Clinical trials: Postoperative Nausea and Vomiting
Spinal Disease
Effects of Preoperative Oral Carbohydrates Loading in Patients at High Risk of Postoperative Nausea and Vomiting Undergoing Spinal Surgery
Many patients receiving opioid based analgesia after spinal surgery experience postoperative nausea and vomiting (PONV) despite prophylaxis and treatment with antiemetic agents.
- Trial name
- NCT02809950
- Testing
- oral carbohydrate beverage, control group
- Where
- South Korea
- Volunteers
- 288 people
- Sponsor
- Yonsei University
Postoperative Nausea and Vomiting
Anti Emetic Efficacy of Combination of Ramosetron and Premixture of Naloxone With Patient-controlled Analgesia
Postoperative nausea and vomiting (PONV) is one of the most undesirable complications after general anesthesia, and may lead to increased hospital stay and health care costs.
- Trial name
- NCT02416115
- Testing
- Ramosetron, Naloxone, saline
- Volunteers
- 90 people
- Sponsor
- Kyungpook National University Hospital
Postoperative Nausea and Vomiting (PONV)
A Study of TAK-951 to Stop Adults Getting Nausea and Vomiting After Planned Surgery
Some adults are at a higher risk of feeling sick (nausea) or being sick (vomiting) after they have surgery. In this study, these adults will have planned surgery.
- Trial name
- NCT04557189
- Testing
- TAK-951, Ondansetron
- Where
- 7 sites in United States
- Volunteers
- 89 people
- Sponsor
- Takeda
Nausea, Postoperative Nausea and Vomiting
Development of a Predictive Model for Post-Discharge Nausea and Vomiting (PDNV)
The primary purpose of this prospective cohort study is to develop a simplified risk model for post-discharge nausea and vomiting (PDNV) in adult same-day surgery patients in the US that will allow clinicians to identify those…
- Conditions
- Nausea, Postoperative Nausea and Vomiting, Postdischarge Nausea and Vomiting, Postoperative Pain
- Trial name
- Apfel-PDNV (NCT00514878)
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- University of California, San Francisco
Laparoscopic Surgery, Pneumoperitoneum
Low-pressure vs Standard-pressure in Laparoscopic Cholecystectomy
Background. Many studies have demonstrated reduced postoperative pain in patients undergoing lower pneumoperitoneum pressure level during laparoscopic cholecystectomy.
- Conditions
- Laparoscopic Surgery, Pneumoperitoneum, Cholecystitis; Choledocholithiasis, Quality of Life
- Trial name
- NCT04146090
- Testing
- Low-pressure pneumoperitoneum, Standard pressure pneumoperitoneum
- Where
- Brazil
- Volunteers
- 80 people
- Sponsor
- Pontificia Universidade Catolica de Sao Paulo
Bariatric Surgery Candidate
Rates and Severity of PONV for Neuromuscular Block Reversal in Patients Receiving Gastric Bypass Bariatric Surgery
Patients who require bariatric surgery frequently bring a panoply of pre-existing comorbidities to the operating theatre. With body mass indices routinely in the 50s and 60s, patients who have bariatric surgery frequently have…
- Trial name
- NCT03432845
- Testing
- compare reversal agents
- Sponsor
- WellSpan Health
Breast Cancer
Preoperative Oral Dexamethasone to Improve Recovery After Surgery
Randomized controlled trial of pre-operative oral dexamethasone vs placebo for the improvement of quality of recovery from surgery. The study population is limited to breast surgery patients.
- Trial name
- NCT02234466
- Testing
- Oral dexamethasone, Ondansetron, Gelatin capsule
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- University of Manitoba
Postoperative Nausea
The Effect of Glycyrrhizin on the Occurrence of Postoperative Nausea and Vomiting
The investigators investigate the association between the administration of glycyrrhizin during induction of general anesthesia and the occurrence of postoperative nausea and vomiting (PONV) in patients undergo breast surgery
- Trial name
- NCT04742660
- Testing
- Ammonium Glycyrrhizinate
- Where
- South Korea
- Volunteers
- 224 people
- Sponsor
- Konkuk University Medical Center
Postoperative Nausea, Postoperative Vomiting
Influence of Monitoring the Depth of General Anesthesia Upon the Incidence of PONV and Emergence Delirium in Children Undergoing Endoscopic Adenoidectomy in General Anesthesia
The study has been designed as a prospective randomized clinical trial. Due to the use of a bispectral (BIS) monitor in the interventional arm, the study will not be blinded for the anesthetist.
- Conditions
- Postoperative Nausea, Postoperative Vomiting, Emergence Delirium
- Trial name
- NCT04466579
- Testing
- BIS monitor, Standard care
- Where
- Czechia
- Volunteers
- 100 people
- Sponsor
- University Hospital Ostrava
Genetic Predisposition to Disease, Postoperative Nausea
Genetic Polymorphism and Post Operative Nausea and Vomiting (PONV)
Nausea and vomiting affects 25-30% of individuals in the post-operative period and can reach more than 70-80% in high-risk patients.
- Conditions
- Genetic Predisposition to Disease, Postoperative Nausea, Polymorphism, Genetic
- Trial name
- ponv (NCT03627780)
- Testing
- DNA extraction
- Where
- 2 sites in Brazil
- Volunteers
- 300 people
- Sponsor
- Instituto do Cancer do Estado de São Paulo
PONV
Aprepitant to Improve Same Day Discharge for TKA
The purpose of this research is to study whether adding an FDA approved medication called aprepitant (a medication given to patients like you to reduce or eliminate nausea and vomiting) to the usual treatment to prevent nausea…
- Trial name
- NCT07639723
- Testing
- Aprepitant Injection, Ondansetron (Zofran), Dexamethasone
- Where
- United States
- Volunteers
- 350 people
- Sponsor
- Endeavor Health
PONV
Phase IIIb Study of APD421 in Combination as PONV Prophylaxis
A comparison of the efficacy of APD421 and placebo when combined with a standard anti-emetic in the prevention of PONV in patients at high risk of Post-operative Nausea and Vomiting (PONV).
- Trial name
- NCT02337062
- Testing
- APD421
- Where
- 25 sites in United States, France and 1 more
- Volunteers
- 1,147 people
- Sponsor
- Acacia Pharma Ltd
PONV
Comparison Between Opioid-Free Anaesthesia Versus Opioid Based Anesthesia in Reduction Postoperative Nausea and Vomiting (PONV)After Thoracoscopic Lung Resection.
The invistigators hypothesized that a protocolized OFA technique would lower the occurance of PONV in patients undergoing thoracoscopic lung surgery compared to standard opioid-based anaesthesia.
- Trial name
- NCT07806162
- Testing
- Opioid Free Anaesthesia, conventential opioid-based anaesthesia (OBA,
- Volunteers
- 120 people
- Sponsor
- Sohag University
Sore Throat, Nausea and Vomiting, Postoperative
Effects of Two Packing Type in Maxillofacial Surgery
Operations of oral maxillofacial surgery cause the blood escape into stomach and trachea. Therefore, throat packing is applied. Endotracheal tube cuff is not protective from aspiration.
- Trial name
- NCT03574246
- Testing
- chlorhexidine gluconate %0,12 benzydamine hydrochloride %0,15, %0.9 NaCl Solution
- Where
- Turkey (Türkiye)
- Volunteers
- 111 people
- Sponsor
- Ankara University
Postoperative Vomiting, Nausea
Postoperative Nausea and Vomiting and Acupuncture/Acupressure
Postoperative nausea and vomiting (PONV) remain a significant challenge in the investigators practice. However, pharmaceutical prophylaxis can imply unpleasant adverse effects.
- Trial name
- NCT00965367
- Testing
- Acustimulation
- Where
- Norway
- Volunteers
- 154 people
- Sponsor
- National Research Centre of Complementary and Alternative Medicine, Norway
Nausea, Vomiting
Predictive Factors for Postoperative Pain, Nausea and Vomiting in Oncological Patients
1809 patients were evaluated in postoperative period. They were asked about nausea, vomiting, retching and pain in the first postoperative 24 hours
- Conditions
- Nausea, Vomiting, Pain, Postoperative
- Trial name
- PONV (NCT04889534)
- Testing
- Analgesia
- Where
- Brazil
- Volunteers
- 1,500 people
- Sponsor
- Instituto do Cancer do Estado de São Paulo
Post Operative Nausea and Vomiting
A Pilot Study to Evaluate Barhemsys for the Prevention of Postoperative Nausea And Vomiting in the Bariatric Surgery Population
To assess the effectiveness of Amisulpride to treat Post Operative Nausea and Vomiting (PONV) and to assess the effectiveness of Amisulpride to prevent PONV following bariatric surgery.
- Trial name
- NCT06585540
- Testing
- Amisulpride IV Prevention, Amisulpride IV Treatment
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Benaroya Research Institute
Breast Cancer Female, Postoperative Pain
Multimodal Pain Treatment for Breast Cancer Surgery - a Prospective Cohort Study
Breast cancer is one of the most common types of cancer among women worldwide. (1) Breast-conserving surgery or mastectomy is indicated for the majority of patients with this type of cancer.
- Conditions
- Breast Cancer Female, Postoperative Pain, Postoperative Nausea and Vomiting
- Trial name
- NCT04875559
- Testing
- Standardised multimodal pain treatment regimen
- Where
- Denmark
- Volunteers
- 236 people
- Sponsor
- Zealand University Hospital
Postoperative Nausea and Vomiting
A Machine Learning Prediction Model for Delayed CIPONV
Postoperative nausea and vomiting (PONV) can lead to serious postoperative complications, but most symptoms are mild. Clinically important PONV (CIPONV) refers to PONV symptoms that have a significant impact on the patient's…
- Trial name
- NCT06443697
- Testing
- No intervention
- Where
- China
- Volunteers
- 1,154 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Pain, Postoperative, Postoperative Nausea and Vomiting
Trigonelline Plus Sufentanil for Postoperative Analgesia After Laparoscopic Hysterectomy: A Randomized Controlled Clinical Trial
The goal of this clinical trial is to learn whether the combination of trigonelline and sufentanil can better control postoperative pain in adult women undergoing gynecologic laparoscopic surgery, while reducing discomforts such…
- Trial name
- TPS-GLS (NCT07914946)
- Testing
- Sufentanil, Trigonelline
- Where
- China
- Volunteers
- 165 people
- Sponsor
- Hainan Medical College