Clinical trials: Postoperative Chronic Pain
Cardiac Surgery
Efficacy of Ultrasound Guided PIFB Versus Lidocaine Infusion on Postoperative Pain After Sternotomy
Chronic pain is a common complication after cardiothoracic surgery. The prevalence of post-sternoyomy pain syndrome (PSPS) ranges from 33% to 91%.
- Trial name
- NCT05885230
- Testing
- pecto intercostal fascial block using bupivacaine 0.25%, lidocaine infusion
- Where
- Egypt
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Beni-Suef University
Knee Osteoarthritis, Knee Pain Chronic
iPACK Block for Total Knee Arthroplasty
This randomized, double-blinded, placebo-controlled trial seeks to evaluate the efficacy of the rehabilitation process of the Interspace between the Popliteal Artery and Capsule of the Posterior Knee (iPACK) block in total knee…
- Conditions
- Knee Osteoarthritis, Knee Pain Chronic, Knee Disease
- Trial name
- NCT06087562
- Testing
- Ropivacaine 0.5% Injectable Solution 20mL, 0,9% normal saline 20mL
- Where
- Poland
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Poznan University of Medical Sciences
Chronic Postoperative Pain
Validation of Predictive Scale of Chronic Postsurgical Pain
To asses the precision of a score to predict chronic post surgical pain in patients undergoing inguinal hernia repair, abdominal hysterectomy, vaginal hysterectomy and thoracotomy.
- Trial name
- NCT02991287
- Testing
- Inguinal hernia repair, Abdominal hysterectomy, Vaginal hysterectomy
- Where
- 21 sites in Spain
- Volunteers
- 1,040 people, healthy volunteers welcome
- Sponsor
- Parc de Salut Mar
Ilioinguinal Nerve Section, Pain Prevention
Prophylactic Ilioinguinal Neurectomy During Open Tension-Free Inguinal Hernia Repair
postoperative chronic inguinal pain is a common postoperative complication after open inguinal hernia repair. Chronic inguinal pain is a common complication following open inguinal hernia repair.
- Conditions
- Ilioinguinal Nerve Section, Pain Prevention, Hernioplasty
- Trial name
- NCT06327763
- Testing
- ilioinguinal nerve section
- Where
- Egypt
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Hip Osteoarthritis, Hip Arthropathy
PENG Block for Total Hip Arthroplasty
This randomized, double-blinded, placebo-controlled trial seeks to evaluate the efficacy of the pericapsular nerve group block on postoperative rehabilitation.
- Conditions
- Hip Osteoarthritis, Hip Arthropathy, Hip Disease, Hip Pain Chronic
- Trial name
- NCT05944380
- Testing
- Ropivacaine 0.5% Injectable Solution, 0,9% normal saline
- Where
- Poland
- Volunteers
- 556 people, healthy volunteers welcome
- Sponsor
- Poznan University of Medical Sciences
Pain, Postoperative, Intrathoracic Procedure
Cryoablation Effects on Acute and Chronic Pain After Thoracotomy and Thoracoscopy
The researchers will compare the common methods of post-surgical pain control, such as epidural or intercostal nerve block with a newer method called cryoablation.
- Trial name
- NCT06384664
- Testing
- Atricure's crysoSPHERE probe, Standard of Care
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Postoperative Pain, Chronic Pain
Safety, Tolerability, and Pharmacokinetics of HSK21542 in Healthy Volunteers
This is a A Phase 1, Randomized, Double-Blind, Placebo-Controlled, Single-Ascending-Dose Study To Investigate the Safety, Tolerability, and Pharmacokinetics of a kappa receptor agonist HSK21542 in Healthy Volunteers.
- Trial name
- NCT04110886
- Testing
- HSK21542
- Where
- Australia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Sichuan Haisco Pharmaceutical Group Co., Ltd
Postoperative Pain
Pain After PRP Revascularization and Endodontic Treatment of Non-vital Mandibular Molars With Apical Periodontitis
randomized clinical trial which Evaluate thr Post-operative Pain Following Platelet Rich Plasma (PRP) Revascularization versus Conventional Endodontic Treatment of Non-vital Mature Mandibular Molars with Chronic Peri-apical…
- Trial name
- NCT03350841
- Testing
- Platelet rich plasma PRP, root canal treatment
- Where
- Egypt
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Cairo University
Post Surgical Pain, Post Operative Pain
Chronic Postsurgical Pain: Multivariate Prediction Model
The goal of this observational study is to identify the risk factors of Chronic Postoperative pain (or Chronic Post Surgery Pain - CPSP) three months after surgery and, subsequently.
- Conditions
- Post Surgical Pain, Post Operative Pain, Postoperative Pain, Chronic
- Trial name
- CPoP (NCT06417528)
- Testing
- Chronic Post Surgery Pain (CPSP)
- Where
- Italy
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Societa Italiana Anestesia Analgesia Rianimazione e Terapia Intensiva
Post Operative Pain, Spinal Surgery
Methadone to Reduce Chronic Opioid Use After Major Spine Surgery: The MEND Pilot Feasibility Study
The investigators propose a randomized, triple-blinded (patients, investigators, outcomes assessors), placebo-controlled pilot feasibility trial (Methadone to End Narcotic Dependence, MEND trial) to assess the feasibility and…
- Trial name
- MEND (NCT07222072)
- Testing
- Methadone
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Phantom Limb Pain
Electrical Stimulus Therapy for Chronic Phantom Limb Pain
The goal of this pilot study is to assess the effectiveness of an electrical stimulation therapy option for the treatment of chronic phantom limb pain in upper or lower limb amputees.
- Trial name
- NCT03030079
- Testing
- Experimental Electrical Stimulation Regimen
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Post-Operative Pain, Chronic, Necrotic Pulp
Propolis Versus Calcium Hydroxide on Post-Operative Pain in Patients With Necrotic Pulp
Propolis is a resinous product of honeybees. Propolis is said to be effective against resistant microorganisms inside the root canal compared to the gold standard medication known as calcium hydroxide.
- Trial name
- NCT04983524
- Testing
- propolis, Calcium Hydroxide
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Cairo University
Pain
From Acute to Chronic Postoperative Pain in Patients for Elective Cholecystectomy. Immunological Tests
Chronic Pain after Cholecystectomy is a well known problem. One theory is that it is due to persisting inflammation. The purpose of the study is to measure inflammatory factors in cerebrospinal fluid and blod at patients 12…
- Trial name
- NCT01546480
- Where
- 2 sites in Denmark
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Breast Cancer, Mastectomy
Preoperative Regional Nerve Block for Acute and Chronic Post-Operative Pain Following Mastectomy
The purpose of this study is to see if pre-operative regional nerve blocks compared to a placebo nerve block can decrease chronic post mastectomy pain, immediate postoperative pain and postoperative narcotic consumption.
- Conditions
- Breast Cancer, Mastectomy, Anesthesia, Local, Narcotic Use
- Trial name
- RELIEF (NCT04019834)
- Testing
- regional nerve block with local anesthesia of bupivacaine with steroid
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Periapical Periodontitis, Root Canal Infection
The Effects of EndoActivator on Postoperative Pain and Root Canal Treatment Success
This study evaluates postoperative pain and radiographic healing of asymptomatic posterior teeth with chronic apical periodontitis following root-canal treatment performed using EndoActivator for irrigation activation.
- Trial name
- NCT06339905
- Testing
- Sonic Activation with EndoActivator, Control Needle Irrigation
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Postoperative Delirium, Chronic Postsurgical Pain
Peripheral Blood Single Cell Sequencing Analysis of POD and CPSP in Elderly Patients After Total Knee Arthroplasty
Single-celled sequencing for evaluating differences in gene expression patterns in different cell types of the dynamics of a means of this research as a starting point, to study the postoperative delirium and chronic pain at the…
- Trial name
- NCT05572307
- Where
- China
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Xuzhou Central Hospital
Postoperative Analgesia
Quadratus Lumborum in Cesarean Section Trial
Postoperative pain of a caesarean section may be of high intensity, especially in the first 48 hours after the procedure, which affects the mother / newborn relationship, in addition to having the potential to progress to chronic…
- Trial name
- QUALICS (NCT03673280)
- Testing
- Quadratus Lumborum Block
- Where
- Brazil
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Sensation Disorders, Sensation, Phantom
Prospective Study of Sensation and Satisfaction in Cancer and Transgender Mastectomy Patients
During breast surgery, sensory nerves are cut which may lead to reduced sensation and pain. Surgical reinnervation techniques have been developed with the aim of improving postoperative sensation by preserving the nerves and…
- Conditions
- Sensation Disorders, Sensation, Phantom, Pain, Postoperative, Pain, Chronic
- Trial name
- NCT06094257
- Testing
- Sensory testing
- Where
- 2 sites in United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Hernia, Inguinal, Chronic Postoperative Pain
Surgical Outcomes Following Neurectomy Based Upon Response to Local Anesthetic Injection in Chronic Groin Pain
The management of chronic pain after inguinal hernia surgery presents unique challenges. Ilioinguinal nerve blocks are often used in the initial treatment of this disease.
- Trial name
- NCT05386693
- Testing
- Ilioinguinal nerve block
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Chronic Postoperative Pain
euCPSP: European Observational Study on Chronic Post Surgical Pain,PAIN-OUT Study
This project a European observational study on the incidence and characteristics of chronic post surgical pain (CPSP). Research Questions What is the incidence of chronic post surgical pain (CPSP) in Europe? What are the risk…
- Trial name
- PAIN-OUT (NCT01467102)
- Where
- 24 sites in Belgium, France and 9 more
- Volunteers
- 3,618 people, healthy volunteers welcome
- Sponsor
- European Society of Anaesthesiology