Clinical trials: Prescription Opioid Misuse
Opioid Overdose
Pharmacokinetic Evaluation of a New Naloxone Nasal Swab, Naloxone Nasal Spray, and Intramuscular Naloxone Injection in Healthy Volunteers
The study consists of two Phases with the first phase (Pilot Phase) divided into two sub phases. In each study phase, subjects will be admitted to the clinical unit from 10 hours prior to the first drug administration on Day -1…
- Trial name
- NCT05363501
- Testing
- IM Naloxone Injection, Naloxone Nasal Spray, Naloxone Nasal Swab
- Where
- Canada
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Pocket Naloxone Corp
Chronic Non Cancer Pain
Pharmacist for Detecting Opioid Misuse
Opioid use is increasing in Western countries and is associated with harms as hospitalization, addiction and deaths(1). Community pharmacists interact frequently with patients, giving them the opportunity to identify and prevent…
- Trial name
- NCT04544696
- Where
- France
- Volunteers
- 414 people
- Sponsor
- University Hospital, Montpellier
Opiate Overdose, Fentanyl Overdose
Evaluation of a Novel Intervention to Prevent Polysubstance Overdoses Involving Illicit Stimulants
The purpose of the study is to investigate the feasibility, acceptability, and associated benefits and harms of integrating FTS education and distribution into select courts in rural and urban communities in Ohio.
- Conditions
- Opiate Overdose, Fentanyl Overdose, Harm Reduction
- Trial name
- NCT05493475
- Testing
- Fentanyl Test Strips
- Where
- United States
- Volunteers
- 653 people
- Sponsor
- Nationwide Children's Hospital
Opioid-Related Disorders
The OPT-IN Project
Prescription opioid overdose represents a public health crisis. A number of efforts have been implemented to address opioid prescribing and opioid risk mitigation strategies for prescribers, but relatively few efforts have sought…
- Trial name
- NCT03526380
- Testing
- Behavioral: the OPT-IN Intervention
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- University of Michigan
Chronic Disease, Pain
Conversion to Embeda With Rescue Trial
The purpose of the research study is to find out if opioid dependent chronic pain patients who are judged by their physician to be eligible to change their current opioid medicine and to participate in this study can be…
- Trial name
- ConvERT (NCT01179191)
- Testing
- morphine sulfate and naltrexone hydrochloride (EMBEDA)
- Where
- 166 sites in United States
- Volunteers
- 684 people
- Sponsor
- Pfizer
Opioid Overdose, Substance Use Disorders
Quantitative Xylazine Measurement in ED
Quantitative Xylazine Measurement Among Non-Fatal Opioid Overdose (OD) Patients in the Emergency Department (ED)
- Trial name
- NCT06949605
- Where
- 2 sites in United States
- Volunteers
- 75 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Opioid Misuse, Opioid-Related Disorders
Healthy Opioid Prescription Engagement
This study is a randomized controlled trial across 14 community pharmacies to test the efficacy of the Brief Intervention-Medication Therapy Management intervention (BI-MTM).
- Conditions
- Opioid Misuse, Opioid-Related Disorders, Pharmacist-Patient Relations
- Trial name
- HOPE (NCT05141266)
- Testing
- Patient Navigation, Standard Medication Counseling (SMC)
- Where
- United States
- Volunteers
- 350 people
- Sponsor
- Jerry Cochran
Opioid Overdose, Drug Overdose
Preventing Overdose Using Information and Data From the Environment
The objectives of this project are to leverage surveillance data to predict future overdose outbreaks, and to evaluate the impact of a randomized, statewide, community-level intervention trial to target overdose prevention…
- Trial name
- PROVIDENT (NCT05096429)
- Testing
- PROVIDENT
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Brown University
Overdose, Risk Behavior
The Impact of a Web-Based Naloxone Intervention Under Standing Orders to Patients Prescribed Chronic Opioid Therapy
In the setting of naloxone standing orders, this study will assess the impact of a targeted, web-based overdose prevention and naloxone intervention for patients prescribed chronic opioid therapy.
- Trial name
- NCT03337009
- Testing
- Naloxone Navigator (NN)
- Where
- United States
- Volunteers
- 1,004 people
- Sponsor
- Kaiser Permanente
Chronic Pain, Opioid Misuse
French Version of POMI Scale
French translation and validation of the Prescription Opioid Misuse Index scale (POMI), a brief questionnaire to assess opioid prescription misuse.
- Trial name
- POMI (NCT04979364)
- Volunteers
- 154 people
- Sponsor
- University Hospital, Clermont-Ferrand
Opioid Overdose
Serious Game to Teach Opioid Overdose Response
This study evaluates the efficacy of a serious game to teach students how to recognize and respond to opioid overdose
- Trial name
- NCT06727786
- Testing
- Serious game training
- Volunteers
- 850 people, healthy volunteers welcome
- Sponsor
- University of Nevada, Reno
Drug Prescriptions
Effect of an Opioid Disposal Pouch Versus Usual Care on Post Discharge Disposal of Unused Medication
The purpose of the study is to determine if opioid disposal bags/pouches are an effective method for disposing of unused opioid medications postoperatively
- Trial name
- NCT04553588
- Testing
- Disposal pouch
- Where
- United States
- Volunteers
- 313 people
- Sponsor
- The Cleveland Clinic
Substance Use, HIV Infections
Kentucky Communities and Researchers Engaging to Halt the Opioid Epidemic (CARE2HOPE)
This study will test the effects of an intervention to reduce substance use and related harms among people leaving rural jails or otherwise involved in the criminal justice system.
- Conditions
- Substance Use, HIV Infections, HCV Infection, Sexually Transmitted Infections (Not HIV or Hepatitis)
- Trial name
- NCT04134767
- Testing
- Health Linkage, Overdose Education
- Where
- United States
- Volunteers
- 234 people, healthy volunteers welcome
- Sponsor
- April M Young
Opioid Use Disorder
Mobile Peer Support for OUD Recovery
The COVID-19 pandemic puts individuals recovering from opioid use disorders (OUDs), an already vulnerable population, at increased risk of overdose due to decreased access to treatment, decreased social support, and increased…
- Trial name
- MPS (NCT05405712)
- Testing
- Mobile Phone App
- Where
- 2 sites in United States
- Volunteers
- 1,300 people
- Sponsor
- Brown University
Opioid Overdose, Opioid Use Disorder
Safety, Tolerability, and Pharmacokinetics of CSX-1004
This is a Phase 1a, randomized, double-blind, single ascending dose study, designed to assess the safety, tolerability, and PK of a single CSX-1004 injection, administered by IV infusion across a range of doses in healthy adult…
- Trial name
- NCT06005402
- Testing
- CSX-1004
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Cessation Therapeutics, Inc.
Opioid-use Disorder, Opioid Misuse
Comparing a Patient Self-Assessment Software to Treatment as Usual in Opioid Prescriber and Patient Opioid Outcomes
The Care Continuity Program (CCP), a product of Sure Med Compliance, is a novel, online patient self-assessment used by prescribers of opioids to better identify patient risk factors and therapy benefit.
- Conditions
- Opioid-use Disorder, Opioid Misuse, Opioid Use, Chronic Pain
- Trial name
- NCT04945525
- Testing
- Care Continuity Program
- Where
- United States
- Volunteers
- 1,840 people
- Sponsor
- Sure Med Compliance
Substance-Related Disorders
Abuse Liability of Controlled-Release Oxycodone Formulations
The objective of this study is to examine the abuse liability of a single 40mg dose of 2 controlled release oxycodone formulations (Apo-Oxycodone CR® and OxyNEO®) in non-dependent recreational opioid users by assessing the…
- Trial name
- NCT02101840
- Testing
- Apo-Oxycodone CR®, OxyNEO®
- Where
- Canada
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Drug Overdose, Opioid-Related Disorders
Safety & Prevention Outcomes Study
Unintentional poisoning is a developing public health problem in the U.S. Unintentional poisoning (or "overdose") deaths increased 157% among adults between 1999 and 2008.
- Trial name
- SPOS (NCT01894087)
- Testing
- TBI - Cohort 1, TBI - Cohort 2
- Where
- United States
- Volunteers
- 204 people
- Sponsor
- University of Michigan