Clinical trials: Postoperative Atrial Fibrillation
Atrial Fibrillation
The Effect of Posterior Pericardiotomy on the Incidence of Atrial Fibrillation After Cardiac Surgery
The purpose of this study is to determine if preforming a posterior left pericardiotomy prevents atrial fibrillation after cardiac surgery.
- Trial name
- PALACS (NCT02875405)
- Testing
- Posterior left pericardiotomy
- Where
- United States
- Volunteers
- 420 people
- Sponsor
- Weill Medical College of Cornell University
Pulmonary Embolism, Atrial Fibrillation
Study to Find Out the Appropriate Initial Dose of the Anticoagulant Drug Phenprocoumon
Oral anticoagulation is often initiated in hospitalized patients. Although the therapeutic range of phenprocoumon is narrow, the individual drug demands unfortunately vary greatly between persons.
- Conditions
- Pulmonary Embolism, Atrial Fibrillation, Hip Replacement Postoperative, Knee Replacement Postoperative
- Trial name
- NCT00586287
- Testing
- Algorithm for phenprocoumon, Phenprocoumon
- Where
- Switzerland
- Volunteers
- 302 people
- Sponsor
- Cantonal Hospital of St. Gallen
Atrial Fibrillation
Impact of Sodium-glucose Cotransporter 2 Inhibitors on Post-operative Atrial Fibrillation in Cardiothoracic Surgery
SGLT2 inhibitors are oral anti-diabetic medications that were found to improve cardiorenal outcomes in patients with type 2 diabetes mellitus (DM), chronic heart failure with reduced and preserved ejection fraction, and chronic…
- Trial name
- NCT06251453
- Testing
- SGLT2 inhibitor
- Where
- 2 sites in Qatar
- Volunteers
- 3,280 people
- Sponsor
- Hamad Medical Corporation
Post Cardiac Surgery Atrial Fibrillation
The Outcomes of Sympathetic Cardiac Denervation on Postoperative Atrial Fibrillation After Cardiac Surgery, Randomized Controlled Trial
we compare the effect of cutting heart nerves in one group of patients with open heart surgery and other group without cutting oh development of disturbance of heart beat after surgery
- Trial name
- NCT07811817
- Testing
- cardiac sympathetic denervation, Standard open-heart surgery without additional epicardial or fat pad dissection.
- Where
- Egypt
- Volunteers
- 560 people
- Sponsor
- Zagazig University
Atrial Fibrillation, Cardiac Surgery
Prevention of Atrial Fibrillation by Low-dose Landiolol Administration After Cardiac Surgery
Postoperative atrial fibrillation (POAF) is a common complication that occurs in 30-50% of patients after cardiac surgery and increases morbidity and mortality and hospital length of stay.
- Trial name
- LANDIPROTEC (NCT04607122)
- Testing
- Landiolol, Saline
- Where
- 3 sites in France
- Volunteers
- 400 people
- Sponsor
- CMC Ambroise Paré
Amyotrophic Lateral Sclerosis (ALS), Angina, Stable
Quest to Analyze One Thousand Humans Meditating
This study will be focused on assessing the molecular, physiological, and emotional correlates of an intensive meditation experience in the context of a retreat setting in a large 2000 plus-person cohort comprised of healthy and…
- Conditions
- Amyotrophic Lateral Sclerosis (ALS), Angina, Stable, Anxiety, Asthma
- Trial name
- QUANTUM (NCT06583395)
- Testing
- Advanced multi-component meditation practice
- Where
- United States
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Tobias Moeller-Bertram
Atrial Fibrillation, Atrial Flutter
A Retrospective Analysis of the Use of ACE-inhibitors and Angiotensin Receptor Blockers
It is well known that atrial fibrillation (AF) and atrial flutter occur frequently after most types of cardiac surgeries.(1-4) Postoperative AF is associated with significant morbidity, longer hospital stay, and higher related…
- Trial name
- NCT00321945
- Testing
- ACE-Inhibitors and Angiotensin Receptor Blockers
- Where
- 3 sites in United States
- Volunteers
- 546 people
- Sponsor
- Emory University
Atrial Fibrillation, Postoperative
Amiodarone-Infused CardiaMend Patches for the Prevention of New-Onset POAF in Cardiac Surgery Subjects
The goal of this clinical trial is to is to test the safety of a new way to deliver a commonly used drug (amiodarone) used in heart surgery by placing a patch containing the drug directly on the heart instead of in an IV (vein).
- Trial name
- AMIOMEND (NCT06730828)
- Testing
- The intervention includes Amiodarone-Infused CardiaMend patches (70mg, 150mg and 300mg)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Helios Cardio Inc.
Atrial Fibrillation
Gene Expression Profiling in Subjects With Postoperative Atrial Fibrillation After Cardiac Surgery (GENEXPRO Surg)
Atrial fibrillation is a type of irregular heartbeat that is common after having heart surgery. There may be many different reasons why some people get atrial fibrillation after their heart surgery.
- Trial name
- NCT00833313
- Testing
- Atrial biopsy
- Where
- United States
- Volunteers
- 350 people
- Sponsor
- Brigham and Women's Hospital
Atrial Fibrillation New Onset
Stellate Ganglion to Prevent Atrial Fibrillation
New onset atrial fibrillation is a common problem after cardiac surgery. The reported incidence after coronary artery bypass grafting (CABG) is 15-40%, 37-50% after valve surgery, and up to 60% after CABG and valve surgery.
- Trial name
- NCT05656170
- Testing
- Stellate ganglion block, Bupivacain, Saline
- Sponsor
- Rush University Medical Center
Postoperative Delirium (POD), Postoperative Bleeding
GENECARD - the Use of Genetic, Epigenetic, Metabolomic, Proteomic and Microbiotic Markers, Image and Voice Biomarker Analyses, and Pre- and Intraoperative Clinical Data - to Predict Early Complications After Cardiac Surgery.
The goal of this observational cohort study is to prove whether genetic, epigenetic, transcriptomic, proteomic, metabolomic, imaging, voice, and clinical markers can improve prediction of early complications after cardiac surgery…
- Conditions
- Postoperative Delirium (POD), Postoperative Bleeding, Acute Kidney Injury, Atrial Fibrillation (AF)
- Trial name
- GENECARD (NCT07345403)
- Testing
- Multi-Omics Data and Clinical Data Collection
- Where
- Poland
- Volunteers
- 3,000 people
- Sponsor
- Medical University of Gdansk
Atrial Fibrillation
Omega-3 Fatty Acids for Prevention of Post-Operative Atrial Fibrillation
This is a large multi-center study to examine whether peri-operative intake of n-3 polyunsaturated fatty acids (PUFA) will reduce the occurrence of post-operative atrial fibrillation or flutter (AF) in patients undergoing cardiac…
- Trial name
- OPERA (NCT00970489)
- Testing
- Omega -3 fatty acids
- Where
- United States
- Volunteers
- 1,516 people
- Sponsor
- Brigham and Women's Hospital
Cardiac Denervation, Postoperative Atrial Fibrillation
A New Way of Cardiac Denervation to Reduce the Incidence of AF After CABG.
This is a prospective, random controlled trial(RCT) study. 430 patients undergoing coronary artery bypass grafting were enrolled.
- Trial name
- NCT05009914
- Testing
- cardiac denervation
- Where
- China
- Volunteers
- 430 people
- Sponsor
- China National Center for Cardiovascular Diseases
Coronary Heart Disease
Supplementation With Polyphenol-Rich Foods and Atrial Fibrillation After a Cardiac Surgery
Post-operative atrial fibrillation (POAF) is a major cause of morbidity and mortality after a cardiac surgery. Both systemic inflammation and oxidative stress play a role in the initiation of POAF after a cardiac surgery.
- Trial name
- Polyphemus (NCT02045134)
- Testing
- High-anthocyanin rich corn flour
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Neuromed IRCCS
Atrial Fibrillation
Prophylaxis for Patients at Risk to Eliminate Post-operative Atrial Fibrillation
After surgery on the lungs or esophagus, 12-46% of patients experience an irregular heart rhythm called atrial fibrillation. Although usually transient, post-operative atrial fibrillation is associated with longer stay in…
- Trial name
- PREP-AF (NCT04392921)
- Testing
- Amiodarone
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Ottawa Hospital Research Institute
Postoperative Atrial Fibrillation, Genomics
Genomics and Postoperative Atrial Fibrillation
This research study is done to find out if genetic make up of a person plays a role in complications and recovery after the Coronary Artery Bypass Graft (CABG) operation.
- Trial name
- NCT00280163
- Where
- United States
- Volunteers
- 336 people
- Sponsor
- University of Pittsburgh
Postoperative Atrial Fibrillation, Post PCI Atrial Fibrillation
Atrial Fibrillation After CABG and PCI
Atrial fibrillation (AF) is the most common arrhythmia seen in clinical practice and is associated with an increased risk of stroke, heart failure and death.
- Conditions
- Postoperative Atrial Fibrillation, Post PCI Atrial Fibrillation, Stroke, Oral Anticoagulation
- Trial name
- AFAF (NCT04307225)
- Testing
- Zenicor
- Where
- Sweden
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Region Örebro County
Atrial Fibrillation, Atrial Flutter
Detection of Atrial Fibrillation After Cardiac Surgery
The aim of the SEARCH-AF trial is to evaluate a novel diagnostic tool for detecting post-operative atrial fibrillation or flutter (POAF/AFL) in cardiac surgical subjects during the early, sub-acute post-operative period.
- Conditions
- Atrial Fibrillation, Atrial Flutter, C.Surgical Procedure; Cardiac, Arrhythmias, Cardiac
- Trial name
- SEARCH-AF (NCT02793895)
- Testing
- Medtronic SEEQ™ mobile cardiac telemetry system, Usual Care, CardioSTAT (Icentia Inc.) cardiac rhythm monitoring device
- Where
- 10 sites in Canada
- Volunteers
- 336 people
- Sponsor
- Unity Health Toronto
Coronary Artery Bypass Grafting, Postoperative Atrial Fibrillation
Once Versus Twice Bisoprolol Dosage Regimen in Prevention of Atrial Fibrillation Post Coronary Artery Bypass Graft Surgery
The goal of this interventional clinical trial is compare between two different dose regimens of bisoprolol (beta-blocker) in CABG patients in terms of efficacy and safety.
- Conditions
- Coronary Artery Bypass Grafting, Postoperative Atrial Fibrillation, Coronary Artery Disease
- Trial name
- NCT05730413
- Testing
- Bisoprolol
- Where
- Egypt
- Volunteers
- 122 people
- Sponsor
- Cairo University
Coronary Artery Disease, Low Cardiac Output Syndrome
Anesthesia Standard Operating Procedure During On-pump Coronary Artery Bypass Grafting
Background: Despite improvements in surgical and anesthesia procedures over the past 15 years complications during cardiac surgery still remain high. Bridgewater B et al.
- Conditions
- Coronary Artery Disease, Low Cardiac Output Syndrome, Atrial Fibrillation, Postoperative Complications
- Trial name
- NCT05514652
- Testing
- Low opioid anesthesia
- Where
- Ukraine
- Volunteers
- 120 people
- Sponsor
- Heart Institute, Ministry of Health of Ukraine