Clinical trials: Preterm Labor
Preterm Labor, Fetal Glucocorticoid Exposure
The Effect of Antenatal Corticosteroids on the Fetal Thymus - a Possible Role in Fetal Immune Programming
Administration of corticosteroids is standard practice for pregnant patients at risk of preterm labour to reduce the risk of neonatal respiratory distress syndrome, intraventricular hemorrhage, necrotizing enterocolitis and…
- Trial name
- NCT03057717
- Testing
- 2D ultrasound assessment
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Threatened Preterm Labor
Nifedipine Plus Magnesium Sulfate Versus Magnesium Sulfate for Very Early Preterm Tocolysifs
Objective: This trial is designed to compare between the effectiveness of nifedipine plus magnesium sulfate (MgSO4) and MgSO4 alone for tocolysis in women with threatened preterm labor.
- Trial name
- ASTOS1 (NCT05345132)
- Testing
- Nifedipine 20 Mg, Magnesium sulfate
- Where
- Egypt
- Volunteers
- 264 people
- Sponsor
- Assiut University
PreTerm Labor, Threatened Preterm Labor
Labor Status Monitor for Diagnosing True vs False Labor in Preterm Patients
This is an observational study of pregnant persons in threatened labor. The study device will record electromyography signals, then the signals will be examined to determine who is in true labor and who is in threatened labor.
- Conditions
- PreTerm Labor, Threatened Preterm Labor, Preterm Birth
- Trial name
- NCT06157203
- Testing
- Uterine electromyography
- Where
- 2 sites in United States
- Volunteers
- 181 people, healthy volunteers welcome
- Sponsor
- PreTeL, Inc
Cervical Length, Preterm Birth
Development of a Screening Tool By Utilising Cervical Length Measurement In Relation To Body Mass Index (BMI) For Early Identification And Intervention Of Preterm Birth
This is a prospective study where pregnant women between 16-24 weeks gestation attending the Antenatal Clinic, Fetomaternal clinic or Obstetrics \& Gynaecology Admission Centre (OGAC) at Hospital Serdang or Hospital Pengajar UPM…
- Trial name
- NCT04922671
- Where
- 2 sites in Malaysia
- Volunteers
- 145 people
- Sponsor
- Universiti Putra Malaysia
Cesarean Delivery Affecting Fetus, Preterm Labor
Baby Smell Visual Stimulus Program Cortical and Breast Oxygenation Milk Amount Mother-Infant Attachment
In this study, the effect of infant odor and visual stimulus program applied to mothers who had delivered by cesarean section and whose babies were taken to the NICU on cortical and breast oxygenation (rSO2), amount of breast…
- Trial name
- NCT06058208
- Testing
- Olfactory stimulation, Visual stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Selcuk University
Preterm Birth, Threatened Preterm Labor
Cervical Softening and the Prediction of Preterm Birth
Currently, transvaginal cervical length measurement is used to screen in asymptomatic pregnant women with a history of PTB. In symptomatic women, presenting with threatened PTB cervical length in combination with the fibronectin…
- Conditions
- Preterm Birth, Threatened Preterm Labor, Premature Birth, Premature Labor
- Trial name
- STIPP (NCT05477381)
- Testing
- Measurement of cervical stiffness by Pregnolia Device
- Where
- Netherlands
- Volunteers
- 390 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Preterm Labor
Adjunctive Vaginal Progesterone in Management of Preterm Labor
This study evaluates the addition of vaginal micronized progesterone effervescent to standard treatment in the treatment of preterm labor.
- Trial name
- NCT05997563
- Testing
- Micronized progesterone
- Where
- Thailand
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
Preterm Birth, Complication of Prematurity
Single Dose Antenatal Corticosteroids (SNACS) for Women at Risk of Preterm Birth
Antenatal corticosteroids (ACS) reduce the risks of neonatal death and morbidities, such as respiratory distress syndrome, in preterm infants.
- Conditions
- Preterm Birth, Complication of Prematurity, Obstetric Labor, Premature, Obstetric Labor Complications
- Trial name
- SNACS Pilot (NCT04494529)
- Testing
- 24 mg betamethasone
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- McMaster University
Preterm Labor
Effect Of Azithromycin in Women at Risk of Preterm Labour
The aim of this study is to evaluate the benefit of the addition of azithromycin to standard treatments to prolong pregnancy in women having intact membranes and is at risk of or in preterm labour.
- Trial name
- NCT05971654
- Testing
- azithromycin
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Beni-Suef University
Preterm Birth, Obstetric Labor, Premature
Azithromycin to Improve Latency in Exam Indicated Cerclage Control Trial
Azithromycin is an antibiotic that is effective against bacteria that been associated with preterm birth (PTB). The purpose of this study is to evaluate if the addition of azithromycin prior to exam indicated cerclage prolongs…
- Conditions
- Preterm Birth, Obstetric Labor, Premature, Obstetric Labor Complications, Pregnancy Complications
- Trial name
- ALEC (NCT05132829)
- Testing
- Azithromycin 1 gram IV, Cefazolin and indomethacin
- Where
- 2 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Preterm Labor
Cyclin-dependent Kinase Inhibitor 2A (Placental Senescence Marker) on Labor-related Signals
Onset of labor in human is initiated by progesterone withdrawal. Over many decades researchers had proposed hypotheses to explain the functional withdrawal of progesterone.
- Trial name
- NCT05864066
- Volunteers
- 81 people
- Sponsor
- Assiut University
Gasdermin D Levels in Preterm Labor
The Relationship Between Serum Gasdermin-D Levels and Pyroptosis and Preterm Labor
In this study, the investigators aimed to investigate the relationship between Gasdermin D levels measured from the maternal serum of patients diagnosed with preterm labor and spontaneous preterm labor in pregnant women.
- Trial name
- NCT05835700
- Testing
- Gasdermin-d
- Where
- Turkey (Türkiye)
- Volunteers
- 327 people, healthy volunteers welcome
- Sponsor
- Sanliurfa Mehmet Akif Inan Education and Research Hospital
Pregnancy, Preterm Labor
Biomarkers in Obstetrical Complications
Objective: To study the natural history of normal pregnancy and the most frequent pregnancy complications responsible for the excessive rate of perinatal morbidity and mortality, in order to develop models to predict the…
- Conditions
- Pregnancy, Preterm Labor, Maternal Fetal Factors, Preterm Birth
- Trial name
- NCT03480139
- Where
- United States
- Volunteers
- 746 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Preterm Labor
Vaginal Progesterone for the Prolongation of Pregnancy After Arrested Pre-term Labor
Patients diagnosed with arrested pre-term labor following tocolytics at 24-34 gestational weeks will be randomly allocated to receive either vaginal micronized progesterone 400 mg/day or no treatment.
- Trial name
- NCT02430233
- Testing
- micronized progesterone 400 mg (Utrogestan)
- Where
- 3 sites in Israel
- Volunteers
- 129 people
- Sponsor
- HaEmek Medical Center, Israel
Preterm Labor, Preterm Birth
Establishment of a Perinatal Database and a Bank of Biological Materials
The aim of this project is to establish a clinical database and a bank of biological materials which will be used to improve the pathophysiologic understanding of the mechanisms underlying various pregnancy diseases.
- Conditions
- Preterm Labor, Preterm Birth, Pregnancy
- Trial name
- NCT00339235
- Where
- United States
- Volunteers
- 30,570 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Preterm Labor, Premature Birth
Maintenance Gabapentin to Prolong Pregnancy.
This is a pilot study to evaluate the tolerability and effects of maintenance gabapentin therapy on the rate of premature birth in women who have had preterm labor.
- Trial name
- NCT02056899
- Testing
- Gabapentin
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- State University of New York at Buffalo
Preterm Labor
Uterocervical Angle in Prediction of Preterm Labor
Preterm delivery occurs in about 5-18% of pregnancies before 37 weeks' gestation all over the world.It is associated with a high prevalence of neurological deficits, developmental disabilities and is a leading cause of infant and…
- Trial name
- Preterm labor (NCT05632003)
- Where
- Egypt
- Volunteers
- 77 people
- Sponsor
- Ain Shams Maternity Hospital
Preterm Labor, Parathyroid Diseases
The Association Between Parathyroid Hormone and Preterm Labor
This observational study aims to test the level of parathyroid hormone in pregnant women. The main question it aims to answer is: n Pregnant women, are the levels of serum PTH, calcium, magnesium, phosphorus \& albumin similar in…
- Trial name
- NCT05688007
- Testing
- parathyroid hormone level, serum electrolytes
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Ain Shams Maternity Hospital
Preterm Labor
Impact of Suspected Preterm Labour on Cardiometabolic Profile and Neurodevelopment
Suspected preterm labour (SPL), define as the presence of regular and painful uterine contractions and cervical shortening, constitute a prenatal insult with potential long-term consequences.
- Trial name
- SKs (NCT05211297)
- Where
- Spain
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Instituto de Investigación Sanitaria Aragón
Preterm Labor
The Cervical Length and Thickness of Cesarean Section Scar With Preterm Labor
Although the Cesarean section is one of the most common obstetric operations around the world, the World Health Organization recognizes that where cesarean rates are higher than 10%, there is no increase in beneficial maternal…
- Trial name
- NCT04554745
- Testing
- Ultrasound
- Where
- Egypt
- Volunteers
- 260 people
- Sponsor
- Assiut University