Clinical trials: Poverty
Metastatic Castration-Resistant Prostatic Cancer
Cabazitaxel vs Abiraterone or Enzalutamide in Patients With Poor Prognosis Metastatic Castration-resistant Prostate Cancer
The purpose of this study is to assess and compare the clinical benefit rate in patients with metastatic castrate-resistant prostate cancer and poor prognostic factors treated with cabazitaxel or novel hormonal agents…
- Trial name
- NCT02254785
- Testing
- cabazitaxel, Abiraterone, Enzalutamide 160mg daily (oral)
- Where
- 15 sites in Australia, Canada
- Volunteers
- 120 people
- Sponsor
- British Columbia Cancer Agency
Depression, Child Development
Healthcare Providers as Trusted Messengers to Increase Receipt of Tax Credits Among Low-income Families
The purpose of this study is to pilot test the feasibility and preliminary efficacy of healthcare provider referrals to a tax filing app within parent-child health programs to test whether such referrals can increase receipt of…
- Conditions
- Depression, Child Development, Stress, Physical Illness
- Trial name
- NCT05612685
- Testing
- Healthcare provider referral to a tax filing app
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Malaria
Revaccination of Young Children With Bacille Calmette Guerin (BCG) Vaccine
BCG has marked immune stimulatory effects in both animal and human studies and observational studies suggest that BCG is associated with a non-specific reduction in mortality in areas with high infant and child mortality.
- Trial name
- NCT00126217
- Testing
- Bacille Calmette Guerin (BCG)
- Where
- Guinea-Bissau
- Volunteers
- 2,871 people
- Sponsor
- Bandim Health Project
Poor Quality Sleep, Fatigue
The SleepTrackTXT2 Randomized Trial With Air-medical Personnel
The overarching goal of this proposal is to address the MedEvac foundation priority of educational techniques and technologies and improve Helicopter Emergency Medical Services (HEMS) safety by determining if overall sleep…
- Trial name
- SleepTrack2 (NCT02783027)
- Testing
- SleepTrackTXT2
- Where
- United States
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Vaccination, Education
Manicaland Cash Transfer Trial for Children in Zimbabwe
The purpose of this study is to determine whether cash transfers (conditional and unconditional) can improve health and social outcomes amongst children living in vulnerable households in Manicaland, eastern Zimbabwe.
- Conditions
- Vaccination, Education, Birth Registration, Financial Support
- Trial name
- NCT00966849
- Testing
- Conditional Cash Transfer, Unconditional Cash Transfers, Standard Agricultural Package
- Where
- Zimbabwe
- Volunteers
- 4,043 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Arthritis, Rheumatoid
Uncontrolled Study to Evaluate Efficacy of Tocilizumab in Patients With Moderate or Severe Rheumatoid Arthritis
The purpose of this project is to evaluate the efficacy of Tocilizumab (TCZ) given as monotherapy in patients with active rheumatoid arthritis (RA) according to EULAR response at 24 weeks after treatment initiation.
- Trial name
- NCT02087696
- Testing
- Tocilizumab
- Where
- 20 sites in Spain
- Volunteers
- 122 people
- Sponsor
- Spanish Foundation of Rheumatology
Brain and Central Nervous System Tumors
Combination Chemotherapy Plus Radiation Therapy in Treating Adult Patients With Brain Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells.
- Trial name
- NCT00003309
- Testing
- filgrastim, cisplatin, cyclophosphamide
- Where
- 14 sites in United States
- Volunteers
- 33 people
- Sponsor
- Eastern Cooperative Oncology Group
Multiple Myeloma, Non-Hodgkins Lymphoma
Study of Plerixafor for Rescue of Poor Mobilizers in Autologous Stem Cell Transplant
Plerixafor, administered at a dose of 240 ug/kg, potentiates the effect of granulocyte colony-stimulating factor (G-CSF) to increase peripheral blood progenitor cells in both healthy volunteers and cancer patients.
- Conditions
- Multiple Myeloma, Non-Hodgkins Lymphoma, Hodgkins Disease
- Trial name
- NCT00901225
- Testing
- G-CSF plus Plerixafor
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Duke University
Stroke, Poor Quality Sleep
Rise & Shine: Promoting Sleep Quality in Chronic Stroke With Exercise
health problems, such as heart disease, diabetes, cognitive impairment, and dementia. After a person suffers a stroke, they often experience difficulties in getting a good night's sleep.
- Trial name
- NCT06847074
- Testing
- Multimodal Exercise, Cognitve and Social Activities
- Where
- Canada
- Volunteers
- 62 people
- Sponsor
- University of British Columbia
Peripheral Arterial Disease
Supervised Treadmill Exercise and Ranolazine for Intermittent Claudication of Lower Extremities
The goal of this study is to evaluate whether supervised treadmill exercise combined with ranolazine 1000 mg twice daily provides an incremental benefit in absolute walking distance over supervised exercise alone in patients with…
- Trial name
- STERILE (NCT00914316)
- Testing
- Ranolazine
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Corewell Health East
Diabetes Mellitus, Type 2, Depressive Symptoms
Towards a Better Understanding of Diabetes Distress, Depression and Poor Glycaemic Control in T2DM
DIA-LINK2 is a prospective observational study analysing longitudinal associations and mediating links between diabetes distress (DD), depressive symptoms (DS) and glycaemic outcomes in people with type 2 diabetes (T2DM).
- Conditions
- Diabetes Mellitus, Type 2, Depressive Symptoms, Stress, Psychological, Glucose, High Blood
- Trial name
- DIA-LINK2 (NCT04438018)
- Where
- Germany
- Volunteers
- 205 people
- Sponsor
- Norbert Hermanns
Obesity
A Mobile Application to Improve Procurement and Distribution of Healthful Foods & Beverages in Baltimore City
Low-income urban communities have many small food stores, but poor access to healthier foods and beverages. The investigators will develop, implement and evaluate the feasibility of a Baltimore Urban food Distribution (BUD)…
- Trial name
- BUD (NCT05010018)
- Testing
- Web-based application connecting small food store owners and suppliers of healthier foods and beverages
- Where
- United States
- Volunteers
- 310 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Smoking Cessation
Integrated Smoking Cessation Treatment for Low Income Community Corrections
This study recruited cigarette smokers under supervision in community corrections (e.g., probation, parole, drug courts, etc.) in the Birmingham, Alabama area.
- Trial name
- NCT01257490
- Testing
- counseling vs. advice
- Where
- United States
- Volunteers
- 689 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Hematologic Malignancies
Cloretazine (VNP40101M) With Hematopoietic Cell Transplantation for Hematologic Malignancies
Primary: Define the maximal tolerated dose (MTD) of VNP40401M when given with hematopoietic cell transplantation (HCT) Secondary: Describe the change in pharmacokinetic (PK) parameters with increasing doses of drug.
- Trial name
- NCT00521859
- Testing
- Cloretazine, Fludarabine
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- M.D. Anderson Cancer Center
Poor Ovarian Response
SIRT3 Expression in Granulosa Cells and the Levels of Follicular Fluid Metabolites Among POR Subgroups
The goal of this prospective, observational study is to learn about the pathogenesis and biological target of the subtypes of poor ovarian response (POR) during In vitro fertilization and embryo transfer (IVF-ET).
- Trial name
- POR SIRT3 (NCT06617988)
- Testing
- Not applicable- observational study
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Shandong University of Traditional Chinese Medicine
Physical Activity
Promoting Small Business Support of Youth Physical Activity in Low-income, Minority Neighborhoods
An unacceptably high percentage of our nation's low-income, minority youth (< 18 years of age) are not regularly physically active.
- Trial name
- NCT03936582
- Testing
- Treatment
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Delaware
Colorectal Cancer, Nutrition Poor
Feasibility, Acceptability, and Effectiveness of an Individualized Plant-based (iPLANT) Diet Plan in Colorectal Cancer: Mixed Method Embedded Design
The goal of this intervention study is to investigate the effectiveness of individualized plant-based diet plan on nutritional indices and clinical outcomes in colorectal cancer patients receiving chemotherapy.
- Conditions
- Colorectal Cancer, Nutrition Poor, Gastrointestinal Complication, Quality of Life
- Trial name
- NCT06250166
- Testing
- iPLANT diet plan and diet counselling, Usual diet counselling
- Where
- 2 sites in Malaysia
- Volunteers
- 92 people
- Sponsor
- National Cancer Institute, Malaysia
Non-small Cell Lung Cancer
Perceptions on Expected Outcomes of Immunotherapy in Advanced Cancer Patients With Poor Performance Status
To better understand your feelings and expectations about immunotherapy
- Trial name
- NCT05634551
- Testing
- Questionnaires, Interview
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- M.D. Anderson Cancer Center
Other Complications Associated With Artificial Fertilization
Delayed Start Versus Conventional Antagonist Protocol in Poor Responders Pretreated by Estradiol in Luteal Phase
40 patients attending IVF center during 2013 \&2014 were fulfilling criteria of poor response and they failed to go through OPU as they gave <3 mature follicles on a dose of 300U GN or more.
- Trial name
- NCT02333253
- Testing
- cetrotide
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Adult Supratentorial Primitive Neuroectodermal Tumor (PNET), Ewing Sarcoma of Bone
Whole-Body Radiation Therapy, Systemic Chemotherapy, and High-Dose Chemotherapy Followed By Stem Cell Rescue in Treating Patients With Poor-Risk Ewing Sarcoma
This pilot clinical trial studies whole-body radiation therapy, systemic chemotherapy, and high-dose chemotherapy followed by stem cell rescue in treating patients with poor-risk Ewing sarcoma.
- Conditions
- Adult Supratentorial Primitive Neuroectodermal Tumor (PNET), Ewing Sarcoma of Bone, Extraosseous Ewing Sarcoma, Metastatic Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor
- Trial name
- NCT01795430
- Testing
- etoposide, ifosfamide, intensity-modulated radiation therapy
- Where
- United States
- Sponsor
- City of Hope Medical Center