Clinical trials: Postprandial Hyperglycemia
Pre-diabetes
Incretins in Impaired Fasting Glucose
People with high fasting glucose can develop type 2 diabetes with the passage of time. This study is being done to determine the effect of a novel medication in people with this elevated fasting glucose.
- Trial name
- NCT00364377
- Testing
- Sitagliptin
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Mayo Clinic
Type 1 Diabetes, Hyperglycemia, Postprandial
Glucagon Response to Prandial Insulin Administration in Persons With Type 1 Diabetes
Glucagon regulation and response in persons with T1D at the basal state and in response to various stimuli remains unclear. Dr. Philip Cryer has previously reported that, in T1D young adults with a course of the disease of 16+9…
- Trial name
- NCT04079881
- Testing
- Insulin
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Washington University School of Medicine
Type 1 Diabetes
Liraglutide Versus Insulin Mono-therapy in the Closed Loop Setting
Hypothesis: In type 1 diabetes mellitus, in the setting of a closed loop glucose control system: adjunctive therapy with Liraglutide will afford better post-prandial glycemic excursions than insulin mono-therapy.
- Trial name
- NCT01755416
- Testing
- Closed loop with sensor and Insulin, Closed loop with sensor, Insulin and Liraglutide
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Albert Einstein College of Medicine
Impaired Glucose Tolerance
The Vascular Effects of Exenatide Versus Metformin in Patients With Pre-Diabetes
The purpose of this study is to compare the effects of exenatide versus metformin on vascular health with chronic (3-month) therapy and during a 2-hour period following a meal in patients with pre-diabetes.
- Trial name
- NCT00546728
- Testing
- Exenatide, Metformin
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- St. Paul Heart Clinic
Pre-Diabetes
BTI320 (SUGARDOWN®) on Post-Prandial Hyperglycaemia in Subjects With Pre-Diabetes
This is a single-centre, 16-week, randomized, double-blind, placebo-controlled, 3-treatment arm pilot study to evaluate the efficacy and safety of BTI320 in the treatment of high risk subjects with pre-diabetes.
- Trial name
- NCT02358668
- Testing
- BTI320
- Where
- Hong Kong
- Volunteers
- 60 people
- Sponsor
- Chinese University of Hong Kong
Type 1 Diabetes
Effect of Apidra Compared to Humalog in Decreasing Post-Prandial Hyperglycemia
This study aims to compare the post-meal blood glucose values of two drugs in a "real-world" setting.
- Trial name
- NCT01621776
- Testing
- Apidra, Humalog, Novolog
- Where
- United States
- Volunteers
- 107 people
- Sponsor
- University of Florida
Endothelial Dysfunction
The Effects of Watermelon Juice Supplementation on Postprandial Vascular Endothelial Function
The purpose of this study is to test if watermelon juice supplementation improves vascular dysfunction experience during hyperglycemia.
- Trial name
- WMJ (NCT04092439)
- Testing
- Watermelon Juice
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Prediabetes, Cardiovascular Disease
Cardioprotective Activities Of Whole Eggs On Vascular Endothelial Function In Prediabetic Adults
Cardiovascular disease (CVD) is largely a lifestyle-related condition that is the #1 killer of adults in the United States. Our work is aimed at understanding how short-term increases in blood sugar, like those that accompany…
- Trial name
- NCT02364570
- Testing
- Glucose (100g), Glucose (75g), Whole Eggs
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Type 1 Diabetes Mellitus
Post-meal Insulin Dosing With Adjuvant Pre-meal Pramlintide in Children With Type 1 Diabetes Mellitus
The primary objective of this study is to examine the effect of pramlintide given pre-meal and insulin given just after a meal vs. standard therapy of pre-meal insulin on post-prandial glucose excursions.
- Trial name
- NCT00442767
- Testing
- Insulin, Pramlintide + Insulin
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Montefiore Medical Center
Hyperglycemia, Cardiovascular Disease
Green Tea Confections For Managing Postprandial Hyperglycemia-Induced Vascular Endothelial Dysfunction
The objective of this study is to formulate and validate a green tea confection (i.e. "gummy" candy) as a strategy to attenuate postprandial hyperglycemia-induced impairments in vascular function.
- Trial name
- NCT01857258
- Testing
- Green Tea Concentrate
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Diabetes Mellitus, Type 2
Effects of Nateglinide vs Acarbose on Postprandial Glucose Fluctuation, Dyslipidemia, and Inflammatory Factors
This study was conducted to demonstrate superiority of nateglinide in postprandial glucose fluctuation, dyslipidemia, and inflammatory status improvement.
- Trial name
- ENERGY (NCT00928889)
- Testing
- Nateglinide 120 mg, Acarbose 50 mg
- Where
- 6 sites in China
- Volunteers
- 160 people
- Sponsor
- Novartis Pharmaceuticals
Pregnancy Related, Stress, Psychological
Emotion-Diet Interactions in Pregnancy
This study will investigate how maternal emotional state following a controlled stress exposure in pregnancy influences blood glucose and insulin levels after eating a standardized meal, and whether the effects of emotional state…
- Conditions
- Pregnancy Related, Stress, Psychological, Glucose Intolerance During Pregnancy, Emotional Stress
- Trial name
- PREDIP (NCT04430439)
- Testing
- Psychosocial stress, Control non-stress
- Where
- 2 sites in United States
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Type2 Diabetes
Validation of Machine Learning Based Personalized Nutrition Algorithm to Reduce Postprandial Glycemic Excursions Among North American Individuals With Newly Diagnosed Type 2 Diabetes
This is an initial validation study of the Personal Nutrition Project (PNP) algorithm in a North American population with recently diagnosed Type 2 Diabetes (T2D).
- Trial name
- NCT03053518
- Testing
- Abbott Freestyle Libre Pro, LifeStyle
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- NYU Langone Health
Prevention of Hyperglycaemia
Effects of an Apple Extract on Glycaemia: The GLU-Pomme Study
Postprandial hyperglycaemia can lead to adverse modifications to functional proteins within the body and eventually lead to the development of type 2 diabetes.
- Trial name
- GLU-Pomme (NCT02940249)
- Testing
- Apple polyphenols
- Where
- United Kingdom
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- King's College London
Cardiovascular Diseases, Endotoxemia
Cardiometabolic Benefits of Potatoes Mediated Along the Gut-Vessel Axis in Adults With Metabolic Syndrome
This study is focused on assessing potential health benefits of daily consumption of potatoes, specifically its resistant starch content (i.e.
- Conditions
- Cardiovascular Diseases, Endotoxemia, Endothelial Dysfunction, Postprandial Hyperglycemia
- Trial name
- NCT03624569
- Testing
- Bagel, Potato
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Ohio State University
Type 1 Diabetes
Use of Exenatide and Pramlintide to Decrease Post-prandial Hyperglycemia
The main purpose of the study is to determine the effects of 16 weeks of adjunctive pramlintide or exenatide use on glycemic control in Type 1 Diabetes.
- Trial name
- NCT01269047
- Testing
- Pramlintide, Exenatide, Insulin
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Albert Einstein College of Medicine
Type 2 Diabetes Mellitus
The Study of Exenatide Action on Vessel Function in Type 2 Diabetes and Prediabetes
The purpose of this investigation is to evaluate whether exenatide, a type 2 diabetes medication, will improve the function of the innermost part of the arterial wall called the endothelium after a fat-enriched meal and to…
- Trial name
- NCT01181986
- Testing
- Exenatide SC, Exenatide IV, Exendin-9
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Carl T. Hayden VA Medical Center
Type 2 Diabetes Treated With Insulin
Novolog vs. Fiasp Insulin in Non-critically Ill Hospitalized Patients With Type 2 Diabetes Mellitus
Hyperglycemia affects 30-40% of hospitalized patients. Despite the fact that basal/bolus insulin therapy has been demonstrated to improve glycemic control and clinical outcomes in patients, achieving good glucose control remains…
- Trial name
- In-FI (NCT04460326)
- Testing
- Insulin glargine, NovoLog, Insulin Fiasp
- Where
- United States
- Volunteers
- 137 people
- Sponsor
- Boston Medical Center
Pediatric Obesity, Insulin Resistance
Study of Post-meal Blood Sugar Peaks in Association With Vascular Disease in Childhood Obesity
The main purpose of this study is to determine whether treatment with acarbose attenuates post-prandial glycemic excursions in non-diabetic/pre-diabetic obese children as determined by continuous glucose monitoring systems…
- Conditions
- Pediatric Obesity, Insulin Resistance, Impaired Glucose Tolerance, Cardiovascular Disease
- Trial name
- NCT00846521
- Testing
- Acarbose
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Yale University
Prediabetes
Regulation of Postprandial Nitric Oxide Bioavailability and Vascular Function By Dairy Milk
Cardiovascular disease (CVD) is the leading cause of death in the United States. Short-term increases in blood sugar, or postprandial hyperglycemia (PPH), affect blood vessel function and increase the risk of CVD.
- Trial name
- NCT02482675
- Testing
- Glucose, Glucose with Non-fat Milk, Glucose with Whey Protein Isolate
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Ohio State University