Clinical trials: Prediction
Myopia
Pharmacological and Non-pharmacological Treatment Effects on Children With Different Predicted Myopia Progression Rate
The goal of this clinical trial is to compare pharmacological and non-pharmacological treatment effects on the children with different predicted myopia progression rate measured by modified multifocal electroretinogram.
- Trial name
- NCT06282848
- Testing
- Atropine 0.05%, DIMS lens
- Where
- Hong Kong
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Oral Cavity Squamous Cell Carcinoma
Neoadjuvant Nivolumab for Oral Cancer Combined With FDG and Anti-PD-L1 PET/CT Imaging for Response Prediction
Safety and tolerability of neoadjuvant nivolumab for locally advanced resectable oral cancer, combined with [18F]BMS-986192 / [18F]-FDG PET imaging and immunomonitoring for response prediction
- Trial name
- NeoNivo (NCT03843515)
- Testing
- Nivolumab
- Where
- Netherlands
- Volunteers
- 17 people
- Sponsor
- Amsterdam UMC, location VUmc
Acute Appendicitis
The Utility of Immature Granulocyte Count on the Prediction of Acute Appendicitis in the Suspected Acute Appendicitis
Acute appendicitis is the most common cause of abdominal pain requiring surgery in the emergency department. The whole life acute appendicitis rate is 7%.
- Trial name
- NCT05033249
- Testing
- Immature granulocyte count, Immature granulocyte percentage
- Where
- Turkey (Türkiye)
- Volunteers
- 186 people
- Sponsor
- Kahramanmaras Sutcu Imam University
Postoperative Pain
Prospective External Validation of an Early Prediction Model for Adverse Postoperative Pain Trajectories After Orthopedic Surgery
This prospective observational study will externally validate a previously developed and locked prediction model for identifying adult patients at risk of adverse postoperative pain trajectories after elective orthopedic surgery.
- Trial name
- NCT07846878
- Testing
- Elective Orthopedic Surgery
- Where
- China
- Volunteers
- 400 people
- Sponsor
- First Affiliated Hospital of Chongqing Medical University
Pain, Pain, Postoperative
Prediction and Characterization of Acute and Chronic Postoperative Pain
Despite enormous progress insufficient postoperative pain management remains a frequent problem in the early postoperative phase after surgery.
- Conditions
- Pain, Pain, Postoperative, Funnel Chest
- Trial name
- NCT01308385
- Testing
- Conditioned pain modulation
- Where
- Denmark
- Volunteers
- 52 people
- Sponsor
- University of Aarhus
Primary Central Nervous System Lymphoma (PCNSL)
Registry of an Integrated Longitudinal Multimodal Biospecimen Biobank for Primary CNS Lymphoma in China
This project aims to establish and prospectively register a longitudinal, multimodal biobank for primary central nervous system lymphoma (PCNSL).
- Trial name
- CLIMB (NCT07842835)
- Testing
- High-dose methotrexate-based therapy, Bruton tyrosine kinase inhibitor-based therapy
- Where
- 3 sites in China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Xiaohui Ren
Congenital Heart Disease, Pregnancy
Accuracy of Risk Prediction Scores in Pregnant Women
Management of pregnancy and risk stratification in congenital heart disease (CHD) population might be challenging especially due to physiological haemodynamic modifications that inevitably occur during pregnancy.
- Trial name
- PREG-GUCH (NCT04221048)
- Testing
- Retrospective observational
- Where
- France
- Volunteers
- 70 people
- Sponsor
- University Hospital, Montpellier
Healthy Elderly
Generation of Prediction Equations for BIA of the Elderly
The objective of the study is to develop prediction equations for calculating Fat-Free Mass FFM, Total Body Water TBW, Extracellular Water ECW, Visceral Adipose Tissue VAT, total Skeletal Muscle Mass SMM and segmental SMM in a…
- Trial name
- NCT04028648
- Where
- Germany
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Seca GmbH & Co. Kg.
Non-alcoholic Fatty Liver Disease
Non-invasive Diagnostic Model of Liver Fibrosis Associated With NAFLD and Prediction of Prognosis
In a retrospective study, 200 patients with non-alcoholic fatty liver disease, fatty liver hepatitis, and fatty liver fibrosis have been identified for pathological diagnosis of liver histology and exclusion of other liver…
- Trial name
- NCT03842748
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Beijing Municipal Administration of Hospitals
Tumor Disease Including Colorectal Cancer, Head & Neck Squamous Cell Carcinoma
Assessment and Prediction of Cetuximab-Induced Hypersensitivity Reactions Using Cetuximab Specific IgE Detection
1. Background Cetuximab (trade name Erbitux) is a murine-human chimeric monoclonal antibody to human epidermal growth factor receptor (EGFR). This drug has been used as a treatment for colorectal cancer and head and neck cancer.
- Trial name
- NCT03485638
- Where
- South Korea
- Volunteers
- 400 people
- Sponsor
- Yonsei University
Gestational Diabetes Mellitus
Early Prediction of Postpartum Glucose Metabolism Abnormalities in Gestational Diabetes Mellitus
This project is expected to screen reliable serum markers in pregnant women with gestational diabetes mellitus (GDM) by using metabolic profiling and lipid profiling clinical high-throughput mass spectrometry technology.
- Trial name
- NCT05670548
- Testing
- Questionnaire survey and specimen collection
- Where
- China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
Pancreatic Cancer, Pancreatic Ductal Adenocarcinoma (PDAC)
PRedictiOn Algorithms for the DeTECTion of Early Stage Pancreatic Cancer
Conduct a prospective study to assess the accuracy of a pancreatic cancer risk prediction model.
- Trial name
- PRO-TECT (NCT04883450)
- Testing
- Magnetic resonance imaging (MRI)
- Where
- United States
- Volunteers
- 126 people
- Sponsor
- Kaiser Permanente
Preeclampsia
Fetal Renal Artery Doppler in Patients With Preeclampsia
Preeclampsia is a major devastating disorder affects 2:10% of pregnancies worldwide. preeclampsia may be associated with placental insufficiency which may cause fetal blood redistribution to essential organs like brain, heart…
- Trial name
- NCT06395974
- Testing
- fetal ultrasound
- Where
- Egypt
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Assiut University
Unruptured Intracranial Aneurysm
Unruptured Cerebral Aneurysm: Prediction of Evolution
The protocol has many assets. A prospective nationwide recruitment allows for the inclusion of a large cohort of patients with UIA. It will combine accurate clinical phenotyping and comprehensive imaging with CAWE screening.
- Trial name
- U-CAN (NCT04578808)
- Testing
- Unruptured intracranial aneurysms
- Where
- 29 sites in France, Netherlands and 1 more
- Volunteers
- 1,000 people
- Sponsor
- Nantes University Hospital
Rheumatoid Arthritis
A Specification Clinical Application Research of Tripterygium Wilfordii Treating Rheumatoid Arthritis
Rheumatoid Arthritis (RA) is an autoimmune disease that results in a chronic inflammatory disorder that may affect many synovial joints, and may cause serious disability.
- Trial name
- NCT03337815
- Where
- China
- Volunteers
- 264 people
- Sponsor
- Guang'anmen Hospital of China Academy of Chinese Medical Sciences
Sepsis, Obstructive Shock
Use of Renin Versus Lactic Acid as Tissue Perfusion Biomarkers for Mortality Prediction in Hypotensive Critically Ill Patients
Measurement of Whole Blood Lactate Concentrations Whole blood lactate concentrations will be measured at the time of study enrollment and at 24, 48, and 72 hours.
- Conditions
- Sepsis, Obstructive Shock, Critical Illness, Hypotensive
- Trial name
- NCT05810415
- Testing
- Renin levels and lactic acid levels
- Where
- 2 sites in Egypt
- Volunteers
- 84 people
- Sponsor
- Al-Azhar University
Breast Cancer, Bone Metastases
A Study for Dynamic Prediction Model of Breast Cancer Bone Metastases
The purpose of this study is to identify the risk factors of bone metastasis in breast cancer patients so as to develop a dynamic prediction model using real world clinical data.
- Trial name
- NCT06544668
- Testing
- Breast cancer patients with bone metastasis, Breast cancer patients without bone metastasis
- Where
- China
- Volunteers
- 3,500 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Tree Nut Allergy, Food Allergy
Thresholds In Food Allergy evaluaTion And predictioN
Thresholds In food allergy evaluaTion And predictioN, a prospective, observational registry. The aim is to quantify food allergy thresholds in Canada and their clinical predictors.
- Trial name
- TITAN (NCT06038019)
- Testing
- Oral food challenge
- Where
- Canada
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Hamilton Health Sciences Corporation
Internal Medicine
Polypharmacy Among Internal Medicine Patients
The World Health Organisation Patient Safety Challenge: Medication Without Harm has brought our attention to the importance of medication-related harm as a global public health issue.
- Trial name
- NCT05756400
- Where
- Iceland
- Volunteers
- 85,942 people
- Sponsor
- University of Iceland
Preterm Labour
Fetal Adrenal Gland Volume Estimation Compared to Cervical Length Assessment in Prediction of Preterm Birth
If the investigators could prove that three -dimensional ultrasound measurement of fetal adrenal gland volume can accurately predict the likelihood of preterm birth in patients having symptoms and signs of PTL , they would be…
- Trial name
- NCT02351336
- Testing
- Ultrasound imaging
- Where
- Egypt
- Volunteers
- 78 people
- Sponsor
- Wessam Magdy Abouelghar