Clinical trials: Prenatal Diagnoses
Complicated Twin Pregnancy
The Value of Prenatal Ultrasound in Complicated Twin Pregnancy and Its Correlation With Chromosomal Anomalies
Recent years, women with infertility have become more and more and thus assisted reproductive technology has been applied in a broad range. And the quantities of twin pregnancies are larger and larger.
- Trial name
- NCT02732717
- Testing
- ultrasound (observation)
- Where
- China
- Volunteers
- 580 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Trisomy 13, Trisomy 18
Prenatal Non-invasive Aneuploidy Test Utilizing SNPs Trial
This prospective blinded study will assess the diagnostic capability of an informatics enhanced SNP based technology (Parental Support) to identify pregnant women who are carrying a fetus with an aneuploidy from fee floating DNA…
- Conditions
- Trisomy 13, Trisomy 18, Trisomy 21, Aneuploidy
- Trial name
- PreNATUS (NCT01545674)
- Testing
- Blood Draw
- Where
- 29 sites in United States, Canada and 4 more
- Volunteers
- 937 people, healthy volunteers welcome
- Sponsor
- Natera, Inc.
Copy Number Abnormality, Prenatal Diagnosis
Technology Development for Noninvasive Prenatal Genetic Diagnosis Using Whole Fetal Cells From Maternal Peripheral Blood
Amniocentesis (amnio) and chorionic villus sampling (CVS) can reliably detect many smaller DNA/genetic abnormalities that cannot be reliably diagnosed by cell-free noninvasive prenatal testing (NIPT) that is in widespread use.
- Conditions
- Copy Number Abnormality, Prenatal Diagnosis, Genetic Disease
- Trial name
- NCT04285814
- Testing
- Whole Fetal Cell (WFC) Testing
- Where
- 2 sites in United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Columbia University
Prenatal Diagnosis
Mapping of Genomic Structural Variations in Major Birth Defects
In the context of intricate cases with ambiguous prenatal genetic diagnoses, this project intends to carry out long - read DNA sequencing data analysis on birth defect cases and family samples.
- Trial name
- NCT07515976
- Testing
- Long - read DNA sequencing
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Prenatal Genetic Diagnosis
guideSEQ: Genomic Understanding, Impact, Decision & Ethics in Prenatal Sequencing
This study looks at whether genome sequencing should be used more routinely during pregnancy, even when ultrasounds look normal.
- Trial name
- guideSEQ (NCT07610590)
- Testing
- Genome Sequencing (GS)
- Where
- 3 sites in United States
- Volunteers
- 1,042 people, healthy volunteers welcome
- Sponsor
- Columbia University
Trisomy 21
Down Syndrome Screening Based on Dried Blood Spots and Cell-free Fetal DNA
There are 26,600 Down Syndrome newborns every year in China. The economic burden of this disease is 65,000 USD for lifetime of every patient.
- Trial name
- DBS&CFF (NCT01837979)
- Testing
- cell-free fetal DNA
- Where
- China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Mindfulness Breath Awareness Meditation, Preeclampsia
Mindfulness Breath Awareness Meditation and Preeclampsia
The effect of mindfulness breath awareness meditation on health profile, vital signs, and fetal heart rate in pregnant women with preeclampsia
- Trial name
- NCT06065709
- Testing
- Mindfulness breath awareness meditation
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Aysegul Kilicli
Meningomyelocele, Spinal Dysraphism
Management of Myelomeningocele Study (MOMS)
Spina bifida (myelomeningocele) is a complex birth defect in which a portion of the spinal cord is not fully developed. The overlying bones and skin are incompletely formed and the underdeveloped area of the spinal cord is…
- Trial name
- MOMS (NCT00060606)
- Testing
- Prenatal Myelomeningocele Repair Surgery, Postnatal Myelomeningocele Repair Surgery
- Where
- 3 sites in United States
- Volunteers
- 183 people, healthy volunteers welcome
- Sponsor
- The George Washington University Biostatistics Center
Disorder of Cardiac Function
Myocardial Screening in Fetuses With Congenital Cytomegalovirus (CMV) Infection
BACKGROUND Myocarditis and pericarditis are inflammatory conditions of the heart commonly due to viral or autoimmune etiologies. Human CMV represents one of the leading causes of congenital infections worldwide.
- Trial name
- NCT02787382
- Testing
- echocardiographic examination
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Tuberculosis (TB), Tuberculosis Infection, Latent
Burden of Tuberculosis Among Pregnant and Postpartum Women in Guinea-Bissau
This study aims to address critical diagnostic and data gaps in tuberculosis (TB) care among pregnant and postpartum women in Guinea-Bissau, a high-burden, resource-limited setting.
- Conditions
- Tuberculosis (TB), Tuberculosis Infection, Latent, Pregnancy, Tuberculosis Diagnosis
- Trial name
- TIPP (NCT07419568)
- Testing
- Enhanced protocol
- Where
- Guinea-Bissau
- Volunteers
- 720 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Fetal Alcohol Spectrum Disorders
Fetal Alcohol Spectrum Disorder : Clinical Description and Search for Epigenetic Biomarker (EPI-TSAF)
The goal of this clinical trial is to carry out a clinical description of a Reunionese series of patients (aged 0 to 18 inclusive) with Fetal Alcohol Spectrum Disorders followed up in the Genetics Department of the University…
- Trial name
- EPI-TSAF (NCT06471335)
- Testing
- Extraction of microRNAs extracted from plasma (4 ml recovered as part of treatment), Extraction of microRNAs extracted from bucal swabs (act added for research).
- Where
- France
- Volunteers
- 188 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de la Réunion
Antenatal Care, Maternal Health
AI Blind-Sweep Ultrasound for Antenatal Screening by Non-Specialist Health Workers in Rural DR Congo
FS2 evaluates the diagnostic accuracy and implementation feasibility of an AI-assisted blind-sweep obstetric ultrasound (SPAQ E-con AI), operated by trained non-specialist health workers, for antenatal screening in rural…
- Conditions
- Antenatal Care, Maternal Health, Gestational Age, Placenta Praevia
- Trial name
- FS2 (NCT07677670)
- Testing
- SPAQ E-con AI blind-sweep ultrasound
- Where
- Democratic Republic of the Congo
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- SOIK Corporation Sarl
Pregnancy Related
Diagnostic Performance of Antenatal Ultrasound for High-Risk Intestinal Malrotation
The aims of this study are: To assess the performance of third-trimester ultrasound scan in the localization of intestinal structures (small bowel, gut, mesenteric vessels..) involved in malrotations with a higher-risk of…
- Trial name
- MALGRE (NCT03968107)
- Testing
- Reference ultrasound examination
- Where
- France
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Cystic Fibrosis
Non-invasive Prenatal Diagnosis of Monogenic Disorders by Linked-reads Technology
Description of the presence of cell-free fetal DNA in maternal plasma allowed the possibility of non-invasive prenatal diagnosis.
- Trial name
- NID (NCT03622892)
- Where
- 6 sites in France
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Fetal Distress, Fetal Hypoxia
Application of Electronic Endoscope in Fetal Distress
Fetal distress is a common emergency in obstetrics, which refers to the combined symptoms of fetal health and life in utero due to acute or chronic hypoxia, with an incidence of 2.7% to 38.5%.
- Trial name
- NCT06608654
- Testing
- endoscope application
- Where
- China
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Fetal Growth Retardation, Fetal Macrosomia
A Comparative Study of AI Methods for Fetal Diagnostic Accuracy in Ultrasound
This study serves as a supplemental investigation to the randomized controlled SCAN-AID study (NCT0632187). This study will evaluate and compare the fetal growth estimation outcomes of AI-supported groups, expert sonographers…
- Conditions
- Fetal Growth Retardation, Fetal Macrosomia, Fetal Growth
- Trial name
- NCT06268392
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Copenhagen Academy for Medical Education and Simulation
Urinary Tract Dilatation
Urinary Tract Dilations in Prenatal and Postnatal Life
The goals of this study are to use a questionnaire survey to determine the state of awareness of the diagnosis and management of patients with urinary tract dilation across several medical professionals, to predict the severity…
- Trial name
- NCT06317623
- Testing
- Prenatal and postnatal ultrasound examination
- Where
- Slovakia
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- SonoClinic
Congenital Cystic Adenomatoid Malformation
Prenatal Steroids for Treatment of Congenital Cystic Adenomatoid Malformations (CCAM)
Congenital cystic adenomatoid malformations (CCAMs) are theorized to be growing immature lung tissue. Administration of maternal steroids in the mid-trimester may stop the growth or decrease the size of the CCAM, thus increasing…
- Trial name
- CCAM Steroids (NCT00670956)
- Testing
- Betamethasone
- Where
- 3 sites in United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Pregnancy, Cancer, Cancer in Pregnancy, Gestational Breast Cancer, Pregnancy Related
Maternal Cancer Diagnosis and Treatment During Pregnancy:a Database for Maternal, Fetal, and Neonatal Outcomes
The objective of this study is to follow the treatment options offered to pregnant women diagnosed with cancer and study the impact that their treatment or delay of treatment has on their own health and that of their children.
- Trial name
- CANCRPREGREG (NCT02749474)
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Cooper Norcross Health
Down Syndrome, Prenatal Stress
Amniotic Fluid Ischemia Modified Albumin as a Novel e Prenatal Diagnostic Marker for Down Syndrome
Down syndrome is the most common genetic disorder in the society that causes mental retardation. Today, screening tests (combined test, triple screening, ultrasonography and age) are performed for the diagnosis of down syndrome…
- Conditions
- Down Syndrome, Prenatal Stress, Cytokines
- Trial name
- NCT04293380
- Testing
- amniosyntesis
- Where
- Turkey (Türkiye)
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Karadeniz Technical University