Clinical trials: Post-Operative Confusion
Postoperative Delirium
Association Between Burst Suppression During Anesthetic Induction With Postoperative Delirium in Cardiac Surgery
The population over 65 years of age will be increasingly exposed to surgical procedures that require general anesthesia. Postoperative delirium is one of the main causes of preventable postoperative morbidity in the elderly…
- Trial name
- NCT04713644
- Testing
- Standardized Propofol Administration
- Where
- Chile
- Volunteers
- 78 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Remimazolam, Emergence Delirium
Remimazolam for Emergence Delirium Prevention in Patients Undergoing Rhinoseptoplasty, FESS or Septoplasty
The aim of this research is to confirm the effectiveness of remimazolam in preventing delirium during recovery from anesthesia in adult patients who have undergone one of the rhinological surgeries (septoplasty, rhinoseptoplasty…
- Conditions
- Remimazolam, Emergence Delirium, Rhinoplasty
- Trial name
- NCT06398275
- Testing
- Remimazolam 20 MG Injection [Byfavo], NaCl 0.9%
- Where
- Croatia
- Volunteers
- 80 people
- Sponsor
- University Hospital of Split
Postoperative Delirium, Postoperative Cognitive Dysfunction
Trajectory of Neuroinflammatory Markers in Cerebrospinal Fluid Prior to and After Thoracic Aortic Surgery
Observational prospective pilot study to analyze the trajectory of neuroinflammatory protein expression in cerebrospinal fluid (CSF) in relation to systemic compartment in patients undergoing thoracic aortic surgery.
- Conditions
- Postoperative Delirium, Postoperative Cognitive Dysfunction, Thoracic Aortic Aneurysm
- Trial name
- TURBO (NCT04523909)
- Testing
- Trajectory of neuroinflammatory proteins in CSF and blood
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- Radboud University Medical Center
Delirium
Validation of a Delirium Monitor
Delirium is a common disorder in hospitalized patients, nevertheless it is poorly recognized by physicians and nurses, even when screening instruments are used.
- Trial name
- NCT02404181
- Where
- Netherlands
- Volunteers
- 159 people
- Sponsor
- UMC Utrecht
Delirium, Dexmedetomidine, Postoperative PCA
Dexmedetomidine and Delirium in Elderly Patients
Investigators investigates the effect of perioperative dexmedetomidine 0.5 ug/kg/hr followed by a postoperative continuous infusion fentanyl-based PCA(Patient-Controlled Analgesia) drug mixed with dexmedetomidine 0.2ug/kg/hr for…
- Trial name
- NCT03938831
- Testing
- Dexmedetomidine, Fentanyl-based PCA infusion
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Korea University Guro Hospital
Anesthesia, Delirium
Anesthesia Depth Increases the Degree of Postoperative Dementia, Delirium, and Cognitive Dysfunction
Anesthetics and anesthesia are suspicious to induce dementia or aggravate preexistent cognitive deficits with or without evoking postoperative delirium.
- Conditions
- Anesthesia, Delirium, Dementia, Bispectral Index Monitor
- Trial name
- BIS & Dementia (NCT02382445)
- Testing
- Anesthesia depth monitor, propofol and sevoflurane
- Where
- Germany
- Volunteers
- 138 people
- Sponsor
- Heidelberg University
Postoperative Delirium, Postoperative Cognitive Dysfunction
Risk Factor of POD and POCD After Cardiac Surgery
Postoperative delirium (POD) and postoperative cognitive decline (POCD) are common after surgeries in the elderly, especially after cardiothoracic surgery.
- Trial name
- NCT03635229
- Where
- Thailand
- Volunteers
- 360 people
- Sponsor
- Mahidol University
Strabismus
Anesthetic Depth and the Incidence of Emergence Agitation in Children Undergoing Strabismus Surgery
This study evaluates the association between the depth of general anesthesia and the occurrence of emergence agitation (EA). The investigators hypothesized that optimal level of anesthetic depth could decrease the incidence of EA…
- Trial name
- NCT02521259
- Testing
- BIS
- Where
- South Korea
- Volunteers
- 68 people
- Sponsor
- Seoul National University Bundang Hospital
Agitation, Anesthesia
Use of Dexmedetomidine to Reduce Emergence Delirium Incident in Children
Emergence delirium (ED) from general anesthesia posts risk and harm to pediatric population undergo general anesthesia. The purpose of the study is to compare the use of dexmedetomidine versus placebo in reducing the incidence…
- Conditions
- Agitation, Anesthesia, Pediatrics
- Trial name
- DexPeds (NCT00857727)
- Testing
- Dexmedetomidine, Saline
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- St. Luke's-Roosevelt Hospital Center
Delirium
Cerebral Blood Flow During CPB During Cardiac Surgery and the Presence of Post op Delirium
Cardiac surgery is associated with multiple events and issues that increase risk for adverse postoperative neurological outcomes including postoperative cognitive dysfunction.
- Trial name
- NCT02084394
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Johns Hopkins University
Postoperative Delirium, Postoperative Cognitive Dysfunction
Ketamine and Dexmedetomidine for Delirium in Joint Arthroplasty
This prospective, randomized, double-blind, placebo-controlled clinical trial aims to evaluate the effects of intraoperative ketamine and dexmedetomidine on the incidence of postoperative delirium (POD) and postoperative…
- Trial name
- NCT06963294
- Testing
- Ketamine
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Istinye University
Anesthesia, Postoperative Delirium
STimulation Electronically of Acupoints for Postoperative Delirium in elderlY Patients
Transcutaneous electrical acupoint stimulation (TEAS) was reported to benefit the patients undergoing surgeries by reducing anesthetics consumption and decreasing anesthesia related adverse effects.
- Conditions
- Anesthesia, Postoperative Delirium, Electroencephalogram
- Trial name
- STEADY (NCT06161662)
- Testing
- transcutaneous electrical acupoint stimulation, Control
- Where
- China
- Volunteers
- 226 people
- Sponsor
- Zhihong LU
Delirium, Cardiac Surgery
Neuroinflammation and Postoperative Delirium in Cardiac Surgery
Up to 50% of patients over 60 years old develop postoperative delirium following cardiac surgery. Delirium increases morbidity and mortality, and may lead to long-term cognitive impairment similar to patients with a diagnosis of…
- Trial name
- NCT02688179
- Where
- United States
- Volunteers
- 630 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Pain, Postoperative, Delirium
Study to Determine if Pre- and Post- Operative TAP Catheters With Ropivacaine Versus Placebo Affects Anesthetic, Narcotic Dosing, and Pain Scores
A randomized controlled trial to determine if pre- and post- operative regional pain control (transversus abdominis plane block) with ropivacaine versus placebo leads to lower anesthetic and narcotic dosing, and alters pain…
- Conditions
- Pain, Postoperative, Delirium, Anesthesia, Local
- Trial name
- TAP RCT (NCT03149783)
- Testing
- Ropivacaine HCL, sodium chloride
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Colorado, Denver
Anesthesia Emergence Delirium
Dexmedetomidine Versus Ketamine Versus Magnesium Sulfate for the Prevention of Emergence Agitation Following Sevoflurane Induced Anesthesia in Cardiac Catheterization in Pediatrics
Emergence agitation (EA) is a post-operative behavioral disturbance was first reported in early 1960s. EA is a term used to describe non purposeful restlessness and agitation, thrashing, crying or moaning, disorientation and…
- Trial name
- NCT06077539
- Testing
- Dexmedetomidine, Ketamine, Magnesium
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Cairo University
Prostate Cancer, Carcinoma of the Rectum
Minocycline Attenuate Postoperative Cognitive Dysfunction and Delirium
Postoperative cognitive dysfunction (POCD) and postoperative delirium occurs mainly in aged patients. POCD and POD may increase the mortality and morbidity.
- Conditions
- Prostate Cancer, Carcinoma of the Rectum, Colon Cancer, Renal Carcinoma
- Trial name
- MAPOCD (NCT02928692)
- Testing
- Minocycline
- Where
- 5 sites in China
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- RenJi Hospital
Emergence Delirium in Pediatric Anesthesia, Perioperative Ketonemia and Its Association With Recovery Outcomes in Children
"KETOMED: Ketonemia and Risk of Emergence Delirium in Children Undergoing General Anesthesia - A Multicenter Observational Study"
The objective of this observational study is to evaluate the relationship between ketonemia and emergence delirium in children undergoing general anesthesia.
- Trial name
- KETOMED (NCT07249736)
- Where
- Spain
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Hospital Clínico Universitario de Valladolid
Delirium, Postoperative
Effectiveness of Delirium Care Protocol After Cardiac Surgery
This study was conducted as a quasi-experimental study to determine the effectiveness of the postoperative delirium prevention, diagnosis and intervention protocol in patients monitored in the intensive care unit after cardiac…
- Trial name
- NCT06268119
- Testing
- training nurses and caring for patients to prevent, diagnose, and intervene in postoperative delirium.
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Gonul Kara Soylemez
Pain, Postoperative
Transversus Abdominis Plane Block in Iliac Crest harvest-is it Beneficial?
The purpose of this study is to determine whether a supplemental Transversus Abdominis Plane block administered intraoperatively improves the postoperative parameters in patients undergoing Alveolar bone grafting with iliac crest…
- Trial name
- NCT02997124
- Testing
- local infiltration and TAP block, local infiltration only
- Volunteers
- 143 people
- Sponsor
- Jubilee Mission Medical College and Research Institute
Hearing Loss, Hearing Loss, Age-Related
Sight and Hearing Investigation Into Effects on Delirium
The goal of this observational study is to learn about sensory loss in hospital patients with delirium. The main questions it aims to answer are: Are hearing and vision loss related to increased risk of having delirium? Do…
- Conditions
- Hearing Loss, Hearing Loss, Age-Related, Hearing Disability, Delirium
- Trial name
- SHIELD (NCT06176625)
- Testing
- Communication Signage, Amplifier Use
- Where
- United States
- Volunteers
- 1,543 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University