Clinical trials: Polypharmacy
Polypharmacy (Individuals Treated With 4 or More Medications)
THE EFFECTS OF MULTIPLE DRUG USE ON BALANCE, FALL RISK, AND COGNITIVE STATUS
This study aims to evaluate the effects of polypharmacy on balance, fall risk, cognitive status, vestibular function, and hearing among individuals living in nursing homes.
- Trial name
- NCT07816276
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Polypharmacy, Incontinence
An Intervention Study to Reduce the Use and Impact of Potentially Inappropriate Medications Among Older Adults
An educational intervention targeting community-dwelling older adults will lead to a reduction in potentially inappropriate prescriptions (e.g. benzodiazepines, oxybutynin).
- Conditions
- Polypharmacy, Incontinence, Insomnia, Anxiety
- Trial name
- NCT01148186
- Testing
- knowledge transfer tool
- Where
- Canada
- Volunteers
- 300 people
- Sponsor
- Centre de Recherche de l'Institut Universitaire de Geriatrie de Montreal
COVID, Drug Effect
Simulation of Risk of Adverse Drug Events Associated With the Initiation of Drugs Repurposed for the Treatment of COVID-19 in Frail Elderly Adults With Polypharmacy
This retrospective study aims to perform a medication risk stratification using drug claims data and to simulate the impact of the addition of various repurposed drugs on the Medication Risk Score (MRS) in elderly people enrolled…
- Conditions
- COVID, Drug Effect, Drug Interaction, Adverse Drug Event
- Trial name
- NCT04339634
- Testing
- Simulation of Repurposed Drugs for COVID-19
- Where
- United States
- Volunteers
- 12,873 people
- Sponsor
- Tabula Rasa HealthCare
Frail Elderly Syndrome
Subjective Factors of Polymedication in the Elderly: a Qualitative Study of the Perceptions of Patients, Relatives and Referent Physicians.(DOSAGE)
The DOSAGE Study is a qualitative transversal study aiming to describe and understand the subjective factors of polymedication in the elderly population (75 years old and more), defined as 10 simultaneous drugs.
- Trial name
- DOSAGE (NCT03309228)
- Testing
- individual interviews
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Fall, Fall Injury
A Clinical Decision Support System and Patient Portal for Preventing Medication-related Falls in Older Patients
Falls in older adults represents a growing public health challenge. The use of certain medication is recognized as an important modifiable risk factor for falls.
- Conditions
- Fall, Fall Injury, Fall Patients, Accidental Fall
- Trial name
- ADFICE_IT (NCT05449470)
- Testing
- CDSS, Patient Portal
- Where
- 10 sites in Netherlands
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Polypharmacy
Rationalisation of Polypharmacy by the RASP-instrument and Discharge Counselling of Geriatric Inpatients
Systematic evaluation of polypharmacy in geriatric patients, through a validated list by a clinical pharmacist. The goal is reduction of potentially inappropriate medications (PIMs).
- Trial name
- NCT05816967
- Testing
- Medication review and discharge counseling
- Where
- Belgium
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Adverse Drug Event
Reducing Post-discharge Adverse Drug Events Amongst the Elderly: a Multi-centre Electronic Deprescribing Intervention
Reducing medications and associated side effects in older adults: an electronic hospital-based intervention
- Trial name
- NCT03272607
- Testing
- Deprescribing opportunities
- Where
- 7 sites in Canada
- Volunteers
- 6,582 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Multiple Chronic Conditions, End Stage Disease
Optimising Drug Therapy in Polymedicated Patients According to the Person-centered Care Model
Introduction: In recent years, multi-aging has increased by 25%. This is related to plutipatology, frailty, polymedications, elevated sanitary cost, low quality of life, adverse events and mortality.
- Trial name
- NCT04188470
- Testing
- person-centered care model
- Where
- 2 sites in Spain
- Volunteers
- 208 people
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
Polypharmacy
Reducing High-Risk Geriatric Polypharmacy Via EHR Nudges R01 Trial
High-risk polypharmacy is common among older adults in the United States, is particularly dangerous for individuals with dementia or cognitive impairment, and is associated with harms such as adverse drug reactions, falls, and…
- Trial name
- HRPP (NCT05656560)
- Testing
- Clinical decision support (CDS)-Commitment nudge, Clinician education, Clinical decision support (CDS)-Justification nudge
- Where
- 2 sites in United States
- Volunteers
- 786 people
- Sponsor
- Northwestern University
Chronic Disease
Prioritising and Optimising Multi-medication in Multimorbidity
Objective: To investigate whether the complex intervention will improve the appropriateness of prescriptions in elderly multi-morbid patients with multi-medication in general practices.
- Trial name
- PRIMUM (NCT01171339)
- Testing
- Optimization strategy (complex intervention)
- Where
- Germany
- Volunteers
- 505 people
- Sponsor
- Goethe University
Schizophrenia, Schizoaffective Disorder
Comparison of Antipsychotic Combination Treatment of Olanzapine and Amisulpride to Monotherapy
A study to examine whether an antipsychotic combination treatment of olanzapine and amisulpride is more effective than olanzapine and amisulpride alone.
- Trial name
- COMBINE (NCT01609153)
- Testing
- Olanzapine, Amisulpride, Olanzapine and Amisulpride
- Where
- 21 sites in Germany
- Volunteers
- 328 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Medication Review, Polypharmacy
Medication Review in Chronic Complex or Polymedicated Patients After Hospital Discharge.
The goal of this prospective multicentre clustered randomized controlled trial is to evaluate the effect on new hospitalization episodes of a multidisciplinary medication review in primary care patients with polypharmacy or…
- Conditions
- Medication Review, Polypharmacy, Disease, Chronic
- Trial name
- NCT05799430
- Testing
- Multidisciplinary medication review, Control group
- Where
- Spain
- Volunteers
- 372 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Metabolic Syndrome
Pomegranate Consumption by Poly-medicated Metabolic Syndrome Patients
The objective is to evaluate whether the medication in polymedicated metabolic syndrome patients could determine the effects of a pomegranate extract on i) metabolic markers, ii) inflammatory markers, and iii) the modulation of…
- Trial name
- NCT04075032
- Testing
- Pomegranate extract
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- National Research Council, Spain
Comorbidity, Medication Therapy Management
Team Approach to Polypharmacy Evaluation and Reduction
In an aging population, most seniors suffer from multiple chronic conditions. When the number of medications taken is ≥5 (polypharmacy), the burden of taking so many together can do more harm than good.
- Trial name
- TAPER (NCT02562352)
- Testing
- TAPER program
- Where
- Canada
- Volunteers
- 38 people
- Sponsor
- McMaster University
Primary Open Angle Glaucoma, Open Angle Glaucoma
Safety and Effectiveness of Minimally Invasive Micro Sclerostomy (MIMS®) to Reduce Intraocular Pressure in Open-Angle Glaucoma Which is Not Controlled Despite Polypharmacy
The goal of this clinical trial is to show non-inferiority of the MIMS® device/procedure with Mitomycin-C, in terms of its surgical success rate, compared to trabeculectomy with Mitomycin-C in subjects diagnosed with primary open…
- Trial name
- NCT06313749
- Testing
- Minimally Invasive Micro Sclerostomy Device
- Where
- United States
- Volunteers
- 129 people
- Sponsor
- Sanoculis Ltd
Polypharmacy
Development & Pilot of the Technology-Enabled Alliance for Medication Therapy Management
The investigators will link community pharmacy and primary care practices via a shared electronic health record to improve medication therapy management for older patients taking complex prescription (Rx) regimens.
- Trial name
- TEAM (NCT04575155)
- Testing
- TEAM Strategy
- Where
- United States
- Volunteers
- 119 people
- Sponsor
- Northwestern University
Chronic Lower Back Pain (CLBP)
Mechanistic Evaluation of Polypharmacy Effects for Pain
This is a single-group, within-subject, double-blind, double-dummy, placebo-controlled study evaluating whether gabapentin (Neurontin) changes the analgesic, safety, and subjective effects of the opioid hydromorphone (Dilaudid)…
- Trial name
- PAT (NCT07846020)
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- University of Maryland, Baltimore
Chronic Heart Failure With Reduced and Mildly Reduced Ejection Fraction (HFrEF and HFmrEF)
Polypharmacy, Safety, and Medication Adherence in Patients With Chronic Heart Failure With Reduced and Mildly Reduced Ejection Fraction
This prospective registry study (FARAON) aims to assess the prevalence, structure, safety profile, and dynamics of polypharmacy, as well as its association with medication adherence, quality of life, and clinical outcomes in…
- Trial name
- FARAON (NCT07640854)
- Where
- Russia
- Volunteers
- 130 people
- Sponsor
- National Medical Research Center for Therapy and Preventive Medicine
Polypharmacy, Deprescribing
Effect of Medication Management at Home Via Pharmacy Home Televisits
Older Veterans, particularly those with multiple chronic conditions requiring complex medication regimens, are more susceptible to adverse effects of medications.
- Conditions
- Polypharmacy, Deprescribing, Telemedicine
- Trial name
- NCT04340570
- Testing
- Medication management via televisit to home
- Where
- 2 sites in United States
- Volunteers
- 304 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Polypharmacy, Drug-drug Interactions
Epidemiology of Polipharmacy and Potential Drug-Drug Interactions in Elderly Cardiac Outpatients
As the proportion of elderly population increasing over the last years, polypharmacy and drug-drug interactions (DDI) has been a common health care problem.
- Trial name
- EPIC (NCT03370523)
- Testing
- No intervention is planned in our study
- Where
- Turkey (Türkiye)
- Volunteers
- 5,000 people
- Sponsor
- Muğla Sıtkı Koçman University