Clinical trials: Presymptomatic Disease, open to volunteers
Candida Auris Infection, Colonization, Asymptomatic
Nasal Antisepsis for C. Auris Prevention
This is a randomized, controlled, open-label trial of effect of 10% povidone iodine intranasal antisepsis on the detection of Candida auris.
- Trial name
- NCT06282510
- Testing
- Povidone Iodine Topical
- Where
- 3 sites in United States
- Volunteers
- 120 people
- Sponsor
- Mary K Hayden
Clostridium Infections, Methicillin-resistant Staphylococcus Aureus (MRSA)
A Clinical Trial of Resistant Potato Starch for Gut MDRO Decolonization
Multidrug-resistant organisms (MDROs) cause serious infections that are difficult to treat, leading to increased morbidity and mortality, longer hospital stays, and increased healthcare costs.
- Conditions
- Clostridium Infections, Methicillin-resistant Staphylococcus Aureus (MRSA), Vancomycin-Resistant Enterococci, Carbapenem-Resistant Enterobacteriaceae
- Trial name
- MDRO-Fiber (NCT07792915)
- Testing
- Resistant Potato Starch, Maltodextrin
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- VA Office of Research and Development
Colonization, Asymptomatic, Colonization
Probiotic Delivered to the Small Intestine Changes Microbiota
This study will determine whether encapsulation of probiotic bacteria using natural plant protein can enhance bacterial colonisation.
- Trial name
- Probiotic (NCT07510282)
- Testing
- Probiotic containing L.rhamnosus R0011 strain, 200 ml yogurt drink
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University College Dublin
Asymptomatic Condition
Effect of Osteopathic Technique on Maximum Mouth Opening Width, Masseter Muscle Tone and Stiffness
The purpose of this study is to assess the effect of compression and decompression thecnique on the temporomandibular joint on maximum mouth opening width, masseter muscle tone and stiffness in asymptomatic adults, compared with…
- Trial name
- NCT07670832
- Testing
- Osteopathic Intervention Techniques
- Where
- Portugal
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Escola Superior de Tecnologia da Saúde do Porto
Hereditary Spastic Paraplegia, Hereditary, Spastic Paraplegia, Autosomal Dominant
The preSPG4 Study - Studying the Prodromal and Early Phase of SPG4
Study goals 1. Prospective longitudinal data on progression in the natural course of SPG4 in presymptomatic mutation carriers prior to clinical disease onset and in early stages of disease 2.
- Trial name
- NCT03206190
- Testing
- SPRS Score and clinical signs, Cognition Testing using CANTAB, Lumbar Puncture and blood draw
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- University Hospital Tuebingen
Phenylketonuria
Announcement of Rare Metabolic Diseases in Systematic Newborn Screening: the Phenylketonuria Experience.
The aims of this collaborative, interdisciplinary research project are to understand and describe the psychological impact of the announcement of a rare, serious disease present since birth and detected in the context of the…
- Trial name
- ANNPHE (NCT06289348)
- Testing
- socio-psychological questionnaire, revised event impact scale (IER-S), Non directive interview
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Colonization, Asymptomatic
Safety and Efficacy of Lyophilized Fecal Microbiota Transplantation Via Capsules for Intestinal Multidrug-resistant Bacteria Decolonization
The goal of this clinical trial is to learn if oral capsules containing lyophilized stool from healthy donors (fecal microbiota transplantation or FMT) can safely and effectively decolonize multidrug-resistant organisms (MDROs)…
- Trial name
- FORCE (NCT07106580)
- Testing
- lyophilized FMT capsules
- Where
- Croatia
- Volunteers
- 52 people
- Sponsor
- University of Rijeka
Heart Failure, Ventricular Dysfunction, Left
ECG Low Ejection Fraction Detection and Guiding in AI Navigated Treatment Era
Asymptomatic left ventricular systolic dysfunction (ALVSD), identified as a key component of stage B heart failure (HF) by AHA/ACC guidelines, is a common precursor to clinically overt HF.
- Conditions
- Heart Failure, Ventricular Dysfunction, Left, Artificial Intelligence, Early Diagnosis
- Trial name
- ELEGANT (NCT06968533)
- Testing
- AI-ECG guided diagnosis
- Where
- Taiwan
- Volunteers
- 13,350 people, healthy volunteers welcome
- Sponsor
- National Defense Medical Center, Taiwan
Type 1 Diabetes (T1D), Autoantibodies
Standardized Italian netwoRk Enrolling iNdividuals With Islet-Autoantibodies
This project characterizes the longitudinal progression of children and adults who have tested positive for one or more islet cell autoantibodies across the early stages of type 1 diabetes (T1D).
- Conditions
- Type 1 Diabetes (T1D), Autoantibodies, Hyperglycemia, Impaired Glucose Tolerance (Prediabetes)
- Trial name
- SIRENA (NCT07503366)
- Where
- 24 sites in Italy
- Volunteers
- 300 people
- Sponsor
- Società Italiana di Endocrinologia e Diabetologia Pediatrica
Colonization, Asymptomatic, Colonisation
Encapsulated Probiotics & Gut Microbiota
The aim of this study is to determine whether encapsulation of probiotic bacteria using natural plant protein can enhance bacterial colonisation.
- Trial name
- Probiotics (NCT07439978)
- Testing
- probiotic containing L.rhamnosus R0011 strain, 200 ml yogurt drink
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University College Dublin
Vestibular Diseases, DFNA9
Genotype-phenotype Correlation Study of Presymptomatic and Symptomatic DFNA9 Patients
DFNA9 (Deafness Autosomal Dominant 9) is an autosomal dominant hereditary hearing loss which is associated with vestibular deterioration.
- Trial name
- NCT03716908
- Where
- Belgium
- Volunteers
- 70 people
- Sponsor
- Jessa Hospital
Choledocholithiasis, Asymptomatic Condition
The Treatment Effect for Asymptomatic Common Bile Duct Stone
This study is prospective, multicenter study for identify the characteristics of asymptomatic common bile duct stones and effectiveness of treatment.
- Conditions
- Choledocholithiasis, Asymptomatic Condition, Quality of Life
- Trial name
- NCT06215040
- Testing
- Endoscopic retrograde cholangiopancratography
- Where
- South Korea
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Kyungpook National University Hospital
Alzheimer Disease, Cognitive Decline
Computerized Tests of Cognitive Decline in Presymptomatic Alzheimer's Disease
The investigators will study performance on computerized cognitive tasks in healthy participants of different ages to gather normative data for newly developed computerized cognitive tests.
- Conditions
- Alzheimer Disease, Cognitive Decline, Aging
- Trial name
- NCT04800588
- Testing
- California Cognitive Assessment Battery
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Neurobehavioral Systems, Inc.
Sturge - Weber Syndrome (SWS)
Epidiolex Trial for Presymptomatic Treatment of Sturge-Weber Syndrome
Patients with Sturge-Weber syndrome (SWS) are frequently affected by seizures, and seizures are associated with poorer neurological outcomes. To date there is no established means of predicting or preventing seizure onset.
- Trial name
- Epi-Pre (NCT07778810)
- Testing
- Epidiolex 100 mg/mL Oral Solution
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Johns Hopkins University
Muscular Atrophy, Spinal
A Study to Learn About Salanersen's (BIIB115) Effects on Movement and Its Safety When Given Before Symptoms Appear in Babies With Genetically Diagnosed Spinal Muscular Atrophy (SMA)
In this study, researchers will learn more about the effects and safety of BIIB115, also known as salanersen. Specifically, researchers will learn more about how salanersen works in babies who have been diagnosed with SMA through…
- Trial name
- STELLAR-1 (NCT07221669)
- Testing
- Salanersen
- Where
- 14 sites in United States, Australia and 5 more
- Volunteers
- 30 people
- Sponsor
- Biogen
Presymptomatic Diabetes Type 1 (Stage 1), Diabetes Mellitus, Type I
Treatment of Presymptomatic (Stage 1) Type 1 Diabetes Pediatric Patients With Treg Cell Preparations and Anti-CD20 Antibody
The main purpose of the study is to check: Can therapy with a preparation of regulatory cells (Tregs lymphocytes) and/or an anti-CD20 antibody preparation (rituximab) be successfully used in children with pre-diabetes to treat or…
- Conditions
- Presymptomatic Diabetes Type 1 (Stage 1), Diabetes Mellitus, Type I, Diabetes Mellitus, Type 1
- Trial name
- PreTreg (NCT06688331)
- Testing
- ex vivo expanded CD4+CD25+CD127- regulatory T cells (Tregs), Anti-CD20 (rituximab)
- Where
- 9 sites in Poland
- Volunteers
- 150 people
- Sponsor
- PolTREG S.A.
Presymptomatic Disease, Mild Cognitive Impairment
Digitally-enhanced, Decentralized, Multi-omics Observational Cohort
The study is carried out as part of the GR2021 Priority project "Healthy Brains for life (Age 20-99): Digitally-enhanced personalized medicine study ANANEOS" and code numbered GR-00546 and it will look at the decentralized and…
- Conditions
- Presymptomatic Disease, Mild Cognitive Impairment, Memory Loss (Excluding Dementia), Cognitive Change
- Trial name
- ANANEOS (NCT04701177)
- Testing
- Teleph0s digital phenotyping platform
- Where
- 4 sites in Greece, Spain
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- Greece 2021 Committee
Neurodegenerative Diseases
Multimodal Markers of Neurodegenerative Disorders at Presymptomatic Stages
NeuroPrems is a prospective, monocentric, longitudinal, not relating to a medicinal product for human use, non-randomized, non-controlled research.
- Trial name
- NEUROPREMS (NCT06516016)
- Testing
- PET, MRI 3T, Oculomotricity assessment
- Where
- France
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Paris Brain Institute (ICM)
Cardiovascular Diseases, Asymptomatic Condition
Cardiovascular Screening in Asymptomatic South Asians
Cardiovascular disease (CVD) is the leading cause of morbidity, mortality and healthcare costs in the United Kingdom. Ethnic minorities like South Asians (SA) have a 3-5 times higher incidence of CVD as predicted by various risk…
- Conditions
- Cardiovascular Diseases, Asymptomatic Condition, South Asian
- Trial name
- NCT06765785
- Testing
- CTCA
- Volunteers
- 50 people
- Sponsor
- Sandwell & West Birmingham Hospitals NHS Trust
Type 1 Diabetes (T1D)
Platform Trial in Stage 1 Diabetes: Comparing Golimumab vs Placebo
The goal of this clinical trial is to learn if golimumab is effective at preventing progression to Stage 2 diabetes in participants with presymptomatic Type 1 Diabetes.
- Trial name
- NCT07683026
- Testing
- Golimumab
- Where
- United States
- Volunteers
- 255 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)