Clinical trials: Post-Concussion Syndrome
Brain Concussion, Mild Traumatic Brain Injury
Repetitive Transcranial Magnetic Stimulation for Post-concussion Headaches
This study aims to examine the long-term effect of repetitive transcranial magnetic stimulation (rTMS), a non-invasive brain stimulation technique, on chronic headaches following mild traumatic brain injury (mTBI).
- Conditions
- Brain Concussion, Mild Traumatic Brain Injury, Headache, Post-Concussion Symptoms
- Trial name
- NCT06112093
- Testing
- Repetitive Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- State University of New York - Upstate Medical University
Brain Concussion, Post-Concussion Syndrome
Investigating the Physiological, Cognitive, and Psychological Effects of a Cognitive-Based Intervention
The primary purpose of this study is to investigate the effectiveness of a brief mindfulness-based intervention for targeting chronic physiological underarousal and post-concussive symptoms following a mild head injury (MHI), as…
- Trial name
- IPCPE-Mind (NCT02906449)
- Testing
- Meditation Technique
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Brock University
Mild Traumatic Brain Injury
BLOOD BIOMARKERS in PAEDIATRIC MTBI
The goal of this observational study is to identify blood biomarkers that could help in the management of paediatric patients with mild TBI. The main questions it aims to answer are: 1.
- Trial name
- t-BIOMAP (NCT06233851)
- Where
- Switzerland
- Volunteers
- 600 people
- Sponsor
- Pediatric Clinical Research Platform
Post Concussion Symptoms
Evaluating Altius Tinted Contact Lenses as an Option Managing for Post-Concussion Visual Syndrome
This pilot study evaluates whether ALTIUS® daily disposable performance-tinted contact lenses provide symptom relief comparable to tinted spectacle lenses in adults with post-concussion visual syndrome.
- Trial name
- NCT07869927
- Testing
- ALTIUS® daily disposable performance-tinted contact lenses
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Southern College of Optometry
Concussion Post Syndrome
Blood Flow Restriction Concussion
The purpose of this study is to examine the effect that blood flow restriction training will have on patients with concussion who demonstrate an intolerance to physical activity.
- Trial name
- NCT03695042
- Testing
- Blood Flow Restriction Training with Exercise
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Duke University
Traumatic Brain Injury, Post-Concussive Symptoms
Role of NSI in Differentiating Between Mild Traumatic Brain Injury And Behavioral Health Conditions
The purpose of this study is to examine differences in post-concussive (PC) symptom endorsement among four groups of Operation Enduring Freedom (OEF)/Operation Iraqi Freedom (OIF) Veterans: those with a history of target…
- Conditions
- Traumatic Brain Injury, Post-Concussive Symptoms, Post-Traumatic Stress Disorder
- Trial name
- NCT01502839
- Testing
- No Intervention
- Where
- United States
- Volunteers
- 887 people
- Sponsor
- VA Eastern Colorado Health Care System
Traumatic Brain Injury With Brief Loss of Consciousness, Post-Concussion Syndrome
mTBI Mechanisms of Action of HBO2 for Persistent Post-Concussive Symptoms
Purpose of this study is to investigate the mechanisms of action of hyperbaric oxygen therapy for persistent post-concussive symptoms after mild tramatic brain injury
- Trial name
- BIMA (NCT01611194)
- Testing
- Hyperbaric oxygen (HBO2) at 1.5 atms
- Where
- 5 sites in United States
- Volunteers
- 71 people
- Sponsor
- U.S. Army Medical Research and Development Command
Post-Concussive Syndrome, Chronic, Post-Concussion Syndrome
Impact of Photobiomodulation on Objective, Physiological Measures of Brain Function in Individuals With Post-Concussion Syndrome
Photobiomodulation therapy (PBMT) uses light to influence the mitochondria of cells. PBMT of the brain enhances the metabolic capacity of neurons and stimulates anti-inflammatory, anti-apoptotic, and antioxidant responses, as…
- Conditions
- Post-Concussive Syndrome, Chronic, Post-Concussion Syndrome, Mild Traumatic Brain Injury
- Trial name
- NCT05097222
- Testing
- BioFlex Dualport System
- Where
- 2 sites in Canada
- Volunteers
- 19 people
- Sponsor
- Dr George Medvedev
Post-Concussion Syndrome
Interest of the 7 Tesla MRI in the Diagnosis of Post-concussion Syndromes Among Patients With Mild Traumatic Brain Injury
We aimed to conduct a prospective longitudinal interventionnal monocentric study to assess the ability of seven tesla MRI to detect diffuses axonal lesions in patients presenting a post concussional syndrom (PCS) at seven days…
- Trial name
- SPIN (NCT04982562)
- Testing
- 7T MRI
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Poitiers University Hospital
Concussions, Mild Traumatic Brain Injury, Concussion
Mindfulness-Based Intervention for Pediatric Mild Traumatic Brain Injury
Formal MBIs, such as Mindfulness-Based Stress Reduction (MBSR), have been shown to increase resiliency and teach affect regulation.
- Conditions
- Concussions, Mild Traumatic Brain Injury, Concussion, Concussion Mild
- Trial name
- MBI-4-mTBI (NCT07272941)
- Testing
- Mindfulness Based Intervention (MBI)
- Where
- 5 sites in Canada
- Volunteers
- 362 people
- Sponsor
- Children's Hospital of Eastern Ontario
Post-Concussion Syndrome, Post-Traumatic Headache
Aerobic Exercise and Cognitive Training Effects on Postconcussive Symptomology
The purpose of this study is to compare a 4-week, moderately intensive, lab and home-based aerobic exercise program versus exercise plus cognitive training.
- Conditions
- Post-Concussion Syndrome, Post-Traumatic Headache, Post-Concussive Syndrome, Chronic, Head Injury
- Trial name
- NCT03674398
- Testing
- Exercise+CT, Exercise only
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Concussion, Post-concussion Syndrome
Aerobic Training for Management of Post-Concussion Syndrome in Adolescents
Sports-related concussions are common in adolescent-athletes. Prolonged recovery after concussion or post-concussion syndrome (PCS) is a public health problem.
- Conditions
- Concussion, Post-concussion Syndrome, Sports Injury
- Trial name
- NCT02035579
- Testing
- Aerobic Training Intervention, Stretching Intervention
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Headache, Migraine, Persistent Post Traumatic Headache
Validating a Modified COMPASS 31questionnaire for Treatment Outcomes
Eligible participants will complete the COMPASS 31 (year), modified COMPASS 31(one month) and the NSI (one month) questionnaires at baseline and complete the modified COMPASS 31 and the NSI after usual care of treatment.
- Conditions
- Headache, Migraine, Persistent Post Traumatic Headache, Cervicogenic Headache
- Trial name
- COMPASS (NCT05302479)
- Testing
- COMPASS 31 questionnaire
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Brooke Army Medical Center
Headache, Post-Concussion Syndrome
The Effectiveness of Osteopathic Manipulative Medicine in the Management of Headaches Associated With Post Concussion Syndrome
Pilot study looking at the Osteopathic Manipulative Treatment (OMT) for various headache types in patients with post-concussion syndrome (PCS).
- Trial name
- NCT04732338
- Testing
- Osteopathic Manipulative Therapy
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Hackensack Meridian Health
Transcranial Magnetic Stimulation, Functional Near-Infrared Spectroscopy
Treatment of Post-concussion Syndrome With TMS: Using FNIRS as a Biomarker of Response
Every year, approximately 2 million people in the United States and 280,000 in Canada experience a mild traumatic brain injury/concussion.
- Conditions
- Transcranial Magnetic Stimulation, Functional Near-Infrared Spectroscopy, Post-Concussion Syndrome, Concussion
- Trial name
- NCT04568369
- Testing
- rTMS
- Where
- Canada
- Volunteers
- 91 people
- Sponsor
- University of Calgary
Post-Concussion Syndrome, Concussion, Brain
Personalized Brain Stimulation to Treat Chronic Concussive Symptoms
The goal of this study is to investigate a new treatment for chronic symptoms after concussion or mild traumatic brain injury in people aged 18-65 years old.
- Conditions
- Post-Concussion Syndrome, Concussion, Brain, Mild Traumatic Brain Injury, Head Injury
- Trial name
- NCT06073886
- Testing
- Active cTBS, Imaginal exposure
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of California, Los Angeles
Brain Concussion, Post-Concussion Symptoms
Use of Salt-Water Solution to Improve Symptoms in Concussion
The purpose of this study is to find out if 3% hypertonic saline (salt-water solution) given in a vein improves the headache that may be caused by a concussion.
- Trial name
- NCT00142090
- Testing
- 3% Hypertonic saline
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Rady Children's Hospital, San Diego
Patients With Persistent Post-concussion Symptoms
Electroencephalography Markers of Brain Stimulation in Post-Concussion Patients
In this randomized, sham-controlled, two-group, parallel, single-session study, the investigators aim to identify EEG biomarkers associated with cerebellar transcranial direct current stimulation (tDCS) in patients with…
- Trial name
- Stim-PPCS (NCT07895797)
- Testing
- tDCS 8 channels
- Where
- Belgium
- Volunteers
- 38 people
- Sponsor
- University of Liege
Traumatic Brain Injury, PTSD
An Investigation of the Biological and Neuronal Mechanisms of Post Traumatic Stress Disorder, Depression and Post-Concussive Syndrome Onset Following a Traumatic Brain Injury
Background: A traumatic brain injury (TBI) could mean a person is at high risk for other long-lasting problems. These problems could include post-traumatic stress disorder (PTSD), depression, and post-concussive syndrome (PCS).
- Conditions
- Traumatic Brain Injury, PTSD, Depression
- Trial name
- NCT02019654
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- National Institute of Nursing Research (NINR)
Concussion, Sport-Related Concussion
Trial Study of an Exercise Program for Youth With Persistent Symptoms After Concussion
The purpose of this randomized control trial study is to determine if an active rehabilitation (low intensity exercise program) in combination with a comprehensive education intervention (standard care) is more effective than the…
- Conditions
- Concussion, Sport-Related Concussion, Mild Traumatic Brain Injury
- Trial name
- NCT02257749
- Testing
- Active Rehabilitation, Comprehensive Education Intervention (Standard Care)
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- Holland Bloorview Kids Rehabilitation Hospital