Clinical trials: Prediabetes, open to volunteers
Sudden Sensorineural Hearing Loss (SSNHL), Prediabetes / Type 2 Diabetes
CGM-guided Patch Pump vs Basal-Bolus Injection for Steroid-Induced Hyperglycemia in Sudden Sensorineural Hearing Loss: SHIP Trial
This exploratory randomized controlled trial evaluates whether a CGM-guided temporary patch pump (CareLevo CSII) reduces glucocorticoid-induced hyperglycemia (GIH) compared to a Lantus-based basal-bolus injection (MDI) regimen in…
- Trial name
- SHIP (NCT07652528)
- Testing
- CareLevo Patch-type Insulin Pump, Insulin Glargine U-100 (Lantus), Fast-acting Insulin Aspart (Fiasp)
- Volunteers
- 50 people
- Sponsor
- Hallym University
Impaired Fasting Glucose (IFG), Impaired Glucose Tolerance (Prediabetes)
Effect of a Food Supplement on Glycemic Parameters in Patients With Impaired Glucose Metabolism
The primary objective will be to evaluate the efficacy of GlycoDual in reducing fasting plasma glucose (FPG) and post-prandial plasma glucose (PPG) levels compared to placebo after 90 days of treatment.
- Trial name
- NCT07263802
- Testing
- GlycoDual
- Volunteers
- 90 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Prediabetes
Integrating a Prescription Produce Program Within a Diabetes Prevention Program
Type 2 Diabetes remains a major chronic disease among adults in the United States. A way to prevent Type 2 Diabetes is to engage in a diabetes prevention program.
- Trial name
- NCT07472712
- Testing
- Diabetes Prevention Program (DPP), Produce Prescription Plan (PPP)
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- Virginia Commonwealth University
Diabetes Mellitus, Type 2, Obesity
Time-restricted Eating, Window Timing, Type 2 Diabetes Status and Sex on Glycemic Control
This study will evaluate the effectiveness of time-restricted eating (TRE), which is a form of intermittent fasting. When performing TRE, individuals consume all of their calories within a specific time window and then only…
- Conditions
- Diabetes Mellitus, Type 2, Obesity, Prediabetic State, Hyperglycemia
- Trial name
- NCT06118931
- Testing
- Early (7:00 - 16:00) TRE, Mid (9:30 - 18:30) TRE, Late (12:00 - 21:00) TRE
- Where
- Canada
- Volunteers
- 123 people
- Sponsor
- University of Toronto
Prediabetes
Fiber mHealth Intervention for Prediabetes
This is a single-arm feasibility trial to examine an mHealth intervention that combines high fiber education, home-delivered high fiber foods, and use of continuous glucose monitors.
- Trial name
- GO-FAR (NCT07491653)
- Testing
- GO-FAR
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Oklahoma
Community-Based Participatory Research
Evaluating Family & Community-Based Interventions to Improve Treatment Adherence in Metabolic Health Among Negev Bedouins (EFIT-BED)
Background: The Bedouin community in the Negev faces high rates of type 2 diabetes, low treatment adherence, and increased disease complications.
- Trial name
- EFIT-BED (NCT06575465)
- Testing
- Healthy lifestyle nutrition, culture and physical activity workshops, Usual care
- Where
- Israel
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Ariel University
Prediabetes
Evaluation of Chiglitazar Sodium With Lifestyle Intervention for Reversing Prediabetes
This multicenter, randomized, double-blind, placebo-controlled trial aims to evaluate the efficacy and safety of Chiglitazar Sodium combined with lifestyle intervention for reversing prediabetes to normal glucose metabolism.
- Trial name
- NCT07558525
- Testing
- Chiglitazar sodium
- Where
- 30 sites in China
- Volunteers
- 472 people
- Sponsor
- Second Xiangya Hospital of Central South University
Gut Health, LBP
The Effects of Mango on Gut Health Markers
This is an ancillary study of NCT06159543, which was a clinical trial that examined the effect of a 12-week 1.5 cups daily mango crossover intervention on cardiometabolic outcomes in individuals with prediabetes, male and female…
- Conditions
- Gut Health, LBP, Short Chain Fatty Acids, sCD14
- Trial name
- NCT07559604
- Testing
- Mango
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Loma Linda University
Type 1 Diabetes (T1D), Pre Diabetes
INNODIA Family & Friends Early-Stage T1D Detection Protocol
The purpose of INNODIA DETECT is to identify people who are at increased risk of developing T1D. Investigators are doing this by testing for markers in the blood (autoantibodies) that tell them an individuals risk of getting T1D…
- Trial name
- INNODIA DETECT (NCT07118098)
- Where
- 21 sites in Austria, Belgium and 6 more
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- INNODIA iVZW
Prediabetes
Effect of Increased Physical Activity and Stopping Evening Snacking in Metabolic Health in Youth With Prediabetes
Non-healthy eating habits and a lack of exercise contribute to prediabetes and type 2 diabetes (T2D). Evening snacking is linked to abnormal weight gain in adults and healthy adolescents.
- Trial name
- NCT06782906
- Testing
- ≥10,000 daily steps (≥5 days/week) and stopping evening snacking
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Baylor College of Medicine
Prediabetes
Piloting FUERTE: Federally qUalified Health Centers Engaging Hispanic Men at Risk of diabeTEs
The goal of this study is to learn whether FUERTE (Federally qUalified Health Centers Engaging Hispanic Men at Risk of diabeTEs) can facilitate referrals of Hispanic men with prediabetes to the Diabetes Prevention Program (DPP)…
- Trial name
- FUERTE (NCT07878806)
- Testing
- FUERTE Arm, Standard care, No Intervention
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Weill Medical College of Cornell University
Type2diabetes, PreDiabetes
SGLT2 Inhibition in Addition to Lifestyle Intervention and Risk for Complications in Subtypes of Patients With Prediabetes
More than 50% of patients with type 2 diabetes develop micro- and/or macrovascular complications during the course of the disease.
- Conditions
- Type2diabetes, PreDiabetes, Renal Failure
- Trial name
- NCT06054035
- Testing
- Dapagliflozin (Forxiga®), Lifestyle Intervention
- Where
- 9 sites in Germany
- Volunteers
- 170 people
- Sponsor
- University Hospital Tuebingen
PreDiabetes
Effect of Glucagon on Fasting Insulin Secretion and Glucose Metabolism in Subjects Without Type 2 Diabetes
Fasting hyperglycemia contributes disproportionately to nonenzymatic glycosylation and the microvascular complications of type 2 diabetes.
- Trial name
- NCT06424106
- Testing
- Glucagon, Glucose
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Diabetes (DM), Pre Diabetes
FastForward: A Prospective Analysis of Long-term Fasting and Subsequent Food Reintroduction in Humans
This study explores what happens in the body and wellbeing during and after a period of long-term fasting. At the Buchinger Wilhelmi Clinic, participants follow a medically supervised fasting program lasting five or more days…
- Conditions
- Diabetes (DM), Pre Diabetes, Overweight (BMI > 25)
- Trial name
- FastForward (NCT07155993)
- Where
- Germany
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Buchinger Wilhelmi Development & Holding GmbH
Diabete Type 2
Effect of a Healthy Food Voucher on Blood Glucose Control in People With Type 2 Diabetes or Prediabetes
This randomized controlled trial (RCT) will determine if access to a voucher for healthy foods reduces blood sugar levels among people living on a low income who have type 2 diabetes or elevated blood sugar.
- Trial name
- VOUCH4DIABETES (NCT05776420)
- Testing
- Food voucher
- Where
- Canada
- Volunteers
- 390 people
- Sponsor
- Unity Health Toronto
Schizophrenia, Schizophrenia Spectrum and Other Psychotic Disorders
Sex, Psychopharmacology, and Diabetes
The term sexual (SD) dysfunction covers conditions that prevent people from having a satisfactory sex life. SD is a frequent and sometimes debilitating complication of mental illness and a known adverse reaction to…
- Conditions
- Schizophrenia, Schizophrenia Spectrum and Other Psychotic Disorders, Diabetes Mellitus, PreDiabetes
- Trial name
- SECRET (NCT05951660)
- Testing
- Educational intervention
- Where
- Denmark
- Volunteers
- 256 people
- Sponsor
- Zealand University Hospital
Pre Diabetes, Type2 Diabetes
Diabetes Prevention AI: Enhancing Prevention Strategies Using Personalized Nutrition and Fitness Coaching for the Next Generation
This study is testing an artificial intelligence (AI) chatbot designed to help adults at risk for type 2 diabetes adopt healthier lifestyles.
- Trial name
- NCT07824154
- Testing
- AI-Powered Diabetes Prevention Chatbot
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Emory University
Diabete Mellitus, Type2diabetes
CGM Experience, Preferences & Blood Glucose Parameters
This is an open-label, prospective, multicenter observational study designed to evaluate the perceived benefits, device experience, preference, and glucose-related parameters associated with the Instara-1 Continuous Glucose…
- Conditions
- Diabete Mellitus, Type2diabetes, type1diabetes, Gestational Diabetes
- Trial name
- NCT07607015
- Testing
- CGM
- Volunteers
- 75 people
- Sponsor
- Getz Pharma
PreDiabetes, Lifestyle, Healthy
Study of a Diabetes Prevention Patient Activation Clinical Decision Support Tool
The investigators overarching goal is to increase the percentage of patients engaging in diabetes prevention activities to reduce the incidence of diabetes.
- Conditions
- PreDiabetes, Lifestyle, Healthy, Activation, Patient
- Trial name
- NCT06358261
- Testing
- Diabetes Prevention Patient Activation Clinical Decision Support Tool
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Pre Diabetic, Hyperglycaemia (Non Diabetic)
Diabetes Prevention by Group Intervention and CGM Use in Pre-diabetic Adults
This study is being done to find better ways to help people with prediabetes prevent or delay the development of type 2 diabetes.
- Trial name
- CGM (NCT07543068)
- Testing
- Combines group sessions and CGM-based behavioral feedback
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Sam Houston State University