Clinical trials: Postoperative Ocular Pain
Pain, Postoperative, Anxiety, Dental
Identification of Predictive Factors of Postoperative Pain After Oral Surgery From Phenotypic Parameters Easily Accessible Preoperatively (PHEDOPO)
This project aims to study various predictive factors of postoperative pain after oral surgery among different parameters accessible preoperatively, in order to build a predictive model.
- Trial name
- PHEDOPO (NCT05405088)
- Testing
- Questionnaires
- Where
- France
- Volunteers
- 148 people
- Sponsor
- University Hospital, Clermont-Ferrand
Cataract, Cataract (Post-operative Cataract Surgery Follow-up)
Randomized Controlled Trial of the STEIN Protocol: A Neuroplastic Pain Education and Guided Breathing Intervention During Awake Cataract Surgery
This randomized controlled trial evaluates whether a standardized perioperative neuroplastic intervention: the STEIN Protocol (Strategies and Techniques for Enhancing Integration and Neuroplasticity), consisting of pain…
- Trial name
- SLin (NCT07715591)
- Testing
- Music and Guided Imagery, Control, Music Only
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of California, Los Angeles
Myopia, Hyperopia
Comparison of Acular LS Versus Nevanac for Pain Control in Eyes Undergoing PRK
To determine the ability of two topical Nonsteroidal Anti-inflammatory drops (Acular LS \& Nevanac) to help control pain following Photorefractive Keratectomy (PRK).
- Trial name
- NCT00347204
- Testing
- ketorolac (Acular LS), Nepafenac (Nevanac)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Center For Excellence In Eye Care
Intraocular Lens Replacement
Safety and Efficacy of OMS302 in Subjects Undergoing Intraocular Lens Replacement With Phacoemulsification
The purpose of this study is to determine the safety and efficacy of OMS302 (the study drug) for maintaining intraoperative mydriasis in individuals undergoing Intraocular Lens Replacement (ILR) surgery.
- Trial name
- OMS302-ILR-003 (NCT01454063)
- Testing
- OMS302
- Where
- 16 sites in United States
- Volunteers
- 405 people
- Sponsor
- Omeros Corporation
Strabismus, Bradycardia
Strabismus Recovery With Proparacaine and Oculocardiac Reflex
Observational study to determine if topical anesthetic and intraoperative oculocardiac reflex influence post strabismus surgery recovery.
- Conditions
- Strabismus, Bradycardia, Nausea, Pain
- Trial name
- OCRprop (NCT03672435)
- Testing
- Topical Solution
- Volunteers
- 140 people
- Sponsor
- Alaska Blind Child Discovery
Postoperative Pain, Intracranial Hypertension
The Effect of Caudal Block on Optic Nerve Sheath Diameter in Pediatric Patients
Caudal epidural block has been a widely used regional anesthesia method, especially in pediatric surgery, to provide intraoperative and postoperative analgesia.
- Trial name
- NCT05216211
- Testing
- Bupivacaine Hydrochloride
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ataturk University
Myopia, Astigmatism
Photorefractive Keratectomy (PRK) : Comparison of Corneal Haze Between Two Modes of De-epithelialisation (Laser Versus Manual Alcohol)
surgical correction of ametropia. A number of improvements have been introduced to overcome the side effects and complications such as corneal haze, epithelial irregularities induced by wound healing, pain and delayed visual…
- Trial name
- H-TransPKR (NCT05072977)
- Testing
- TransPRK, Alcohol PRK
- Where
- France
- Volunteers
- 71 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Keratoconus, Unstable, Collagen Crosslinking
Intracanalicular Dexamethasone Insert for Post-Corneal Cross-Linking Inflammation and Pain- The LINK Study
There is no standard of care medication regimen for the management of pain and inflammation post-corneal crosslinking (CXL), although most cornea specialists agree on use of an antibiotic and steroid eye drop in the immediate…
- Conditions
- Keratoconus, Unstable, Collagen Crosslinking, Postoperative Pain
- Trial name
- NCT04168112
- Testing
- Dextenza, Prednisolone Acetate
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Sight Medical Doctors PLLC
Pain, Inflammation
Safety/Efficacy of Nepafenac Punctal Plug Delivery System Compared to Placebo to Control Ocular Pain/Inflammation After Cataract
This is a Phase 2, multi-center, randomized, parallel-arm, double-masked, placebo-controlled study. One (1) to 2 days prior to their scheduled cataract surgery, each study subject will be randomized (2:1) in to one of two…
- Trial name
- NCT03496467
- Testing
- Nepafenac PPDS
- Where
- 3 sites in United States
- Volunteers
- 56 people
- Sponsor
- Mati Therapeutics Inc.
Inflammation Eye Pain, Postoperative Cataract
A Phase 3 Study Evaluating the Efficacy and Safety of OCS-01 Eyedrops Compared to Vehicle for the Treatment of Ocular Inflammation and Pain Following Cataract Surgery
This was a randomized, double-masked, vehicle-controlled, Phase 3 study evaluating the efficacy and safety of OCS-01 QD compared to vehicle in the treatment of inflammation and pain following cataract surgery.
- Trial name
- OPTIMIZE-1 (NCT05147233)
- Testing
- OCS-01, Vehicle
- Where
- 25 sites in United States
- Volunteers
- 241 people
- Sponsor
- Oculis
Retinal Detachment, Proliferative Vitreoretinopathy
Postoperative Pain Control Following Vitreoretinal Surgery
The aim of this study is to evaluate if patients receiving a steroid (triamcinolone acetonide) combined with local anesthesia and antibiotic following retina surgery have better postoperative pain control those receiving local…
- Conditions
- Retinal Detachment, Proliferative Vitreoretinopathy, Retinoschisis
- Trial name
- NCT01995045
- Testing
- Triamcinolone, Bupivicaine Hydrochloride
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Emory University
Retinal Detachment
REtinal Detachment Outcomes Study
Background: Few large randomized controlled trials provide strong evidence to guide surgical repair of primary rhegmatogenous retinal detachment (RRD) repair.
- Trial name
- REDOS (NCT05863312)
- Testing
- Pars plana vitrectomy, Pars plana vitrectomy with scleral buckle, Sulfur hexafluoride gas tamponade
- Where
- Canada
- Volunteers
- 560 people
- Sponsor
- CHU de Quebec-Universite Laval
Inflammation Eye Pain, Postoperative Cataract
A Phase 3 Study Evaluating the Efficacy and Safety of OCS-01 Opthalmic Suspension Compared to Vehicle for the Treatment of Ocular Inflammation and Pain Following Cataract Surgery
This was a randomized, double-masked, vehicle-controlled, Phase 3 study evaluating the efficacy and safety of OCS-01 QD compared to vehicle in the treatment of inflammation and pain following cataract surgery.
- Trial name
- OPTIMIZE-2 (NCT06128369)
- Testing
- OCS-01, Vehicle
- Where
- 24 sites in United States
- Volunteers
- 117 people
- Sponsor
- Oculis
Post-COVID-19 Condition, Ulcerative Colitis
Emerging Indications for Hyperbaric Oxygen Treatment
This study will evaluate the effectiveness of hyperbaric oxygen therapy (HBOT) on treating emerging indications (i.e., conditions that have shown to potentially benefit from HBOT) using the Multicenter Registry for Hyperbaric…
- Conditions
- Post-COVID-19 Condition, Ulcerative Colitis, Crohn Disease, Calciphylaxis
- Trial name
- NCT07240649
- Testing
- Hyperbaric oxygen treatment (HBOT), 100% Oxygen
- Volunteers
- 100 people
- Sponsor
- Jay C. Buckey Jr.
Unilateral Cataract Extraction, Congenital Cataract
A Randomized Study in Children Ages Birth Through Three Years Undergoing Unilateral Cataract Extraction With or Without Lens Replacement
The purpose of this study is to evaluate the effect of OMS302 compared to phenylephrine when administered in irrigation solution during cataract extraction on intraoperative pupil diameter, acute postoperative pain, and safety in…
- Trial name
- ILR7 (NCT02132312)
- Testing
- OMS302, Phenylephrine HCl
- Where
- 11 sites in United States
- Volunteers
- 78 people
- Sponsor
- Omeros Corporation
Sleep Deprivation, Postoperative Pain
The Effect of Night Eye Mask on Post-operative Pain in Cardiac Surgery Patients
Environmental factors such as noise and light have been cited as important causes of sleep deprivation in Intensive care unit (ICU) patients.
- Trial name
- NCT03213860
- Testing
- Flight Eye-masks; Dreaming, Zhuji City, Zhejiang, China
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Assiut University
Post Surgical Ocular Inflammation
A Study of TRS01 in Participants With Post-surgical Ocular Inflammation
The objective of this study is to evaluate the safety and preliminary efficacy of TRS01 eye drops as compared to placebo on participants with ocular inflammation after cataract surgery.
- Trial name
- NCT04222725
- Testing
- TRS01 eye drops
- Where
- 5 sites in United States
- Volunteers
- 37 people
- Sponsor
- Tarsier Pharma
Topical Anaesthesia, General Anesthetic Drug Adverse Reaction
Evaluation of Postoperative Pain in Cases Undergoing Cataract Surgery Under Topical Versus General Anesthesia
Comparison between cataract surgery under local versus general anesthesia regarding postoperative pain, complications and patient satisfaction and need for rescue analgesic intake after surgery The results will be followed up at…
- Conditions
- Topical Anaesthesia, General Anesthetic Drug Adverse Reaction, Cataract
- Trial name
- NCT07287683
- Testing
- Topical Anaesthesia group, General Anaesthesia group
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Alexandria University
Pterygium of Both Eyes
Dextenza for Post-operative Treatment of Pterygium
DEXTENZA for the Treatment of Post-Surgical Pain and Inflammation Compared to Standard of Care Topical Cortico-steroid Treatment in Patients who Undergo Bilateral Pterygium Surgery
- Trial name
- PERSIST (NCT04351737)
- Testing
- Intracanalicular Dexamethasone, (0.4 mg) Insert, Prednisolone Acetate
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Brandon Eye Associates, PA
Pterygium, Preoperative Anxiety
Video-Assisted Patient Education and Eye Fixation Training in Pterygium Surgery
This randomized controlled trial aims to investigate the effects of preoperative video-assisted patient education combined with eye position fixation training on anxiety, pain, intraoperative compliance, operation duration, and…
- Conditions
- Pterygium, Preoperative Anxiety, Postoperative Pain
- Trial name
- NCT07858045
- Testing
- Video-Assisted Patient Education
- Where
- Turkey (Türkiye)
- Volunteers
- 152 people
- Sponsor
- Ataturk University