Clinical trials: Premenopause
Glycemic Response, Menopause Symptoms
Impact of Reducose® on Glycemic Response and Menopausal Symptoms in Perimenopausal Women (CALM-R)
The purpose of this double-blind, randomized, placebo-controlled trial is to. evaluate daily Reducose® (mulberry leaf extract) supplementation taken with the two largest meals for 12 weeks on improving glycemic response and…
- Trial name
- CALM-R (NCT07333885)
- Testing
- Reducose® (Mulberry leaf extract)
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Phynova Group Ltd
Perimenopausal
Effect of Rapamycin in Ovarian Aging
The investigators are proposing a prospective, randomized, double-blind, placebo-controlled pilot study assessing the ability of low-dose rapamycin to delay ovarian aging in women.
- Trial name
- Rapamycin (NCT05836025)
- Testing
- Rapamycin
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Columbia University
Premenopause, Iron-deficiency
A Clinical Study on Adherence and Efficacy of Different Doses of Active Iron in Treatment Resistant Subjects
A randomized, placebo controlled, parallel group, double blind study to compare the 3-month adherence and efficacy of Active Iron in subjects with or at-risk of iron deficiency and a history of intolerance to oral iron.
- Conditions
- Premenopause, Iron-deficiency, Iron Adverse Reaction, Iron Deficiency Anemia
- Trial name
- NCT04778072
- Testing
- Ferrous sulfate 14mg once daily, Ferrous sulfate 25mg once daily, Ferrous sulfate 25mg twice daily
- Where
- Ireland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Solvotrin Innovations Ltd
Apparently Healthy and Not Receiving Hormonal Therapy
Examining the Impact of Phytoestrogens Supplementation on the Gene Expression, and Premenstrual Syndrome in Primenopausal Women
This randomized, double-blind, placebo-controlled clinical trial investigated the effects of flaxseed-derived phytoestrogen supplementation on selected gene-expression markers and premenstrual syndrome (PMS) severity among…
- Trial name
- NCT07310485
- Testing
- SDG lignans
- Where
- Jordan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Jordan
Perimenopausal Disorder
Effects of a Standardised Saffron Extract Supplementation on Symptoms Associated With Perimenopause in Healthy Women
The aim of the present study is to assess the effects of a normalised saffron extract supplementation, which is an extract of the flower Crocus sativus, on perimenopausal symptoms.
- Trial name
- NCT06227858
- Testing
- Safr'Inside supplement (Activ'Inside, SAS), Plcebo
- Where
- Pakistan
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Liaquat University of Medical & Health Sciences
Depression, Healthy
Bone Loss in Premenopausal Women With Depression
The purpose of this study is to determine whether women with major depression lose bone mass at a faster rate than women without depression.
- Conditions
- Depression, Healthy, Osteopenia, Osteoporosis
- Trial name
- NCT00006180
- Testing
- Alendronate
- Where
- United States
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Osteoporosis, Osteopenia
Melatonin Osteoporosis Prevention Study
Osteoporosis is one of the most common skeletal disorders. Today in the United States, 10 million individuals have osteoporosis and 34 million more have low bone mass or osteopenia, which places them at an increased risk of some…
- Trial name
- MOPS (NCT01152580)
- Testing
- melatonin, sugar pill
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Duquesne University
Menopause
Menopause Symptom Management in Perimenopause and Postmenopausal Period
Aim:The aim of this study is to relieve menopause symptoms and improve quality of life by applying progressive muscle relaxation exercises to women in perimenopause and postmenopausal period.
- Trial name
- Menopause (NCT04140240)
- Testing
- intervention group
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Menopause
The Development, Validation and Application of a Novel Questionnaire Developed by ZOE Ltd Measuring Menopause Symptoms and Subjective Quality of Life
The MenoScale has been developed from the most common symptoms identified in over 70,000 women to reflect symptom prevalence and user-friendly terminology. It builds and improves on pre-existing scoring tools in four main ways.
- Trial name
- NCT06800560
- Testing
- MenoScale, Greene Climacteric Scale, RAND 36-Item Health Survey 1.0
- Where
- United Kingdom
- Volunteers
- 1,100 people
- Sponsor
- Zoe Global Limited
Menopause, Perimenopause
Effects of a Synbiotic Intervention on Perimenopausal/Menopausal Symptoms
FemmeBiome Meno is a synbiotic supplement, meaning it contains both probiotics (beneficial bacteria) and prebiotics (a special kind of fiber that feeds these bacteria).
- Conditions
- Menopause, Perimenopause, Perimenopausal Women
- Trial name
- NCT07759908
- Testing
- Femmebiome Meno
- Where
- Ireland
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- University College Cork
Sleep Disturbances in Perimenopause
A Study Comparing the Effects of Two Types of Natural Oils Used in a Bedtime Foot Massage Routine on Sleep and Emotional Well-Being in Perimenopausal Women.
This study is being done to find out whether a nightly 5-minute foot massage (Padabhyanga) using Brahmi-Gotukola oil can help women ages 40 to 55 sleep better and feel calmer during perimenopause.
- Trial name
- BG-SLEEP (NCT07274371)
- Testing
- Brahmi-Gotukola oil padabhyanga, Sesame oil Padabhyanga
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Saipriya Gowrishankar
Osteoporosis
Bone Adaptation to Impact Loading
Ageing populations have made osteoporosis and fragility fractures a major public health concern worldwide. Half of all women and 30% of all men will suffer a fracture related to osteoporosis during their lifetime.
- Trial name
- NCT00697957
- Testing
- Exercise
- Where
- Finland
- Volunteers
- 120 people
- Sponsor
- University of Oulu
Bariatric Surgery, Osteoporosis
Skeletal Health in Bariatric Surgery Patients
The investigators propose a prospective cohort trial that will help to understand the impact of Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) in pre- and post-menopausal female bariatric patients.
- Conditions
- Bariatric Surgery, Osteoporosis, Fractures, Bone, Roux En-Y Gastric Bypass
- Trial name
- NCT03331536
- Testing
- Roux en Y Gastric Bypass Pre-menopausal, Roux en Y Gastric Bypass Post-menopausal, Sleeve Gastrectomy Pre-menopausal
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Turner Syndrome, Ovarian Failure, Premature
Dry Eye in Women With Turner Syndrome and Women With Premature Ovarian Failure
Premature ovarian failure (POF) is known to be associated with an increased risk of ocular surface disease (dry eye), likely due to the reduction of both estrogens and androgens seen in this condition.
- Conditions
- Turner Syndrome, Ovarian Failure, Premature, Sex Chromosome Aberrations, Menopause
- Trial name
- NCT00471731
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- National Eye Institute (NEI)
Menopause, Pre-menopause
Following Lipectomy to Understand Adipose Tissue Re-accumulation
The typical female pattern of accumulating fat in the hips and thighs has long been thought to confer less risk for disease than the typical male abdominal fat pattern.
- Trial name
- FLARE (NCT00995631)
- Testing
- Femoral lipectomy
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Obesity & Overweight, Perimenopausal Women
Prebiotic Inulin for Late-Reproductive Individuals
This study aims to evaluate the effects of 2 weeks of inulin supplementation in perimenopausal women with overweight or obesity. The primary questions this study seeks to answer are: 1.
- Conditions
- Obesity & Overweight, Perimenopausal Women, Prebiotics, Inulin
- Trial name
- PILI (NCT07724522)
- Testing
- Inulin
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- George Washington University
Major Depressive Disorder, Menopause
A Neurosteroid Intervention for Menopausal and Perimenopausal Depression
HYPOTHESIS: Pregnenolone administration will be associated with greater reduction in depressive symptom severity than placebo in women with current mMDD.
- Conditions
- Major Depressive Disorder, Menopause, Perimenopause
- Trial name
- NCT03505905
- Testing
- Pregnenolone
- Where
- United States
- Volunteers
- 73 people
- Sponsor
- University of Texas Southwestern Medical Center
Breast Cancer, Breast Neoplasm
Effects of Raloxifene on the Uterus and Ovaries of Premenopausal Patients
This research study is designed to work in cooperation with another study being conducted by the National Cancer Institute. The National Cancer Institute (NCI) is studying the effects of a drug called raloxifene on premenopausal…
- Trial name
- NCT00001837
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Hot Flashes
Eight-Week Efficacy & Safety Study of Brisdelle™ (Formerly Known as Mesafem) in the Treatment of Vasomotor Symptoms Associated With Menopause
This is an exploratory 8-week, multicenter, double-blind, randomized, placebo-controlled study of Brisdelle (paroxetine mesylate) Capsules 7.5 mgin subjects with moderate to severe postmenopausal vasomotor symptoms (VMS), defined…
- Trial name
- NCT00786188
- Testing
- Brisdelle (paroxetine mesylate), Sugar pill
- Where
- 10 sites in United States
- Volunteers
- 102 people
- Sponsor
- Noven Therapeutics
Aging, Anxiety
The Relationship Between Leisure Activities and Aging Anxiety in Women
The goal of this observational study is to learn about the effect of leisure activities on aging anxiety of middle-aged (45-59) women.
- Conditions
- Aging, Anxiety, Premenopause, Womans Health
- Trial name
- NCT06206057
- Where
- Turkey (Türkiye)
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Marmara University Pendik Training and Research Hospital