Clinical trials: Preconditioning
Preconditioning
Personalized Hypoxic-hyperoxic Preconditioning in Elderly People
This study investigates an original protocol of personalized hypoxic-hyperoxic preconditioning utilizing a personalized approach on the basis of cerebral tissue oxygenation assessed with near-infrared spectroscopy.
- Trial name
- NCT07018895
- Testing
- FiO2 reduced by 20% alternating with 34% FiO2
- Where
- Russia
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Hemodialysis, Ischemia Preconditioning
Assessment of the Impact of Repeated Ischemic Preconditioning Episodes on Hemodynamic and Metabolic Parameters in Patients at Various Stages of Chronic Kidney Disease
The aim of our study is to evaluate the impact of repeated episodes of ischemic quenching on changes in blood pressure, heart rate and laboratory parameters of inflammation in patients with kidney diseases.
- Conditions
- Hemodialysis, Ischemia Preconditioning, Chronic Kidney Disease, Blood Pressure Disorders
- Trial name
- NCT07746102
- Testing
- Preconditioning with control ischemic episodes
- Where
- 2 sites in Poland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Medical University of Lodz
Ischemic Preconditioning
Effects of Remote Ischemic Preconditioning on Peripheral Blood Biomarkers in Healthy Adults (EMINENT)
The aim of this study is to investigate the effects of remote ischaemic preconditioning on the peripheral blood characteristics of healthy adults and to explore the possible mechanisms for improving ischaemia/reperfusion injury…
- Trial name
- EMINENT (NCT05957523)
- Testing
- Remote ischaemic preconditioning
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Ischemic Preconditioning, Aerobic Capacity
Research on the Enhancement of Aerobic Metabolic Energy Supply Capacity by Ischemic Preconditioning.
The purpose of this clinical trial is to investigate whether IPC can improve aerobic capacity during exercise. The primary question it aims to answer is: Does IPC enhance the aerobic capacity of athletes? The researchers will…
- Trial name
- NCT07170774
- Testing
- Ischemic Preconditioning
- Where
- China
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Ziyue Ou
Ischemic Preconditioning, Autonomic Nervous System (ANS) Functioning and Mood State
The Impact of Ischemic Preconditioning on Exercise Performance and Physiological Function
Ischemic Preconditioning has been confirmed to prevent long-term ischemic damage to tissues, among which the improvement of autonomic nerve system function may be one of its mechanisms of action.
- Trial name
- NCT07146399
- Testing
- Ischemic Preconditioning
- Where
- China
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Ziyue Ou
Sport Medicine, Sport
Ischemic Preconditioning - Perspectives of Use Vivio/in Vitro Studies
Both in sports and medicine, methods that can significantly contribute to improving the ability of tissues to perform their functions are constantly being searched.
- Conditions
- Sport Medicine, Sport, Physiological Adaptations, Sport Performance
- Trial name
- NCT07117643
- Testing
- Ischemic Preconditioning
- Where
- 2 sites in Poland
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Gdansk University of Physical Education and Sport
Metabolic Syndrome, Vascular Injury
Therapeutic Strategies to Reduce Endothelial Ischemia-reperfusion Injury
The objective of this clinical trial is to better understand how lactate, a naturally occurring energy substance, can be used to lessen damage to the vascular system in adults with a high cardiovascular disease risk.
- Conditions
- Metabolic Syndrome, Vascular Injury, Ischemic Preconditioning, Endothelial Function (reactive Hyperemia)
- Trial name
- NCT06825143
- Testing
- Ischemic preconditioning, Intravenous lactate infusion, No ischemic preconditioning (control)
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Gary Van Guilder
Cardiac Function and Preconditioning
Effects of Remote Cardiac Ischemic Preconditioning
A heart attack occurs when blood flow is disrupted to the heart and is related to both the blockage and flow restoration (reperfusion injury).
- Trial name
- NCT06390358
- Testing
- Tefillin
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Jack Rubinstein
Physical Performance, Neuromuscular Function
Tissue Flossing and Lower Limb Neuromuscular Function
There is no study investigating different volumes, that is various sets of the configuration of tissue flossing on neuromuscular function.
- Conditions
- Physical Performance, Neuromuscular Function, Tissue Flossing, Ischemic Preconditioning
- Trial name
- MF2-TMG-CMJ (NCT05219344)
- Testing
- Tissue flossing
- Where
- Slovenia
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Ljubljana
Microcirculation, Orthostatic Intolerance
Influence of RIC on the Orthostatic Competence of the Microcirculation
The goal of this clinical trial (pilot study) is to learn about the microcirculatory regulation of the lower extremity under orthostatic stress with and without RIC - Remote Ischemic Preconditioning in healthy participants.
- Conditions
- Microcirculation, Orthostatic Intolerance, Remote Ischemic Preconditioning, Hemodynamics
- Trial name
- NCT05990907
- Testing
- Remote ischemic preconditioning
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- ISAR Klinikum
Ischemic Preconditioning, Dietary Exposure
Factors That Influence Blood Vessel Regulation During Exercise in Humans
This study will examine two separate interventions: 1) the effects of ischemic preconditioning or 2) a high fat meal on the capacity of the brachial artery to overcome sympathetic activation and dilate during exercise (also known…
- Trial name
- NCT04887610
- Testing
- Ischemic preconditioning, Ischemic preconditioning control, Low fat meal
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Guelph
Ischemic Preconditioning, Coenzyme Q Deficiency
Effect of CoQ10 on the Endocrine Function of Skeletal Muscle
Recent studies have also shown that repeated episodes of ischemia, followed by reperfusion (IPC), can contribute to the development of adaptive changes not only in the area of the heart muscle, but also in the structure of the…
- Conditions
- Ischemic Preconditioning, Coenzyme Q Deficiency, Exercise Training
- Trial name
- NCT05412888
- Testing
- CoQ10 supplementation, Ischemic preconditioning training, IPC training combined with CoQ10 supplementation
- Where
- Poland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Medical University of Gdansk
Limb Ischemia, Ischemic Preconditioning
Model System for Transient Forearm Blood Vessel Dysfunction
This study will develop a model system that can be used to test medications for improving the ability of blood vessels to resist damage from diseases such as heart attack and stroke.
- Trial name
- NCT00453531
- Testing
- Limb Ischemia, Acetylcholine
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Ischemic Preconditioning
Remote Ischemic Preconditioning of Dynamic Cerebral Autoregulation in Healthy Adults
The purpose of this study is to determine the impact of remote ischemic preconditioning on dynamic cerebral autoregulation and related hematology indexes in healthy adults.
- Trial name
- RIPCA (NCT02965547)
- Testing
- Remote ischemic conditioning equipment, Intravenous blood collection, dCA measurement
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Yi Yang
Ischemic Preconditioning
Conditioning Based Intervention Strategies
The overall objective of this study is to uncover and utilize the mechanisms behind the activation of endogenous organ protection by remote ischemic conditioning (RIC), high intensity traditional resistance training (TRT) and low…
- Trial name
- ConBIS (NCT03380663)
- Testing
- Remote Ischemic Conditioning (RIC)
- Where
- Denmark
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Contrast Induced Nephropathy, Remote Ischaemic Preconditioning
Can Remote Ischaemic Preconditioning Reduce Contrast Induced Nephropathy in Patients Receiving Contrast for Computed Tomography?
Computated tomography (CT) is an invaluable medical resource for both physicians and surgeons. Contrast media are an aid to improve the diagnostic yield of CT.
- Trial name
- CT RIPC CIN (NCT01741896)
- Testing
- Remote ischaemic preconditioning
- Where
- Ireland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Mid Western Regional Hospital, Ireland
Ischemic Preconditioning
The Biology of Chronic Preconditioning: Genomic and Physiologic Mechanisms of Response
The purpose of this study is to assess the effects of repeated RIPC and exercise, on exercise performance, skeletal muscle responses and circulating cellular and humoral biology in humans
- Trial name
- NCT01164618
- Testing
- Remote ischemic preconditioning (RIPC), Exercise
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Ischemic Preconditioning
Cutaneous Remote Ischemic Preconditioning in Plastic Surgery
Background: In plastic and reconstructive surgery, free flaps are routinely used for treatment of soft tissue defects. Treatment strategies aim at reducing or preventing flap necrosis by conditioning tissue tolerance against…
- Trial name
- RIPC (NCT01235286)
- Testing
- remote ischemic preconditioning
- Where
- Germany
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Hannover Medical School
Ischemic Preconditioning
Study on the Cardioprotection and Humoral Mechanism of Limb Ischemia Preconditioning
Numerous studies Have shown that limb ischemic preconditioning can protect vital organs (including the heart) from ischemia-reperfusion injury,which has a broad application prospect.But its mechanism is still unclear.
- Trial name
- NCT01118000
- Testing
- limb ischemia preconditioning
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Caffeine, Ischemic Preconditioning
The Effect of Caffeine on Ischemic Preconditioning
Ischaemic preconditioning (IP) describes the phenomenon that brief periods of ischaemia render the (myocardial) muscle more resistant to a subsequent more prolonged period of ischaemia and reperfusion.
- Conditions
- Caffeine, Ischemic Preconditioning, Ischemia-Reperfusion Injury
- Trial name
- NCT00184912
- Testing
- caffeine, Technetium-TC99m-labeled Annexin A5, ten minutes forearm ischemia
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center