Clinical trials: Pre Diabetic
Prediabetes
Effects of Blueberry Dry Powder on Glycemic Status in Subjects With Prediabetes
The purpose of the present study is to evaluate the effect of blueberry dry powder on glycemic status (fasting plasma glucose, 2h glucose concentration after the oral glucose tolerance test (OGTT), or HbA1c) in subjects with…
- Trial name
- NCT02023320
- Testing
- Low dose of blueberry dry powder, High dose of blueberry dry powder
- Where
- Japan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Hiroshima University
Pre Diabetes, Postprandial Hyperglycemia
Evaluating the Acute Glycemic Response to Different Strategies of Breaking Up Sedentary Time
This study aims to determine the most effective strategy of reducing sedentary behavior to improve health. Specifically, we aim to answer the following questions: (a) To determine if there is a significant difference in acute…
- Trial name
- NCT04144920
- Testing
- CS: Continuous sitting, HFLD: HIgh frequency, low duration standing breaks, LFHD: Low frequency, high duration standing breaks
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Arizona State University
NAFLD, Obesity
Ernährungs-Interventions-Fettleber-Studie (Interventional Study on Nutritional Effects on NAFLD)
Epidemiological data and studies in animal models suggest, that polyunsatured fatty acids (PUFA) rather than mono-unsatured fatty acids (MUFA) are associated with lower hepatic lipid content (HCL) and may facilitate a decrease of…
- Conditions
- NAFLD, Obesity, Prediabetes, Dyslipoproteinemia
- Trial name
- UFOP-2 (NCT02458586)
- Testing
- Dietary intervention / counseling
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- German Institute of Human Nutrition
Obesity, Pre Diabetes
Inulin and Acetate Production and Human Substrate Metabolism
Based on our hypothesis that orally administered resistant starch and inulin/beta glucan will be fermented into a SCFA pattern high in acetate and that this will lead to beneficial effects on human substrate and energy…
- Trial name
- NCT03711383
- Testing
- Inulin and Resistant Starch, Inulin
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Kidney Failure, Chronic, Prediabetic State
The Effect of Liraglutide in Patients With Prediabetes and Kidney Failure
The present study will examine the effects of liraglutide treatment during 26 weeks on several cardiovascular risk factors in patients with prediabetes and end-stage renal disease (ESRD).
- Trial name
- LiRA2 (NCT02284230)
- Testing
- Liraglutide
- Where
- Denmark
- Sponsor
- Bo Feldt-Rasmussen
PreDiabetes, Overweight and Obesity
Zein Nanoparticles for Glycemic Control
The use of zein nanoparticles as vehicles for drug delivery is under study, but of the effects observed in empty nanoparticles, in laboratory animals, the reduction of glucose levels was something worth studying.
- Conditions
- PreDiabetes, Overweight and Obesity, Adult ALL
- Trial name
- GLUCOCAPS (NCT05560412)
- Testing
- Zein nanocapsules, control
- Where
- Spain
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Impaired Fasting Glucose, Newly Diagnosed Type 2 Diabetes
Dietary Effects on Circulating Lipoprotein-associated Phospholipase A2 (Lp-PLA2) Activity and Enzyme Activity in Peripheral Blood Mononuclear Cells (PBMCs) in Patients With Prediabetes or Newly Diagnosed Type 2 Diabetes
We determined the effects of dietary intervention (replacement of refined rice with whole grains and legumes and a high intake of vegetables) on circulating Lp-PLA2 activity and enzyme activity in peripheral blood mononuclear…
- Trial name
- NCT01895387
- Testing
- Dietary intervention-whole grains and legumes, Dietary intervention-Refined rice
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Yonsei University
Type 2 Diabetes, Diabetes (DM)
Detecting Type 2 Diabetes From Voice
The goal of this observational study is to learn if computer analysis of voice recordings can detect Type 2 diabetes in adults. The main questions it aims to answer are: Can advanced voice analysis accurately identify…
- Conditions
- Type 2 Diabetes, Diabetes (DM), T2DM, T2DM (Type 2 Diabetes Mellitus)
- Trial name
- NCT07421921
- Where
- United Kingdom
- Volunteers
- 7,319 people, healthy volunteers welcome
- Sponsor
- Thymia Limited
Aging
SGLT2 Inhibition in Older Obese Adults With Pre-diabetes
Inhibitors of the sodium-glucose co-transporter (SGLT2) are FDA-approved for the treatment of type 2 diabetes (T2DM). Their mechanism of action involves lowering of blood glucose concentration secondary to increased glucose…
- Trial name
- SGLT2i (NCT04401904)
- Testing
- Dapagliflozin 10 mg, Nutritional counseling
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Type 2 Diabetes, PreDiabetes
Evaluating a Type 2 Diabetes Prevention Program
This study aims to test the effectiveness of a Type 2 Diabetes (T2D) prevention program for individuals who have been diagnosed with prediabetes compared to a T2D educational control group.
- Trial name
- NCT05822648
- Testing
- Project Health, Educational Video Control
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Stanford University
Pre Diabetes
BRInging the Diabetes Prevention Program to GEriatric Populations
Over 24 million Americans are over 65 years and have prediabetes. Prediabetes can be addressed using a public health approach: among the 20% of participants in the Diabetes Prevention Program (DPP) who were ages 60 and over, the…
- Trial name
- BRIDGE (NCT05166785)
- Testing
- DPP Tailored for Older Adults and delivered via Telehealth, In-Person Diabetes Prevention Program (DPP)
- Where
- United States
- Volunteers
- 238 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Healthy, PreDiabetes
Efficacy of Milk Product Supplemented With Bioactives in Lowering Post Meal Glucose Response
This is a monocentric, randomized controlled, open-label, 2x2 cross-over study. The main objective of the study is to Evaluate the efficacy of Nestle YIYANG TangLv milk powder in lowering the Post Prandial Glucose Response (PPGR)…
- Conditions
- Healthy, PreDiabetes, Adult, Asian
- Trial name
- NCT05570435
- Testing
- Blood collection
- Where
- China
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Metabolic Syndrome, Pre-diabetes
Long Term Impact of Time-Restricted Eating on Parameters of Cardiometabolic Health
In a randomized controlled trial, the investigators intend to measure the health impact of time restricted eating (TRE) in patients with metabolic syndrome (with elevated blood pressure and at least 2 of the following: increased…
- Trial name
- TIMET 2 (NCT07189234)
- Testing
- Time-restricted eating (TRE) + Standard of Care, Standard of Care
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- University of California, San Diego
Non-communicable Diseases (NCD), Neoplams
Health for Hungary (H4H) - Longitudinal Collection of Blood Samples and Corresponding Data
The Health for Hungary (H4H) study collects blood samples and corresponding health data to investigate healthy aging and health-to-disease transitions in middle-aged and elderly participants.
- Conditions
- Non-communicable Diseases (NCD), Neoplams, Cancer, Lung Cancer (NSCLC)
- Trial name
- H4H (NCT07743021)
- Where
- 33 sites in Hungary
- Volunteers
- 15,000 people, healthy volunteers welcome
- Sponsor
- Center for Molecular Fingerprinting Research Nonprofit LLC
Painful Diabetic Neuropathy (PDN), Diabetic Nephropathies
Modality Choice Before and After Failure for the Treatment of Painful Diabetic Neuropathy
The research team will perform a comparative-effectiveness sequential, multiple assignment, randomized trial in painful diabetic neuropathy (PDN) patients for 8 total months, divided into two 4-month stages.
- Trial name
- MCPAIN (NCT07795593)
- Testing
- Cognitive Behavioral Therapy (CBT), Oral Medication, Topical Medication
- Where
- 23 sites in United States
- Volunteers
- 600 people
- Sponsor
- University of Michigan
Poor Glycemic Control, Cardiovascular Risk Factors
The Potential of Carnosine Supplementation in Optimising Cardiometabolic Health
The investigators hypothesise that carnosine supplementation will improve: 1. glycaemic control 2. cardiovascular risk factors 3.
- Conditions
- Poor Glycemic Control, Cardiovascular Risk Factors, Cognitive Function 1, Social
- Trial name
- NCT02917928
- Testing
- carnosine
- Where
- Australia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Monash University
Gum Disease, Prediabetes
Improving Oral and Systemic Health in Individuals With Prediabetes Through Personalized Oral Hygiene Advice Provided by Dentists or by AI
Prediabetes is an intermediate stage before the development of diabetes, characterized by elevated blood glucose levels but lower than the diagnostic criteria of diabetes and is associated with multiple long-term complications.
- Trial name
- NCT06980701
- Testing
- AI OHI group, Dental professionals OHI group
- Where
- Hong Kong
- Volunteers
- 148 people
- Sponsor
- The University of Hong Kong
Prediabetes, Autonomic Nervous System Imbalance
Enhancing the Vagal Tone in Prediabetes Individuals
This is a 2-year course of study. A randomized control trial will be conducted, in which 90 prediabetes individuals will be recruited and randomly assigned them into the wait-list control group or experimental group to test the…
- Conditions
- Prediabetes, Autonomic Nervous System Imbalance, Poor Glycemic Control, Psychological Distress
- Trial name
- NCT03616275
- Testing
- HRV biofeedback
- Where
- Taiwan
- Volunteers
- 90 people
- Sponsor
- National Defense Medical Center, Taiwan
Oxidative Stress, Healthy Aging
Efficacy of Solarplast for Health and Oxidative Stress
Solarplast is a unique mixture of antioxidant enzymes and single antioxidant molecules that are capable of attack oxidants that cause damage to the cells in the human body and cause premature aging.
- Conditions
- Oxidative Stress, Healthy Aging, Skin Health
- Trial name
- NCT04144777
- Testing
- Solarplast
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Deerland Enzymes
PreDiabetes, Impaired Glucose Tolerance
Almonds and Health Effects on Metabolism, Vascular Function and Cognition
The primary objective of the proposed study is to examine and understand the impact of long-term almond consumption on chronic glucose metabolism in subjects with impaired glucose tolerance and/or impaired fasting glucose.
- Conditions
- PreDiabetes, Impaired Glucose Tolerance, Impaired Fasting Glucose, Overweight and Obesity
- Trial name
- NCT03419702
- Testing
- Almonds
- Where
- Netherlands
- Volunteers
- 43 people
- Sponsor
- Maastricht University Medical Center