Clinical trials: Postsurgical Pain Management
Acute Postoperative Pain, Non-steroidal Anti-inflammatory Drugs
Non-steroidal Anti-inflammatory in Cardiac Surgery
Non-steroidal anti-inflammatory drugs (NSAID) are part the multimodal strategy in pain management after surgery. However, major concerns are raised in cardiac surgery given the potential side effects of NSAID with more bleeding…
- Conditions
- Acute Postoperative Pain, Non-steroidal Anti-inflammatory Drugs, Cardiac Surgery, Pain Intensity
- Trial name
- KETOPAIN (NCT06381063)
- Testing
- pain management, ketoprofen
- Where
- France
- Volunteers
- 238 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Breast Cancer, Postoperative Pain
Ultrasound-Guided SPSIP Versus ESPB for Postoperative Pain After Modified Radical Mastectomy
Breast cancer is the most common cancer affecting women worldwide. Modified radical mastectomy is one of the main surgical treatments for breast cancer.
- Conditions
- Breast Cancer, Postoperative Pain, Acute Post-surgical Pain
- Trial name
- SPSIP-ESPB (NCT07446868)
- Testing
- Serratus Posterior Superior Intercostal Plane Block, Erector Spinae Plane Block
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Cairo University
Postoperative Pain Management, Analgesia, Postoperative
Superficial vs Deep Serratus Anterior Plane Block for Analgesia After Mammoplasty
The serratus anterior plane block (SAPB) is an ultrasound-guided fascial plane block used for perioperative analgesia in thoracic and breast surgeries.
- Conditions
- Postoperative Pain Management, Analgesia, Postoperative, Breast Surgery, Mammoplasty Patient
- Trial name
- DSAPvsSSAP (NCT07502846)
- Testing
- Superficial Serratus Anterior Plane Block, Deep Serratus Anterior Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 58 people
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Postoperative Pain
Comparison of Interpectoral+Serratus Anterior Block With Erector Spinae Block in Minimally Invasive Cardiac Surgery
Adequate pain management after minimally invasive cardiac surgery is essential for early ambulation and patient satisfaction. However, an incision similar to thoracotomy surgery is made by entering between the ribs, and a…
- Trial name
- NCT05743231
- Testing
- interpectoral area block + serratus anterior area block group
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Namik Kemal University
Pain, Postoperative
Intraoperative Liposomal Bupivacaine vs. Bupivacaine for Total Hip Replacement Pain Management
The purpose of this study is to compare two medications currently injected intra-operatively to help decrease pain after surgery in patients undergoing a primary total hip replacement (THR).
- Trial name
- NCT03001453
- Testing
- Liposomal Bupivacaine, 0.25% Bupivacaine with epinephrine, Saline
- Where
- 2 sites in United States
- Volunteers
- 107 people
- Sponsor
- American Hip Institute
Postoperative Pain Management
Nursing Heat Therapy After Cholecystectomy
This randomized controlled study aims to evaluate the effect of local heat application to the feet on postoperative pain and abdominal distension in patients undergoing open or laparoscopic cholecystectomy.
- Trial name
- nursing (NCT07417319)
- Testing
- Local Heat Application
- Where
- Turkey (Türkiye)
- Volunteers
- 82 people
- Sponsor
- Aydin Adnan Menderes University
Knee Osteoarthritis, Pain Management
Phase 3 Adductor Canal Block With EXPAREL in Subjects Undergoing Primary Unilateral Total Knee Arthroplasty
The purpose of the study is to compare magnitude of postsurgical analgesic effect in different groups following a single dose of study drug when administered via adductor canal block in subjects undergoing primary unilateral…
- Trial name
- NCT05139030
- Testing
- bupivacaine liposome injectable suspension, Bupivacaine Hydrochloride
- Where
- 6 sites in United States
- Volunteers
- 167 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Osteoarthritis, Total Knee Arthroplasty
Effectiveness of Intraoperative Exparel for Postoperative Pain Control in Total Knee Arthroplasty
Does the use of periarticular Exparel in total knee arthroplasty prove to more effectively manage post operative pain control than another local analgesic, Ropivacaine, when both are used as part of a multimodal pain management…
- Conditions
- Osteoarthritis, Total Knee Arthroplasty, Pain Management
- Trial name
- NCT02808728
- Testing
- Pain Cocktail with Exparel, Pain Cocktail with Ropivacaine
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- DeClaire LaMacchia Orthopaedic Institute
Lumbar Disc Disease
Erector Spinae Plane Block in Spine Surgeries
Aim of this study was to assess the efficacy of erector spinae plane block (ESB) for postoperative pain management in lumbar spine surgery.
- Trial name
- ESB (NCT05247021)
- Testing
- erector spinae block for group E
- Where
- Egypt
- Volunteers
- 44 people
- Sponsor
- Ain Shams University
Postoperative Pain
Parasternal Block and TENS for Cardiac Surgery
the objective of the present study was to compare the efficacy of TENS and parasternal block with local anesthetic infiltration in relieving pain during the first 24 h period following median sternotomy.
- Trial name
- NCT02725229
- Testing
- parasternal block, TENS group, control group
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Antalya Training and Research Hospital
Postoperative Pain
TAP Block With Plain Bupivacaine Versus Wound Infiltration With Exparel for Postoperative Pain Management
In this randomized, controlled, observer-blinded study we plan to evaluate pain relief after ultrasound-guided transversus abdominis plane (TAP) block using bupivacaine and wound infiltration using liposomal bupivacaine in…
- Trial name
- NCT02074709
- Testing
- Plain bupivacaine, Liposomal bupivacaine
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Postoperative Pain
Analgesic Efficacy of Ultrasound-guided Transverse-abdominal Plain Blockade in Urological Surgery
The purpose of this study is to compare pain level (according to numerical score)at 4, 8, 12 and 24 postoperative hours between patients under transverse abdominal plain blockade (TAP) and patients under conventional analgesia.
- Trial name
- NCT01501565
- Testing
- Postoperative transverse abdominal plain (TAP) blockade
- Where
- Spain
- Volunteers
- 141 people
- Sponsor
- Fundacio Puigvert
Postoperative Pain
The Effect of Intermittent Cryotherapy Exposure on Patients' Quality of Recovery After Surgery
"Cryotherapy", or cold therapy, can include the use of gel packs, ice bags, ice baths, whole body chambers, and cold aerosol sprays.
- Trial name
- ICE (NCT04564963)
- Testing
- Cryotherapy
- Where
- 3 sites in Canada
- Volunteers
- 196 people
- Sponsor
- Sunnybrook Health Sciences Centre
Ketamine, Morphine
PCA Ketamine-Morphine VS PCA Morphine as Post-Operative Analgesia in Colorectal Surgery.
The goal of this clinical trial is to compare the effectiveness of PCA ketamine-morphine versus conventional PCA morphine in postoperative patients undergoing elective laparotomy colorectal surgery under general anaesthesia.
- Trial name
- NCT06010056
- Testing
- Ketamine-Morphine, Morphine
- Where
- Malaysia
- Volunteers
- 60 people
- Sponsor
- National University of Malaysia
Pain, Postoperative, Donor Site Complication
Pain Management in Laparoscopic Living-donor Nephrectomy: The Impact of Erector Spinae Plane Block (ESPB) on Perioperative Period
Laparoscopic living donor nephrectomy (LLDN) is a safe procedure and rapid wound healing, affecting the quality of life. The physiology of postoperative pain after LLDN has been attributed to reasons such as tissue damage…
- Trial name
- NCT04867070
- Testing
- NAS score
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Dental Pain
Evaluation of EXPAREL for Prolonged Postsurgical Analgesia in Subjects Undergoing Third Molar Extraction
This is a Phase 3, randomized, double-blind, placebo-controlled study in subjects scheduled to undergo elective bilateral third molar extraction under local anesthesia.
- Trial name
- NCT02517905
- Testing
- Bupivacaine liposome
- Where
- United States
- Volunteers
- 166 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Anxiety, Postoperative Pain
Developing a Virtual Reality (VR)-Based Prototype for Perioperative Care - a Proof of Concept Study
Preoperative anxiety and acute post-operative pain are common and have been associated with the development of chronic post-surgical pain and longer hospitalisation.
- Conditions
- Anxiety, Postoperative Pain, Pain, Acute
- Trial name
- NCT05564013
- Testing
- Virtual reality
- Where
- 2 sites in Singapore
- Volunteers
- 160 people
- Sponsor
- Changi General Hospital
Postoperative Pain
Pain Management for Pectus Excavatum Repair
The objective of this study is to scientifically evaluate two different management strategies for post-operative pain after pectus excavatum repair.
- Trial name
- NCT00413582
- Testing
- Epidural Analgesia, Patient-Controlled IV Analgesia
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Children's Mercy Hospital Kansas City
Laminectomy
Esmolol Infusion During Laminectomy: Effect on Quality of Recovery
The purpose of this study is to evaluate the effects of esmolol, a drug which is commonly administered during surgery to help control blood pressure and heart rate, on postoperative pain levels and requirements for pain…
- Trial name
- NCT01179113
- Testing
- Esmolol, Saline
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Cedars-Sinai Medical Center
Postoperative Pain Management
Low-Dose Lidocaine Infusion for Acute Pain Management Pilot Study
The purpose of this study is to evaluate the safety and efficacy of lidocaine infusion in acute pain management following open abdominal surgery, including opiate use after surgery and the incidence of postoperative nausea and…
- Trial name
- NCT06725485
- Testing
- Low-Dose Lidocaine
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- The Methodist Hospital Research Institute