Clinical trials: Post-Operative Cognitive Dysfunction
Surgery, Postoperative Cognitive Dysfunction
Five Years Follow-up of Neurological Outcome After Minimally Invasive Cardiac Surgery
A monocenter observational study will be started to investigate postoperative cognitive dysfunction 5 years after minimally invasive cardiac surgery.
- Trial name
- FUNOMICS (NCT05330260)
- Testing
- neurocognitive test battery
- Where
- Belgium
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Jessa Hospital
Cognitive Dysfunction
Use of Electrophysiological Markers to Predict Post-operative Cognitive Dysfunction
As the population ages and medical progress is made, many elderly patients that previously would not have been candidates for surgery are now undergoing operations.
- Trial name
- NCT04512989
- Testing
- Cognitive assesment using MOCA test
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Postoperative Cognitive Dysfunction
Postoperative Cognitive Dysfunction After Total Knee or Hip Replacement Surgery in Fast-track Set-up
The aim of this study is to quantify the incidence of postoperative cognitive dysfunction in the elderly patient (>60y) after total hip or knee replacement surgery.
- Trial name
- NCT01103752
- Testing
- no intervention, descriptive study
- Where
- Denmark
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- Lene Krenk
Anesthesia, Neuroinflammation
Neuroinflammatory Biomarkers After General Anesthesia: A Comparison Study
This prospective, observational study investigates the impact of repeated general anesthesia exposure on neuroinflammatory biomarkers and neurotrophic factors.
- Conditions
- Anesthesia, Neuroinflammation, Cognitive Disorders
- Trial name
- NCT07388160
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Health Sciences Balikesir Hospital Eduation and Research
Cognitive Dysfunction, Emergence Delirium
Effects of Hypothermia on Delayed Neurocognitive Recovery (DNR): an Observational Trial Among Patients Undergoing Cardiac-Surgery
Post-operative cognitive dysfunction is a common disease in patient undergoing general anaesthesia, especially in older patients.
- Conditions
- Cognitive Dysfunction, Emergence Delirium, Hypothermia
- Trial name
- DNR (NCT03636074)
- Testing
- Hypothermia during Extracorporeal Circulation
- Where
- Italy
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- University of Padova
Cardiac Surgery, Postoperative Cognitive Dysfunction
The Effects of Dexmedetomidine on Postoperative Cognitive Function in Open Heart Surgery
To assess the impact of Dexmedetomidine on postoperative cognitive function and serum Neuron Specific Enolase levels as an indicator of neuronal injury in patients undergoing open heart surgery
- Conditions
- Cardiac Surgery, Postoperative Cognitive Dysfunction, Neurologic Manifestations
- Trial name
- NCT06655025
- Testing
- Dexmedetomidine
- Where
- Egypt
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Sohag University
Post Operative Cognitive Dysfunction
Sugammadex and Cognitive Function
Post operative cognitive dysfunction (POCD) is recognized as a frequent complication after both cardiac and non cardiac surgery, affecting approximately 1/3 of the patients.
- Trial name
- NCT02419352
- Testing
- Sugammadex, Neostigmine/atropine
- Where
- Greece
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Attikon Hospital
Delirium
Rate of Postoperative Delirium and Postoperative Cognitive Dysfunction After Spinal Anesthesia
The aim of this investigation is to compare the standard of general anesthesia used in these patients with these short-acting local anesthetics (Chloroprocain (Ampres®) and Prilocain (Takipril®)) for spinal anesthesia as well as…
- Trial name
- NCT03715244
- Testing
- Spinal anesthesia with short-acting local anesthetics, General anesthesia (current standard)
- Where
- Germany
- Volunteers
- 237 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Postoperative Cognitive Dysfunction
Retrospective Evaluation of POCD Data of Studies From KAI, Charité - Universitätsmedizin Berlin
Data on prevention of perioperative neurocognitive disorders (pNCDs) are limited. The purpose of this monocentric parallel - grouped observational registry is to collect study data from studies with pNCDs as primary or secondary…
- Trial name
- NCT02832193
- Where
- 2 sites in Germany
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
POCD
Association Study Postoperative Cognitive Dysfunction Associated With Inflammation Polymorphism
This study use Loewenstein cognitive function rating scale to meet the standards of the elderly cognitive function assessment. POCD diagnostic criteria used is the recommended value Z current international law, in order to reduce…
- Trial name
- NCT02843152
- Where
- China
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- dengji wang
Melatonin, Cognitive Dysfunction
Use of Melatonin for Preventing POCD in Transurethral Prostate Resection Under Spinal Anesthesia
This study aims to evaluate the possible effect of melatonin on prevention of cognitive dysfunction in the postoperative period of elderly patients undergoing transurethral resection of the prostate (TURP) under spinal anesthesia
- Conditions
- Melatonin, Cognitive Dysfunction, Postoperative Complications, Prostate Hyperplasia
- Trial name
- NCT03966950
- Testing
- melatonin
- Where
- Brazil
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
PND, POCD - Postoperative Cognitive Dysfunction
Effects of Ciprofol on Perioperative Neurocognitive Function in Elderly Patients Undergoing Daytime Surgery
As life expectancy increases, the rate of disability among elderly individuals is also rising. Elderly patients undergoing home-based rehabilitation after surgery without medical supervision may experience complications and…
- Trial name
- NCT07895407
- Testing
- Ciprofol, propofol
- Where
- China
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Post Operative Cognitive Dysfunction
Effect of Preoperative Hospitalization Duration on Post-operative Cognitive Dysfunction
Post-operative cognitive dysfunction is defined as a decrease in cognitive functions which develop following surgery and anesthesia administration that can last up to weeks or even months after surgery.
- Trial name
- NCT03290599
- Testing
- Mini Mental and Modified Mini Mental Test
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Burcu Ozalp Horsanali
Postoperative Cognitive Dysfunction, Postoperative Delirium
Study of Depressive Symptoms Predicting Postoperative Cognitive Dysfunction
Postoperative cognitive dysfunction (POCD) describes a condition where cognitive functions such as attention, perception, concentration, learning, abstract thinking and problem solving are impaired postoperatively.
- Conditions
- Postoperative Cognitive Dysfunction, Postoperative Delirium, Depressive Symptoms
- Trial name
- DeprPOCD (NCT02210312)
- Where
- Germany
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Postoperative Cognitive Dysfunction, Acute Postoperative Pain
Effect of TPVB on Postoperative Pain and Cognitive Function After VATS in Elderly Patients
To investigate the effect of ultrasound-guided thoracic paravertebral nerve block on postoperative acute and chronic pain and cognitive function in elderly patients with thoracoscopic partial lung resection.
- Conditions
- Postoperative Cognitive Dysfunction, Acute Postoperative Pain, Chronic Postsurgical Pain
- Trial name
- NCT05364216
- Testing
- Measurement of cognitive function, Thoracic paravertebral block, The assessment of cognitive function
- Where
- China
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- The First Hospital of Qinhuangdao
Delirium, Cognitive Impairment
Preoperative BAMCOG and Cortisol and Postoperative DeltaScan in AVR Patients (Aortic Valve Replacement)
There is lack of attention to preoperative cognitive function and delirium in elderly who underwent surgery. The investigators are investigating different tools that can help to screen for cognitive dysfunction and delirium in…
- Conditions
- Delirium, Cognitive Impairment, Cognitive Dysfunction, Cognitive Dysfunction, Postoperative
- Trial name
- NCT05209555
- Testing
- MoCA, BAMCOG, DeltaScan
- Where
- Netherlands
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Catharina Ziekenhuis Eindhoven
POSTOPERATIVE DELIRIUM AND POSTOPERATIVE COGNITIVE DECLINE
INVESTIGATE THE ASSOCIATION BETWEEN VIRAL NEUROTOXIC INFECTION AND POSTOPERATIVE DELIRIUM AND POSTOPERATIVE COGNITIVE DECLINE
In the last two decades, viral infections have increased dramatically : the 2003 severe acute respiratory syndrome coronavirus outbreak, the 2009 swine flu pandemic, the 2012 Middle East respiratory syndrome coronavirus outbreak…
- Trial name
- CONNECTED (NCT05806827)
- Testing
- Virological screening
- Volunteers
- 1,685 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Postoperative Cognitive Dysfunction
Effect of Sedation on Cognitive Performance in the Elderly
The main goal of this study is to allow the anesthesiologist to make a more informed decision about the anesthetic requirement of a person prior to starting anesthesia.
- Trial name
- NCT03089866
- Testing
- Midazolam (0.02mg/kg)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham