Clinical trials: Preterm Labour
Twin Pregnancy, Antepartum Condition or Complication, Fetal Thymus Volume
Fetal Thymus Volume of Dichorionic Diamniotic Twin
In some studies of fetal thymus volume, fetal stress factors; infection, preterm premature premature rupture of membranes, preeclampsia, preterm delivery risk.
- Conditions
- Twin Pregnancy, Antepartum Condition or Complication, Fetal Thymus Volume, Preterm Birth
- Trial name
- NCT04055701
- Testing
- assesment of thymus volume
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Karadeniz Technical University
Preterm Labor
Uterocervical Angle and Preterm Labour
To determine whether a novel ultrasonographic marker, uterocervical angle, correlates with risk of spontaneous preterm birth
- Trial name
- NCT04532086
- Testing
- Uterocervical angle
- Volunteers
- 197 people
- Sponsor
- Ain Shams Maternity Hospital
Preterm Labor With Preterm Delivery, Premature Birth
Pharmacokinetics and Placental Transfer of Caffeine
The goal of this study is to learn how a pregnant person's body processes caffeine and how much caffeine crosses the placenta to the baby. A small dose of caffeine will be given to each pregnant participant before delivery.
- Conditions
- Preterm Labor With Preterm Delivery, Premature Birth, Apnea of Prematurity, Respiratory Distress Syndrome
- Trial name
- AnteCaff (NCT07570121)
- Testing
- Caffeine citrate
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Indiana University
Preterm Labor
Nanovectors to Prevent Placental Passage of Tocolytic Agents
The purpose of the study is to find out whether indomethacin encapsulated within a nanovector can stop contractions in pregnant human uterine tissue. Preterm delivery is a major contributor to newborn deaths.
- Trial name
- NCT02199756
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Preterm Birth, Preterm Labor
The Biomarker Study
Preterm birth (PTB) is a leading contributor to perinatal morbidity and mortality. While patients with preterm labor (PTL) are at an increased risk for PTB, not all PTL patients will deliver preterm.
- Trial name
- NCT01148654
- Where
- United States
- Volunteers
- 1,076 people
- Sponsor
- University of Pennsylvania
Labor, Premature
Correlation Between Vitamin D and B Regulatory Cell in Pregnancy
During pregnancy , the maternal immune system is always confronted with fetal alloantigens. the immunological mechanisms that prevent the rejection of the fetus are still not under understood.
- Trial name
- NCT04105881
- Testing
- Investigation
- Where
- 2 sites in Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Assiut University
Gestational Diabetes, Hypertension in Pregnancy
Sleep Improvement Therapy Affects Pregnancy Outcomes in Chinese Singletons and Twins by Improving Sleep Quality
During pregnancy, the physical and psychological changes of pregnant women, hyperemesis gravidarum, uterine compression, frequent urination, hip or pelvic pain, back pain, leg cramps, gastroesophageal reflux, changes in mental…
- Conditions
- Gestational Diabetes, Hypertension in Pregnancy, Preterm Labor, NICU Infants
- Trial name
- NCT06687044
- Testing
- Sleep restriction, Stimulation control, Cognitive therapy
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Jun Wei
Obstetric Labor, Premature
Vaginal Indomethacin for Preterm Labor
Indometacin is a cyclooxygenase agent from the NSAID family that has been used to treat preterm contractions since the 70's by preventing the synthesis of prostaglandins.
- Trial name
- TOCOMED (NCT04404686)
- Testing
- Indomethacin, Nifedipine
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Preterm Labor
Vaginal Progesterone for the Prolongation of Pregnancy After Arrested Pre-term Labor
Patients diagnosed with arrested pre-term labor following tocolytics at 24-34 gestational weeks will be randomly allocated to receive either vaginal micronized progesterone 400 mg/day or no treatment.
- Trial name
- NCT02430233
- Testing
- micronized progesterone 400 mg (Utrogestan)
- Where
- 3 sites in Israel
- Volunteers
- 129 people
- Sponsor
- HaEmek Medical Center, Israel
Obstetric Labour, Premature
This Study Will Investigate the Effect of Single Oral Doses of Retosiban on Cardiac Repolarization, With Moxifloxacin as a Positive Control in Healthy Volunteers.
This will be a randomized, placebo-controlled, single, oral dose, four-way Williams crossover study design in healthy male and female subjects.
- Trial name
- NCT01702376
- Testing
- Retosiban 100 mg, Retosiban 800 mg, Moxifloxacin 400 mg
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Obstetric Labor, Premature
Impact of Threatened Preterm Labour in Fetal Cardiovascular and Metabolic Programming (SHs)
The goal of this observational study is to learn about cardiac function and remodelling and metabolomic profiles in fetuses and infants who were exposed to a threatened preterm labor (TPL) during pregnancy.
- Trial name
- SHs (NCT05670665)
- Testing
- Threatened preterm labor
- Where
- Spain
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Instituto de Investigación Sanitaria Aragón
Labor Preterm Multiple
Tocolytic Therapy for Preterm Labor in Multiple Gestation
To compare the tocolytic efficacy oxytocin receptor antagonist (Atosiban) with that of calcium channel blockers (Nifedipine) among women with multiple gestation who present with threatened preterm labor.
- Trial name
- NCT02725736
- Testing
- Atosiban, Nifedipine
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Preterm Labor, Preterm Birth
Establishment of a Perinatal Database and a Bank of Biological Materials
The aim of this project is to establish a clinical database and a bank of biological materials which will be used to improve the pathophysiologic understanding of the mechanisms underlying various pregnancy diseases.
- Conditions
- Preterm Labor, Preterm Birth, Pregnancy
- Trial name
- NCT00339235
- Where
- United States
- Volunteers
- 30,570 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Preterm Birth, Preterm Labor With Preterm Delivery, Unspecified Trimester, Fetus 2
Cerclage for Twins With Short Cervix
A prospective randomized control trial that will compare cervical cerclage plus vaginal progesterone to vaginal progesterone along in twin pregnancies complicate by a short cervix (</= 15.0mm) between 16w0d to 25w6d.
- Conditions
- Preterm Birth, Preterm Labor With Preterm Delivery, Unspecified Trimester, Fetus 2, Cervical Incompetence, Cervical Shortening
- Trial name
- NCT03077633
- Testing
- Cervical Cerclage placement, Vaginal Progesterone
- Volunteers
- healthy volunteers welcome
- Sponsor
- Pediatrix
Preterm Labor, Cervical Incompetence
Cervical Cerclage for Singleton Pregnant on Vaginal Progesterone With Progressive Cervical Length Shortening
The aim of this study is to Determine whether cerclage with vaginal progesterone will: 1. Reduce the overall spontaneous preterm birth rate. 2. Prolong pregnancy latency. 3. Improve neonatal outcome.
- Trial name
- NCT03837288
- Testing
- Cerclage
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Preterm Birth, Premature Birth
Single Dose of Antenatal Corticosteroids for Pregnancies at Risk of Preterm Delivery (SNACS)
Antenatal corticosteroids (ACS) reduce the risks of neonatal death and morbidities in preterm infants, such as respiratory distress syndrome.
- Conditions
- Preterm Birth, Premature Birth, Complication of Prematurity, Obstetric Labor, Premature
- Trial name
- SNACS (NCT05114096)
- Testing
- Celestone + Celestone
- Where
- 25 sites in Canada
- Volunteers
- 3,254 people
- Sponsor
- McMaster University
Premature Labour
Vaginal Progesterone Versus Cervical Cerclage for Pregnant Women With Short Cervix and History of PTL and/or MTM
The aim of this study to compare vaginal progesterone supplementation to cervical cerclage for prevention of preterm labor in women with short cervical length and history of previous midtrimester miscarriage and/or preterm labor.
- Trial name
- NCT02673359
- Testing
- Progesterone, Cervical cerclage
- Where
- 3 sites in Egypt
- Volunteers
- 220 people
- Sponsor
- Mohamed Sayed Abdelhafez
Preterm Labor
Extended Release Nifedipine Treatment as Maintenance Tocolysis to Prevent Preterm Delivery
To evaluate the treatment efficacy and safety usig extended release nifedipine, as maintenance therapy to pregnant women who were hospitalized and treated for preterm labor until 34 weeks' gestation.
- Trial name
- NCT00525486
- Testing
- Nifedipine extended release
- Volunteers
- healthy volunteers welcome
- Sponsor
- The Baruch Padeh Medical Center, Poriya
Pregnancy Complications, Preterm Labor
Strengthening Facility-based Intrapartum/Immediate Newborn Care to Reduce Mortality of Preterm Infants in Migori County, Kenya and Busoga Region, Uganda
The purpose of this study is to determine whether a combination of evidence-based strategies can improve intrapartum and newborn care in facilities to reduce mortality among preterm infants.
- Conditions
- Pregnancy Complications, Preterm Labor, PreTerm Birth, Stillbirth
- Trial name
- PTBi-KE-UG (NCT03112018)
- Testing
- data strengthening, modified Safe childbirth checklist - control, modified Safe childbirth checklist - enhanced
- Where
- 2 sites in Kenya, Uganda
- Volunteers
- 102,988 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Induction of Labor, Cervical Ripening
Balloon + Oxytocin Versus Oral Misoprostol to Induce Labor in Case of PROM (RUBAPRO2)
Premature rupture of membranes (PROM) at term complicates 6 to 22% of singleton pregnancies. Spontaneous labour occurs in 60-67% of these patients within 24h.
- Conditions
- Induction of Labor, Cervical Ripening, Premature Rupture of Fetal Membranes, Nulliparous
- Trial name
- RUBAPRO2 (NCT05568745)
- Testing
- Balloon for cervical ripening (Teleflex French Dufour catheter CH20 reference 174000), Oxytocin, Misoprostol Oral Tablet
- Where
- 5 sites in France
- Volunteers
- 152 people
- Sponsor
- University Hospital, Clermont-Ferrand