Clinical trials: Prediction of Disease Progression, open to volunteers
Heart Failure
Decision Support System for Diagnosis and Progression of Heart Failure
Heart failure (HF) is a complex clinical syndrome associated with impaired heart function, poor quality of life for patients and high healthcare costs.
- Trial name
- STRATIFYHF (NCT06377319)
- Testing
- Cardiac Output Response to Stress (CORS) test
- Volunteers
- 1,600 people
- Sponsor
- Coventry University
Type 2 Diabetes, Insulin Resistance
Characteristics of Papez Loop Neural Network in T2DM （Type 2 Diabetes Mellitus）
This is a cross-sectional and longitudinal study to investigate the characteristic changes in Papez's circuit neural network activity and connectivity based on multimodal MRI, and through follow-up study of the interaction…
- Conditions
- Type 2 Diabetes, Insulin Resistance, Cognitive Impairment
- Trial name
- T2DM (NCT06912321)
- Testing
- No Intervention: Observational Cohort
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Chronic Respiratory Diseases
Belgian Lung Function Study
Currently, it remains unclear how to manage serial lung function measurements in a clinical setting. The investigators aimed to tackle this problem by developing a machine learning (ML) model that can accurately predict…
- Trial name
- AIRCAST (NCT07419555)
- Where
- 5 sites in Belgium
- Volunteers
- 5,000 people
- Sponsor
- KU Leuven
Adolescence Idiopathic Scoliosis
Machine Learning Prediction of Disease Progression in Adolescent Idiopathic Scoliosis
Background and Problem Overview Adolescent Idiopathic Scoliosis (AIS) is a progressive musculoskeletal disorder characterized by a three-dimensional deformation of the spine occurring during adolescence.
- Trial name
- NCT07556042
- Testing
- Core Stabilization Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Istanbul University
Alzheimer Disease, Chronic Traumatic Encephalopathy
Visualizing Brain Proteinopathies Using [F-18]Flornaptitril-PET in the Prediction of Clinical Progression of Mild Cognitive Impairment With Either Suspected Chronic Traumatic Encephalopathy or Alzheimer's Disease
CMK-0301 is a multi-site, randomized clinical trial to evaluate the safety and efficacy of [F-18]Flornaptitril-PET (F-18 FNT-PET) for the prediction of clinical progression of Mild Cognitive Impairment (MCI) with either Suspected…
- Trial name
- NCT06254469
- Testing
- [F-18]Flornaptitril
- Where
- United States
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- CereMark Pharma, LLC
Ulcerative Colitis
Personalised Prediction of Disease Course in Ulcerative Colitis Using Multimodal Machine Learning - Part of the Presager Project
In patients achieving clinical remission following a flare, artificial intelligence can reliably predict a new flare within the next 12 months utilizing clinical and objective information at day 0 and week 8.
- Trial name
- Presager II (NCT05479617)
- Testing
- Deep learning model
- Where
- Denmark
- Volunteers
- 400 people
- Sponsor
- Copenhagen University Hospital, Hvidovre
Prediction of Disease Progression, Multiple Sclerosis
Disease Progression in ms
Demographic and clinical data will be obtained from people with MS. Based on this data, the progression of the disease will be predicted with artificial intelligence.
- Trial name
- NCT07292116
- Volunteers
- 53 people
- Sponsor
- Hüseyin Bektaş
Pulmonary Embolism (Diagnosis), Pulmonary Embolism Acute
Repeated Examinations for Typing Pulmonary Embolism
PURPOSE The two related purposes of the RE-TyPE study are: 1. To improve understanding of the early clinical course of intermediate-high risk pulmonary embolism and its association with outcome and 2.
- Conditions
- Pulmonary Embolism (Diagnosis), Pulmonary Embolism Acute, Pulmonary Embolism With Acute Cor Pulmonale, Pulmonary Embolism With Right Ventricle Enlargement
- Trial name
- RE-TyPE (NCT07491094)
- Where
- 3 sites in Sweden
- Volunteers
- 400 people
- Sponsor
- Sahlgrenska University Hospital
Prostate Cancer
PSMA-PET: Deep Radiomic Biomarkers of Progression and Response Prediction in Prostate Cancer
Prostate cancer (PCa) is the most common non-skin malignancy and the third leading cause of cancer death in North American men. The accurately mapped metastatic state is a necessary prerequisite to guiding treatment in practice…
- Trial name
- NCT03594760
- Testing
- 18F-DCFPyL IV injection
- Where
- Canada
- Volunteers
- 1,000 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Coronary Heart Disease (CHD)
AI-Driven Dynamic Prediction of Non-Target Lesion Progression After PCI: A Chinese Multicenter Cohort Study
Coronary artery disease remains a leading cause of global mortality. Although percutaneous coronary intervention (PCI) improves patient outcomes, the long-term risk of major adverse cardiovascular events (MACE) driven by the…
- Trial name
- VISION-PCI (NCT07312318)
- Testing
- percutaneous coronary intervention
- Where
- China
- Volunteers
- 12,000 people
- Sponsor
- China-Japan Friendship Hospital
Pulmonary Nodules, Lung Neoplasms
Deep Learning Time-Series Prediction of Long-Term Growth Patterns of Pulmonary Ground-Glass Nodules Using Serial CT
Pulmonary ground-glass nodules (GGNs) are commonly found on chest CT scans. Some stay stable for years, while others slowly or rapidly turn into lung cancer.
- Conditions
- Pulmonary Nodules, Lung Neoplasms, Adenocarcinoma of Lung
- Trial name
- GGN-Trajectory (NCT07647692)
- Testing
- Serial Thin-Slice Chest CT
- Where
- China
- Volunteers
- 4,750 people
- Sponsor
- Peking University People's Hospital
Pulmonary Embolism and Thrombosis, Deterioration, Clinical
Adverse Outcome of Acute Pulmonary Embolism by Artificial Intelligence System Based on CT Pulmonary Angiography
The investigators aim to build a predictive tool for Adverse Outcome of Acute Pulmonary Embolism by Artificial Intelligence System Based on CT Pulmonary Angiography.
- Conditions
- Pulmonary Embolism and Thrombosis, Deterioration, Clinical, Artificial Intelligence
- Trial name
- PEAICTPA (NCT05482269)
- Testing
- no intervention
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Shengjing Hospital
Hidradenitis Suppurativa (HS)
Early Pathophysiology of Hidradenitis Suppurativa and Prediction of the Risk of Progression: a Prospective Cohort
Hidradenitis suppurativa (HS) is a chronic inflammatory disease affecting approximately 1% of the population. Most pathophysiological studies have focused on advanced forms (Hurley II-III), which obscures the initial mechanisms.
- Trial name
- Early-HS (NCT07920848)
- Testing
- Biological samples and questionnaires, Analysis of residual skin tissue
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Coronary Disease, Young Adult
Risk Prediction of Disease Progression in Early-Onset Coronary Atherosclerosis
This study is part of a nationwide research project in China that aims to better understand how coronary artery disease develops and progresses in young adults.
- Trial name
- NCT07316452
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Fu Wai Hospital, Beijing, China
Membranous Nephropathy, Nephrotic Syndrome
Clinical Prediction Model for Disease Progression in Primary Membranous Nephropathy
This prospective observational study aims to evaluate predictors of disease progression in patients with primary membranous nephropathy and to assess the performance of a prognostic nomogram in predicting renal outcomes in the…
- Conditions
- Membranous Nephropathy, Nephrotic Syndrome, Kidney Diseases
- Trial name
- NCT07785739
- Volunteers
- 128 people
- Sponsor
- Assiut University
Diabetic Retinopathy (DR)
Multimodal Biomarkers in Prediction of Diabetic Retinopathy
The goal of this observational study is to enroll diabetic patients with diabetic retinopathy and those without diabetic retinopathy, follow up and observe the long-term changes in ocular structure and function of the subjects by…
- Trial name
- ZOCDR (NCT07098832)
- Where
- China
- Volunteers
- 1,538 people, healthy volunteers welcome
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Mild Cognitive Impairment (MCI)
A Prospective Cohort Study of Multimodal Biomarkers and Progression From Mild Cognitive Impairment to Dementia
This prospective, longitudinal observational cohort study will examine clinical, cognitive, blood-based, and neuroimaging features across the cognitive continuum.
- Trial name
- NCT07876570
- Testing
- Observational Multimodal Assessment
- Where
- China
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Xuanwu Hospital, Beijing
Inflammatory Bowel Diseases, Crohn Disease (CD)
Early Inflammatory Bowel Disease Progression
The purpose of this study is to assess the capacity of the gut microbial composition and function to predict the course of IBD during the first year after diagnosis.
- Conditions
- Inflammatory Bowel Diseases, Crohn Disease (CD), Ulcerative Colitis (UC)
- Trial name
- PRO-IBD (NCT06756100)
- Where
- Chile
- Volunteers
- 140 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Breech Presentation
Prediction of Version Outcomes for External Maneuvers of Breech Fetus by Assessment of Breech Progression Angle
Breech presentation complicates about 3-4% of single pregnancies at term. Although vaginal delivery is also possible in breech presentations, this is associated with an increased risk of fetal morbidity and mortality.
- Trial name
- ECV (NCT06816563)
- Where
- 2 sites in Italy
- Volunteers
- 200 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Sepsis, Acute Respiratory Distress Syndrome
A Validation Study on a Prognostic Prediction Model for Respiratory Tract Infections
This study adopted a prospective, single-center, open-label design, aiming to evaluate the efficacy of the RTI clinical outcome prediction model in predicting clinical outcomes in subjects with acute respiratory tract infections.
- Conditions
- Sepsis, Acute Respiratory Distress Syndrome, Community Acquired Pneumonia, Transcriptome
- Trial name
- NCT07109310
- Testing
- RTImodel001
- Volunteers
- 150 people
- Sponsor
- Peking Union Medical College Hospital