Clinical trials: Preterm Neonates
Apnea, Bradycardia
microEEG for Neonatal Apnea, Bradycardia and Desaturation
The study utilizes microEEG (a novel miniaturized, FDA approved EEG device) to prospectively investigate the cerebral electrical activity of infants with Apnea, Bradycardia and Desaturation events.
- Conditions
- Apnea, Bradycardia, Premature Birth, Seizures
- Trial name
- NCT02436616
- Testing
- microEEG
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- Bio-Signal Group Corp.
Necrotizing Enterocolitis
STP206 for the Prevention of Necrotizing Enterocolitis (NEC)
This study is a sequential dose escalation study to assess the safety, tolerability, and preliminary NEC-preventative efficacy of two doses of STP206 versus control in very low birth weight and extremely low birth weight neonates.
- Trial name
- NCT01954017
- Testing
- STP206, Control
- Where
- 13 sites in United States
- Volunteers
- 103 people
- Sponsor
- Leadiant Biosciences, Inc.
Osteopenia of Prematurity
Comparison of Two Different Doses of Vitamin D in Preterm Infants
randomized clinical trial comparing two different doses of vitamin d supplementation in preterm infants
- Trial name
- NCT03889717
- Testing
- vitamin D
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Cairo University
Neonatal Sepsis
Oral Lactoferrin Supplementation for Prevention of Sepsis in Preterm Neonate
Hypothesis: Orally ingested lactoferrin has effects on promotion of growth and differentiation of the immature gut; also it has immunomodulatory properties, so it will prevent serious infections in preterm infants.
- Trial name
- NCT01821989
- Testing
- Lactoferrin
- Where
- Egypt
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Mooselmokadem
Pain, Development
Trial of Repeated Analgesia With Kangaroo Care
Mothers can provide pain relief to their newborns, even in the context of intensive neonatal care. There is a recent accumulation of data, being analyzed by ourselves in a Cochrane review, that mothers holding their infants in a…
- Trial name
- TRAKC (NCT01561547)
- Testing
- Kangaroo Mother Care, Sucrose
- Where
- Canada
- Volunteers
- 242 people
- Sponsor
- IWK Health Centre
Feeding Disorder Neonatal
Effects of PIOMI on Oral Feeding of the Premature Infants
Randomized controlled clinical trial aimed at evaluating the effects of the "Premature infant oral motor intervention" method on the oral feeding skills of the premature infants.
- Trial name
- PIOMI2020 (NCT04290338)
- Testing
- PIOMI
- Volunteers
- 40 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Infant, Premature, Diseases, Fatty Acid Deficiency
Prospective Evaluation in Older Premature, Untreated Breast Milk and Milk Processed by the Breast-milk Bank
The purpose of this study is to evaluate the impact of the enteral nutrition type (untreated breast milk, or breast milk processed by the breast-milk bank) on the longitudinal evolution of the total content and plasma profile of…
- Trial name
- ADiLL (NCT01626508)
- Where
- 2 sites in France
- Volunteers
- 9 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Pain
Analgesic Effect of Oral 25% Glucose Versus Oral 24% Sucrose for Pain Relief During Heel Lance in Preterm Neonates
RESEARCH HYPOTHESIS-In preterm neonates during heel lance oral 25% glucose is more efficacious in reducing pain as compared to oral 24% sucrose when assessed by PIPP(Premature infant pain profile)
- Trial name
- NCT01931020
- Testing
- Sucrose, Glucose
- Where
- India
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Lady Hardinge Medical College
Premature, Pacifiers
Clinical Effects of Pacifier Use in Preterm During Orogastric Tube Feeding: Randomized Controlled Trial
The purpose of the study was to assess how preterm babies' vital signs, feeding time, and gastric residual volume were affected by using a pacifier only or a pacifier with breast milk during orogastric tube feeding.
- Conditions
- Premature, Pacifiers, Tube Feeding, Neonatal Nursing
- Trial name
- NCT05530733
- Testing
- Pacifier, Breast milk
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Zonguldak Bulent Ecevit University
Neonatal Death, Prematurity
Outcomes Following Early Parenteral Nutrition Use in Preterm Neonates
BACKGROUND An essential part of neonatal care is providing nutrition to ensure that babies grow and develop. Providing this can be difficult in premature babies because their intestines are underdeveloped.
- Trial name
- NCT03767634
- Testing
- Parenteral nutrition
- Where
- United Kingdom
- Volunteers
- 97,507 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Prematurity
Electrocardiography Versus Pulse Oximetry for Newborn Heart Rate Determination
The goal of this study is to compare the time required for accurate heart rate measurement of the preterm newborn when using pulse oximetry versus electrocardiography leads.
- Trial name
- NCT01256346
- Testing
- Apparatuses
- Where
- United States
- Sponsor
- University of Oklahoma
Nose Deformities, Acquired
Objectives and Measures Dimensions Nasal Resistance of Preterm and Term (MODERN)
During the resuscitation of preterm infants, withdrawal of non-invasive ventilation is difficult. In a recent study in children gestational age <30 weeks of amenorrhea (SA), definitive withdrawal rate from the first attempt to…
- Trial name
- MODERN (NCT02815345)
- Testing
- Rhinometry
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Premature Birth, Respiratory Distress Syndrome
Non-invasive Ventilation in Preterm Infants
This is a prospective, observational cohort study. For the study part on noninvasive neurally adjusted ventilatory assist (NIV-NAVA) the design is interventional.
- Conditions
- Premature Birth, Respiratory Distress Syndrome, Ventilator Lung; Newborn
- Trial name
- NCT05987800
- Testing
- Titration procedure, Electrical impedance tomography, Lung and diaphragm ultrasound
- Where
- Belgium
- Volunteers
- 136 people
- Sponsor
- Universitair Ziekenhuis Brussel
Prematurity
Care Outcomes in Preterm Infants Following the Implementation of Family-centered Interventions
The proposed study evaluates the effects of two family-centered interventions on the length of stay and outpatient visits and growth of preterm infants.The interventions are 1) the Close Collaboration with Parents training for…
- Trial name
- NCT05765136
- Where
- Finland
- Volunteers
- 30,000 people
- Sponsor
- University of Turku
Bronchopulmonary Dysplasia
Clinic Features and Outcome of BPD (SGBPD)
This study described the perinatal high-risk factors and clinical manifestations of the children, and compared the high-risk factors, clinical manifestations and prognosis of BPD among different clinical subtypes by comparison…
- Trial name
- NCT04237844
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Wang Jianhui
Metabolic Bone Disease, Osteopenia
A Study to Assess Metabolic Bone Disease of Prematurity Using an Acoustic Method
The goal of this project is to develop a new noninvasive ultrasound based technique, called vibro-acoustic analysis (VAA), for evaluation of infant bone health with particular application in assessment of bone health in premature…
- Conditions
- Metabolic Bone Disease, Osteopenia, Neonatal Rickets
- Trial name
- NCT04752098
- Testing
- Vibro-acoustic analysis (VAA), based on ultrasound radiation force
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Mayo Clinic
Respiratory Syncytial Virus Infections
Prospective Study for the Use of Palivizumab (Synagis®) in High-risk Children in Germany
The SYNAGIS Registry was carried out in order to gather comprehensive real-world data on the use of palivizumab in children at high risk for serious respiratory syncytial virus (RSV) disease.
- Trial name
- NCT01155193
- Volunteers
- 30,804 people
- Sponsor
- AbbVie (prior sponsor, Abbott)
Neonatal Respiratory Distress Syndrome, Gestational Age Conditions
The Use of Sedation Drugs in the Procedure of Administering Surfactant Without Intubation (LISA/MIST)
The purpose of this study is to evaluate the efficacy and impact of intravenous ketamine or sublingual 30% glucose as sedation drugs used in preterm premature babies during the LISA procedure.
- Trial name
- LISA KGS (NCT04409665)
- Testing
- Ketamine, Glucose
- Where
- Poland
- Volunteers
- 60 people
- Sponsor
- Medical University of Warsaw
Preterm Birth
Effect of Early Use of Caffeine Citrate in Preterm Neonates
This work is designed to study the effect of the early use of caffeine citrate in preterm neonates who need respiratory support on morbidity and short term neonatal outcome.
- Trial name
- NCT04001712
- Testing
- Caffeine Citrate
- Where
- Egypt
- Volunteers
- 54 people
- Sponsor
- Ain Shams University
Premature Birth
Facilitating Safe Transition to Home for Preterm Infants - a National Database Study
Preterm infants (i.e. born before 37 completed weeks of pregnancy) often require additional care and are admitted to neonatal units.
- Trial name
- NCT06284044
- Where
- United Kingdom
- Volunteers
- 250,000 people
- Sponsor
- University Hospitals of Derby and Burton NHS Foundation Trust