Clinical trials: Post Transplant Diabetes Mellitus
New Onset Diabetes After Transplantation
Continuous Glucose Monitoring in Peri-operative Period in Kidney Transplant Recipients
his study aims to utilize Continuous Glucose Monitoring (CGM) to observe glucose fluctuations in kidney transplant recipients and predict New-Onset Diabetes After Transplantation (NODAT) based on these patterns.
- Trial name
- NCT06012799
- Testing
- continuous glucose monitoring
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Seoul National University Hospital
Diabetes, Renal Failure
MR-Evaluation of Renal Function-After-Pancreas-transplantation
The purpose of this study is to evaluate the beneficial effect of pancreas transplantation for long term kidney function in patients undergoing single-pancreas transplantation.
- Conditions
- Diabetes, Renal Failure, Pancreas Transplantation
- Trial name
- MERFAP (NCT01537445)
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Uppsala University
Kidney Transplantation, Pancreas Transplantation
PK Study in Diabetic Transplant récipients : From Twice-daily Tacrolimus to Once-daily Extended-release Tacrolimus
The investigators believe that the pharmacological properties of Envarsus®, well studied in kidney transplantation, may be also suitable after simultaneous kidney and pancreas transplantation than Prograf.
- Conditions
- Kidney Transplantation, Pancreas Transplantation, Diabetes
- Trial name
- SPK-PK (NCT04496401)
- Testing
- Tacrolimus and Tacrolimus Extended Release Oral Tablet [Envarsus]
- Where
- France
- Volunteers
- 25 people
- Sponsor
- Nantes University Hospital
Diabetes, Liver Transplant; Complications
Optimal A1c Control in Post Liver or Combined Liver and Kidney Transplant Recipients Who Have Diabetes Mellitus
Major cardiovascular events are greatest in liver transplant recipients with sustained post-transplantation diabetes1. However, the optimal A1c target after transplantation has not been studied.
- Conditions
- Diabetes, Liver Transplant; Complications, Kidney Transplant Failure
- Trial name
- NCT04216303
- Testing
- hemoglobin A1c
- Where
- United States
- Sponsor
- Methodist Health System
Hyperglycemia
Sensor-Augmented Insulin-Pump Therapy in New-onset Diabetes After Transplantation
The SAPT-NODAT study will test the hypotheses that intensive subcutaneous insulin treatment with short acting insulin, applied continuously through an insulin pump, (i) improves glycemic control, (ii) reduces the prevalence of…
- Trial name
- SAPT-NODAT (NCT01680185)
- Testing
- Insulin lispro, Humalog (Eli Lilly) in insulin pump, Human insulin isophane, Humulin N (Eli Lilly), Standard of care
- Where
- Austria
- Volunteers
- 85 people
- Sponsor
- Medical University of Vienna
Liver Transplant, Post Transplant Diabetes
Liver Transplant CGM
This investigator initiated study aims to describe continuous glucose monitoring (CGM) based glycemic metrics after discharge from liver transplant and assess relationship with glycemic metrics and liver transplant outcomes.
- Conditions
- Liver Transplant, Post Transplant Diabetes, Type 2 Diabetes
- Trial name
- NCT07216508
- Testing
- Libre 3+
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Diabetes Mellitus
Islet After Kidney Transplantation (IAK) in Patients With Type 1 Diabetes
The purpose of this study is to determine the safety of islet transplantation in patients with type 1 diabetes who have had a successful kidney transplant and have been maintained for at least three months on anti-rejection…
- Trial name
- NCT00708604
- Testing
- Islet Transplantation, Islet cell transplantation
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- City of Hope Medical Center
Pancreatitis, Chronic; Diabetes; Transplant
Anti-inflammatory Therapy to Improve Outcomes After TPIAT
Patients with severe chronic pancreatitis may be candidates to have their pancreas removed and their islets transplanted into the liver to reduce the risk of diabetes mellitus, a procedure called total pancreatectomy with islet…
- Trial name
- NCT02713997
- Testing
- etanercept, Alpha 1-Antitrypsin
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- University of Minnesota
Acute Cellular Graft Rejection, New Onset Diabetes After Transplant
Budesonide for Liver Transplant Immune Suppression
This is a pilot study that investigates the efficacy and safety of budesonide as an immune suppressing agent for liver transplant recipients in the early post-transplant period.
- Trial name
- NCT03304626
- Testing
- Budesonide 3Mg Capsule, Standard of Care Prednisone
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Cincinnati
de Novo Kidney Transplantation
Study to Evaluate the Safety and Efficacy of Advagraf vs Prograf in Kidney Transplantation Patients 1 Month After the Transplantation
To investigate the efficacy, safety, and drug compliance of Advagraf® (Extended Release Tacrolimus) by comparing the Advagraf® + steroid + Mycophenolate Mofetil combined therapy and the Prograf® + steroid + Mycophenolate Mofetil…
- Trial name
- AdProCISE (NCT01742624)
- Testing
- Advagraf, Prograf, Corticosteroid
- Where
- 3 sites in South Korea
- Volunteers
- 60 people
- Sponsor
- Astellas Pharma Korea, Inc.
Diabetes Mellitus
Comparison of Insulin Therapy in Treating Post-Transplant Diabetes
To determine if the use of insulin isophane results in improved control of blood sugars compared to the use of insulin glargine in new onset diabetes after kidney, lung, or heart transplantation (NODAT).
- Trial name
- NCT01963728
- Testing
- Insulin, Isophane, insulin glargine
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Inova Health Care Services
Type 1 Diabetes (T1D), Islet Transplantation
Extended Follow-Up After Islet Transplantation in T1D
The purpose of this study is to provide patients who have received at least one islet transplant as a previous participant in a Clinical Islet Transplantation Consortium (CIT) clinical trial with maintenance immunosuppressive…
- Trial name
- NCT01369082
- Testing
- Maintenance Immunosuppressive Treatment
- Where
- 8 sites in United States
- Volunteers
- 75 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Kidney Transplant
Evaluation of Cyclosporine Microemulsion and Tacrolimus on the Rate of New Onset Diabetes Mellitus in Kidney Transplantation Recipients
The purpose of this study is to evaluate the impact of tacrolimus and cyclosporine microemulsion on glucose metabolism in kidney transplant recipients and the efficacy and safety in preventing organ rejection
- Trial name
- NCT00171496
- Testing
- Cyclosporine microemulsion, Tacrolimus
- Volunteers
- 693 people
- Sponsor
- Novartis
Diabetes
Comparison of New-onset Diabetes After Transplantation Between Two Steroid Withdrawal Group With CellCept
With improvements in patient and graft survival, increasing attention has been placed on complications that contribute to long-term patient morbidity and mortality.
- Trial name
- NODAT (NCT02095418)
- Testing
- Mycophenolate mofetil, Corticosteroids, Corticosteroids, Mycophenolate mofetil
- Where
- 5 sites in South Korea
- Volunteers
- 152 people
- Sponsor
- Samsung Medical Center
Diabetes Mellitus
Trial of Steroid Avoidance and Low-dose CNI by ATG-induction in Renal Transplantation
Balancing immunosuppressive treatment in organ transplantation in order to achieve effective prevention of rejection on one side and avoidance of negative side effects on the other side is a major challenge, leading to developing…
- Trial name
- SAILOR (NCT02083991)
- Testing
- Steroid-free low TAC-arm: Thymoglobulin Standard low-TAC arm: Simulect, prednisolon
- Where
- Sweden
- Volunteers
- 224 people
- Sponsor
- Vastra Gotaland Region
Renal Transplant Recipients, Posttransplant Diabetes Mellitus
Efficacy and Safety of Nateglinide Treatment in Renal Transplant Recipients
The objective of the present study is to evaluate both the efficacy and safet of nateglinide in renal transplanta recipients with posttransplant diabetes mellitus or impaired glucose tolerance.
- Conditions
- Renal Transplant Recipients, Posttransplant Diabetes Mellitus, Posttransplant Impaired Glucose Tolerance
- Trial name
- NCT00319189
- Testing
- Nateglinide
- Where
- Norway
- Volunteers
- 15 people
- Sponsor
- University of Oslo School of Pharmacy
Diabetes Mellitus, Cancer
Finding the Cause for Post-Transplant Diabetes Mellitus After Allogeneic Hematopoietic Cell Transplant
This clinical research studies the physiology and immunology of new-onset post-transplant diabetes mellitus in patients undergoing allogeneic stem cell transplantation.
- Trial name
- NCT03415139
- Testing
- Oral Glucose Tolerance Test (OGTT), 2 OGTTs with and without GLP-1 analogue, Hyperglycemic clamp procedure
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
Type 1 Diabetes
Incretin Effect and Use After Clinical Islet Transplantation
We aim to study if the administration of medications to increase the secretion of hormones from the intestines can improve glycemic control, reduce insulin use and promote β-cell regeneration/expansion in subjects with type 1…
- Trial name
- NCT00768651
- Testing
- Pantoprazole, Sitagliptin
- Where
- Canada
- Volunteers
- 8 people
- Sponsor
- University of Alberta
Disorder Related to Renal Transplantation, Diabetes
Prevention of Diabetes After Transplantation by Vildagliptin in the Early Post-transplant Period
Post-transplant diabetes affects 15 to 20% of renal transplant patients and contributes to increased morbidity and reduced survival of transplants and patients.
- Trial name
- PRODIG (NCT02849899)
- Testing
- Vildagliptin
- Where
- France
- Volunteers
- 47 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Diabetes Mellitus
Use of Campath for Induction and Maintenance Therapy in Pancreas After Kidney Transplantation
This is a single center, prospective, open-label, randomized trial at the University of Minnesota Medical Center,Fairview. Primary objectives are to determine if rejection episodes and loss rates, graft survival, level of renal…
- Trial name
- NCT00177138
- Testing
- Tacrolimus, Alemtuzumab
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Minnesota