Clinical trials: PreDiabetes, open to volunteers
Prediabetes, Brain Insulin Sensitivity
Long-term Effects of Avocado Consumption on Health in Pre-diabetic Individuals
Primary aim of the study is to assess the effect of 12-week daily avocado consumption on cerebral blood flow and markers of cardio- and vascular health in both, the periphery and the brain, in pre-diabetic individuals with…
- Conditions
- Prediabetes, Brain Insulin Sensitivity, Cerebral Blood Flow, Satiety and Food Intake
- Trial name
- NCT07752225
- Testing
- Avocados
- Where
- Netherlands
- Volunteers
- 34 people
- Sponsor
- Maastricht University Medical Center
Diabetes
Study of the Factors Favoring the Transition From Prediabetes to Diabetes on Reunion Island.
The management of diabetes and its complications in Reunion island is one of the priority areas of health. Indeed, the impact of diabetes on the health of the Reunion island population is major: the prevalence of diabetes treated…
- Trial name
- PREDIABRUN (NCT04463160)
- Testing
- prevention program for prediabetes "Say No to Diabetes"
- Where
- France
- Volunteers
- 2,000 people
- Sponsor
- Centre Hospitalier Universitaire de la Réunion
Pre Diabetic
Effects of Intermittent Fasting Variations on Metabolic, Inflammatory, and Nutrigenomic Profiles in Prediabetes: A Randomized Controlled Trial
Prediabetes is a metabolic condition associated with increased risk of type 2 diabetes and cardiovascular disease. Intermittent fasting (IF) has emerged as a potential dietary intervention to improve metabolic health, yet…
- Trial name
- NCT07408791
- Testing
- Diet
- Where
- Indonesia
- Volunteers
- 120 people
- Sponsor
- DINA KEUMALA SARI
Prediabetes or Overweight
Whole Food Fibers for Support of Key Gut Bacteria for Human Health
The purpose of this supplementation study is to understand how whole food fibers may affect gut microbiota composition and overall health. The investigators will enroll up to 24 people in this study.
- Trial name
- NCT07840170
- Testing
- Whole food fiber mixture, inulin
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Purdue University
Prediabetes, Overweight , Obesity
Exercise, Chronotype, and Prediabetes
The goal of this clinical trial is to find out whether exercising at the right time of day, based on a person's natural body clock, leads to greater health benefits in people living with prediabetes.
- Trial name
- NCT07389005
- Testing
- Timing of exercise, Control
- Where
- Germany
- Volunteers
- 28 people
- Sponsor
- German Diabetes Center
Cardio Vascular Disease, Acute Coronary Syndromes (ACS)
Qatar Cardiometabolic Retrospective Cohort-Analysis Using Artificial Intelligence
Cardiovascular disease is the leading cause of death worldwide, and individuals with diabetes or other cardiometabolic conditions are at increased risk of adverse cardiovascular outcomes.
- Conditions
- Cardio Vascular Disease, Acute Coronary Syndromes (ACS), Type 2 Diabetes, Pre Diabetes
- Trial name
- QCRC-AI (NCT07515807)
- Where
- Qatar
- Volunteers
- 10,000 people
- Sponsor
- Weill Cornell Medical College in Qatar
Pre-diabetes
Continuous Glucose Monitoring (CGM) in Prediabetes
Part 1 and 2 of study (For Patient Participants) The purpose of this study is to examine if the wearing of a medical device called a continuous glucose monitor (CGM) can guide adults with prediabetes modify their behaviors and…
- Trial name
- NCT07371546
- Testing
- Continuous Glucose Monitoring
- Where
- 2 sites in Singapore
- Volunteers
- 76 people
- Sponsor
- SingHealth Polyclinics
Autism Spectrum Disorder (ASD), Cardiometabolic Health Indicators
This Study Will Evaluate Cardiorespiratory and Muscular Fitness to Examine Associations With Anthropometric Characteristics and Other Indicators of Cardiometabolic Risk Among Patients With or Without Autism Spectrum Disorder
The goal of this observational study is to evaluate cardiorespiratory and muscular fitness in children with obesity, with and without autism spectrum disorder (ASD), and examine how fitness relates to body measurements, body…
- Conditions
- Autism Spectrum Disorder (ASD), Cardiometabolic Health Indicators, Cardiometabolic Risk Factors, Metabolic Syndrome
- Trial name
- ROACH (NCT07804680)
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Virginia
Pre-diabetes
7-Ketolithocholic Acid in Prediabetes
7-Ketolithocholic Acid, a naturally occurring bile acid, is a novel food currently under investigation for potential metabolic benefits, including glucose-lowering effects.
- Trial name
- NCT07650123
- Testing
- 7-KLCA, Diet and Physical Activity
- Where
- 8 sites in Italy
- Volunteers
- 100 people
- Sponsor
- ICE S.p.A.
Pre Diabetes, Diabetes (DM)
Preventing Diabetes: Impact of an EMR-Based Intervention for Enhanced Pre-Diabetes Management in Primary Care
The goal of this study is to find out if adding electronic medical record (EMR) prompts helps prevent people with pre-diabetes from developing diabetes. It will also look at how these prompts affect doctor and patient behaviors.
- Trial name
- NCT07252700
- Testing
- Electronic Medical Record-Based Clinical Decision Support
- Where
- Singapore
- Volunteers
- 6,000 people
- Sponsor
- Lynette Goh
PreDiabetes, Pre Diabetes
Comparative Effects of High-Intensity Interval Training and Continuous Endurance Training Among Prediabetic Patients
Prediabetics is a condition where blood sugar levels are normal but not yet high enough to be diagnosed as type 2 diabetes. This phase offers a crucial point for timely intervention to delay or prevent type 2 diabetes.
- Conditions
- PreDiabetes, Pre Diabetes, Prediabetic State
- Trial name
- NCT07713030
- Testing
- High-Intensity Interval Training, Continuous Endurance Training
- Where
- Pakistan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Obesity & Overweight, Prediabetes
Precision Nutrition for Obesity and Prediabetes Prevention in Under-supported Communities
This randomized controlled trial will evaluate the effectiveness of a culturally sensitive precision nutrition intervention for improving obesity- and diabetes-related outcomes among African American and Hispanic/Latino adults…
- Trial name
- PNOD (NCT07850531)
- Testing
- Precision Nutrition Intervention, Standard Nutrition Counseling
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Prairie View A&M University
Prediabetes / Type 2 Diabetes
Heterogeneity of Diabetes: Integrated Muli-Omics to Identify Physiologic Subphenotypes and Evaluate Targeted Prevention
The study team will invite participants with prediabetes or mild diabetes (HbA1c 5.7-7.0) to join a 5-year research study that will define subphenotypes of type 2 diabetes based on underlying physiology (eg insulin resistance…
- Trial name
- NCT06682351
- Testing
- Metformin, GLP-1A, MED
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Stanford University
Prediabetes / Type 2 Diabetes
A Clinical Trial to Examine the Efficacy and Safety of an Investigational Product With and Without Use of Semaglutide on Glycemic Response in Adults With Prediabetes or Type 2 Diabetes
This is a randomized, single-blind, controlled, parallel clinical trial to examine the efficacy and safety of AMPK Charge+® with and without use of semaglutide on glycemic response in adults with prediabetes or Type 2 Diabetes.
- Trial name
- NCT07195994
- Testing
- AMPK Charge+®, AMPK Charge+® with semaglutide
- Where
- Canada
- Volunteers
- 90 people
- Sponsor
- QuickSilver Scientific
PreDiabetes
Small Steps for Big Changes - Healthy Cities Implementation Science
Small Steps for Big Changes (SSBC) is a diet and exercise counselling program that significantly reduces the risk of developing Type 2 Diabetes (T2D).
- Trial name
- HCIS (NCT06440395)
- Testing
- Behavioural: Small Steps for Big Changes Diabetes Prevention Program
- Where
- 12 sites in Canada
- Volunteers
- 4,400 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Hyperglycaemia (Non Diabetic), Prediabetes
Effects of Lean Pork Loin Intake on Protein Homeostasis and Glucose Regulation in Prediabetic Adults
We will be directly comparing a high-quality protein diet composed primarily of lean pork loin (PORK) to a lower-quality plant-based protein diet (PLANT) in individuals with prediabetes on muscle and whole-body protein turnover…
- Trial name
- PORK (NCT06025292)
- Testing
- Lean Pork vs Plant-Based Protein
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Arkansas
Pre-biabetes
Effects of Milk Probiotics Intervention on Blood Glucose Control Middle-aged and Elderly People With Pre-diabetes
This study aims to conduct a 8-week probiotics intervention involving for middle-aged and elderly individuals with pre-diabetes, assessing its impact on blood glucose control in comparison to placebo
- Trial name
- NCT06972524
- Testing
- a special probiotics from Mengniu Group, supplemented with milk powder, regular milk powder does not contain any additional supplementation, and the color, flavor, shape, taste, and weight are same with the probiotic milk powder
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Huilian Zhu
Prediabetic State, Hyperglycemia
Effect of Zinc on Glucose Homeostasis
The purpose of this investigation is to evaluate the impact of zinc supplementation on fasting glucose levels, hemoglobin A1c (HbA1c), and other indices of glucose homeostasis in individuals with prediabetes.
- Trial name
- NCT05835037
- Testing
- Zinc Gluconate 30 MG
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Maryland, Baltimore
Pre Diabetic, Obesity & Overweight
PREdiabetes GLycemic Impact and Data Evaluation
This prospective, randomized controlled trial evaluates whether real-time continuous glucose monitoring (CGM) improves glycemic control and lifestyle adherence in adults with prediabetes compared to conventional self-monitoring…
- Conditions
- Pre Diabetic, Obesity & Overweight, Insulin Resistance
- Trial name
- PRE-GLIDE (NCT07599072)
- Testing
- CGM Sibionics, On-Call Extra Glucometer
- Where
- 3 sites in Ukraine
- Volunteers
- 80 people
- Sponsor
- Nazarii Kobyliak
Gestational Diabetes Mellitus in Pregnancy, Glucose Intolerance During Pregnancy
Effects of a Non-nutritive Sweetener Reduction Intervention in Pregnancy and Lactation on Maternal and Infant Outcomes
The effects of consuming non-nutritive sweeteners (NNS) during pregnancy and lactation on infant obesity and cardiometabolic disease risk are not well understood.
- Conditions
- Gestational Diabetes Mellitus in Pregnancy, Glucose Intolerance During Pregnancy, Non-nutritive Sweeteners Consumption in Pregnancy and/or Lactation
- Trial name
- NCT06548828
- Testing
- NNS Restriction Intervention, Control Intervention
- Where
- United States
- Volunteers
- 324 people, healthy volunteers welcome
- Sponsor
- George Washington University