Clinical trials: Pouchitis
Ulcerative Colitis, Pouchitis
Intestinal Ultrasound for the Evaluation of Pouchitis and Other Outcomes After Ileal Pouch-Anal Anastomosis
Intestinal ultrasound (IUS) has been studied in the evaluation of inflammatory bowel disease (IBD) and is increasingly used as a non-invasive, easy to use, cost-effective tool for point-of-care to assess disease activity and more…
- Trial name
- NCT06316999
- Testing
- Intestinal Ultrasound
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Pouchitis, Irritable Pouch Syndrome
Efficacy of Liraglutide Therapy in Patients With IPAA
Patients with an ileal pouch-anal anastomosis(IPAA; pouch) due to refractory inflammatory bowel disease and increased bowel frequency in the absence of significant pouch inflammation will be randomized to liraglutide or placebo…
- Trial name
- NCT04763564
- Testing
- Liraglutide Pen Injector
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of North Carolina, Chapel Hill
Pouchitis, Ileal Pouchitis
Tofacitinib For Treatment Of Chronic Pouchitis
A phase 2 pilot study to evaluate the effectiveness of tofacitinib in subjects with chronic pouchitis
- Conditions
- Pouchitis, Ileal Pouchitis, Ileal Pouch
- Trial name
- NCT04580277
- Testing
- Tofacitinib 10 mg
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Cedars-Sinai Medical Center
Pouchitis
A Study to Evaluate the Efficacy and Safety of Vedolizumab in the Treatment of Chronic Pouchitis
The purpose of this study is to compare the efficacy of vedolizumab intravenous (IV) and placebo in terms of the percentage of participants with chronic or recurrent pouchitis achieving clinically relevant remission.
- Trial name
- EARNEST (NCT02790138)
- Testing
- Ciprofloxacin, Vedolizumab
- Where
- 34 sites in United States, Belgium and 7 more
- Volunteers
- 102 people
- Sponsor
- Takeda
Pouchitis, Ulcerative Colitis
Fecal Microbiota Transplantation (FMT) in the Treatment of Pouchitis
The aim of our study is to investigate the efficacy and safety of fecal microbiota transplantation (FMT) in the treatment of antibiotic dependent chronic pouchitis. This is a double-blinded randomized placebo controlled study.
- Trial name
- NCT03378921
- Testing
- Fecal microbiota transplantation
- Where
- Finland
- Volunteers
- 26 people
- Sponsor
- Helsinki University Central Hospital
Pouchitis
Efficacy of Alicaforsen in Pouchitis Patients Who Have Failed to Respond to at Least One Course of Antibiotics
A Phase III, multi-centre, double-blind randomised controlled trial in subjects with chronic antibiotic refractory pouchitis. Subjects will undertake a <2 week screening period to provide baseline data and be assessed for…
- Trial name
- NCT02525523
- Testing
- Alicaforsen
- Where
- 41 sites in United States, Belgium and 8 more
- Volunteers
- 138 people
- Sponsor
- Atlantic Pharmaceuticals Ltd
Pouchitis
Safety and Efficacy of Fecal Microbiome Transplantation (FMT) in the Treatment of Antibiotic Dependent Pouchitis (ADP)
Antibiotic dependent pouchitis (ADP) is predestined to benefit from FMT, since bacterial dysbiosis, which can only be controlled with antibiotics, appears to be the major driver of the clinical symptoms.
- Trial name
- NCT02782325
- Testing
- Active FMT, then open label FMT
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of North Carolina, Chapel Hill
Ulcerative Colitis Associated Pouchitis
FMT in Ulcerative Colitis-Associated Pouchitis
The purpose of this study is to test whether Fecal Microbiota Transplant (FMT) is a safe and effective treatment for people who have Ulcerative Colitis and have had an ileal pouch anastomosis.
- Trial name
- NCT02049502
- Testing
- biologically active human fecal microbiota, sigmoidoscopy
- Where
- 2 sites in United States
- Volunteers
- 8 people
- Sponsor
- Virginia O. Shaffer