Clinical trials: Post Traumatic Stress Disorder
Posttraumatic Stress Disorder
TOP Implementation Project
The Veterans Health Administration (VHA) provides care to 3.3 million Veterans living in rural areas, comprising 36% of all VHA enrollees.
- Trial name
- NCT02737098
- Testing
- Enhanced Implementation Strategy, Standard Implementation Strategy
- Where
- 6 sites in United States
- Volunteers
- 544 people
- Sponsor
- VA Office of Research and Development
Post-traumatic Stress Disorder
A mGlu2/3 Agonist in the Treatment of PTSD
In this study, we propose to employ a randomized, double-blind, placebo-controlled, outpatient clinical trial to test the efficacy, safety, and tolerability of a 160 mg and 40 mg challenge of the mGlu2/3 agonist pomaglumetad…
- Trial name
- NCT02234687
- Testing
- Pomaglumetad Methionil 160mg, Pomaglumetad Methionil 40mg
- Volunteers
- 10 people
- Sponsor
- NYU Langone Health
Posttraumatic Stress Disorder
Study of Safety and Effects of MDMA-assisted Psychotherapy for Treatment of PTSD (Canada)
The goal of this clinical trial is to learn if MDMA-assisted therapy is safe and effective at reducing PTSD symptoms in people with at least severe PTSD.
- Trial name
- NCT03485287
- Testing
- Midomafetamine HCl, Manualized therapy
- Where
- 2 sites in Canada
- Volunteers
- 4 people
- Sponsor
- Resilient Pharmaceuticals
Post Traumatic Stress Disorder, Major Depressive Disorder
Accelerated TMS to a Novel Brain Target in MDD and PTSD
This is a Clinical Trial designed to evaluate novel transcranial magnetic stimulation (TMS) methods for treating depression/PTSD. TMS is an FDA-approved procedure for treatment-resistant depression.
- Trial name
- NCT03114891
- Testing
- Transcranial Magnetic Stimulation (TMS), Task, fMRI-guided TMS target
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Pennsylvania
Brain Injury, Chronic
Treatment of Traumatic Brain Injury With Hyperbaric Oxygen Therapy
The purpose of this study is to determine if hyperbaric oxygen therapy (HBOT) improves the cognitive function of OIF/OEF individuals who have chronic mild to moderate traumatic brain injury (TBI).
- Trial name
- NCT00810615
- Testing
- Hyperbaric oxygen @ 2.4 ATA
- Volunteers
- 50 people
- Sponsor
- San Antonio Military Medical Center
Chronic Pain, Traumatic Brain Injury
Establishing Efficacy of a Functional-Restoration Based CAM Pain Management Program in Post-9/11 Veterans
This is a research study of an interdisciplinary pain management program for U.S. military veterans who served during the post-9/11 combat eras (e.g., Operations Iraqi Freedom [OIF], Enduring Freedom [OEF], New Dawn [OND])…
- Conditions
- Chronic Pain, Traumatic Brain Injury, Posttraumatic Stress Disorder, Depression
- Trial name
- NCT02657317
- Testing
- FORT-A, VA Treatment as Usual
- Where
- United States
- Volunteers
- 103 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Posttraumatic Stress Disorder
Enhancement of PTSD Treatment With Computerized Executive Function Training
This study focuses on helping Iraq and Afghanistan Veterans with posttraumatic stress disorder (PTSD) benefit fully from therapy by first enhancing their thinking abilities.
- Trial name
- NCT03260127
- Testing
- Computerized executive function training plus CPT (CEFT-CPT), Word game training plus CPT (WT-CPT)
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- VA Office of Research and Development
PTSD, Overweight
MOVE!+UP: Testing a Tailored Weight Management Program for Veterans With PTSD
Posttraumatic Stress Disorder (PTSD) is common among Veterans and results in poor psychological functioning, quality of life, and physical health.
- Conditions
- PTSD, Overweight, Obesity
- Trial name
- NCT04563741
- Testing
- MOVE!+UP, MOVE!
- Where
- United States
- Volunteers
- 174 people
- Sponsor
- VA Office of Research and Development
Posttraumatic Stress Disorder
A Controlled Trial of Losartan in Posttraumatic Stress Disorder
This study is being conducted to determine if losartan, an angiotensin receptor blocker (ARB), is safe and effective in the treatment of posttraumatic stress disorder (PTSD) symptoms.
- Trial name
- LOSe-PTSD (NCT02709018)
- Testing
- losartan
- Where
- 6 sites in United States
- Volunteers
- 149 people
- Sponsor
- University of California, San Diego
Posttraumatic Stress Disorder (PTSD)
Oxytocin and Affect Processing in Posttraumatic Stress Disorder
The investigators will use multiple methods (including Oxytocin intranasal inhalation, neuroimaging, behavioral measures, peripheral hormone measurements) to examine how individuals' behavior, cognition, and brain function is…
- Trial name
- NCT02546570
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Yale University
Stress Disorder - Post-traumatic (Acute)
Prevention of Post-traumatic Stress Disorder by Telephone Based Cognitive Behavioral Therapy
This is a randomized controlled study comparing telephone-based cognitive behavioral therapy (CBT) for recent survivors of traumatic events with Acute Stress Disorder (ASD) or acute PTSD with a waitlist control group.
- Trial name
- NCT00889005
- Testing
- Telephone Based Cognitive Behavioral Therapy
- Where
- Israel
- Volunteers
- 139 people
- Sponsor
- Hadassah Medical Organization
PTSD
Implementing PTSD Treatment in FQHCs for Michigan Medicaid Enrollees
The purpose of this project is to expand access to trauma-focused treatment among Medicaid Enrollees with PTSD, thereby improving the quality of mental health services delivered to this population.
- Trial name
- PE-PC Pilot (NCT03711266)
- Testing
- PE-PC
- Where
- 2 sites in United States
- Volunteers
- 35 people
- Sponsor
- University of Michigan
Guilt, Shame
Trauma Informed Guilt Reduction Therapy
The goal of this project is to determine if a 6-session psychotherapy intervention will help Veterans feel less deployment-related guilt and less distress related to their guilt.
- Conditions
- Guilt, Shame, Post-traumatic Stress Disorders
- Trial name
- TrIGR (NCT02512445)
- Testing
- Trauma Informed Guilt Reduction Therapy, Supportive Care Therapy
- Where
- 3 sites in United States
- Volunteers
- 145 people
- Sponsor
- Veterans Medical Research Foundation
Posttraumatic Stress Disorder
A Self-Management Program for Completers of Trauma-Focused Therapy for PTSD
Veterans who complete trauma-focused therapies (TFTs) report improvements in posttraumatic stress disorder symptoms, quality of life, and social and role functioning.
- Trial name
- EMPOwER (NCT03225859)
- Testing
- Self-Management Program
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- VA Office of Research and Development
Pain, Stress Disorders, Post-Traumatic
Evaluating an eHealth Solution for Screening in Pediatric Care
This study will evaluate the predictive validity of a game-based screening system based on child self-report measures. The core study hypotheses are that (1) in-game assessments will predict problematic recovery (child pain and…
- Trial name
- NCT04506294
- Testing
- eScreen system
- Where
- 2 sites in United States
- Volunteers
- 320 people
- Sponsor
- Children's Hospital of Philadelphia
PTSD, Addiction
N-acetylcysteine in the Treatment of PTSD and Addiction
Examine the effects of N-acetylcysteine on PTSD symptoms, craving and substance use in veterans with PTSD and comorbid substance use disorders.
- Trial name
- NAC (NCT02499029)
- Testing
- N-acetylcysteine
- Volunteers
- 35 people
- Sponsor
- Medical University of South Carolina
Post Traumatic Stress Disorder (PTSD), Addiction
Clinical Trial for Alcohol Use Disorder and Post Traumatic Stress Disorder (PTSD)
This is a randomized controlled Phase II clinical trial designed to evaluate the effects of N-acetylcysteine (NAC) in reducing Alcohol Use Disorder (AUD) severity and Post Traumatic Stress Disorder (PTSD) symptomatology among…
- Conditions
- Post Traumatic Stress Disorder (PTSD), Addiction, Alcohol Abuse
- Trial name
- NCT02966873
- Testing
- N-Acetylcysteine (NAC) Treatment, Cognitive Behavioral Therapy (CBT), Functional magnetic resonance imaging (fMRI)
- Where
- 2 sites in United States
- Volunteers
- 182 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
PTSD
12-Week Open-Label Extension Study of TNX-102 SL in PTSD Patients
This is an open-label, extension trial designed to evaluate safety over 12 additional weeks of TNX-102 SL therapy taken daily at bedtime for the treatment of PTSD.
- Trial name
- NCT03110575
- Testing
- TNX-102 SL
- Where
- 32 sites in United States
- Volunteers
- 190 people
- Sponsor
- Tonix Pharmaceuticals, Inc.
Stress Disorders, Post-Traumatic, Depression
A School Program for Children Exposed to Violence
This study will develop a program to help school children deal with violence-related trauma.
- Trial name
- NCT00260195
- Testing
- School-based cognitive behavioral support group
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- RAND
Psychological Distress, Depression
Mobile Mindfulness to Improve Psychological Distress After Critical Illness
Many survivors of the intensive care unit (ICU) suffer from persistent symptoms of depression, anxiety, and post-traumatic stress disorder (PTSD).
- Conditions
- Psychological Distress, Depression, Anxiety, Post-traumatic Stress Disorder
- Trial name
- NCT02701361
- Testing
- mobile mindfulness, standard mindfulness, education
- Where
- 2 sites in United States
- Volunteers
- 90 people
- Sponsor
- Duke University