Clinical trials: Postoperative Cognitive Function
Cognitive Dysfunction, Postoperative, Cognitive Dysfunction
Assessment of Brain Oxygen Drops During Surgery and Related Risk Factors for Cognitive Problems After Heart Surgery
This study examines whether decreases in brain oxygen levels during cardiac surgery are linked to postoperative cognitive dysfunction and identifies other factors that may increase the risk of cognitive impairment.
- Conditions
- Cognitive Dysfunction, Postoperative, Cognitive Dysfunction, Cardiac Surgery
- Trial name
- NCT07361068
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Femoral Neck Fractures, Postoperative Complications
Postoperative Recovery in Elderly Patients Undergoing Hip Hemi-arthroplasty
Hip fractures incidence grows rapidly with the aging of the population. After indicated surgical treatment, hip fracture patients experience high rates of postoperative complications, postoperative delirium (PD), postoperative…
- Conditions
- Femoral Neck Fractures, Postoperative Complications, Inflammatory Response, Postoperative Delirium
- Trial name
- NCT01934049
- Testing
- hip arthroplasty, Total Intravenous Anesthesia and Peripheral nerve blocks
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Chinese PLA General Hospital
Postoperative Cognitive Dysfunction, Postoperative Delirium
Perioperative GDNF as a Predictive Factor for Postoperative Delirium and Adverse Neurological Outcomes in Pediatric Surgery
To observe the dynamic changes in serum levels of inflammatory cytokines (e.g., IL-6, TNF-α), Brain-Derived Neurotrophic Factor (BDNF), and Glial Cell Line-Derived Neurotrophic Factor (GDNF) during the perioperative period in…
- Trial name
- NCT07192549
- Testing
- Sevoflurane group, Propofol group
- Volunteers
- 200 people
- Sponsor
- General Hospital of Ningxia Medical University
Postoperative Delirium, Postoperative Cognitive Dysfunction
Cognitive Dysfunction and Delirium After TUR-M in Elderly Patients
Elderly patients undergoing transurethral resection are at increased risk of postoperative cognitive dysfunction (POCD) and delirium, which are associated with prolonged hospital stay, increased morbidity, and decreased quality…
- Conditions
- Postoperative Delirium, Postoperative Cognitive Dysfunction, Cognitive Dysfunction
- Trial name
- POCDTURMSTUD (NCT07719712)
- Testing
- Cognitive and Delirium Assessment (MoCA and CAM)
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Muğla Sıtkı Koçman University
Cognitive Dysfunction
Transcutaneous Electrical Stimulation of the Vagus Nerve
This study evaluate the cognitive functions of patient after hip or kneel replacement.Half of the patient will receive transcutaneous vagus nerve electrical stimulation during the surgery while the other half will get placebo…
- Trial name
- TESVNR (NCT03989375)
- Testing
- transcutaneous vagus nerve electric stimulator
- Where
- China
- Volunteers
- 110 people
- Sponsor
- RenJi Hospital
Postoperative Cognitive Decline, Biomarkers
Patients Experiences of Early Postoperative Cognition
The study has a mixed-methods design i.e. integration of qualitative and quantitative data within a single investigation. Participants included will be patients ≥60 years that are undergoing major elective joint replacement…
- Conditions
- Postoperative Cognitive Decline, Biomarkers, Postoperative Recovery, Joint Replacement Surgery
- Trial name
- COME (NCT05361460)
- Testing
- Cognitive decline
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Karolinska Institutet
Radiography, Orthopedic Surgery
Brain Power Spectral Density Under Propofol
In the operating room, the state of anesthesia is monitored during general anesthesia-induced hypnosis through EEG-based neuro-monitoring.
- Conditions
- Radiography, Orthopedic Surgery, Interventional
- Trial name
- PROBRAIN (NCT03876379)
- Volunteers
- 60 people
- Sponsor
- Joaquim MATEO
Cognitive Dysfunction
Cerebral Oximetry With Near-infrared Spectroscopy and Negative Postoperative Behavioral Changes in Pediatric Surgery
The main objective of the present study was to evaluate whether cerebral oxygen saturation is associated with an increase of NPOBC in pediatric patients undergoing major surgery.
- Trial name
- NCT02773186
- Testing
- monitoring cerebral oxygen saturation
- Volunteers
- 198 people
- Sponsor
- Hospital Clínico Universitario de Valladolid
Intracranial Pressure, Circulation System
The Effect of Arterial Carbon Dioxide Levels on Cerebral Blood Flow and Cerebral Autoregulation in the Steep Trendelenburg Position During Robot-assisted Prostatectomy, and Its Effect on Postoperative Cognition
Patients scheduled for robot-assisted prostatectomy will be randomized to either high or low concentrations of carbon dioxide in the blood.
- Conditions
- Intracranial Pressure, Circulation System, Cerebral Perfusion Pressure, Cognitive Function
- Trial name
- TILTDOWN-3 (NCT06865027)
- Testing
- Ventilation strategy
- Where
- Norway
- Volunteers
- 46 people
- Sponsor
- University Hospital, Akershus
Endovascular Repair of Aortic Aneurysm, Endovascular Treatment of Arteriosclerosis Obliterans of Lower Extremities
Effects of Anesthetics on Postoperative Cognitive Function of Patients Undergoing Endovascular Repair of Aortic Aneurysm and Endovascular Treatment of Arteriosclerosis Obliterans of Lower Extremities.
Endovascular repair of aortic aneurysm and endovascular treatment of arteriosclerosis obliterans of lower extremities are two kinds of common surgeries in the investigators' hospital.
- Trial name
- NCT02107170
- Testing
- Sevoflurane, Propofol, Remifentanil
- Where
- China
- Volunteers
- 68 people
- Sponsor
- Tao Zhang
Mild Cognitive Impairment
The Effect of Nimodipine on the Postoperative Cognitive Dysfunction
The calcium channel blocker nimodipine dilates cerebral blood vessels and can pass through the blood-brain barrier, providing neuroprotective effects by selectively improving cerebral blood flow and inhibiting neuronal necrosis…
- Trial name
- NCT02537080
- Testing
- Nimodipine group, Control group
- Where
- Czechia
- Volunteers
- 15 people
- Sponsor
- University Hospital Hradec Kralove
Supratentorial Brain Tumor, Exercise
The Effect of Preoperative Walking Exercises on the Prognosis of Supratentorial Brain Tumours Patients After Craniotomy
The goal of this clinical trial is to learn about in patients with supratentorial brain tumours. The main questions it aims to answer is: Can short-term preoperative walking exercise protect cognitive function in the short term…
- Conditions
- Supratentorial Brain Tumor, Exercise, Cognition, Postoperative Complications
- Trial name
- NCT05930288
- Testing
- Walking exercise
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Xiangya Hospital of Central South University
Postoperative Cognitive Dysfunction, Coronary Artery Disease
Short-Term and Long-Term Cognitive Outcomes in Adults After Cardiac Surgery
Adults with coronary artery disease (250 patients) undergoing cardiac surgery participated in the study. The aim is to investigate short-term and long-term cognitive outcomes and the patterns of organization of functional brain…
- Trial name
- NCT05172362
- Where
- Russia
- Volunteers
- 250 people
- Sponsor
- Research Institute for Complex Problems of Cardiovascular Diseases, Russia
Postoperative Cognitive Dysfunction, Postoperative Delirium
Study of Prevention of Postoperative Delirum to Reduce Incidence of Postoperative Cognitive Dysfunction
Postoperative cognitive dysfunction describes a condition where cognitive functions such as attention, perception, concentration, learning, abstract thinking and problem solving are impaired postoperatively.
- Trial name
- DelPOCD (NCT03060174)
- Testing
- monitoring and non-medical prophylaxis of delirium
- Where
- Germany
- Volunteers
- 638 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Coronary Artery Bypass, Delirium
Organ Protection for Coronary Artery Bypass Graft (CABG): Propofol Versus Desflurane
Background: Different anaesthetic agents have been shown to have different protective effects upon heart, brain and renal function under ischaemic conditions (oxygen starvation).
- Conditions
- Coronary Artery Bypass, Delirium, Dementia, Amnesia
- Trial name
- NCT00400790
- Testing
- propofol, desflurane
- Where
- Australia
- Volunteers
- 182 people
- Sponsor
- University of Melbourne