Clinical trials: Preeclampsia Severe
Hypertension in Pregnancy, Preeclampsia Severe
Comparing Nifedipine and Enalapril in Medical Resources Used in the Postpartum Period
This study evaluates whether nifedipine or enalapril is better at decreasing the amount of medical resources used in the postpartum period by women who have high blood pressure in pregnancy and the postpartum period.
- Conditions
- Hypertension in Pregnancy, Preeclampsia Severe, Gestational Hypertension, Postpartum Preeclampsia
- Trial name
- NCT04236258
- Testing
- NIFEdipine ER, Enalapril
- Where
- United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Hypertension
Nonsteroidal Antiinflammatory Drugs in Women With Postpartum Pre-eclampsia
Hypertensive disorders of pregnancy are a major cause of maternal mortality and morbidity, especially in developing countries. Postpartum hypertension can be related to persistence of gestational hypertension, preeclampsia, or…
- Trial name
- NCT01988298
- Testing
- Ibuprofen, Acetaminophen
- Where
- Panama
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Complejo Hospitalario Dr. Arnulfo Arias Madrid
Fetal Growth Restriction, Preeclampsia Severe
Expanded NIPT for Pregnancy Complications
This study evaluates the utility of expanded panel non-invasive prenatal testing (NIPT) in detecting confined placental mosaicism of rare autosomal trisomies among pregnancies with placentally-mediated complications, including…
- Trial name
- NCT04311749
- Testing
- Expanded panel cell free DNA testing (non-invasive prenatal testing), Placental biopsy, Umbilical cord blood
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of California, San Francisco
Pressor Response
Lignocaine Nebulization for Attenuation of Intubation Stress Response
To study the effect of lignocaine nebulization on attenuation of the pressor response during induction and emergence of anesthesia in patients with severe pre-eclampsia
- Trial name
- NCT04441073
- Testing
- Lignocaine
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University
Preeclampsia
Usefulness of Extracorporeal Removal of sFLT-1 in Women With Very Early Severe Preeclampsia
Introduction Preeclampsia is a multifactorial disease that is responsible of important adverse maternal and perinatal outcomes. Recently, it has been suggested that soluble fms-like tyrosine kinase 1, s-Flt1, induces…
- Trial name
- ADENA (NCT02286284)
- Testing
- Apheresis for extracorporal removal of sFlt-1
- Where
- France
- Volunteers
- 2 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Severe Preeclampsia, Postpartum Hemorrhage
Carbetocin vs. Oxytocin for Prevention of Postpartum Bleeding in Patients With Severe Preeclampsia
Postpartum hemorrhage is an important cause of maternal morbidity and mortality. In patients with severe preeclampsia there is an increased risk of postpartum hemorrhage but the hemodynamic changes associated with this pathology…
- Trial name
- NCT01382732
- Testing
- Carbetocin, Oxytocin
- Where
- Panama
- Volunteers
- 636 people
- Sponsor
- Saint Thomas Hospital, Panama
Severe Preeclampsia
Study of the Efficacy and Safety of AMAG-423 (Digoxin Immune Fab) in Antepartum Subjects With Severe Preeclampsia
This study evaluates the use of AMAG-423 (Digoxin Immune Fab) in addition to expectant management in the treatment of severe preeclampsia as compared to placebo.
- Trial name
- NCT03008616
- Testing
- AMAG-423 (digoxin immune fab)
- Where
- 18 sites in United States, Poland and 1 more
- Volunteers
- 58 people
- Sponsor
- AMAG Pharmaceuticals, Inc.
Pre-Eclampsia
Restrictive Fluid Therapy in Severe Preeclampsia
Introduction: Pre-eclampsia is a multifactorial syndrome which occurs in hypertension and proteinuria in pregnant women over 20 weeks gestation.
- Trial name
- NCT02214186
- Testing
- Restrictive Fluid Therapy
- Where
- Brazil
- Volunteers
- 46 people
- Sponsor
- University of Sao Paulo General Hospital
Magnesium Sulfate, Labetalol
Evaluation of Intravenous Infusion of Labetalol Versus Magnesium Sulfate
the purpose of this study is to compare Intravenous infusion of Labetalol versus Magnesium Sulfate on Cerebral Hemodynamics of Severe Preeclampsia Patients using Transcranial Doppler
- Trial name
- NCT04539379
- Testing
- Magnesium sulfate, Labetolol
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Zagazig University
Severe Preeclampsia
Role of Postpartum Furosemide in Recovery of Patients With Severe Preeclampsia
This randomized controlled trial will compare oral furosemide with placebo for improving blood pressure control in women with severe preeclampsia after delivery.
- Trial name
- NCT07861685
- Testing
- Furosemide and Potassium
- Where
- Pakistan
- Volunteers
- 434 people
- Sponsor
- Lady Reading Hospital, Pakistan
Hypertension, Pregnancy Induced, Hydralazine Adverse Reaction
Randomized Controlled Trial of Labetalol Versus Hydralazine for Severe Hypertension in Obstetric Patients.
Severe Hypertension in pregnancy demands urgent treatment because of high mortality \& morbidity in obstetric patients. Hydralazine, the most commonly used agent, causes sudden hypo tension and tachycardia.
- Conditions
- Hypertension, Pregnancy Induced, Hydralazine Adverse Reaction, Pre-eclampsia, Pre-eclampsia Superimposed Pre-existing Hypertension
- Trial name
- NCT02050529
- Testing
- Labetalol, Hydralazine
- Where
- Pakistan
- Volunteers
- 190 people
- Sponsor
- Dow University of Health Sciences
Postpartum Hemorrhage, Postpartum Preeclampsia
Postpartum Video Education
This is a prospective, single-center, randomized control study to determine if video education at the time of postpartum discharge improves patient knowledge on the warning signs for the top three causes of severe maternal…
- Conditions
- Postpartum Hemorrhage, Postpartum Preeclampsia, Postpartum Sepsis, Postpartum Depression
- Trial name
- NCT05159726
- Testing
- Video Education
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Yale University
Hypertensive Disorder of Pregnancy, Pre-Eclampsia, Severe
Low-Sodium Diet for Postpartum Blood Pressure Control
The goal of this randomized controlled trial is to learn if a low-sodium diet improves postpartum blood pressure control in adults who were diagnosed with a late-onset hypertensive disorder of pregnancy.
- Conditions
- Hypertensive Disorder of Pregnancy, Pre-Eclampsia, Severe, Pre-Eclampsia; Mild, Postpartum
- Trial name
- NCT07752056
- Testing
- Low Sodium Diet
- Volunteers
- 110 people
- Sponsor
- Women and Infants Hospital of Rhode Island
Mild Pre-eclampsia, Severe Preeclampsia
İs There a Relationship Between Severity of Preeclampsia and Maternal Heavy Metal Levels?
The purpose of this study, to investigate whether severity of preeclampsia is associated with altered levels of heavy metals (Cd, Hg, arsenic and Pb) in maternal blood, fetal blood, and maternal hair.
- Trial name
- NCT01906567
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Zekai Tahir Burak Women's Health Research and Education Hospital
Severe Preeclampsia
Risk Prediction Models for Adverse Maternal and Neonatal Outcomes in Preeclampsia
This proposal describes a single centre retrospective cross-sectional study which will address the need to further develop and test statistical risk prediction models for adverse maternal and neonatal outcomes in low-resource…
- Trial name
- NCT04058405
- Testing
- Observational
- Where
- Zimbabwe
- Volunteers
- 549 people
- Sponsor
- Mpilo Central Hospital
Preeclampsia Severe or Mild, Cardiac Complication
Persistent Postpartum Cardiovascular Dysfunction in Patients With Preeclampsia
The investigators plan to enroll women with PE prospectively to evaluate incremental cardiovascular risk in those who have PE with severe features. This study includes detailed echocardiographic evaluation at several time points.
- Trial name
- ECHO (NCT04063397)
- Testing
- Echocardiogram, Blood draw
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Pre-Eclampsia
Maternal Serum Stathmin-1 Levels in Preeclampsia
This study investigates maternal serum Stathmin-1 (STMN-1) levels in pregnancies complicated by preeclampsia and severe preeclampsia, compared to healthy pregnancies.
- Trial name
- NCT06623955
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Preeclampsia Severe, Preeclampsia Postpartum
Effects of Vitamin C Administration on Extravascular Lung Water in Patients With Severe Features of Preeclampsia
The objective of the study is to determine whether administration of vitamin C (1.5g/6 hours) in the first three days post-partum reduces the amount of extravascular lung water assessed by lung ultrasound in patients with severe…
- Trial name
- NCT03451266
- Testing
- Vitamin C
- Where
- Slovenia
- Volunteers
- 34 people
- Sponsor
- University Medical Centre Ljubljana
Preeclampsia (PE), Intrauterine Growth Restriction (IUGR)
Statin Intervention for Severe Early-Onset Placental Insufficiency. (STATIN-PRE Trial)
In pregnancies with placental insufficiency, the only available treatment is close monitoring to determine the point at which the risks of preterm birth for the baby are lower than the risks of continuing the pregnancy.
- Conditions
- Preeclampsia (PE), Intrauterine Growth Restriction (IUGR), Placental Insufficiency
- Trial name
- STATIN-PRE (NCT07098975)
- Testing
- Pravastatin 40 mg
- Where
- 2 sites in Spain
- Volunteers
- 154 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Preeclampsia Severe, Pre-Eclampsia
Metformin and Esomeprazole in Preterm Pre-eclampsia
The purpose of this study is to better understand diagnosis and treatment of preterm preeclampsia. Currently, there are limited laboratory tests that can be used to diagnosis preeclampsia.
- Conditions
- Preeclampsia Severe, Pre-Eclampsia, Preeclampsia, Preeclampsia Second Trimester
- Trial name
- NCT06359015
- Testing
- Metformin, Esomeprazole
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Christiana Care Health Services