Clinical trials: Preventive Intervention
Weight Gain, Obesity
Chromium Piccolinate in the Prevention of Weight Gain Induced by Serotonergic Medications Initiated on Psychiatric Inpatient Units.
A majority of patients who suffer from mental illness are treated with serotonin regulating FDA approved medications. Some of these medications also block histamine transmission, increase blood prolactin levels, induce insulin…
- Trial name
- NCT00759993
- Testing
- chromium piccolinate
- Volunteers
- 60 people
- Sponsor
- State University of New York - Upstate Medical University
Childhood Obesity, Overweight and Obesity
Childhood Obesity - Prevention of Diabetes Through Changed Eating Patterns
The main purpose of the present study is to perform a 10 weeks dietary intervention study with a follow-up for 52 weeks in children from 7-14 years of age with overweight or obesity.
- Conditions
- Childhood Obesity, Overweight and Obesity, Adolescent Obesity, Adolescent Overweight
- Trial name
- COPE (NCT04522921)
- Testing
- Diet with a higher amount of protein (25E% per day), Increased follow-up contact after the 10-week intervention, Diet with a lower amount of protein (15E% per day)
- Where
- 2 sites in Denmark
- Volunteers
- 211 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Stroke
Use of Direct Oral Anticoagulants in UK
Many people who suffer from irregular heartbeats (atrial fibrillation) which might cause stroke, need to take blood thinners to prevent it.
- Trial name
- NCT03119116
- Testing
- Rivaroxaban (Xarelto, BAY59-7939), Dabigatran, Apixaban
- Where
- United Kingdom
- Volunteers
- 31,336 people
- Sponsor
- Bayer
Endometritis
Comparison Study of Cefazolin Versus Cefazolin Plus Azithromycin Prophylaxis in Post-Cesarean Endometritis
Despite the generalized use of preoperative antibiotic prophylaxis, endometritis remains as the most frequent post-cesarean delivery complication.
- Trial name
- NCT01721616
- Testing
- Azithromycin, Cefazolin
- Where
- United States
- Sponsor
- University of Missouri, Kansas City
Constipation, Perioperative Nursing
Effect of a Constipation Prevention Checklist in Hip Surgery Patients
Constipation is a common postoperative problem in patients undergoing hip surgery and may be associated with immobilization, opioid analgesic use, and inadequate fluid and fiber intake.
- Conditions
- Constipation, Perioperative Nursing, Checklist, Orthopedic Disorder
- Trial name
- NCT07895316
- Testing
- Constipation prevention and checklist monitoring in hip surgery patients
- Where
- Turkey (Türkiye)
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Cumhuriyet University
Esophageal Varices in Cirrhosis of the Liver
HVPG-Guided Therapy Versus EVL Plus NSBB in Second Prophylaxis of Esophageal Variceal Bleeding
A single-center randomized controlled study comparing endoscopic or interventional therapy guided by the hepatic venous pressure gradient (HVPG) , to standard endosopic variceal ligation plus nonselective beta-blocker therapy…
- Trial name
- NCT03687216
- Testing
- HVPG-guided therapy, Routing Therapy
- Where
- China
- Volunteers
- 160 people
- Sponsor
- West China Hospital
HIV Prevention, HIV Risk
Evaluating an Interactive Digital Toolkit for Women's PrEP Implementation
The goal of this study is to test if a Digital PrEP Toolkit helps cisgender women learn about and access PrEP in Alabama and Mississippi. PrEP is a medication that prevents HIV infection.
- Conditions
- HIV Prevention, HIV Risk, Sexual and Reproductive Health
- Trial name
- NCT07292584
- Testing
- Interactive Digital PrEP Toolkit
- Where
- 4 sites in United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Metabolic Dysfunction-associated Fatty Liver Disease, Cirrhosis
Study on MAFLD-related Cirrhosis Prevention and Treatment Strategies
To establish a prospective, multicenter, biopsie-confirmed clinical cohort of MAFLD-related cirrhosis (F3-F4) in China, and analyze the clinical, histopathological features and natural outcomes of MAFLD-associated liver…
- Trial name
- SMART (NCT06135584)
- Testing
- Pioglitazone metformin tablets, Other drugs, Drug-free
- Volunteers
- 1,000 people
- Sponsor
- The Affiliated Hospital of Hangzhou Normal University
Diabetes Mellitus, Heart Failure
Nt-proBNP Guided Primary Prevention of CV Events in Diabetic Patients
Increased levels of NT-proBNP are known to increase the risk of cardiac events in diabetic patients. The other way around, patients with normal values have an excellent prognosis on short-term.
- Conditions
- Diabetes Mellitus, Heart Failure, Coronary Artery Disease
- Trial name
- PONTIAC (NCT00562952)
- Testing
- Telmisartan, Bisoprolol
- Where
- 2 sites in Austria
- Volunteers
- 300 people
- Sponsor
- Medical University of Vienna
Pre-Exposure Prophylaxis of HIV Infection
Pre-Exposure Prophylaxis Study of Lenacapavir in Cisgender Men, Transgender Women, Transgender Men, and Gender Nonbinary People at Risk for HIV Infection
The goal of this study is to evaluate the efficacy of the study drugs, lenacapavir (LEN) in preventing HIV infection, in participants ≥ 16 years of age who have condomless receptive anal sex with partners assigned male at birth…
- Trial name
- PURPOSE 2 (NCT04925752)
- Testing
- Oral Lenacapavir (LEN), F/TDF, Sub-cutaneous (SC) Lenacapavir (LEN)
- Where
- 93 sites in United States, Argentina and 6 more
- Volunteers
- 3,292 people, healthy volunteers welcome
- Sponsor
- Gilead Sciences
Hemorrhage, Atrial Fibrillation, Postoperative
Prevention of Retained-Blood Outcomes With Active Clearance Technology
Postoperative bleeding is a common consequence after heart surgery which can significantly impact outcomes and costs . When bleeding occurs, reliable postoperative blood evacuation of the pleural, mediastinal and pericardial…
- Trial name
- NCT02145858
- Testing
- Blood drainage post cardiac surgery using PleuraFlow System
- Where
- 2 sites in United States
- Volunteers
- 891 people
- Sponsor
- ClearFlow, Inc.
Intermittent Claudication
Person-centered Follow up and Health Promotion Program After Revascularization for Intermittent Claudication
The overall aim of the study is to evaluate a nurse-led intervention (person-centered follow up and health promotion) program in comparison to standard follow up for patients treated with surgical or endovascular…
- Trial name
- FASTIC (NCT03283358)
- Testing
- Person-centered follow up
- Where
- 2 sites in Sweden
- Volunteers
- 213 people
- Sponsor
- Karolinska Institutet
Pregnancy in Adolescence
Evaluation of the Positive Prevention PLUS Program
This study aims to determine if the Positive Prevention PLUS teen pregnancy prevention program has an impact on abstinence, birth control use, and likelihood of becoming pregnant.
- Trial name
- PP+ (NCT02540278)
- Testing
- Positive Prevention PLUS
- Where
- United States
- Volunteers
- 4,267 people, healthy volunteers welcome
- Sponsor
- California State University, San Bernardino
Colo-rectal Cancer, Polyps of Colon
Optivista : I-SCAN OE for Optical Diagnosis of Small Colon Polyps
This prospective randomized clinical trial aims to evaluate the new Optivista system compared to the iScan for his optical diagnosis and interval agreement monitoring with pathology.
- Trial name
- Optivista (NCT03515343)
- Testing
- Screening colonoscopy according to resect-and-discard strategy
- Where
- Canada
- Volunteers
- 411 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Kidney Transplant
Efficacy and Safety of Leymovir Versus Valganciclovir in Prevention of Cytomegalovirus Infection and Cytomegalovirus Disease in Chinese Kidney Transplant Recipients
the existing anti-CMV drugs mainly include valganciclovir, ganciclovir and foscarnet sodium, all of which act on DNA polymerase (pUL54), making them prone to cross resistance.
- Trial name
- CAPS01 (NCT07266467)
- Testing
- Letermovir, Valganciclovir
- Where
- China
- Volunteers
- 290 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Subarachnoid Hemorrhage, Aneurysmal
Safety and Efficacy Study of Etanercept for Aneurysmal Subarachnoid Hemorrhage
Subarachnoid hemorrhage (SAH) is a special type of stroke that typically results from a ruptured intracranial aneurysm, a weakening in the wall of a blood vessel.
- Trial name
- NCT01865630
- Testing
- Etanercept
- Where
- Canada
- Sponsor
- Unity Health Toronto
Aging, Healthy
Healthy Aging Through Dietary Intervention
To test the impact of flavanol supplementation of cardiac and vascular function and subsequently on exercise capacity in elderly individuals
- Trial name
- NCT05782309
- Testing
- Flavanol
- Where
- Germany
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Heinrich-Heine University, Duesseldorf
Depression, Mental Disorder in Adolescence
The PATHway Study: Primary Care Based Depression Prevention in Adolescents
Prevention of depressive disorders has become a key priority for the NIMH, but the investigators have no widely available public health strategy to reduce morbidity and mortality.
- Trial name
- PATHway (NCT05203198)
- Testing
- Competent Adulthood Transition with Cognitive-Behavioral, Humanistic and Interpersonal Training
- Where
- 6 sites in United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Chicago
Occupational Stress, Work-Related Stress
XR2ESILIENCE - XR-Based Resilience Training for Stress and Mental Health in Healthcare Workers
This study investigates the effectiveness of an extended reality (XR) based resilience training program designed to support the mental health and well-being of nurses working in hospital settings.
- Conditions
- Occupational Stress, Work-Related Stress, Mental Health, Burnout
- Trial name
- XR2ESILIENCE (NCT07544498)
- Testing
- XR-based Resilience Training, Waitlist Control
- Where
- 8 sites in Austria, Croatia and 3 more
- Volunteers
- 232 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Glioma of Brain, Craniopharyngioma
Memantine for Prevention of Cognitive Late Effects in Pediatric Patients Receiving Cranial Radiation Therapy for Localized Brain Tumors
Children with brain tumors who have had radiation therapy are at risk for problems with attention, memory, and problem solving. Such problems may cause difficulty in school and daily life.
- Conditions
- Glioma of Brain, Craniopharyngioma, Ependymoma, Germ Cell Tumor
- Trial name
- NCT03194906
- Testing
- Memantine, Cognitive Assessment
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- St. Jude Children's Research Hospital