Clinical trials: Post-Operative Inflammation
Wounds and Injuries
Effect of Leukoreduced Blood Transfusions on Infection Following Trauma
The purpose of this study is to determine if leukoreduced blood transfusions reduce the risk of infection following trauma. Specifically, the investigators intend to evaluate whether there are clinically relevant differences in…
- Trial name
- NCT00135291
- Testing
- Leukoreduced blood transfusion
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Washington
Facial Swelling, Pain
Effects of Low-level Laser Therapy After Surgical Removal of Impacted Lower Third Molar
Goal: The aim of this study was to evaluate the effects of low-level laser (LLL) after surgical removal of impacted lower third molars (ILTM).
- Conditions
- Facial Swelling, Pain, Trismus
- Trial name
- NCT04280809
- Testing
- GaAlAs laser
- Where
- Vietnam
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
Breast Cancer, Postoperative Pain
Preoperative Sleep Quality and Postoperative Outcomes in Breast Surgery
Brief Summary: This prospective, single-center observational study examined the association between preoperative sleep quality and postoperative outcomes in women undergoing elective breast cancer surgery.
- Conditions
- Breast Cancer, Postoperative Pain, Inflammation
- Trial name
- NCT07547774
- Testing
- Preoperative Sleep Quality Assessment (PSQI)
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Patient Preference, Patient Outcomes
The PRIME Study: A Randomized, Controlled, Prospective Study
To investigate the outcomes of patients undergoing bilateral RLE surgery with treatment of dexamethasone intracanilicular insert compared to topical standard care steroid.
- Conditions
- Patient Preference, Patient Outcomes, Post-Operative Inflammation, Grade of Post-Operative Cystoid Macular Edema
- Trial name
- NCT04549935
- Testing
- Dextenza, Topical Prednisolone
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Vance Thompson Vision - MT
Incisional Hernia, Abdominal Hernia
Hernia Sac Flap Coverage of Mesh in Bony-Edged Ventral Hernia Repair
This trial asks whether covering the inner, bowel-facing surface of a hernia mesh with a flap of the patient's own hernia sac improves healing after repair of a complex ventral (abdominal wall) hernia in which one edge of the…
- Conditions
- Incisional Hernia, Abdominal Hernia, Complex Ventral Hernia, Surgical Site Infection
- Trial name
- PERI-SAC (NCT07720154)
- Testing
- Sac-flap peritonealization of the mesh, Retromuscular (sublay) synthetic mesh repair
- Where
- Egypt
- Volunteers
- 180 people
- Sponsor
- Minia University
POCD
Association Study Postoperative Cognitive Dysfunction Associated With Inflammation Polymorphism
This study use Loewenstein cognitive function rating scale to meet the standards of the elderly cognitive function assessment. POCD diagnostic criteria used is the recommended value Z current international law, in order to reduce…
- Trial name
- NCT02843152
- Where
- China
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- dengji wang
Carotid Artery Diseases, Carotid Artery Stenosis
A Lithium-Based Medication to Improve Neurological Outcomes After Surgical Carotid Reconstruction
There are 10.3 million cases of stroke registered in the world every year; 63% of them lead to death. According to World Health Organization, stroke is one of the most important risk factors of death and early disability.
- Trial name
- NCT05126238
- Testing
- Lithium Carbonate
- Where
- Russia
- Volunteers
- 107 people
- Sponsor
- Negovsky Reanimatology Research Institute
Colorectal Cancer
Inflammation Biomarkers in the Diagnosis of Postoperative Infectious Complications in Colorectal Cancer Surgery
This is a longitudinal, single-center, prospective study to determine the efficiency of WBC Count, CRP, PCT, Neutrophil CD64 and Monocyte Human Leukocyte Antigen- DR in the diagnosis of postoperative infectious complications in…
- Trial name
- NCT03559335
- Where
- Russia
- Volunteers
- 100 people
- Sponsor
- State Scientific Centre of Coloproctology, Russian Federation
Perianal Abscess, Perianal Infections
Packing of Perianal Abscess Cavities
The aim of this trial is to compare internal wound packing to no packing in postoperative management following incision and drainage of perianal abscess.
- Conditions
- Perianal Abscess, Perianal Infections, Peri Rectal Abscess, Abscess; Anus
- Trial name
- PPAC2 (NCT03315169)
- Testing
- External dressing, Packing of perianal abscess cavity
- Where
- 50 sites in United Kingdom
- Volunteers
- 433 people
- Sponsor
- Manchester University NHS Foundation Trust
Sepsis, Vasoplegia
Characterisation of Endothelial Cells in Different Inflammatory Pathologies
The goal of this observational study is to characterise changes in gene expression in endothelial cells in patients with either sepsis or post major abdominal surgery.
- Trial name
- JEDI-2 (NCT06613256)
- Testing
- Endothelial cell biopsy
- Where
- United Kingdom
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Royal Surrey County Hospital NHS Foundation Trust
Breast Implant-Associated Anaplastic Large Cell Lymphoma, Capsular Contracture, Implant
Breast-implant ASsocIated anaplastIc Large Cell Lymphoma and CApsular Contracture
BASILICA is a UK NIHR Biomedical Research Centre funded study recruiting patients at The Royal Marsden NHS Foundation Trust. The study aims to obtain blood and tissue samples from patients with breast implant-associated…
- Conditions
- Breast Implant-Associated Anaplastic Large Cell Lymphoma, Capsular Contracture, Implant, Breast Implant; Complications
- Trial name
- BASILICA (NCT05017337)
- Where
- 2 sites in United Kingdom
- Volunteers
- 100 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Delirium - Postoperative, Neuronal Damage
The Association Between Postoperative Inflammatory and Neurological Serum Biomarker Concentrations and Occurrence of Postoperative Delirium
Postoperative delirium is a frequent and serious complication in older surgical patients, linked to prolonged hospitalization and long-term cognitive decline.
- Conditions
- Delirium - Postoperative, Neuronal Damage, Blood Brain Barrier Defect, Postoperative Complications
- Trial name
- SPOT_ON_BRAIN (NCT07411612)
- Testing
- laboratory biomarker analysis, 3D-CAM/CAM-ICU
- Where
- Austria
- Volunteers
- 1,170 people
- Sponsor
- Medical University of Vienna
Serratus Posterior Superior Intercostal Plane Block (SPSIPB), Breast Cancer
Effects of SPSIP Block on Perioperative Inflammation and TLR4 in Breast Cancer Surgery
This study will investigate whether the serratus posterior superior intercostal plane (SPSIP) block improves postoperative recovery after breast cancer surgery. Participants will be randomly assigned to one of two groups.
- Conditions
- Serratus Posterior Superior Intercostal Plane Block (SPSIPB), Breast Cancer, Toll-Like Receptors
- Trial name
- SPSIP-TLR4 (NCT07843212)
- Testing
- Serratus posterior superior intercostal plane block
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Mucahide Emine Fidancı Kuas
Post Operative Pain, Inflammation
Postoperative Pain Assessment After Canal Preparation by Different NiTi File Systems
The participants were divided into two groups : group one ( Trunatomy file group)(n=10) was mechanically prepared the canals by Trunatomy file and group two ( Edgeendo x7 file group) ( n=10) was prepared the canals by Edgeendo x7…
- Trial name
- NCT06286995
- Testing
- Chemomechanical preparation for root canals
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Pulpal Inflammation
Assessment of Pain Using Two Different Irrigation Systems After Root Canal Treatment
assessment of pain using two different irrigation systems after root canal treatment
- Trial name
- NCT07108842
- Testing
- Conventional Needle Irrigation, Conventional Needle Irrigation (Control Group), endoactivator
- Where
- Pakistan
- Volunteers
- 82 people
- Sponsor
- HITEC-Institute of Medical Sciences
Pneumonia, Bloodstream Infection
Clinical Outcomes in Patients With Infection by Resistant Microorganism
The goal of this individual patient data meta-analysis is to estimate the attributed and the associated health burden related to bloodstream infections, pneumonia, skin and soft tissue infections, surgical site infections and…
- Conditions
- Pneumonia, Bloodstream Infection, Urinary Tract Infections, Skin Infection
- Trial name
- NCT05880069
- Testing
- Pathogen resistant phenotype
- Where
- Spain
- Volunteers
- 5,000 people
- Sponsor
- Hospital Universitario Virgen Macarena
Vitreo-Retinal Surgery
DEXTENZA for the Treatment of Postoperative Pain and Inflammation Following Vitreo-retinal Surgery
The purpose of this study is to evaluate efficacy and safety of Dextenza for the treatment of postoperative pain and inflammation following vitreo-retinal surgery
- Trial name
- NCT04462523
- Testing
- Dextenza 0.4Mg Ophthalmic Insert, Topical Prednisolone
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Patrick R. Oellers, MD
Post Lasik Surgery Inflammation
Efficacy/Safety of Antibiotic Steroid Combination in Prevention of Post Operative Inflammation in LASIK Surgery
Efficacy/Safety of antibiotic steroid combination compared with individual administration in inflammation Post-LASIK
- Trial name
- NCT00330824
- Testing
- antibiotic/steroid combination, moxifloxacin/dexamethasone
- Where
- Brazil
- Volunteers
- 64 people
- Sponsor
- Federal University of São Paulo
Postoperative Complications
Integrating Data, Algorithms and Clinical Reasoning for Surgical Risk Assessment
Brief Summary: The goal of this study is to implement and test an intelligent perioperative system (IPS) that in real-time predicts risk for postoperative complications using routine clinical data collected in electronic health…
- Trial name
- IDEALIST (NCT02741986)
- Testing
- Risk estimation
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- University of Florida
Intravenous Lidocaine and Immunity
Impact of Intravenous Lidocaine During Colorectal Surgery on Pain and Immune Functions
This study evaluates the impact of intraoperative intravenous lidocaine administered during laparoscopic colorectal surgery on the intraoperative remifentanil consumption as well as postoperative pain and opioid requirements.
- Trial name
- NCT03410836
- Testing
- intravenous lidocaine (IVL)
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Ciusss de L'Est de l'Île de Montréal