Safety Of Donepezil Hydrochloride (E2020) In Migraine Prophylaxis
The purpose of this extension study was to evaluate the safety and efficacy of donepezil hydrochloride after extended use in migraine prophylaxis. Efficacy will continue to be evaluated.
- Trial name
- NCT01146509
- Testing
- Aricept (donepezil hydrochloride)
- Where
- 4 sites in United States
- Volunteers
- 89 people
- Sponsor
- Eisai Inc.
Migraine
Efficacy and Safety Trial of Rimegepant for Migraine Prevention in Adults
The purpose of this is study is to compare the efficacy of BHV-3000 (rimegepant) to placebo as a preventive treatment for migraine, as measured by the reduction in the number of migraine days per month.
- Trial name
- NCT03732638
- Testing
- Rimegepant
- Where
- 93 sites in United States
- Volunteers
- 1,590 people
- Sponsor
- Pfizer
Migraine
Efficacy and Safety Study of Rimegepant in Episodic Migraine Prevention With Multiple Dosing Regimens
The purpose of this study is to compare the efficacy and safety of daily and every other day dosing of rimegepant to placebo as a preventive treatment for episodic migraine.
- Trial name
- NCT05217927
- Testing
- Rimegepant 75mg daily dosing, Rimegepant 75mg every other day dosing
- Where
- 107 sites in United States, Austria and 8 more
- Volunteers
- 1,415 people
- Sponsor
- Pfizer
Migraine
A Trial to Test if Fremanezumab is Effective in Preventing Migraine in Children and Adolescents
The primary objective of the study is to evaluate the long-term safety and tolerability of subcutaneous fremanezumab in the preventive treatment of migraine in pediatric participants 6 to 17 years of age (inclusive at enrollment…
- Trial name
- NCT04530110
- Testing
- Fremanezumab
- Where
- 70 sites in United States, Canada and 7 more
- Volunteers
- 499 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D LLC
Migraine
Comparative Effectiveness of Migraine Preventive Medications: The APT Comparison Study
This goal of this study is to compare three medications used for migraine preventive treatment. This study will compare atogepant, a newer migraine preventive medication, with two older preventive medications, topiramate and…
- Trial name
- NCT06972056
- Testing
- Atogepant 60 mg, Propranolol 160 mg, Topiramate 100 mg
- Where
- 37 sites in United States
- Volunteers
- 1,335 people
- Sponsor
- Mayo Clinic
Migraine
An Open-label, Intermediate Size, Expanded Access Study of BHV-3000 in the Acute Treatment of Migraine
The purpose of this protocol is to allow subjects who completed any BHV3000 (rimegepant) clinical study to continue to have access to rimegepant while collecting ongoing safety data.
- Trial name
- NCT03934086
- Testing
- rimegepant
- Sponsor
- Pfizer