Clinical trials: Preterm Labour
Preterm Birth, Pregnancy
Clinical, Biochemical, Histological and Biophysical Parameters in the Prediction of Cerebral Palsy in Patients With Preterm Labor and Premature Rupture of Membranes
A major goal of modern perinatal and neonatal medicine is to reduce the rate of developmental disabilities, especially mental retardation.
- Trial name
- NCT00342667
- Where
- 5 sites in United States, Chile and 2 more
- Volunteers
- 4,673 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Preterm Labor
Vaginal Progesterone Supplementation in the Management of Preterm Labor
This study evaluates the addition of vaginal progesterone in the management of preterm labor. Half of participants will receive vaginal progesterone, tocolysis and corticosteroid, while the other half will receive only tocolysis…
- Trial name
- NCT03202836
- Testing
- progesterone, Tocolytics, Steroids
- Where
- Thailand
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
Preterm Birth
Prevention of Preterm Birth in Singletons Using Pessary After Resolutive Threatened Preterm Labor
In France, threatened preterm labour concerns 6.5% of pregnancies and is associated with a premature birth in 25.4% of cases. After 48 hours effective tocolysis, patients do not receive any further treatment while their risk of…
- Trial name
- PREMAPESSAIRE (NCT02484820)
- Testing
- Silicone pessary
- Where
- France
- Volunteers
- 168 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Preterm Labor
A Phase 2 Study of OBE001 Versus Placebo in the Delay of Preterm Birth
The primary objective of this study is to assess the efficacy of a single dose of OBE001, an oral oxytocin antagonist, given for up to 7 days to delay preterm birth by 7 days compared to placebo.
- Trial name
- TERM (NCT02326142)
- Testing
- OBE001
- Where
- 23 sites in Belgium, Germany and 4 more
- Volunteers
- 10 people
- Sponsor
- ObsEva SA
PreTerm Labor, Threatened Preterm Labor
Labor Status Monitor for Diagnosing True vs False Labor in Preterm Patients
This is an observational study of pregnant persons in threatened labor. The study device will record electromyography signals, then the signals will be examined to determine who is in true labor and who is in threatened labor.
- Conditions
- PreTerm Labor, Threatened Preterm Labor, Preterm Birth
- Trial name
- NCT06157203
- Testing
- Uterine electromyography
- Where
- 2 sites in United States
- Volunteers
- 181 people, healthy volunteers welcome
- Sponsor
- PreTeL, Inc
Preterm Birth
Evaluation of a Novel Diagnostic Kit for the Detection of Placental Alpha-Microglobulin-1 in the Prediction of Preterm Birth in Women Presenting With Signs and Symptoms of Preterm Labor
Currently, the American College of Obstetricians and Gynecologists (ACOG) indicate in their most recent Practice Bulletin on the Management of Preterm Labor that many tests to identify women at risk of preterm birth have been…
- Trial name
- PartoSure (NCT05742997)
- Testing
- PartoSure, Fetal Fibronectine
- Where
- Belgium
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- Ziekenhuis Oost-Limburg
Preterm Birth
Effect of Probiotics on the Preterm Delivery Rate in Pregnant Women at High Risk for Preterm Birth
Preterm birth (PB) continues to be the main cause of perinatal morbidity and mortality, with emotional and economic consequences.
- Trial name
- PROPEV (NCT03689166)
- Testing
- Probiotic
- Where
- Spain
- Volunteers
- 200 people
- Sponsor
- Maternal-Infantil Vall d´Hebron Hospital
Early Labor
Membrane Sweeping in Early Labor and Delivery Outcomes
Membrane sweeping is a routine procedure in obstetrics in term patients. It has been shown to be effective in decreasing post term gestation and in increasing rate of spontaneous vaginal delivery when used in setting of induction…
- Trial name
- NCT03517696
- Testing
- Membrane sweeping
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Labor Pain, Epidural Analgesia for Labour and Delivery
Early Labor Pre-Marking for Epidural Analgesia: Ultrasound vs Manual Palpation
The goal of this clinical trial is to learn if finding and marking the best spot on the back early in labor helps doctors perform epidural pain relief more successfully in pregnant women.
- Conditions
- Labor Pain, Epidural Analgesia for Labour and Delivery, Neuraxial Ultrasound
- Trial name
- NCT07669441
- Testing
- Preprocedural Spinal Ultrasound, Conventional Landmark Palpation
- Where
- Vietnam
- Volunteers
- 100 people
- Sponsor
- University Medical Center Ho Chi Minh City (UMC)
Premature Rupture of Membranes at Term, Induction of Labour
Propess Versus Prostin for Induction of Labour in Women With Term PROM
Premature rupture of membranes (PROM) at term is a rupture that occurs at term (> 37 weeks) before the start of labor. The purpose of the study was to compare the safety and efficacy of two agents used in induction of labor in…
- Trial name
- PESTIBOR (NCT04743297)
- Testing
- Prostaglandin E2 (Propess), Prostaglandin E2 (Prostin)
- Volunteers
- 526 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Maribor
Premature Rupture of Membranes at Term
Comparison of Misoprostol and Prostaglandin E2 (PGE2) Gel for Induction of Labour in Premature Rupture of Membranes at Term
The purpose of this study is to determine whether induction of labor with vaginal misoprostol application will result in fewer cesarean deliveries than vaginal PGE2 gel application in women with premature rupture of membranes at…
- Trial name
- NCT00355303
- Testing
- Misoprostol, PGE2 gel
- Where
- India
- Volunteers
- 932 people
- Sponsor
- Nilratan Sircar Medical College
Preterm Delivery
Betamethasone Dosing Interval - 12 or 24 Hours?
The purpose of this study is to determine if there may be a benefit to the newborn if betamethasone is given 12 hours apart instead of 24 hours apart.
- Trial name
- NCT00453141
- Testing
- dosing of Betamethasone
- Where
- 2 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- The Cooper Health System
Placenta Accreta Spectrum, Placenta Accreta
Evaluation of Cervical Invasion and Length in Placenta Accreta Patients
Placenta accreta spectrum (PAS), also called morbidly adherent placenta, is a serious pregnancy problem where the placenta attaches too deeply to the uterus wall and does not come out normally after birth.
- Conditions
- Placenta Accreta Spectrum, Placenta Accreta, Placenta Previa
- Trial name
- NCT07452185
- Volunteers
- 200 people
- Sponsor
- Sohag University
Preterm Birth
Glycoproteomic Analysis of Urine in Women Undergoing Spontaneous Preterm Delivery
When babies are premature, or born before they are fully developed, they face many different medical problems, some of which are quite devastating, such as cerebral palsy, mental retardation, blindness, deafness, severe…
- Trial name
- NCT01348230
- Testing
- Urine samples
- Where
- United States
- Sponsor
- University of Missouri-Columbia
Premature Labor
Pharmacokinetics (PK) and Modeling of Betamethasone Therapy in Threatened Preterm Birth
Respiratory distress syndrome (RDS) is a life-threatening condition for premature neonates. Antenatal glucocorticoids have been used clinically in women with threatened preterm birth to accelerate lung maturation for more than 40…
- Trial name
- NCT02793700
- Where
- 2 sites in United States
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Indiana University
Labor, Premature
Vaginal Progesterone as a Treatment for Women Active Preterm Labor
The purpose of this study is to compare how well vaginal progesterone works delaying the time to delivery in women with preterm labor compared to placebo.
- Trial name
- VagPro (NCT01206998)
- Testing
- Vaginal progesterone gel
- Where
- United States
- Sponsor
- University of Rochester
Preterm Birth, Preterm Labor
Effect of Supplementation of Fluoride on Maternal Periodontal Health, Preterm Delivery, and Perinatal Well-Being
The purpose of this study is to determine whether fluoride supplementation during pregnancy is effective in extending the length of gestation and improving overall perinatal well-being.
- Conditions
- Preterm Birth, Preterm Labor, Bacteremia, Preterm Premature Rupture of Fetal Membranes
- Trial name
- NCT02536352
- Testing
- Prenatal vitamin-mineral containing 3 mg fluoride, Prenatal vitamin-mineral containing 0 mg fluoride
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University