Clinical trials: Premature Retinopathy
Infant, Premature, Diseases
Serum Vascular Endothelial Growth Factor in Infants With Intravitreal Ranibizumab
To determine the serum concentrations of ranibizumab and vascular endothelial growth factor (VEGF) in infants with retinopathy of prematurity (ROP) who received intravitreal ranibizumab
- Trial name
- NCT03115255
- Testing
- intravitreal ranibizumab
- Where
- China
- Volunteers
- 17 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Infant, Newborn, Infant, Low Birth Weight
Single-Dose Intravenous Inositol Pharmacokinetics in Preterm Infants
This pilot study was a randomized, placebo-controlled, clinical trial to measure changes in blood and urine levels of inositol in premature infants at high risk for retinopathy of prematurity (ROP) following a single intravenous…
- Conditions
- Infant, Newborn, Infant, Low Birth Weight, Infant, Small for Gestational Age, Infant, Premature
- Trial name
- INS-1 (NCT00349726)
- Testing
- Inositol lower volume, Inositol higher volume
- Where
- 11 sites in United States
- Volunteers
- 74 people
- Sponsor
- NICHD Neonatal Research Network
Retinopathy of Prematurity
Bevacizumab Eliminates the Angiogenic Threat for Retinopathy of Prematurity
The purpose of this study was to determine the efficacy and additional advantages of intravitreal bevacizumab in the treatment of ROP for both Zone I and Zone II Posterior.
- Trial name
- BEAT-ROP (NCT00622726)
- Testing
- Bevacizumab, Conventional Laser for ROP
- Where
- 15 sites in United States
- Volunteers
- 150 people
- Sponsor
- The University of Texas Health Science Center, Houston
Retinopathy of Prematurity
A Fatty Acids Study in Preventing Retinopathy of Prematurity
Most fatty acids, important for development and especially the Omega-3 fatty acids for the brain development are transferred in the third trimester with means that in the premature infant this transport via the placenta is…
- Trial name
- DonnaMega (NCT02760472)
- Testing
- SMOFlipid, Clinoleic
- Volunteers
- 90 people
- Sponsor
- Carola Pfeiffer-Mosesson
Infant, Premature, Retinopathy
Registration and Treatment of Pain During Eye Examination of Prematurity
The aim of this study is to see if paracetamol has a pain-relieving effect during eye examination in premature infants.
- Trial name
- NCT01552993
- Testing
- paracetamol, sucrose
- Where
- Norway
- Volunteers
- 5 people
- Sponsor
- St. Olavs Hospital
Infant, Newborn, Infant, Low Birth Weight
Supplemental Therapeutic Oxygen for Prethreshold Retinopathy of Prematurity
The purpose of this trial was to determine the efficacy and safety of supplemental therapeutic oxygen for infants with prethreshold retinopathy of prematurity (ROP) to reduce the probability of progression to threshold ROP and…
- Conditions
- Infant, Newborn, Infant, Low Birth Weight, Infant, Small for Gestational Age, Infant, Premature
- Trial name
- STOP-ROP (NCT01203436)
- Testing
- Supplemental Oxygen Management, Conventional Oxygen Management
- Where
- 9 sites in United States
- Volunteers
- 649 people
- Sponsor
- NICHD Neonatal Research Network
Retinopathy of Prematurity
Oral Propranolol Versus Placebo for Early Stages of Retinopathy of Prematurity: A Randomized and Prospective Study
In premature infants, propranolol (Prop) treatment might suppress continuing neo-vascularization (NV) and decelerate the progression of retinopathy of prematurity (ROP) towards its severe stages (III-V), thus avoiding the need of…
- Trial name
- NCT01238471
- Testing
- propranolol, sucrose 5%
- Where
- 4 sites in Israel
- Volunteers
- 20 people
- Sponsor
- Rambam Health Care Campus
Anemia, Neonatal, Intracranial Hemorrhages
Autologous Cord Blood Infusion for the Prevention and Treatment of Prematurity Complications In Preterm Neonates
The purpose of this study is to test the safety and effectiveness of a whole own (autologous) umbilical cord blood transfusion in the first 5 days after birth if the baby is born premature <34 weeks and developed anemia of…
- Conditions
- Anemia, Neonatal, Intracranial Hemorrhages, Necrotizing Enterocolitis, Respiratory Distress Syndrome, Newborn
- Trial name
- NCT02050971
- Testing
- Umbilical Cord Blood Infusion, Intravenous Infusion of Peripheral Blood or its Components
- Where
- Poland
- Volunteers
- 40 people
- Sponsor
- Pomeranian Medical University Szczecin
Retinopathy of Prematurity
Inhaled Nitrous Oxide for Pain Relief During Eye Exam in the Pre-term Infant
The primary objective of the proposed study is to show that inhaled equimolar mixture of oxygen and nitrous oxide (EMONO) will reduce pain associated with retinal exam in the preterm infant, as compared to the current standard…
- Trial name
- NCT00623220
- Testing
- N2O, oxygen
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Nabeel Ali
Retinopathy
Anesthesia for Retinopathy of Prematurity
Premature infants experience more respiratory problems after surgical procedures. The investigators aimed to compare general anesthesia with sedation on the need for post-operative mechanical ventilation in infants undergoing…
- Trial name
- NCT01955135
- Testing
- Ketamine, Sevoflurane, propofol
- Volunteers
- 60 people
- Sponsor
- TC Erciyes University
Premature Birth, Mortality
Trial to Evaluate a Specified Type of Apgar (TEST-APGAR) Follow Up Study
A specified version of the Apgar-Score, that can be used in newborns under resuscitation, was developed and its value to predict chronic damage in preterm infants will be tested.
- Conditions
- Premature Birth, Mortality, Apgar Score
- Trial name
- NCT01186627
- Where
- Germany
- Volunteers
- 1,500 people
- Sponsor
- Technische Universität Dresden
Retinopathy of Prematurity
Pain Response During Examination for Retinopathy of Prematurity
Newborns infants equal or less than 1500 grams and/or equal and less than 32 weeks will have ophthalmologic examination for ROP at 6 weeks old.
- Trial name
- ROP (NCT00648687)
- Testing
- suck 12.5% dextrose in water 5 minutes before the procedure
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- National Bioethics Commission of Brazil
Preterm Birth, Retinopathy of Prematurity
Vitamin A and Very Low Birthweight Babies (VitAL)
Vitamin A is important for the development of healthy eyes and lungs. Very low birth weight premature babies have low body stores of vitamin A and are prone to diseases of the eye and lungs.
- Trial name
- NCT00417404
- Testing
- Aquasol A
- Where
- 2 sites in United Kingdom
- Volunteers
- 94 people
- Sponsor
- Glasgow Royal Infirmary
Retinopathy of Prematurity (ROP)
Study on Effective Mydriasis in Premature Infants
The purpose of this study is to compare the dilating effect of 0, 1, 2 or 3 drops of mydriatic (pupil dilating) in premature infants undergoing routine retinal (eye) screening exams for Retinopathy of Prematurity (ROP).
- Trial name
- NCT01054027
- Testing
- 1% phenylephrine and 0.2% cyclopentolate
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Georgetown University
Infant, Premature, Leukomalacia, Periventricular
Recombinant Erythropoietin for Neuroprotection in Very Preterm Infants
Periventricular leukomalacia (PVL) is one of the most common brain injuries that occur in preterm infants. Inflammation, hypoxia-ischemia, free oxygen radical formation and excitotoxicity are all known pathogenic mechanisms that…
- Conditions
- Infant, Premature, Leukomalacia, Periventricular, Intraventricular Hemorrhage, Retinopathy of Prematurity
- Trial name
- NCT00910234
- Testing
- recombinant human erythropoietin (rhEpo), Normal saline
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- China Medical University Hospital