Clinical trials: Post-Traumatic Stress
Borderline Personality Disorder, Posttraumatic Stress Disorder
FKBP5 Methylation and Childhood Emotional Abuse in Complex Posttraumatic Stress Disorder: Investigating the Relationship and Its Predictive Role in Therapy Outcome
The aim of this study is to investigate the role FKBP5 DNA methylation levels in patients suffering from complex posttraumatic stress disorder, who participated in a 12-weeks disorder-specific DBT-PTSD inpatient treatment.
- Trial name
- NCT06433843
- Testing
- Dialectical behavioral therapy for the treatment of posttraumatic stress disorder (DBT-PTSD)
- Where
- Germany
- Volunteers
- 29 people
- Sponsor
- University Hospital Tuebingen
PTSD, Alcohol Use Disorder
Pharmacogenetic Treatment With Anti-Glutaminergic Agents for Comorbid PTSD & AUD
The primary study objective is to determine the efficacy of pregabalin administered orally for a period of 12 weeks in reducing risky drinking and symptoms of posttraumatic stress disorder who have selected genotypes at the…
- Trial name
- NCT02884908
- Testing
- Pregabalin plus BBCET
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- University of Maryland, Baltimore
PTSD, Stress Disorders, Post-Traumatic
Memory and the Hippocampus in Twins
The purpose of this project is to measure brain markers and cognitive factors in twins with a history of military service with and without PTSD, and to follow them over time and measure changes in brain function and cognitive…
- Trial name
- NCT00638885
- Where
- United States
- Volunteers
- 142 people
- Sponsor
- US Department of Veterans Affairs
Post Traumatic Stress Disorder
A Study to Assess the Use of Methylone in the Treatment of PTSD
This study is evaluating the safety, tolerability, and efficacy of methylone in adults with PTSD. The study will be conducted in two parts.
- Trial name
- IMPACT-1 (NCT05741710)
- Testing
- Methylone
- Where
- 16 sites in United States, Ireland and 1 more
- Volunteers
- 79 people
- Sponsor
- Transcend Therapeutics
Complex Post-Traumatic Stress Disorder, Post-traumatic Stress Disorder
Trauma-focused Psychodynamic Psychotherapy for LGBT Patients With Post-traumatic Stress Disorder
This is a pilot, open trial of trauma-focused psychodynamic psychotherapy for LGBT-identifying individuals who meet for DSM-5 defined post-traumatic stress disorder and are interested in receiving a research psychotherapy…
- Trial name
- NCT04532996
- Testing
- Trauma-focused psychodynamic psychotherapy
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Weill Medical College of Cornell University
Stress Disorders, Post-Traumatic
Mismatch vs. Standard Intervention During Memory Reconsolidation Blockade With Propranolol: Effect on Psychophysiological Reactivity During Traumatic Imagery
The proposed R21 project will attempt to further develop a novel intervention for posttraumatic stress symptoms inspired by the science of memory reconsolidation.
- Trial name
- NCT05853627
- Testing
- Memory reactivation procedures, Propranolol
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Massachusetts General Hospital
Depression, Physical Inactivity
Physical Exercise as Adjunctive Therapy for Affective Disorder and Anxiety
"Braining" is a clinical method for physical exercise as adjunctive therapy in psychiatric care. The core components are personnel-led group training sessions and motivating contact with psychiatric staff, as well as measurement…
- Conditions
- Depression, Physical Inactivity, Bipolar Disorder, Anxiety Disorders
- Trial name
- NCT05157386
- Testing
- Braining
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Region Stockholm
Neuropathic Pain, PTSD
The Effect of Outpatient Ketamine Infusion on Chronic Neuropathic Pain and PTSD
This study is aimed to evaluate outpatient ketamine infusion within a military chronic neuropathic pain population and its effect on PTSD. Currently, this is a pilot study with 30 participants.
- Trial name
- NCT06414356
- Testing
- Ketamine, Magnesium sulfate, Ketamine + Magnesium sulfate
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Margaux M. Salas, PhD
Post-Traumatic Stress Disorder
Neural Correlates of Cognitive Rehabilitation in Post-Traumatic Stress Disorder (PTSD)
Post Traumatic Stress Disorder (PTSD) is an emotional disorder that can also lead to problems with attention and memory. Cognitive training has been successfully used to improve attention and processing speed in other patient…
- Trial name
- NCT00928941
- Testing
- cognitive training, video game
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Major Depressive Disorder, Depression
Cognitive Training for Mood and Anxiety Disorders
The purpose of this study is to investigate the effects of a computerized cognitive training program (an attention and memory exercise performed on a computer) on thinking and memory in individuals with mood and anxiety…
- Conditions
- Major Depressive Disorder, Depression, Bipolar Disorder, Post-traumatic Stress Disorder
- Trial name
- NCT02256566
- Testing
- emotional memory training exercise, memory training exercise
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Posttraumatic Stress Disorder
Omega-3 Fatty Acids and Post Traumatic Stress Disorder (PTSD)
An increasing literature shows that omega-3 fatty acids provide numerous health benefits, including a variety of psychiatric symptoms and disorders including stress, anxiety, cognitive impairment, mood disorders (major depression…
- Trial name
- NCT00644423
- Testing
- Omega-3 Fatty Acid
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Durham VA Medical Center
PTSD (Childbirth-Related)
Preventing Childbirth-Related PTSD With Expressive Writing
The goal of this clinical trial is to test a brief psychological intervention given to individuals in the first days following childbirth who have experienced a potentially stressful childbirth.
- Trial name
- CARES (NCT05662423)
- Testing
- Expressive Writing about Childbirth, Neutral Writing
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Potential Treatment for Alcohol Dependence-Alcohol Interaction
Effects of Ethanol on the Pharmacokinetics of PT-150 (Formerly ORG34517) (PT150 PK Study)
The purpose of this clinical study is to assess pharmacokinetic interactions between ethanol (EtOH) and PT150 (900 mg qd) in non-treatment-seeking alcohol-experienced volunteers-(to include military service members, veterans…
- Trial name
- NCT04331288
- Testing
- PT150, Beverage
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Pop Test Oncology LLC
Stress Disorders, Post-Traumatic, Substance-Related Disorders
Mindfulness Meditation for the Treatment of Women With Comorbid PTSD and SUD
The current study will modify an already existing therapy for individuals with substance use disorders to address Post Traumatic Stress Disorder (PTSD) in women enrolled in substance use disorders (SUD) treatment who suffer with…
- Trial name
- NCT02755103
- Testing
- Mindfulness Based Relapse Prevention (MBRP)
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Medical University of South Carolina
Combat Disorders, Stress Disorders, Post-Traumatic
Quetiapine Augmentation for Treatment-resistant PTSD
The purpose of this study is to compare the response of veterans with PTSD without an optimal response to paroxetine to quetiapine augmentation versus placebo.
- Trial name
- NCT00292370
- Testing
- Open Label (OL) Paroxetine, Quetiapine
- Where
- 3 sites in United States
- Volunteers
- 124 people
- Sponsor
- VA Office of Research and Development
Post ICU Syndrome, Chronic Pain
Early Care Program for the Management of Post-ICU Syndrome and Chronic Pain After COVID-19 Infection.
COVID-19 (coronavirus 2019) disease has led to a large number of hospital admissions, many of which require admission to intensive care (ICU).
- Conditions
- Post ICU Syndrome, Chronic Pain, Covid-19
- Trial name
- PAIN-COVID (NCT04394169)
- Testing
- Intervention program
- Where
- Spain
- Volunteers
- 102 people
- Sponsor
- Hospital Clinic of Barcelona
ADHD, PTSD
Trauma-adapted Yoga in Child & Adolescent Psychiatry.
The goal of this randomized clinical trial is to evaluate the efficacy of trauma-adapted yoga as a complementary intervention to care as usual in child and adolescents psychiatry clinics, in the population of adolescents with the…
- Conditions
- ADHD, PTSD, Quality of Life, Self-Control
- Trial name
- TAY-CAP (NCT06330779)
- Testing
- Trauma-adapted yoga
- Where
- Sweden
- Volunteers
- 180 people
- Sponsor
- University West, Sweden
Post-Traumatic Stress Disorder, PTSD
Trauma-informed Psilocybin Assisted Psychotherapy (TiPAP) for PTSD
This is an open-label pilot study designed to evaluate the safety, tolerability, and preliminary clinical effects of psilocybin-enhanced trauma-focused psychotherapy in individuals with post-traumatic stress disorder (PTSD).
- Trial name
- TiPAP-PTSD (NCT07737054)
- Testing
- Psilocybin (drug), Trauma-Focused Psychotherapy
- Where
- Israel
- Volunteers
- 13 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
PTSD - Post Traumatic Stress Disorder, Depression Disorders
Empowering Narratives
Background: The Russian invasion of Ukraine has resulted in forced displacement, with over 80,000 Ukrainian refugees now residing in Norway.
- Conditions
- PTSD - Post Traumatic Stress Disorder, Depression Disorders, Dissociation, Refugee
- Trial name
- EN (NCT07062042)
- Testing
- Narrative Exposure Therapy
- Where
- Norway
- Volunteers
- 50 people
- Sponsor
- Kristiania University College
Borderline Personality Disorder, Stress Disorders, Post-Traumatic
Narrative Exposure Therapy in Women With Borderline Personality Disorder and Posttraumatic Stress Disorder
Narrative Exposure Therapy (NET) is an evidence-based trauma-focussed treatment, suitable for survivors of prolonged and repeated exposure to traumatic stress and childhood adversity.
- Trial name
- NCT02517723
- Testing
- Narrative Exposure Therapy, Dialectical Behavior Therapy, Standard Inpatient Care
- Where
- Germany
- Volunteers
- 67 people
- Sponsor
- Evangelisches Krankenhaus Bielefeld gGmbH